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1. 发明申请

WO2009024578A3 DRUG DISPENSER 审中-公开
标题翻译：药物分配器
公开(公告)号：WO2009024578A3
公开(公告)日：2009-04-16
申请号：PCT/EP2008060861
申请日：2008-08-19
申请人： GLAXO GROUP LTD , CROSBY GARY THOMAS
发明人： CROSBY GARY THOMAS
IPC分类号： A61M15/00 , B05B11/00
CPC分类号： A61M11/00 , A61M13/00 , A61M15/0026 , A61M15/0075 , A61M15/009 , A61M2005/2073
摘要： One aspect provides a drug dispenser device (1) comprising a housing (10a, 10b, 12); extending from the housing, an outlet (14) for insertion into a body cavity of a patient; provided to the housing and moveable with respect thereto, a drug discharge device (5) having a longitudinal axis and comprising a container (6) for storing a drug formulation to be dispensed, a discharge mechanism and a discharge channel from the container for discharge of the drug formulation to the outlet; connecting to the container, a container collar (30) connected to the discharge device; connecting to the container collar and moveable with respect thereto along the longitudinal axis of the drug discharge device, a transfer element (40) including an actuating portion (42); provided to the housing, at least one finger operable member (20a, 20b) moveable to apply an actuating force to the actuating portion of the transfer element to move the transfer element from an initial position along the longitudinal axis in a first direction, - provided to the container collar, a pre-load mechanism (34a, 34b) to prevent transfer of the actuating force to the container collar to move the drug discharge device along the longitudinal axis in the first direction to actuate the discharge mechanism until a pre-determined threshold force is overcome; and connecting the container collar with the transfer element, a biasing return mechanism (50a, 50b) acting to bias the transfer element along the longitudinal axis in a second direction to return the transfer element to its initial position.
摘要翻译：一个方面提供了一种药物分配器装置（1），包括壳体（10a，10b，12）; 从所述壳体延伸出用于插入患者体腔的出口（14）; 提供给壳体并且相对于其可移动的药物排出装置（5），具有纵向轴线并包括用于储存待分配的药物制剂的容器（6），排出机构和排出通道，用于从容器排出药物配方到出口处; 连接到所述容器，连接到所述排放装置的容器套环（30）; 连接到所述容器套环并且沿着所述药物排出装置的纵向轴线可相对于所述容器环移动，包括致动部分（42）的传递元件（40）; 提供给壳体的至少一个手指可操作构件（20a，20b）可移动以向传动元件的致动部分施加致动力，以使转移元件沿着第一方向沿着纵向轴线从初始位置移动， - 提供到容器套环，预加载机构（34a，34b），以防止致动力转移到容器套环上，以使药物排出装置沿第一方向的纵向轴线移动，以驱动排放机构，直到预定克服阈值力; 以及将所述容器套环与所述传递元件连接的偏置返回机构（50a，50b），用于沿着所述纵向轴线沿着第二方向偏置所述传递元件，以将所述传递元件返回到其初始位置。

