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1. 发明授权

US5316004A Method for vascular impedance measurement 失效
标题翻译：血管阻抗测量方法
公开(公告)号：US5316004A
公开(公告)日：1994-05-31
申请号：US38357
申请日：1993-03-26
申请人： Charles F. Chesney , Stanley M. Finkelstein , Jay N. Cohn
发明人： Charles F. Chesney , Stanley M. Finkelstein , Jay N. Cohn
IPC分类号： A61B5/021 , A61B5/029 , G09B23/28
CPC分类号： A61B5/02007 , A61B5/021 , A61B5/029 , G09B23/28 , Y10S128/92
摘要： A vascular impedance measurement instrument includes a transducer to obtain a digitized arterial blood pressure waveform. The digitized data is used to determine cardiac output, and to subsequently obtain measurements of impedance parameters using the modified Windkessel model of the arterial system. The instrument is used as an aid in diagnosing, treating and monitoring patients with cardiovascular disease.
摘要翻译：血管阻抗测量仪器包括用于获得数字化的动脉血压波形的换能器。数字化数据用于确定心输出量，并随后使用修改的动脉系统的Windkessel模型获得阻抗参数的测量值。该仪器用于诊断，治疗和监测心血管疾病患者的辅助。

2. 发明授权

US06623434B2 Method and instrument to measure vascular impedance 有权
公开(公告)号：US06623434B2
公开(公告)日：2003-09-23
申请号：US09954673
申请日：2001-09-17
申请人： Charles F. Chesney , Stanley M. Finkelstein , Jay N. Cohn
发明人： Charles F. Chesney , Stanley M. Finkelstein , Jay N. Cohn
IPC分类号： A61B5021
CPC分类号： A61B5/02007 , A61B5/021 , A61B5/029 , G06F19/00 , G09B23/28 , Y10S128/92
摘要： A vascular impedance measurement instrument includes a transducer to obtain a digitized arterial blood pressure waveform. The digitized data is used to determine cardiac output, and to subsequently obtain measurements of impedance parameters using the modified Windkessel model of the arterial system. The instrument is used as an aid in diagnosing, treating and monitoring patients with cardiovascular disease.

3. 发明授权

US06290651B1 Vascular impedance measurement instrument 有权
标题翻译：血管阻抗测量仪
公开(公告)号：US06290651B1
公开(公告)日：2001-09-18
申请号：US09545946
申请日：2000-04-10
申请人： Charles F. Chesney , Stanley M. Finkelstein , Jay N. Cohn
发明人： Charles F. Chesney , Stanley M. Finkelstein , Jay N. Cohn
IPC分类号： A61B5021
CPC分类号： A61B5/02007 , A61B5/021 , A61B5/029 , G06F19/00 , G09B23/28 , Y10S128/92
摘要： A vascular impedance measurement instrument includes a transducer to obtain a digitized arterial blood pressure waveform. The digitized data is used to determine cardiac output, and to subsequently obtain measurements of impedance parameters using the modified Windkessel model of the arterial system. The instrument is used as an aid in diagnosing, treating and monitoring patients with cardiovascular disease.
摘要翻译：血管阻抗测量仪器包括用于获得数字化的动脉血压波形的换能器。数字化数据用于确定心输出量，并随后使用修改的动脉系统的Windkessel模型获得阻抗参数的测量值。该仪器用于诊断，治疗和监测心血管疾病患者的辅助。

