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1. 发明授权

US06218107B1 Compositions and methods for detecting the presence of Mycobacterium kansassii 失效
标题翻译：用于检测堪萨斯分枝杆菌存在的组合物和方法
公开(公告)号：US06218107B1
公开(公告)日：2001-04-17
申请号：US08856963
申请日：1997-05-15
申请人： Steven T. Brentano , Irene Andruszkiewicz , Caroline F. Knott
发明人： Steven T. Brentano , Irene Andruszkiewicz , Caroline F. Knott
IPC分类号： C07H2104
CPC分类号： C12Q1/689
摘要： The featured invention discloses and claims oligonucleotide hybridization assay probes and helper oligonucleotides which are designed to be complementary to specific regions of M. kansasii rRNA or the DNA encoding it, or to an oligonucleotide or nucleic acid comprising, consisting essentially of, or consisting of, a M. kansasii rRNA or rDNA nucleotide sequence. The hybridization probes of the present invention are designed to hybridize to a target nucleic acid in a region of the molecule having a specific target nucleotide sequence under conditions which allow the selective detection of the target nucleic acid. The probes are further designed to detect M. kansasii typical as well as atypical strains. The present invention also discloses and claims double-stranded nucleic acid hybrid molecules formed between the hybridization probes and their specific target nucleic acids.
摘要翻译：本发明公开并要求的是寡核苷酸杂交测定探针和辅助寡核苷酸，其被设计为与堪萨斯堪萨斯大学rRNA或编码它的DNA的特定区域互补，或者涉及包含基本上由...组成或由其构成的寡核苷酸或核酸，堪萨斯大肠杆菌rRNA或rDNA核苷酸序列。本发明的杂交探针被设计为在允许选择性检测靶核酸的条件下与具有特异性靶核苷酸序列的分子区域中的靶核酸杂交。探针进一步设计用于检测典型的堪萨斯（Kansasii）典型菌株和非典型菌株。本发明还公开并要求在杂交探针与其特异性靶核酸之间形成的双链核酸杂交分子。

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