2. 发明申请

WO2008023019A3 DRUG DISPENSER 审中-公开
标题翻译：药物分配器
公开(公告)号：WO2008023019A3
公开(公告)日：2008-05-29
申请号：PCT/EP2007058679
申请日：2007-08-21
申请人： GLAXO GROUP LTD , ANDERSON GREGOR JOHN MCLENNAN , CROSBY GARY THOMAS , KELLY ANDREW MICHAEL , TEUCHER MARK DIGBY , WEST JAMES ANTHONY
发明人： ANDERSON GREGOR JOHN MCLENNAN , CROSBY GARY THOMAS , KELLY ANDREW MICHAEL , TEUCHER MARK DIGBY , WEST JAMES ANTHONY
IPC分类号： B05B11/00 , A61M15/00
CPC分类号： A61M15/009 , A61M15/0025 , A61M15/0075 , A61M15/0081 , A61M15/0096 , A61M2205/276 , A61M2205/8281 , B65D83/16
摘要： There is provided a drug dispenser device (1) comprising a housing (10a, 10b, 12), extending from the housing, an outlet (16) for insertion into a body-cavity of a patient; provided to the housing and moveable with respect thereto, a drug discharge device having a longitudinal axis and comprising a container for storing a drug formulation to be dispensed, a discharge mechanism and a discharge channel from the container for discharge of the drug formulation to the outlet; connecting to the drug discharge device, a container collar; connecting to the container collar and moveable with respect thereto along the longitudinal axis of the drug discharge device, a transfer element, the transfer element including an actuating portion; provided to the housing, at least one finger (20a, 20b) operable member moveable to apply a force to the actuating portion of the transfer element to move the transfer element along the longitudinal axis in a first direction, linking the container collar with the transfer element, a biasing mechanism to store biasing energy on moving the transfer element along the longitudinal axis in the first direction; and provided to the container collar, a pre-load mechanism to prevent transfer of the biasing energy to the container collar to move the drug discharge device along the longitudinal axis in the first direction to actuate the discharge mechanism until a pre-determined threshold force is overcome.
摘要翻译：提供了一种药物分配器装置（1），其包括从壳体延伸的壳体（10a，10b，12），用于插入患者体腔的出口（16）; 提供给壳体并相对于其可移动的药物排出装置，具有纵向轴线并包括用于储存待分配的药物制剂的容器，排出机构和来自容器的排出通道，用于将药物制剂排出到出口 ; 连接到药物排出装置，容器衣领; 连接到所述容器套环并且沿着所述药物排出装置的纵向轴线可相对于其移动;转移元件，所述转移元件包括致动部分; 提供给壳体的至少一个手指（20a，20b）可操作构件可移动以对传递元件的致动部分施加力，以沿第一方向沿着纵向轴线移动传递元件，将容器环与传送件元件，偏置机构，用于在第一方向沿着纵向轴线移动传递元件时存储偏置能量; 并且提供给所述容器套环，所述预加载机构用于防止所述偏置能量转移到所述容器套环，以沿所述纵向轴线沿所述第一方向移动所述药物排出装置，以启动所述排放机构，直到预定的阈值力为克服。

3. 发明申请

WO2008023014A1 ACTUATOR FOR AN INHALER 审中-公开
标题翻译：吸入器的执行器
公开(公告)号：WO2008023014A1
公开(公告)日：2008-02-28
申请号：PCT/EP2007/058670
申请日：2007-08-21
申请人： GLAXO GROUP LIMITED , CROSBY, Gary, Thomas
发明人： CROSBY, Gary, Thomas
IPC分类号： A61M15/00
CPC分类号： A61M15/009 , A61M15/0025 , A61M2206/10 , A61M2210/0618
摘要： An actuator for an inhaler for delivering drug by inhalation, comprising: a housing (11; 111 ) for receiving a canister (5; 106) which comprises a body (7; 107) which includes a base and a head and defines a chamber for containing drug, and a valve stem (8; 108) which extends from the body (7; 107) and from which drug is in use delivered on actuation of the canister (5; 106); and an outlet (13; 105) through which a user in use inhales, wherein the outlet (105) has a substantially closed rear section which partitions the outlet (105) from the housing (111 ), such that, on inhalation through the outlet (105), an air flow is drawn substantially only from an outer peripheral surface of the outlet (105).
摘要翻译：一种用于通过吸入输送药物的吸入器的致动器，包括：用于容纳罐（5; 106）的壳体（11; 111），所述壳体包括主体（7; 107），所述主体包括基部和头部，并且限定用于以及从所述主体（7; 107）延伸并且在所述罐（5; 106）的致动下使用所述药物的药剂的阀杆（8; 108）; 和使用者在其中吸入的出口（13; 105），其中所述出口（105）具有将所述出口（105）与所述壳体（111）分隔开的基本封闭的后部，使得在通过所述出口（105），基本上只从出口（105）的外周面抽出空气流。

