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1. 发明申请

US20080171335A1 METHOD FOR PERSONALIZED DIET DESIGN 审中-公开
标题翻译：个性化饮食设计方法
公开(公告)号：US20080171335A1
公开(公告)日：2008-07-17
申请号：US11948099
申请日：2007-11-30
申请人： Jose M. Ordovas , Dolores Corella , Chao-Qiang Lai
发明人： Jose M. Ordovas , Dolores Corella , Chao-Qiang Lai
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/106 , C12Q2600/156 , C12Q2600/172
摘要： The invention provides methods and kits for designing a diet with a desired fat content for an individual in need thereof to allow the individual to, for example, maintain or reduce healthy weight, manage diabetes, for example by managing weight or accommodate a food allergy. The method comprises determining whether the individual carries APOA5 −1131T and/or C allele or both or any allele in chromosome 11 that is in a tight linkage disequilibrium with said-alleles, wherein if the individual is a homozygote for APOA5 −1131T allele or an allele in tight linkage disequilibrium with APOA5 −1131T allele, the designing of a diet comprises reducing a total fat content of the diet below 30% of total calorie intake and/or reducing the amount of monounsaturated fatty acids in the diet under about 11% of total calorie intake. We surprisingly found that these methods and kits apply to both females and males and to a variety of ethnic backgrounds.
摘要翻译：本发明提供了用于为有需要的个体设计具有所需脂肪含量的饮食的方法和试剂盒，以允许个体例如维持或减少健康体重，例如通过控制体重或适应食物过敏来控制糖尿病。该方法包括确定个体是否携带与所述等位基因处于紧密连锁不平衡中的APOA5 -1131T和/或C等位基因或两者或任何等位基因，其中如果个体是APOA5 -1131T等位基因的纯合子或等位基因与APOA5 -1131T等位基因紧密连锁不平衡，饮食的设计包括将膳食中总脂肪含量降低至总卡路里摄入量的30％以下，和/或减少饮食中单不饱和脂肪酸的量约11％总卡路里摄入量我们惊奇地发现，这些方法和试剂盒适用于女性和男性以及各种种族背景。

2. 发明授权

US06495320B1 Even length proportional amplification of nucleic acids 有权
标题翻译：均匀长度比例扩增核酸
公开(公告)号：US06495320B1
公开(公告)日：2002-12-17
申请号：US09358664
申请日：1999-07-21
申请人： David J. Lockhart , Chao-Qiang Lai , Kevin L. Gunderson
发明人： David J. Lockhart , Chao-Qiang Lai , Kevin L. Gunderson
IPC分类号： C12Q168
CPC分类号： C12Q1/6806 , C12Q1/6853 , C12Q2523/107 , C12Q2521/131 , C12Q2521/107
摘要： The even length proportional amplification of nucleic acids can increase the amount of nucleic acids while preserving the relative abundance of the individual nucleic acid species, or portions thereof, in the original sample. An even length proportionally amplified nucleic acid preparation may be analyzed in a gene expression monitoring system, preferably involving a nucleic acid probe array.
摘要翻译：核酸的均匀长度比例扩增可以增加核酸的量，同时保留原始样品中各个核酸种类或其部分的相对丰度。可以在基因表达监测系统中分析均匀长度的成比例扩增的核酸制备物，优选涉及核酸探针阵列。

