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1. 发明专利

PL1924244T3 Kierowany polem magnetycznym transfer substancji czynnej dla terapii aerozolowej 未知
公开(公告)号：PL1924244T3
公开(公告)日：2011-10-31
申请号：PL06791666
申请日：2006-08-25
申请人： DR CARSTEN RUDOLPH
发明人： RUDOLPH CARSTEN , ROSENECKER JOSEPH
IPC分类号： A61K9/00

2. 发明申请

US20120328520A1 CONJUGATE WITH TARGET-FINDING LIGAND AND USE THEREOF 有权
标题翻译：与目标发现配对并结合使用
公开(公告)号：US20120328520A1
公开(公告)日：2012-12-27
申请号：US13518318
申请日：2010-12-21
申请人： Carsten Rudolph , Johannes-Peter Geiger
发明人： Carsten Rudolph , Johannes-Peter Geiger
IPC分类号： A61K9/48 , A61K49/00 , A61K9/127 , A61K38/00 , A61K31/56 , A61K31/191 , A61K48/00 , A61P11/00 , A61K51/04 , A61K31/7088 , B82Y5/00
CPC分类号： A61K47/48038 , A61K9/007 , A61K47/542 , A61K47/549 , A61K47/59 , A61K47/643 , A61K48/0033 , A61K48/0041 , C12N15/88
摘要： Described is a conjugate of agent complex and at least one target-finding ligand, where the agent complex comprises an agent encapsulated by an encapsulation material and where the target-finding ligand is a prostacyclin analog, and the use of the conjugate.
摘要翻译：描述了药物复合物和至少一种靶发现配体的缀合物，其中药物复合物包含由包封材料包封的试剂，其中靶发现配体是前列环素类似物，以及所述缀合物的用途。

3. 发明申请

US20090299127A1 Magnet-Field Controlled Active Substance Transfer for Aerosol Therapy 有权
标题翻译：用于气溶胶治疗的磁场控制活性物质转移
公开(公告)号：US20090299127A1
公开(公告)日：2009-12-03
申请号：US11991535
申请日：2006-08-25
申请人： Carsten Rudolph , Joseph Rosenecker
发明人： Carsten Rudolph , Joseph Rosenecker
IPC分类号： A61K9/12 , A61K31/7088 , A61K38/02 , A61K9/127 , A61K47/02 , A61P11/00 , A61P35/00 , A61N2/10
CPC分类号： A61K9/0078 , A61K9/0009 , A61K9/008 , A61K9/1272 , A61K9/19 , A61K31/337 , A61K31/65 , A61K31/711
摘要： The present invention relates to aerosols containing magnetic particles, wherein the aerosols comprise magnetic particles and a pharmaceutical active agent. The invention furthermore relates to the use of such aerosols containing magnetic particles for directed magnetic field-guided transfer of the active agents contained therein in aerosol therapy.
摘要翻译：本发明涉及含有磁性颗粒的气溶胶，其中气溶胶包括磁性颗粒和药物活性剂。本发明还涉及使用含有磁性颗粒的这种气溶胶用于气溶胶治疗中所含的活性剂的定向磁场引导转移。

4. 发明申请

US20110223049A1 Fuel Pump For Internal Combustion Engines 审中-公开
标题翻译：内燃机燃油泵
公开(公告)号：US20110223049A1
公开(公告)日：2011-09-15
申请号：US13130219
申请日：2009-11-13
申请人： Carsten Rudolph
发明人： Carsten Rudolph
IPC分类号： F04C2/18 , F04C15/00 , F04C29/02
CPC分类号： F04C15/0073 , F02M37/04 , F04C2/18 , F04C15/0076 , F04C2240/20 , F04C2240/60 , F16D1/101 , F16D2001/102
摘要： A fuel pump is disclosed, especially a prefeed pump for feeding aircraft fuel to the high pressure pump, wherein the form-fit connection between the drive shaft (4) and the driven impeller (2) is produced by a regular, convex, triangular polygonal contour having rounded-off lateral faces and corner faces, the drive shaft and the impeller being provided with the polygonal contour. In this manner, the wear resulting from the poor lubricating power of the kerosene-based aircraft fuel can be reduced and the service life of the fuel pump can be increased.
摘要翻译：公开了一种燃料泵，特别是用于将飞机燃料供给高压泵的预制泵，其中驱动轴（4）和从动叶轮（2）之间的形状配合连接由规则的，凸的，三角形的多边形轮廓具有圆形的侧面和角面，驱动轴和叶轮设置有多边形轮廓。以这种方式，可以减少由基于煤油的飞机燃料的不良润滑功率引起的磨损，并且可以提高燃料泵的使用寿命。