4. 发明申请

WO2008110584A3 DRUG DISPENSER 审中-公开
标题翻译：药物分配器
公开(公告)号：WO2008110584A3
公开(公告)日：2008-11-27
申请号：PCT/EP2008052967
申请日：2008-03-12
申请人： GLAXO GROUP LTD , ANDERSON GREGOR JOHN MCLENNAN , CROSBY GARY THOMAS , ELLIMAN DAVID VINCENT , KELLY ANDREW MICHAEL , TEUCHER MARK DIGBY , WEST JAMES ANTHONY
发明人： ANDERSON GREGOR JOHN MCLENNAN , CROSBY GARY THOMAS , ELLIMAN DAVID VINCENT , KELLY ANDREW MICHAEL , TEUCHER MARK DIGBY , WEST JAMES ANTHONY
IPC分类号： A61M15/00
CPC分类号： A61M15/009 , A61M15/0026 , A61M15/0075 , A61M15/0091 , A61M15/0096 , A61M2205/6081 , G06M1/04 , G06M1/083
摘要： One aspect provides a drug dispenser device comprising a housing; extending from the housing, an outlet for insertion into a body cavity of a patient; provided to the housing and moveable with respect thereto, a drug discharge device having a longitudinal axis and comprising a container for storing a drug formulation to be dispensed, a discharge mechanism and a discharge channel from the container for discharge of the drug formulation to the outlet; connecting to the container, a container collar connected to the discharge device; connecting to the container collar and moveable with respect thereto along the longitudinal axis of the drug discharge device, a transfer element, the transfer element including an actuating portion; provided to the housing, at least one finger operable member moveable to apply a force to the actuating portion of the transfer element to move the transfer element along the longitudinal axis in a first direction; linking the container collar with the transfer element, a biasing mechanism to store biasing energy on moving the transfer element along the longitudinal axis in the first direction; an actuation counter; and provided to the container collar, a pre-load mechanism to prevent transfer of the biasing energy to the container collar to both move the drug discharge device along the longitudinal axis in the first direction to actuate the discharge mechanism and also to actuate the actuation counter until a pre-determined threshold force is overcome.
摘要翻译：一方面提供了一种药物分配器装置，其包括壳体; 从壳体延伸，用于插入患者体腔中的出口; 所述药物排出装置具有纵向轴线并且包括用于储存待分配的药物制剂的容器，排出机构和从容器排出药物制剂到排出口的排出通道 ; 连接到所述容器，连接到所述排放装置的容器套环; 连接到所述容器套环并且能够沿着所述药物排放装置的纵向轴线相对于所述容器套环移动;传递元件，所述传递元件包括致动部分; 提供给所述壳体的至少一个手指可操作构件，所述至少一个手指可操作构件可移动以向所述传递元件的所述致动部分施加力以沿着所述纵向轴线在第一方向上移动所述传递元件; 将所述容器套环与所述传递元件联接;偏置机构，用于在所述传递元件沿着所述纵向轴线在所述第一方向上移动时存储偏置能量; 一个致动计数器; 并向容器套环提供预加载机构以防止偏置能量传递到容器套环以使药物排放装置沿第一方向沿纵向轴线移动以致动排放机构并且还致动致动计数器直到克服预定的阈值力。