3. 发明申请

US20090100536A1 Transgenic plants with enhanced agronomic traits 审中-公开
标题翻译：具有增强农学性状的转基因植物
公开(公告)号：US20090100536A1
公开(公告)日：2009-04-16
申请号：US11879785
申请日：2007-07-18
申请人： Thomas Adams , Ameeta K. Agarwa , Jeffrey Ahrens , James A. Ball , Amarjit Basra , Erin Bell , Terry L. Bradshaw , Paul S. Chomet , James H. Crowley , Jill Deikman , Molian Deng , Meghan Donnarummo , Kimberly Faye Zobrist Duff , Stephen Duff , Michael D. Edgerton , Banu Gopalan , Xiaoping He , Mackenzie Heal , Brendan S. Hinchey , Shihshieh Huang , Richard G. Johnson , Vincent Jung , Keith Kretzmer , Lucille B. Laccetti , Chao Qiang Lai , Garrett J. Lee , Michael H. Luethy , Timothy J. Leland , Jingdong Liu , Bin Lu , Adrian A. Lund , Linda L. Madson , Kathleen P. Malloy , Marcus Paul McNabnay , Manchikanti Padmavati , Thomas Ruff , William Start , Daniel Tennessen , Carl P. Urwin , Gabriela Vaduva , K.R. Vidya , Steven Thomas Voss , Christine Voyles , Zhango Xin , Nanfei Xu , Qingzhang Xu , Qiang Zhang , Yajuan Zhao , Li Zhou
发明人： Thomas Adams , Ameeta K. Agarwa , Jeffrey Ahrens , James A. Ball , Amarjit Basra , Erin Bell , Terry L. Bradshaw , Paul S. Chomet , James H. Crowley , Jill Deikman , Molian Deng , Meghan Donnarummo , Kimberly Faye Zobrist Duff , Stephen Duff , Michael D. Edgerton , Banu Gopalan , Xiaoping He , Mackenzie Heal , Brendan S. Hinchey , Shihshieh Huang , Richard G. Johnson , Vincent Jung , Keith Kretzmer , Lucille B. Laccetti , Chao Qiang Lai , Garrett J. Lee , Michael H. Luethy , Timothy J. Leland , Jingdong Liu , Bin Lu , Adrian A. Lund , Linda L. Madson , Kathleen P. Malloy , Marcus Paul McNabnay , Manchikanti Padmavati , Thomas Ruff , William Start , Daniel Tennessen , Carl P. Urwin , Gabriela Vaduva , K.R. Vidya , Steven Thomas Voss , Christine Voyles , Zhango Xin , Nanfei Xu , Qingzhang Xu , Qiang Zhang , Yajuan Zhao , Li Zhou
IPC分类号： A01H1/02 , C12N1/00 , C12N5/00 , A01H5/00
CPC分类号： C12N15/8279 , A01D45/00 , A01N25/34 , A01N31/16 , A01N41/10 , A01N43/40 , A01N43/653 , A01N43/78 , A01N43/80 , A01N55/02 , C07K14/415 , C12N9/0071 , C12N15/8241 , C12N15/8243 , C12N15/8247 , C12N15/8251 , C12N15/8261 , C12N15/8271 , C12N15/8273 , C12N15/8274 , C12N15/8275 , C12Y114/12017 , A01N25/10 , A01N25/02 , A01N2300/00
摘要： This invention provides transgenic plant cells with recombinant DNA for expression of proteins that are useful for imparting enhanced agronomic trait(s) to transgenic crop plants. This invention also provides transgenic plants and progeny seed comprising the transgenic plant cells where the plants are selected for having an enhanced trait selected from the group of traits consisting of enhanced water use efficiency, enhanced cold tolerance, increased yield, enhanced nitrogen use efficiency, enhanced seed protein and enhanced seed oil. Also disclosed are methods for manufacturing transgenic seed and plants with enhanced traits.
摘要翻译：本发明提供具有用于表达蛋白质的重组DNA的转基因植物细胞，其可用于赋予转基因作物植物增强的农艺性状。本发明还提供包含转基因植物细胞的转基因植物和后代种子，其中植物被选择用于具有增强的性状，所述性状选自由增强的水利用效率，增强的耐寒性，增加的产量，增强的氮利用效率，增强的氮利用效率，种子蛋白和增强种子油。还公开了用于制备具有增强特征的转基因种子和植物的方法。