5. 发明申请

US20080305038A1 Transport of Nano-and Macromolecular Structures Into Cytoplasm and Nucleus of Cells 审中-公开
标题翻译：纳米和大分子结构转运到细胞质和细胞核中
公开(公告)号：US20080305038A1
公开(公告)日：2008-12-11
申请号：US11816989
申请日：2006-02-15
申请人： Joseph Rosenecker , Carsten Rudolph , Christian Plank , Markus Elfinger
发明人： Joseph Rosenecker , Carsten Rudolph , Christian Plank , Markus Elfinger
IPC分类号： A61K51/00 , C07H21/00 , C07H21/02 , C07H21/04 , C12N9/00 , C07K16/42 , C08G59/00 , C08G73/00 , A61P37/00 , A61P35/04 , A61K31/74 , C08G65/34 , C07K16/00 , A61K39/395 , A61K9/127 , A61K31/7088 , A61K38/43
CPC分类号： A61K47/6911 , A61K47/545
摘要： The present invention refers to novel conjugate molecules and their use or the transport of nano- and macromolecular structures into cells and/or the nucleus. More particularly, the present invention refers to conjugate molecules containing a carrier, preferably thiopyridyl moieties, and a cargo moiety. Thereby, the thiopyridyl moiety is bound to the cargo moiety to act as a carrier, particularly for efficient intracellular and/or intranuclear delivery of drugs, nano-or macromolecular structures, etc. The novel conjugate molecules are provided for the manufacture of a medicament for gene therapy, apoptosis, or for the treatment of diseases such as cancer, autoimmune diseases or infectious diseases.
摘要翻译：本发明涉及新型共轭分子及其在细胞和/或细胞核中的纳米和大分子结构的使用或转运。更具体地，本发明涉及含有载体，优选硫代吡啶基部分和货物部分的缀合物分子。因此，硫代吡啶基部分结合到货物部分以起载体的作用，特别是用于药物的有效细胞内和/或核内递送，纳米或大分子结构等。提供新的共轭分子用于制备用于基因治疗，凋亡或用于治疗诸如癌症，自身免疫性疾病或感染性疾病的疾病。

6. 发明授权

US08871230B2 Conjugate with target-finding ligand and use thereof 有权
标题翻译：与靶标发现配体结合并与其结合
公开(公告)号：US08871230B2
公开(公告)日：2014-10-28
申请号：US13518318
申请日：2010-12-21
申请人： Carsten Rudolph , Johannes-Peter Geiger
发明人： Carsten Rudolph , Johannes-Peter Geiger
IPC分类号： A61K9/00 , A61K9/14 , A61K47/48 , C12N15/88
CPC分类号： A61K47/48038 , A61K9/007 , A61K47/542 , A61K47/549 , A61K47/59 , A61K47/643 , A61K48/0033 , A61K48/0041 , C12N15/88
摘要： Described is a conjugate of agent complex and at least one target-finding ligand, where the agent complex comprises an agent encapsulated by an encapsulation material and where the target-finding ligand is a prostacyclin analog, and the use of the conjugate.
摘要翻译：描述了药物复合物和至少一种靶发现配体的缀合物，其中药物复合物包含由包封材料包封的试剂，其中靶发现配体是前列环素类似物，以及所述缀合物的用途。

7. 发明申请

US20120195936A1 RNA WITH A COMBINATION OF UNMODIFIED AND MODIFIED NUCLEOTIDES FOR PROTEIN EXPRESSION 审中-公开
标题翻译：具有蛋白质表达的未修饰和修饰的核苷酸的组合的RNA
公开(公告)号：US20120195936A1
公开(公告)日：2012-08-02
申请号：US13388140
申请日：2010-07-30
申请人： Carsten Rudolph , Michael Kormann
发明人： Carsten Rudolph , Michael Kormann
IPC分类号： A61K31/7088 , A61K9/00 , A61F2/32 , A61F2/44 , A61F2/38 , C07H21/02 , G01N33/53
CPC分类号： C12N15/11 , A61K38/1816 , A61K48/00 , A61K48/0066 , A61L27/227 , C07K14/505 , C07K14/785 , C12N15/67 , C12N2310/334 , C12N2310/335 , C12N2320/30 , C12N2320/50
摘要： The invention relates to a polyribonucleotide with a sequence that codes a protein or protein fragment, wherein the polyribonucleotide comprises a combination of unmodified and modified nucleotides, wherein 5 to 50% of the uridine nucleotides and 5 to 50% of the cytidin nucleotides are modified uridine nucleotides or modified cytidin nucleotides.
摘要翻译：本发明涉及具有编码蛋白质或蛋白质片段的序列的多核糖核苷酸，其中所述多核糖核苷酸包含未修饰和修饰的核苷酸的组合，其中5至50％的尿苷核苷酸和5至50％的胞苷碱核苷酸是修饰的尿苷核苷酸或经修饰的胞质蛋白核苷酸。