5. 发明申请

WO2008110584A2 DRUG DISPENSER 审中-公开
标题翻译：药物分配器
公开(公告)号：WO2008110584A2
公开(公告)日：2008-09-18
申请号：PCT/EP2008/052967
申请日：2008-03-12
申请人： GLAXO GROUP LIMITED , ANDERSON, Gregor John McLennan , CROSBY, Gary Thomas , ELLIMAN, David Vincent , KELLY, Andrew Michael , TEUCHER, Mark Digby , WEST, James Anthony
发明人： ANDERSON, Gregor John McLennan , CROSBY, Gary Thomas , ELLIMAN, David Vincent , KELLY, Andrew Michael , TEUCHER, Mark Digby , WEST, James Anthony
IPC分类号： A61M15/00
CPC分类号： A61M15/009 , A61M15/0026 , A61M15/0075 , A61M15/0091 , A61M15/0096 , A61M2205/6081 , G06M1/04 , G06M1/083
摘要： One aspect provides a drug dispenser device comprising a housing; extending from the housing, an outlet for insertion into a body cavity of a patient; provided to the housing and moveable with respect thereto, a drug discharge device having a longitudinal axis and comprising a container for storing a drug formulation to be dispensed, a discharge mechanism and a discharge channel from the container for discharge of the drug formulation to the outlet; connecting to the container, a container collar connected to the discharge device; connecting to the container collar and moveable with respect thereto along the longitudinal axis of the drug discharge device, a transfer element, the transfer element including an actuating portion; provided to the housing, at least one finger operable member moveable to apply a force to the actuating portion of the transfer element to move the transfer element along the longitudinal axis in a first direction; linking the container collar with the transfer element, a biasing mechanism to store biasing energy on moving the transfer element along the longitudinal axis in the first direction; an actuation counter; and provided to the container collar, a pre-load mechanism to prevent transfer of the biasing energy to the container collar to both move the drug discharge device along the longitudinal axis in the first direction to actuate the discharge mechanism and also to actuate the actuation counter until a pre-determined threshold force is overcome.
摘要翻译：一方面提供了一种药物分配器装置，其包括壳体; 从所述壳体延伸出用于插入患者体腔的出口; 提供给壳体并相对于其可移动的药物排出装置，具有纵向轴线的药物排出装置，并且包括用于储存待分配的药物制剂的容器，排出机构和来自容器的排出通道，用于将药物制剂排出到出口 ; 连接到容器，连接到排放装置的容器套环; 连接到所述容器套环并且沿着所述药物排出装置的纵向轴线可相对于其移动，所述传递元件包括致动部分; 至少一个手指可操作构件，其可移动以向所述传递元件的所述致动部分施加力以沿所述纵向轴线沿第一方向移动所述传递元件; 将所述容器套环与所述传递元件连接;偏置机构，用于在沿所述第一方向的所述纵向轴线移动所述传递元件时存储偏置能量; 启动计数器并且提供给容器套环，预加载机构，用于防止偏置能量传递到容器套环，以沿药物排出装置沿着第一方向的纵向轴线移动以致动排出机构并且还致动致动计数器直到克服了预定阈值力。

6. 发明申请

WO2008023015A1 ACTUATOR FOR AN INHALER 审中-公开
标题翻译：吸入器的执行器
公开(公告)号：WO2008023015A1
公开(公告)日：2008-02-28
申请号：PCT/EP2007/058672
申请日：2007-08-21
申请人： GLAXO GROUP LIMITED , ANDERSON, Gregor, John, McLennan , BURGESS, Penelope, Ann , CROSBY, Gary, Thomas , FAIRBROTHER, Tristan , FARR, Philip, William
发明人： ANDERSON, Gregor, John, McLennan , BURGESS, Penelope, Ann , CROSBY, Gary, Thomas , FAIRBROTHER, Tristan , FARR, Philip, William
IPC分类号： A61M15/00
CPC分类号： A61M15/009 , A61M15/0021
摘要： An actuator for an inhaler for delivering drug by inhalation, comprising: a housing (11; 111 ) for receiving a canister (5; 106) which comprises a body (7; 107) which includes a base and a head and defines a chamber for containing drug, and a valve stem (8; 108) which extends from the body (7; 107) and from which drug is in use delivered on actuation of the canister (5; 106); an outlet (13; 105) through which a user in use inhales; and a nozzle (4; 104) which provides for delivery of drug through the outlet (13; 105); wherein the outlet (105) includes at least one air flow path (122) which provides for a substantially annular air flow at an inner peripheral surface of the outlet (105) on inhalation by the user through the outlet (105), such as to provide a sheathing air flow to an aerosol spray when delivered from the nozzle (104).
摘要翻译：一种用于通过吸入输送药物的吸入器的致动器，包括：用于容纳罐（5; 106）的壳体（11; 111），所述壳体包括主体（7; 107），所述主体包括基部和头部，并且限定用于以及从所述主体（7; 107）延伸并且在所述罐（5; 106）的致动下使用所述药物的药剂的阀杆（8; 108）; 使用者吸入的出口（13; 105）; 和提供药物通过出口（13; 105）输送的喷嘴（4; 104）; 其中所述出口（105）包括至少一个空气流动路径（122），所述至少一个空气流动路径（122）在使用者通过所述出口（105）吸入时提供在所述出口（105）的内周表面处的基本环形空气流，当从喷嘴（104）输送时，向气溶胶喷雾提供护套空气流。

