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1. 发明授权

US08043377B2 Implantable intervertebral fusion device 失效
标题翻译：植入式椎间融合器
公开(公告)号：US08043377B2
公开(公告)日：2011-10-25
申请号：US11469851
申请日：2006-09-02
申请人： Richard D. Guyer , Jack E. Zigler , Randall F. Lee , Cameron Clokie
发明人： Richard D. Guyer , Jack E. Zigler , Randall F. Lee , Cameron Clokie
IPC分类号： A61F2/44
CPC分类号： A61F2/4465 , A61F2/28 , A61F2/30771 , A61F2/4611 , A61F2/4644 , A61F2002/2835 , A61F2002/30112 , A61F2002/302 , A61F2002/3082 , A61F2002/30904 , A61F2230/0004 , A61F2230/0065 , A61F2310/00359
摘要： The present invention relates to an implantable intervertebral fusion device for use when surgical fusion of vertebral bodies is indicated. The implant is comprised of bone conforming in size and shape with the end plates of the adjacent vertebrae and has a wedge-shaped profile with a plurality of footings and grooves located on the top and bottom surfaces.
摘要翻译：本发明涉及用于当指示椎体的外科融合时使用的可植入椎间融合装置。植入物由尺寸和形状与相邻椎骨的端板构成的骨组成，并且具有楔形轮廓，其具有位于顶表面和底表面上的多个基脚和凹槽。

2. 发明申请

US20080097610A1 IMPLANTABLE INTERVERTEBRAL FUSION DEVICE 失效
标题翻译：可植入的椎间融合装置
公开(公告)号：US20080097610A1
公开(公告)日：2008-04-24
申请号：US11469851
申请日：2006-09-02
申请人： Richard D. Guyer , Jack E. Zigler , Randall F. Lee , Cameron Clokie
发明人： Richard D. Guyer , Jack E. Zigler , Randall F. Lee , Cameron Clokie
IPC分类号： A61F2/44
CPC分类号： A61F2/4465 , A61F2/28 , A61F2/30771 , A61F2/4611 , A61F2/4644 , A61F2002/2835 , A61F2002/30112 , A61F2002/302 , A61F2002/3082 , A61F2002/30904 , A61F2230/0004 , A61F2230/0065 , A61F2310/00359
摘要： The present invention relates to an implantable intervertebral fusion device for use when surgical fusion of vertebral bodies is indicated. The implant is comprised of bone conforming in size and shape with the end plates of the adjacent vertebrae and has a wedge-shaped profile with a plurality of footings and grooves located on the top and bottom surfaces.
摘要翻译：本发明涉及用于当指示椎体的外科融合时使用的可植入椎间融合装置。植入物由尺寸和形状与相邻椎骨的端板构成的骨组成，并且具有楔形轮廓，其具有位于顶表面和底表面上的多个基脚和凹槽。

3. 发明申请

US20070056050A1 PRODUCTION OF BONE MORPHOGENIC PROTEINS (BMPs) IN TRANSGENIC MAMMALS 审中-公开
标题翻译：在转基因动物中生产骨形态发生蛋白（BMP）
公开(公告)号：US20070056050A1
公开(公告)日：2007-03-08
申请号：US11427679
申请日：2006-06-29
申请人： Cameron Clokie , Jeffrey Turner , Sean Alexander Peel
发明人： Cameron Clokie , Jeffrey Turner , Sean Alexander Peel
IPC分类号： A01K67/027
CPC分类号： C12N15/8509 , A01K67/0275 , A01K2217/05 , A01K2227/102 , A01K2267/01 , C07K14/475 , C07K14/51
摘要： The present invention provides materials and methods for the production of recombinant BMPs in transgenic animals. In particular, the invention provides materials and methods for the production of recombinant BMPs in the milk of transgenic animals that express recombinant BMPs in the mammary gland.
摘要翻译：本发明提供了用于在转基因动物中生产重组BMP的材料和方法。特别地，本发明提供了在乳腺中表达重组BMP的转基因动物的乳中生产重组BMP的材料和方法。