4. 发明申请

US20130074202A1 GENE SEQUENCES AND USES THEREOF IN PLANTS 审中-公开
公开(公告)号：US20130074202A1
公开(公告)日：2013-03-21
申请号：US13470467
申请日：2012-05-14
申请人： Thomas Adams , Ameeta K. Agarwa , Jeffrey Ahrens , James A. Ball , Amarjit Basra , Erin Bell , Terry L. Bradshaw , Paul S. Chomet , James H. Crowley , Jill Deikman , Molian Deng , Meghan Donnarummo , Kimberly Faye Zobrist Duff , Stephen Duff , Michael D. Edgerton , Banu Gopalan , Xiaoping He , Mackenzie Heal , Brendan S. Hinchey , Shihshieh Huang , Richard G. Johnson , Vincent Jung , Keith Kretzmer , Lucille B. Laccetti , Chao Qiang Lai , Garrett J. Lee , Michael H. Luethy , Timothy J. Leland , Jingdong Liu , Bin Lu , Adrian A. Lund , Linda L. Madson , Kathleen P. Malloy , Marcus Paul McNabnay , Manchikanti Padmavati , Thomas Ruff , William Start , Daniel Tennessen , Carl P. Urwin , Gabriela Vaduva , K. R. Vidya , Steven Thomas Voss , Christine Voyles , Zhango Xin , Nanfei Xu , Qingzhang Xu , Qiang Zhang , Yajuan Zhao , Li Zhou
发明人： Thomas Adams , Ameeta K. Agarwa , Jeffrey Ahrens , James A. Ball , Amarjit Basra , Erin Bell , Terry L. Bradshaw , Paul S. Chomet , James H. Crowley , Jill Deikman , Molian Deng , Meghan Donnarummo , Kimberly Faye Zobrist Duff , Stephen Duff , Michael D. Edgerton , Banu Gopalan , Xiaoping He , Mackenzie Heal , Brendan S. Hinchey , Shihshieh Huang , Richard G. Johnson , Vincent Jung , Keith Kretzmer , Lucille B. Laccetti , Chao Qiang Lai , Garrett J. Lee , Michael H. Luethy , Timothy J. Leland , Jingdong Liu , Bin Lu , Adrian A. Lund , Linda L. Madson , Kathleen P. Malloy , Marcus Paul McNabnay , Manchikanti Padmavati , Thomas Ruff , William Start , Daniel Tennessen , Carl P. Urwin , Gabriela Vaduva , K. R. Vidya , Steven Thomas Voss , Christine Voyles , Zhango Xin , Nanfei Xu , Qingzhang Xu , Qiang Zhang , Yajuan Zhao , Li Zhou
IPC分类号： C12N15/82 , A01D45/00
CPC分类号： C12N15/8279 , A01D45/00 , A01N25/34 , A01N31/16 , A01N41/10 , A01N43/40 , A01N43/653 , A01N43/78 , A01N43/80 , A01N55/02 , C07K14/415 , C12N9/0071 , C12N15/8241 , C12N15/8243 , C12N15/8247 , C12N15/8251 , C12N15/8261 , C12N15/8271 , C12N15/8273 , C12N15/8274 , C12N15/8275 , C12Y114/12017 , A01N25/10 , A01N25/02 , A01N2300/00
摘要： This invention provides transgenic plant cells with recombinant DNA for expression of proteins that are useful for imparting enhanced agronomic trait(s) to transgenic crop plants. This invention also provides transgenic plants and progeny seed comprising the transgenic plant cells where the plants are selected for having an enhanced trait selected from the group of traits consisting of enhanced water use efficiency, enhanced cold tolerance, increased yield, enhanced nitrogen use efficiency, enhanced seed protein and enhanced seed oil. Also disclosed are methods for manufacturing transgenic seed and plants with enhanced traits.