8. 发明申请

US20110220065A1 Common Rail High Pressure Pump 审中-公开
标题翻译：共轨高压泵
公开(公告)号：US20110220065A1
公开(公告)日：2011-09-15
申请号：US13130231
申请日：2009-11-17
申请人： Carsten Rudolph
发明人： Carsten Rudolph
IPC分类号： F02M69/46
CPC分类号： F04B1/0413 , F02M59/102 , F02M59/445 , F02M63/0265 , F02M2200/9038 , F02M2200/9061 , F02M2200/9092 , F04B1/0426 , F04B9/045 , F05C2203/0808 , F05C2251/10 , F05C2253/12
摘要： A common rail high pressure pump for diesel engines operated using aircraft fuel, has an eccentric ring (2) that is disposed in a pump housing (13), shaped in the form of a polygon and driven by an eccentric shaft (1). The pump has pump pistons (8) that can move over the riding surfaces (4) of the eccentric ring and over the contact surface (5) of a tappet plate (3) in the pump cylinders (7) and that is in operative connection with a seating surface (10) of the tappet plate. A thin diamond-like carbon layer (12) is applied onto the previously ground contact surfaces (5) and riding surfaces (4), whereas the uncoated seating surface (10) is designed as a concave bulge. The eccentric ring (2) and the tappet plate (3) have a pre-determined high degree of hardness. Due to the synergistic effects caused by the material hardness and coating and the concave seating surface, the frictional forces are reduced by many times, and the life of the high pressure pump which operates on aircraft fuel is increased by many times.
摘要翻译：用于使用飞行器燃料操作的柴油发动机的共轨高压泵具有设置在泵壳体（13）中的偏心环（2），其形状为多边形并由偏心轴（1）驱动。泵具有能够在偏心环的行进表面（4）上移动并且在泵缸（7）中的挺杆板（3）的接触表面（5）上并且处于操作连接的泵活塞（8）具有挺杆板的座面（10）。将薄的类金刚石碳层（12）施加到预先接地的接触表面（5）和搭接表面（4）上，而未涂覆的座面（10）被设计为凹形凸起。偏心环（2）和挺板（3）具有预定的高硬度。由于材料硬度和涂层以及凹座表面的协同效应，摩擦力减少了很多次，并且对飞机燃料运行的高压泵的寿命增加了很多倍。

9. 发明申请

US20050167633A1 Heat-storage medium II 审中-公开
标题翻译：储热介质II
公开(公告)号：US20050167633A1
公开(公告)日：2005-08-04
申请号：US10513655
申请日：2003-04-16
申请人： Ralf Glausch , Mark Neuschutz , Wolfgang Voight , Carsten Rudolph
发明人： Ralf Glausch , Mark Neuschutz , Wolfgang Voight , Carsten Rudolph
IPC分类号： F24D11/00 , C04B22/08 , C04B40/00 , C09K5/06 , C09K3/18
CPC分类号： C09K5/063 , C04B22/085 , C04B40/0039 , C04B24/04 , C04B2103/0071
摘要： The present invention relates to phase change materials (PCMs) for the storage of thermal energy in the form of phase change heat based on lithium nitrate trihydrate, and to the use thereof.
摘要翻译：本发明涉及用于以基于硝酸锂三水合物的相变热形式储存热能的相变材料（PCM）及其用途。

10. 发明授权

US08567410B2 Magnet-field controlled active substance transfer for aerosol therapy 有权
标题翻译：用于气溶胶治疗的磁场控制活性物质转移
公开(公告)号：US08567410B2
公开(公告)日：2013-10-29
申请号：US11991535
申请日：2006-08-25
申请人： Carsten Rudolph , Joseph Rosenecker
发明人： Carsten Rudolph , Joseph Rosenecker
IPC分类号： A61B19/00
CPC分类号： A61K9/0078 , A61K9/0009 , A61K9/008 , A61K9/1272 , A61K9/19 , A61K31/337 , A61K31/65 , A61K31/711
摘要： The present invention relates to aerosols containing magnetic particles, wherein the aerosols comprise magnetic particles and a pharmaceutical active agent. The invention furthermore relates to the use of such aerosols containing magnetic particles for directed magnetic field-guided transfer of the active agents contained therein in aerosol therapy.
摘要翻译：本发明涉及含有磁性颗粒的气溶胶，其中气溶胶包括磁性颗粒和药物活性剂。本发明还涉及使用含有磁性颗粒的这种气溶胶用于气溶胶治疗中所含的活性剂的定向磁场引导转移。

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