4. 发明授权

US06629343B1 Method for fabricating a pressure-wave sensor with a leveling support element 失效
标题翻译：用于制造具有调平支撑元件的压力波传感器的方法
公开(公告)号：US06629343B1
公开(公告)日：2003-10-07
申请号：US09693458
申请日：2000-10-20
申请人： Charles F. Chesney , Michael Terry Riggs , Charles A. Lemaire
发明人： Charles F. Chesney , Michael Terry Riggs , Charles A. Lemaire
IPC分类号： H04R1700
CPC分类号： G01L19/142 , A61B5/021 , A61B5/0285 , A61B2562/0247 , A61B2562/12 , G01L9/008 , G01L19/147 , Y10T29/42 , Y10T29/49005 , Y10T29/4913
摘要： A method for fabricating a pressure-waveform sensor with a leveling support element. One embodiment provides a pressure-waveform sensor having a housing, a support element, and a piezoelectric element having a first end secured between the support element and the housing, and a second end in a cantilevered orientation. The support element and the piezoelectric element together form a plurality of support regions to level the piezoelectric element and relative to the housing. In some embodiments, the support element includes a ring having three slots spaced apart on one face of the ring, or one or more support regions formed with a shim having a thickness equal to a thickness of the piezoelectric device, or support regions that are integral to the support element. Another aspect provides a method for fabricating a pressure-waveform sensor. The method includes the steps of forming a housing structure with an inner lip, and supporting a cantilevered piezoelectric element with a support structure such that contact is made with the inner lip at a plurality of points in order to level the piezoelectric element relative to the inner lip.
摘要翻译：一种用于制造具有调平支撑元件的压力波形传感器的方法。一个实施例提供一种具有壳体，支撑元件和压电元件的压力波形传感器，其具有固定在支撑元件和壳体之间的第一端和悬臂取向的第二端。支撑元件和压电元件一起形成多个支撑区域以使压电元件和相对于壳体平坦化。在一些实施例中，支撑元件包括环，该环具有在环的一个表面上间隔开的三个槽，或者一个或多个支撑区域，其形成有厚度等于压电装置的厚度的垫片，或者是积分的支撑区域到支撑元件。另一方面提供一种制造压力波形传感器的方法。该方法包括以下步骤：形成具有内唇的壳体结构，并且支撑具有支撑结构的悬臂式压电元件，使得在多个点处与内唇形成接触，以使压电元件相对于内侧唇。

5. 发明授权

US06544188B1 Apparatus and method for holding and positioning an arterial pulse pressure sensor 失效
标题翻译：用于保持和定位动脉脉压传感器的装置和方法
公开(公告)号：US06544188B1
公开(公告)日：2003-04-08
申请号：US09383783
申请日：1999-08-26
申请人： Charles F. Chesney , Bernard M. Graham , E. Paul Maloney , Dennis J. Morgan , Andrew L. Von Duyke
发明人： Charles F. Chesney , Bernard M. Graham , E. Paul Maloney , Dennis J. Morgan , Andrew L. Von Duyke
IPC分类号： A61B504
CPC分类号： A61B5/411 , A61B5/022 , A61B5/6824
摘要： A method and a sensor holding and positioning device. In one embodiment, the device includes a sensor base having two feet, the base forming a raised bridge between the two feet. The bridge has one or more cross members spanning all or part of the space between the two feet. A sensor suspension including a sensor holder and sensor-height-adjustment mechanism is coupled by a pivot-arm axle to the sensor base, such that the sensor suspension is able to rotate in an arc about the long axis of the axle. In one such embodiment, the device further includes a pressure sensor attached to the sensor holder of the sensor suspension. In another such embodiment, the sensor suspension is able to slide back and forth along a line parallel to the long axis of the axle. Another aspect is a method for positioning a sensor over the radial artery, for example in a human's wrist. Yet another aspect is a pulse-waveform acquisition system. In one embodiment, such a system includes a wrist stabilizer, the stabilizer comprising a first member shaped on a forearm portion to conform to contours of a forearm, shaped on a wrist portion to contours of a wrist, and shaped on a hand portion to the contours of a hand, and forming an angle of approximately 150 degrees between the forearm portion and the hand portion, the stabilizer further including straps for holding the forearm and hand to the stabilizer.
摘要翻译：一种方法和传感器保持定位装置。在一个实施例中，该装置包括具有两个脚的传感器基座，该基座在两个脚之间形成升高的桥。桥梁具有跨越两脚之间的全部或部分空间的一个或多个横梁。包括传感器保持器和传感器高度调节机构的传感器悬架通过枢转臂轴耦合到传感器基座，使得传感器悬架能够围绕轴的长轴线旋转。在一个这样的实施例中，该装置还包括附接到传感器悬架的传感器保持器的压力传感器。在另一个这样的实施例中，传感器悬架能够沿着与轴的长轴平行的线来回滑动。另一方面是用于将传感器定位在桡动脉上的方法，例如在人的手腕中。另一方面是脉冲波形采集系统。在一个实施例中，这种系统包括腕部稳定器，该稳定器包括形成在前臂部分上的第一构件，以与前臂成形的轮廓线形成手腕部分的轮廓，并在手部形成手的轮廓，并且在前臂部分和手部分之间形成大约150度的角度，所述稳定器还包括用于将前臂和手保持在稳定器上的带子。

