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1. 发明申请

US20060019319A1 Methods and apparatuses for conducting assays 有权
公开(公告)号：US20060019319A1
公开(公告)日：2006-01-26
申请号：US11145528
申请日：2005-06-03
申请人： Mark Billadeau , Jeff Debad , Eli Glezer , Jonathan Leland , Charles Wijayawardhana
发明人： Mark Billadeau , Jeff Debad , Eli Glezer , Jonathan Leland , Charles Wijayawardhana
IPC分类号： G01N33/567
CPC分类号： G01N33/543 , G01N33/523 , G01N33/54366 , Y10T436/106664 , Y10T436/117497 , Y10T436/25125 , Y10T436/25375
摘要： Disclosed are methods for conducting assays of samples, such as whole blood, that may contain cells or other particulate matter. Also disclosed are systems, devices, equipment, kits and reagents for use in such methods. One advantage of certain disclosed methods and systems is the ability to rapidly measure the concentration of an analyte of interest in blood plasma from a whole blood sample without blood separation and hematocrit correction.

2. 发明申请

US20060205090A1 Water-soluble conjugates for electrochemical detection 审中-公开
标题翻译：用于电化学检测的水溶性共轭物
公开(公告)号：US20060205090A1
公开(公告)日：2006-09-14
申请号：US11081001
申请日：2005-03-14
申请人： Michael Newton , Charles Wijayawardhana
发明人： Michael Newton , Charles Wijayawardhana
IPC分类号： G01N33/543
CPC分类号： G01N33/5438
摘要： The present invention provides water-soluble conjugates and methods of using them in diagnostic and detection assays. Devices for performing detection and quantitation assays are also provided. In various embodiments the conjugates are useful in immunoassays and later flow assays. The invention provides methods of preparing the conjugates that result in higher yields and higher sensitivities for the assays. The invention also provides water-soluble conjugates utilizing electrochemical signal components capable of detecting analytes with very high sensitivity.
摘要翻译：本发明提供水溶性缀合物及其在诊断和检测测定中的使用方法。还提供了用于进行检测和定量测定的装置。在各种实施方案中，缀合物可用于免疫测定和随后的流式测定。本发明提供了制备结合物的方法，其导致更高的产量和更高的敏感性。本发明还提供使用能够以非常高的灵敏度检测分析物的电化学信号分量的水溶性共轭物。

3. 发明申请

US20060216704A1 Water-soluble conjugates for electrochemical detection 审中-公开
标题翻译：用于电化学检测的水溶性共轭物
公开(公告)号：US20060216704A1
公开(公告)日：2006-09-28
申请号：US11446698
申请日：2006-06-05
申请人： Michael Newton , Charles Wijayawardhana
发明人： Michael Newton , Charles Wijayawardhana
IPC分类号： C12Q1/70 , C12Q1/68 , G01N33/574 , G01N33/53
CPC分类号： G01N33/5438
摘要： The present invention provides methods of detecting the presence or amount of an analyte in a sample. The methods involve contacting a surface coated with a specific binding molecule to the analyte to be detected with the sample, contacting the surface coated with the specific binding molecule to the analyte to be detected with a water-soluble conjugate having at least one carrier component, at least one linking component, at least one electrochemical signal enzyme covalently attached to the carrier component, at least one targeting element for the analyte to be detected, and forming a binding complex of the specific binding molecule coated on the surface, the analyte, and the water-soluble conjugate. The binding complex is contacted with a substrate for an electrochemical signal enzyme to form a product solution, and the presence or absence of analyte in the sample is determined.
摘要翻译：本发明提供了检测样品中分析物的存在或量的方法。所述方法包括使涂覆有特异性结合分子的表面与待检样本的分析物接触，将被特异性结合分子涂覆的表面与待检测的分析物与具有至少一种载体组分的水溶性缀合物接触，共价连接到载体组分的至少一种连接组分，至少一种电化学信号酶，用于待检测分析物的至少一种靶向元件，以及形成包被在表面上的特异性结合分子的结合复合物，分析物和水溶性缀合物。将结合复合物与电化学信号酶的底物接触以形成产物溶液，并测定样品中有无分析物。

4. 发明申请

US20130323542A1 Electrochemical Cell Based on Lithium Technology with Internal Reference Electrode, Process for Its Production and Methods for Simultaneous Monitoring of the Voltage or Impedance of the Anode and the Cathode Thereof 审中-公开
标题翻译：基于具有内参参比电极的锂技术的电化学电池，其生产工艺及同时监测阳极及其阴极的电压或阻抗的方法
公开(公告)号：US20130323542A1
公开(公告)日：2013-12-05
申请号：US13879293
申请日：2011-10-12
申请人： Charles Wijayawardhana , Gerold Neumann , Peter Gulde
发明人： Charles Wijayawardhana , Gerold Neumann , Peter Gulde
IPC分类号： G01R31/36 , H01M10/04 , H01M10/48
CPC分类号： G01R31/382 , H01M4/00 , H01M4/13 , H01M6/5005 , H01M10/04 , H01M10/052 , H01M10/0585 , H01M10/48 , Y10T29/49115
摘要： The present invention is directed to an electrochemical cell based on lithium technology, comprising the following components: a positive electrode containing a cathode material, a separator made of an electrically insulating material, a negative a electrode containing an anode material, the electrodes and the separator having layer or sheet form, a liquid and/or solid ion conductor material for transportation of lithium ions between the positive and the negative electrode, the said components being sealed within a casing, wherein the positive and the negative electrode each comprise an electrically conducting structure extending through a wall of the casing for further electrical connection, characterized in that it further comprises: a reference electrode within the said casing which is electrically insulated from the positive and the negative electrode, the reference electrode having layer or sheet form comprising at least one non-metallic lithium compound, and an electrically conducting structure in layer or sheet form being in electrical contact with the said reference electrode, the electrically conducting structure extending through a wall of the casing for further electrical connection. The invention is further directed to a method for the preparation of this electrochemical cell, to a method for measuring the voltage or the impedance of a cathode and/or of an anode of such an electrochemical cell based on lithium technology, and to driving methods of said cell, decreasing aging phenomena and improving its life duration.
摘要翻译：本发明涉及一种基于锂技术的电化学电池，其包括以下组分：包含阴极材料的正电极，由电绝缘材料制成的隔膜，负极包含阳极材料的电极，电极和隔板具有层或片形式，用于在正电极和负电极之间输送锂离子的液体和/或固体离子导体材料，所述部件被密封在壳体内，其中正极和负极各自包括导电结构延伸穿过所述壳体的壁以进一步电连接，其特征在于，其还包括：所述壳体内的参考电极，其与所述正极和所述负极电绝缘，所述参考电极具有层或片形式，包括至少一个非金属锂化合物和电导管层或片形式的电阻结构与所述参考电极电接触，所述导电结构延伸穿过所述壳体的壁以进一步电连接。本发明还涉及一种用于制备该电化学电池的方法，一种用于测量基于锂技术的这种电化学电池的阴极和/或阳极的电压或阻抗的方法以及驱动方法说细胞，减少衰老现象，提高其寿命。

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