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1. 发明申请

WO2005037198A3 PREPARATION OF 1,7-DISUBSTITUTED AZABENZIMIDAZOLES AS KINASE INHIBITORS 审中-公开
标题翻译：作为激酶抑制剂的1,7-取代的AZABENZIMIDAZOLES的制备
公开(公告)号：WO2005037198A3
公开(公告)日：2005-06-09
申请号：PCT/US2004032825
申请日：2004-10-06
申请人： GLAXO GROUP LTD , LEE DENNIS , STAVENGER ROBERT , GOODMAN KRISTA B , HILFIKER MARK A , CUI HAIFENG , MARINO JOSEPH P
发明人： LEE DENNIS , STAVENGER ROBERT , GOODMAN KRISTA B , HILFIKER MARK A , CUI HAIFENG , MARINO JOSEPH P
IPC分类号： A61K20060101 , A61K31/437 , A61K31/444 , A61K31/4545 , A61K31/4725 , A61K31/496 , A61P9/00 , C07D471/04
CPC分类号： C07D471/04
摘要： Novel inhibitors of Rho-kinases are disclosed.
摘要翻译：公开了Rho激酶的新型抑制剂。

2. 发明申请

WO2007051133A2 SUBSTITUTED THIAZOLES AND THEIR USE 审中-公开
标题翻译：取代的噻唑类化合物及其用途
公开(公告)号：WO2007051133A2
公开(公告)日：2007-05-03
申请号：PCT/US2006060248
申请日：2006-10-26
申请人： SMITHKLINE BEECHAM CORP , MARINO JOSEPH P , CUI HAIFENG
发明人： MARINO JOSEPH P , CUI HAIFENG
IPC分类号： A61K31/426
CPC分类号： C07D277/30
摘要： The invention is directed to novel substituted thiazole compounds. Specifically, the invention is directed to compounds according to Formula (I): wherein R1 and R2 are as defined below, and to pharmaceutically-acceptable salts thereof. The compounds are large conductance calcium-activated K channel (BK Ca channel) openers, which can be used in the treatment of urinary conditions, including OAB. Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of treating urinary conditions, such as OAB, using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.
摘要翻译：本发明涉及新的取代的噻唑化合物。具体而言，本发明涉及根据式（I）的化合物：其中R 1和R 2如下定义，并且涉及其药学上可接受的盐。这些化合物是大电导钙激活钾通道（BK _{Ca 通道）开放剂，可用于治疗泌尿疾病，包括OAB。因此，本发明还涉及包含本发明化合物的药物组合物。本发明还涉及使用本发明化合物或包含本发明化合物的药物组合物治疗泌尿疾病例如OAB的方法。}

3. 发明申请

WO2005037197A3 PREPERATION OF 1,6-DISUBSTITUTED AZABENZIMIDAZOLES AS KINASE INHIBITORS 审中-公开
标题翻译： 1,6-二取代亚苄基咪唑作为激酶抑制剂的研制
公开(公告)号：WO2005037197A3
公开(公告)日：2005-06-02
申请号：PCT/US2004032824
申请日：2004-10-06
申请人： GLAXO GROUP LTD , LEE DENNIS , STAVENGER ROBERT A , GOODMAN KRISTA B , HILFIKER MARK A , CUI HAIFENG , VIET ANDREW Q
发明人： LEE DENNIS , STAVENGER ROBERT A , GOODMAN KRISTA B , HILFIKER MARK A , CUI HAIFENG , VIET ANDREW Q
IPC分类号： A61K20060101 , A61K31/437 , A61P9/00 , C07D471/04
CPC分类号： C07D471/04
摘要： Novel inhibitors of Rho-kinases are disclosed.
摘要翻译：公开了新的Rho激酶抑制剂。