6. 发明授权

US5211177A Vascular impedance measurement instrument 失效
标题翻译：波形阻抗测量仪器
公开(公告)号：US5211177A
公开(公告)日：1993-05-18
申请号：US635278
申请日：1990-12-28
申请人： Charles F. Chesney , Stanley M. Finkelstein , Jay N. Cohn
发明人： Charles F. Chesney , Stanley M. Finkelstein , Jay N. Cohn
IPC分类号： A61B5/021 , A61B5/029 , G09B23/28
CPC分类号： A61B5/02007 , A61B5/021 , A61B5/029 , G09B23/28 , Y10S128/92
摘要： A vascular impedance measurement instrument includes a transducer to obtain a digitized arterial blood pressure waveform. The digitized data is used to determine cardiac output, and to subsequently obtain measurements of impedance parameters using the modified Windkessel model of the arterial system. The instrument is used as an aid in diagnosing, treating and monitoring patients with cardiovascular disease.
摘要翻译：血管阻抗测量仪器包括用于获得数字化的动脉血压波形的换能器。数字化数据用于确定心输出量，并随后使用修改的动脉系统的Windkessel模型获得阻抗参数的测量值。该仪器用于诊断，治疗和监测心血管疾病患者的辅助。

7. 发明授权

US6159166A Sensor and method for sensing arterial pulse pressure 失效
标题翻译：用于感测动脉脉压的传感器和方法
公开(公告)号：US6159166A
公开(公告)日：2000-12-12
申请号：US45018
申请日：1998-03-20
申请人： Charles F. Chesney , Dennis J. Morgan , Eugene A. O'Rourke , Michael T. Riggs , Fred Randall Thornton
发明人： Charles F. Chesney , Dennis J. Morgan , Eugene A. O'Rourke , Michael T. Riggs , Fred Randall Thornton
IPC分类号： A61B5/021 , A61B7/00 , A61B7/04 , A61B5/02
CPC分类号： A61B7/00 , A61B5/021 , A61B5/02108 , A61B7/045
摘要： A method and a pulse pressure sensor for sensing an arterial pulse pressure waveform. In one embodiment, the pulse pressure sensor includes a housing, a diaphragm, a piezoelectric device, and a self-contained amplifier. The skin-contact diaphragm is attached across a recess or opening in the housing. The piezoelectric device has a first portion mounted in a fixed relationship to the housing and a second portion displacementally coupled to the diaphragm. The solid-state amplifier has a signal input coupled to the piezoelectric device, wherein the piezoelectric device and amplifier together have a frequency response at least including a range from below approximately 0.1 hertz to above approximately 250 hertz. In one such embodiment, the housing and the skin-contact diaphragm of the sensor are stainless steel. In one such embodiment, the diaphragm has a skin-contact surface with a skin-contact dimension of between approximately 0.4 inch and 0.6 inch. In one embodiment, the sensor includes a solid-state amplifier that includes a high-input-impedance MOSFET input stage having an input resistance high enough to provide a frequency response that extends below approximately 0.1 hertz.
摘要翻译：一种用于感测动脉脉压波形的方法和脉搏压力传感器。在一个实施例中，脉冲压力传感器包括外壳，隔膜，压电装置和独立放大器。皮肤接触隔膜穿过外壳中的凹槽或开口。压电装置具有以与壳体成固定关系的方式安装的第一部分和与隔膜成一体的第二部分。固态放大器具有耦合到压电器件的信号输入，其中压电器件和放大器一起具有频率响应，至少包括从低于约0.1赫兹到大约250赫兹的范围。在一个这样的实施例中，传感器的外壳和皮肤接触隔膜是不锈钢。在一个这样的实施例中，隔膜具有皮肤接触表面，皮肤接触尺寸在大约0.4英寸和0.6英寸之间。在一个实施例中，传感器包括固态放大器，其包括高输入阻抗MOSFET输入级，其具有足够高的输入电阻以提供延伸到大约0.1赫兹以下的频率响应。