5. 发明申请

US20110258734A1 GENE SEQUENCES AND USES THEREOF IN PLANTS 审中-公开
标题翻译：基因序列及其在植物中的应用
公开(公告)号：US20110258734A1
公开(公告)日：2011-10-20
申请号：US13046601
申请日：2011-03-11
申请人： Thomas Adams , Ameeta K. Agarwa , Jeffrey Ahrens , James A. Ball , Amarjit Basra , Erin Bell , Terry L. Bradshaw , Paul S. Chomet , James H. Crowley , Jill Deikman , Molian Deng , Meghan Donnarummo , Kimberly Faye Zobrist Duff , Stephen Duff , Michael D. Edgerton , Banu Gopalan , Xiaoping He , Mackenzie Heal , Brendan S. Hinchey , Shihshieh Huang , Richard G. Johnson , Vincent Jung , Keith Kretzmer , Lucille B. Laccetti , Chao Qiang Lai , Garrett J. Lee , Michael H. Luethy , Timothy J. Leland , Jingdong Liu , Bin Lu , Adrian A. Lund , Linda L. Madson , Kathleen P. Malloy , Marcus Paul McNabnay , Manchikanti Padmavati , Thomas Ruff , William Start , Daniel Tennessen , Carl P. Urwin , Gabriela Vaduva , K.R. Vidya , Steven Thomas Voss , Christine Voyles , Zhango Xin , Nanfei Xu , Qingzhang Xu , Qiang Zhang , Yajuan Zhao , Li Zhou
发明人： Thomas Adams , Ameeta K. Agarwa , Jeffrey Ahrens , James A. Ball , Amarjit Basra , Erin Bell , Terry L. Bradshaw , Paul S. Chomet , James H. Crowley , Jill Deikman , Molian Deng , Meghan Donnarummo , Kimberly Faye Zobrist Duff , Stephen Duff , Michael D. Edgerton , Banu Gopalan , Xiaoping He , Mackenzie Heal , Brendan S. Hinchey , Shihshieh Huang , Richard G. Johnson , Vincent Jung , Keith Kretzmer , Lucille B. Laccetti , Chao Qiang Lai , Garrett J. Lee , Michael H. Luethy , Timothy J. Leland , Jingdong Liu , Bin Lu , Adrian A. Lund , Linda L. Madson , Kathleen P. Malloy , Marcus Paul McNabnay , Manchikanti Padmavati , Thomas Ruff , William Start , Daniel Tennessen , Carl P. Urwin , Gabriela Vaduva , K.R. Vidya , Steven Thomas Voss , Christine Voyles , Zhango Xin , Nanfei Xu , Qingzhang Xu , Qiang Zhang , Yajuan Zhao , Li Zhou
IPC分类号： A01H1/02 , A01D45/00 , A01H5/10 , C12N5/10 , A01H5/00
CPC分类号： C12N15/8279 , A01D45/00 , A01N25/34 , A01N31/16 , A01N41/10 , A01N43/40 , A01N43/653 , A01N43/78 , A01N43/80 , A01N55/02 , C07K14/415 , C12N9/0071 , C12N15/8241 , C12N15/8243 , C12N15/8247 , C12N15/8251 , C12N15/8261 , C12N15/8271 , C12N15/8273 , C12N15/8274 , C12N15/8275 , C12Y114/12017 , A01N25/10 , A01N25/02 , A01N2300/00
摘要： This invention provides transgenic plant cells with recombinant DNA for expression of proteins that are useful for imparting enhanced agronomic trait(s) to transgenic crop plants. This invention also provides transgenic plants and progeny seed comprising the transgenic plant cells where the plants are selected for having an enhanced trait selected from the group of traits consisting of enhanced water use efficiency, enhanced cold tolerance, increased yield, enhanced nitrogen use efficiency, enhanced seed protein and enhanced seed oil. Also disclosed are methods for manufacturing transgenic seed and plants with enhanced traits.
摘要翻译：本发明提供具有用于表达蛋白质的重组DNA的转基因植物细胞，其可用于赋予转基因作物植物增强的农艺性状。本发明还提供包含转基因植物细胞的转基因植物和后代种子，其中植物被选择用于具有增强的性状，所述性状选自由增强的水利用效率，增强的耐寒性，增加的产量，增强的氮利用效率，增强的氮利用效率，种子蛋白和增强种子油。还公开了用于制备具有增强特征的转基因种子和植物的方法。

6. 发明申请

US20060024658A1 Composition and methods for evaluating an organism's response to alcohol or stimulants 审中-公开
标题翻译：评估生物体对酒精或兴奋剂反应的组成和方法
公开(公告)号：US20060024658A1
公开(公告)日：2006-02-02
申请号：US10746794
申请日：2003-12-23
申请人： Michael Miles , Chao-Qiang Lai , David Lockhart
发明人： Michael Miles , Chao-Qiang Lai , David Lockhart
IPC分类号： C12Q1/00 , C12Q1/68
CPC分类号： C12Q1/6809 , C12Q2565/501
摘要： This invention pertains to the identification of genes whose expression levels are altered by chronic exposure of a cell, tissue, or organism to one or more drugs of abuse (e.g. alcohol, stimulants, opiates, etc.). In one embodiment, this invention provides a method of monitoring the response of a cell a drug of abuse. The method involves contacting the cell with the drug of abuse; providing a biological sample comprising the cell; and detecting, in the sample, the expression of one or more genes or ESTs identified herein, where a difference between the expression of one or more of said genes or ESTs in said sample and one or more of said genes or ESTs in a biological sample not contacted with said drug of abuse indicates a response of the cell to the drug of abuse
摘要翻译：本发明涉及通过将细胞，组织或生物体慢性暴露于一种或多种滥用药物（例如酒精，兴奋剂，阿片剂等）来改变其表达水平的基因的鉴定。在一个实施方案中，本发明提供了监测细胞滥用药物的反应的方法。该方法包括使细胞与滥用药物接触; 提供包含细胞的生物样品; 并且在样品中检测本文鉴定的一种或多种基因或EST的表达，其中所述样品中的一种或多种所述基因或EST的表达与生物样品中的所述基因或EST中的一种或多种之间的差异没有与所述滥用药物联系表示细胞对滥用药物的反应

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