4. 发明申请

WO2005046586A3 M3 MUSCARINIC ACETYLCHOLINE RECEPTOR ANTAGONISTS 审中-公开
公开(公告)号：WO2005046586A3
公开(公告)日：2005-05-26
申请号：PCT/US2004/036663
申请日：2004-11-04
申请人： GLAXO GROUP LIMITED , WAN, Zehong , YAN, Hongxing , PALOVICH, Michael, R. , LAINE, Dramane, I. , LEE, Dennis , STAVENGER, Robert, A. , GOODMAN, Krista, B. , HILFIKER, Mark, A. , CUI, Haifeng , VIET, Andrew, W. , MARINO, Joseph, P.
发明人： WAN, Zehong , YAN, Hongxing , PALOVICH, Michael, R. , LAINE, Dramane, I. , LEE, Dennis , STAVENGER, Robert, A. , GOODMAN, Krista, B. , HILFIKER, Mark, A. , CUI, Haifeng , VIET, Andrew, W. , MARINO, Joseph, P.
IPC分类号： A61K31/46
摘要： Muscarinic Acetylcholine receptor antagonists and methods of using them are provided.

5. 发明申请

WO2005037197A2 PREPERATION OF 1,6-DISUBSTITUTED AZABENZIMIDAZOLES AS KINASE INHIBITORS 审中-公开
标题翻译：作为激酶抑制剂的1,6-取代的AZABENZIMIDAZOLES的制备
公开(公告)号：WO2005037197A2
公开(公告)日：2005-04-28
申请号：PCT/US2004/032824
申请日：2004-10-06
申请人： GLAXO GROUP LIMITED , LEE, Dennis , STAVENGER, Robert, A. , GOODMAN, Krista, B. , HILFIKER, Mark, A. , CUI, Haifeng , VIET, Andrew, Q.
发明人： LEE, Dennis , STAVENGER, Robert, A. , GOODMAN, Krista, B. , HILFIKER, Mark, A. , CUI, Haifeng , VIET, Andrew, Q.
IPC分类号： A61K
CPC分类号： C07D471/04
摘要： Novel inhibitors of Rho-kinases are disclosed.
摘要翻译：公开了Rho激酶的新型抑制剂。

6. 发明申请

WO2007051133A3 SUBSTITUTED THIAZOLES AND THEIR USE 审中-公开
公开(公告)号：WO2007051133A3
公开(公告)日：2007-05-03
申请号：PCT/US2006/060248
申请日：2006-10-26
申请人： SMITHKLINE BEECHAM CORPORATION , MARINO, Joseph, P. , CUI, Haifeng
发明人： MARINO, Joseph, P. , CUI, Haifeng
IPC分类号： A61K31/426 , A61K31/03
摘要： The invention is directed to novel substituted thiazole compounds. Specifically, the invention is directed to compounds according to Formula (I): wherein R1 and R2 are as defined below, and to pharmaceutically-acceptable salts thereof. The compounds are large conductance calcium-activated K channel (BK Ca channel) openers, which can be used in the treatment of urinary conditions, including OAB. Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of treating urinary conditions, such as OAB, using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.

7. 发明申请

WO2005037198A2 PREPARATION OF 1,7-DISUBSTITUTED AZABENZIMIDAZOLES AS KINASE INHIBITORS 审中-公开
标题翻译： 1,7-二取代亚苄基咪唑作为激酶抑制剂的制备
公开(公告)号：WO2005037198A2
公开(公告)日：2005-04-28
申请号：PCT/US2004/032825
申请日：2004-10-06
申请人： GLAXO GROUP LIMITED , LEE, Dennis , STAVENGER, Robert , GOODMAN, Krista, B. , HILFIKER, Mark, A. , CUI, Haifeng , MARINO, Joseph, P.
发明人： LEE, Dennis , STAVENGER, Robert , GOODMAN, Krista, B. , HILFIKER, Mark, A. , CUI, Haifeng , MARINO, Joseph, P.
IPC分类号： A61K
CPC分类号： C07D471/04
摘要： Novel inhibitors of Rho-kinases are disclosed.
摘要翻译：公开了Rho激酶的新型抑制剂。

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