4. 发明申请

US20100100084A1 Hybrid Ultrafast Laser Surgery and Growth Factor Stimulation for Ultra-Precision Surgery with Healing. 审中-公开
标题翻译：混合超快激光手术和生长因子刺激超精密手术治疗。
公开(公告)号：US20100100084A1
公开(公告)日：2010-04-22
申请号：US11989951
申请日：2006-08-03
申请人： Bruno Girard , Cameron Clokie , Brian Campbell Wilson , Robert John Dwayne Miller
发明人： Bruno Girard , Cameron Clokie , Brian Campbell Wilson , Robert John Dwayne Miller
IPC分类号： A61B18/20
CPC分类号： A61B18/20 , A61K38/1875 , B23K26/0624 , B23K2103/32 , B23K2103/50
摘要： The present invention relates to methods for laser surgery and growth factor stimulation for ultra-precision surgery with healing. The method is achieved by cutting biological tissue using an ultrafast laser, which produces laser pulses less than 10 picosecond in duration, to induce a cold ablation process in order to avoid the formation of carbonaceous or other materials that cannot be removed efficiently or completely from the wounded area through natural healing mechanisms. By use of femtosecond lasers, a negligible amount of debris is generated and an outer layer of intact but non viable cells are created principally through shock wave induce damage and ionizing radiation effects induced by multiphoton absorption of ultrashort laser pulses. The normal healing process is blocked by this outer layer of cells as all cell contacts are still intact. Therefore the healing process must be stimulated. The healing may be triggered or accelerated, or both, by application of growth factor molecules and/or signal proteins to the effectively undamaged cells causing the damaged cells to be replaced and the wound to close. The combination of very precise laser cutting used in combination with growth factors is the key to this unique tool.
摘要翻译：本发明涉及用于具有愈合的超精密手术的激光手术和生长因子刺激的方法。该方法通过使用超快激光切割生物组织来实现，该超快激光产生持续时间小于10皮秒的激光脉冲，以诱导冷消融过程，以避免形成不能有效或完全地从受伤区域通过自然愈合机制。通过使用飞秒激光器，产生可忽略量的碎片，并且主要通过冲击波诱发损伤和由超短激光脉冲的多光子吸收引起的电离辐射效应产生完整但不活细胞的外层。正常的愈合过程被这个外层的细胞所阻挡，因为所有细胞接触仍然完整。因此，必须刺激愈合过程。通过将生长因子分子和/或信号蛋白应用于有效的未损伤的细胞，导致损伤的细胞被替换并且伤口闭合，可以触发或加速愈合或两者。与生长因子结合使用的非常精确的激光切割的组合是这种独特工具的关键。

5. 发明申请

US20120265307A1 Implantable Intervertebral Fusion Device 审中-公开
标题翻译：植入式椎间融合器
公开(公告)号：US20120265307A1
公开(公告)日：2012-10-18
申请号：US13248266
申请日：2011-09-29
申请人： Richard D. Guyer , Jack E. Zigler , Randall F. Lee , Cameron Clokie
发明人： Richard D. Guyer , Jack E. Zigler , Randall F. Lee , Cameron Clokie
IPC分类号： A61F2/44
CPC分类号： A61F2/4465 , A61F2/28 , A61F2/30771 , A61F2/4611 , A61F2/4644 , A61F2002/2835 , A61F2002/30112 , A61F2002/302 , A61F2002/3082 , A61F2002/30904 , A61F2230/0004 , A61F2230/0065 , A61F2310/00359
摘要： The present application relates to an implantable intervertebral fusion device for use when surgical fusion of vertebral bodies is indicated. The implant is comprised of bone conforming in size and shape with the end plates of the adjacent vertebrae and has a wedge-shaped profile with a plurality of footings and grooves located on the top and bottom surfaces.
摘要翻译：本申请涉及当指出椎体的手术融合时使用的可植入椎间融合装置。植入物由尺寸和形状与相邻椎骨的端板构成的骨组成，并且具有楔形轮廓，其具有位于顶表面和底表面上的多个基脚和凹槽。

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