8. 发明授权

US6132383A Apparatus for holding and positioning an arterial pulse pressure sensor 失效
标题翻译：用于保持和定位动脉脉压传感器的装置
公开(公告)号：US6132383A
公开(公告)日：2000-10-17
申请号：US45449
申请日：1998-03-20
申请人： Charles F. Chesney , Bernard M. Graham , E. Paul Maloney , Dennis J. Morgan , Andrew L. Von Duyke
发明人： Charles F. Chesney , Bernard M. Graham , E. Paul Maloney , Dennis J. Morgan , Andrew L. Von Duyke
IPC分类号： A61B5/022 , A61B5/02
CPC分类号： A61B5/411 , A61B5/022 , A61B5/6824
摘要： A sensor holding and positioning device. In one embodiment, the device includes a sensor base having two feet, the base forming a raised bridge between the two feet. The bridge has one or more cross members spanning all or part of the space between the two feet. A sensor suspension including a sensor holder and sensor-height-adjustment mechanism is coupled by a pivot-arm axle to the sensor base, such that the sensor suspension is able to rotate in an arc about the long axis of the axle. In one such embodiment, the device further includes a pressure sensor attached to the sensor holder of the sensor suspension. In another such embodiment, the sensor suspension is able to slide back and forth along a line parallel to the long axis of the axle. Another aspect is for positioning the sensor over the radial artery, for example in a human's wrist. Yet another aspect is a pulse-waveform acquisition system. In one embodiment, such a system includes a wrist stabilizer, the stabilizer comprising a first member shaped on a forearm portion to conform to contours of a forearm, shaped on a wrist portion to contours of a wrist, and shaped on a hand portion to the contours of a hand, and forming an angle of approximately 150 degrees between the forearm portion and the hand portion, the stabilizer further including straps for holding the forearm and hand to the stabilizer.
摘要翻译：传感器保持定位装置。在一个实施例中，该装置包括具有两个脚的传感器基座，该基座在两个脚之间形成升高的桥。桥梁具有跨越两脚之间的全部或部分空间的一个或多个横梁。包括传感器保持器和传感器高度调节机构的传感器悬架通过枢转臂轴耦合到传感器基座，使得传感器悬架能够围绕轴的长轴线旋转。在一个这样的实施例中，该装置还包括附接到传感器悬架的传感器保持器的压力传感器。在另一个这样的实施例中，传感器悬架能够沿着与轴的长轴平行的线来回滑动。另一方面是将传感器定位在桡动脉上，例如在人的手腕上。另一方面是脉冲波形采集系统。在一个实施例中，这种系统包括腕部稳定器，该稳定器包括形成在前臂部分上的第一构件，以与前臂成形的轮廓线形成手腕部分的轮廓，并在手部形成手的轮廓，并且在前臂部分和手部分之间形成大约150度的角度，所述稳定器还包括用于将前臂和手保持在稳定器上的带子。

9. 发明授权

US6048318A Vascular impedance measurement instrument 有权
标题翻译：血管阻抗测量仪
公开(公告)号：US6048318A
公开(公告)日：2000-04-11
申请号：US237444
申请日：1999-01-26
申请人： Charles F. Chesney , Stanley M. Finkelstein , Jay N. Cohn
发明人： Charles F. Chesney , Stanley M. Finkelstein , Jay N. Cohn
IPC分类号： A61B5/021 , A61B5/029 , G09B23/28
CPC分类号： A61B5/02007 , A61B5/021 , A61B5/029 , G09B23/28 , Y10S128/92
摘要： A vascular impedance measurement instrument includes a transducer to obtain a digitized arterial blood pressure waveform. The digitized data is used to determine cardiac output, and to subsequently obtain measurements of impedance parameters using the modified Windkessel model of the arterial system. The instrument is used as an aid in diagnosing, treating and monitoring patients with cardiovascular disease.
摘要翻译：血管阻抗测量仪器包括用于获得数字化的动脉血压波形的换能器。数字化数据用于确定心输出量，并随后使用修改的动脉系统的Windkessel模型获得阻抗参数的测量值。该仪器用于诊断，治疗和监测心血管疾病患者的辅助。

10. 发明授权

US5876347A Method for vascular impedance measurement 失效
标题翻译：血管阻抗测量方法
公开(公告)号：US5876347A
公开(公告)日：1999-03-02
申请号：US935568
申请日：1997-09-23
申请人： Charles F. Chesney , Stanley M. Finkelstein , Jay N. Cohn
发明人： Charles F. Chesney , Stanley M. Finkelstein , Jay N. Cohn
IPC分类号： A61B5/021 , A61B5/029 , G09B23/28
CPC分类号： A61B5/02007 , A61B5/021 , A61B5/029 , G09B23/28 , Y10S128/92
摘要： A vascular impedance measurement instrument includes a transducer to obtain a digitized arterial blood pressure waveform. The digitized data is used to determine cardiac output, and to subsequently obtain measurements of impedance parameters using the modified Windkessel model of the arterial system. The instrument is used as an aid in diagnosing, treating and monitoring patients with cardiovascular disease.
摘要翻译：血管阻抗测量仪器包括用于获得数字化的动脉血压波形的换能器。数字化数据用于确定心输出量，并随后使用修改的动脉系统的Windkessel模型获得阻抗参数的测量值。该仪器用于诊断，治疗和监测心血管疾病患者的辅助。

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