7. 发明申请

WO2003035509A1 MEDICAMENT DISPENSER 审中-公开
标题翻译：药物分配器
公开(公告)号：WO2003035509A1
公开(公告)日：2003-05-01
申请号：PCT/EP2002/011315
申请日：2002-10-09
申请人： GLAXO GROUP LIMITED , CROSBY, Gary, Thomas , PALMER, Mark, Gregory
发明人： CROSBY, Gary, Thomas , PALMER, Mark, Gregory
IPC分类号： B65D83/04
CPC分类号： B65D83/0472 , A61J1/03 , A61M15/0043 , A61M15/0045 , A61M15/0051 , A61M15/0055 , A61M15/0078 , A61M15/008 , A61M2016/0024 , A61M2202/064
摘要： There is provided a medicament dispenser for use with a medicament carrier (101) having a plurality of pockets for containing medicament wherein said pockets are spaced along the length of and defined between lid (113) and base sheets (111) peelably secured to each other, said dispenser having an internal mechanism for accessing said medicament contained within said medicament carrier. Peeling apart of the two sheets is achieved by drivable motion of a lid sheet drive wheel (218). There is also provided compensation means (222, 322, 522) to compensate for an increase in the diameter of the effective winding surface of the drive wheel (218) during use of the dispenser and thereby to ensure that said medicament carrier is uniformly indexed upon each actuation thereof.
摘要翻译：提供了一种用于与具有多个用于容纳药物的口袋的药物载体（101）一起使用的药物分配器，其中所述口袋沿着彼此可剥离地固定的盖（113）和基片（111）之间的长度间隔开并限定所述分配器具有用于访问包含在所述药物载体内的所述药物的内部机构。通过盖片驱动轮（218）的可驱动运动来实现两片剥离。还提供了补偿装置（222,322,522），用于补偿在使用分配器期间驱动轮（218）的有效绕组表面的直径的增加，从而确保所述药物载体被均匀地分度每个启动。

8. 发明申请

WO2009024578A2 DRUG DISPENSER 审中-公开
标题翻译：药物分配器
公开(公告)号：WO2009024578A2
公开(公告)日：2009-02-26
申请号：PCT/EP2008/060861
申请日：2008-08-19
申请人： GLAXO GROUP LIMITED , CROSBY, Gary Thomas
发明人： CROSBY, Gary Thomas
IPC分类号： A61M15/00 , B05B11/00
CPC分类号： A61M11/00 , A61M13/00 , A61M15/0026 , A61M15/0075 , A61M15/009 , A61M2005/2073
摘要： One aspect provides a drug dispenser device comprising a housing; extending from the housing, an outlet for insertion into a body cavity of a patient; provided to the housing and moveable with respect thereto, a drug discharge device having a longitudinal axis and comprising a container for storing a drug formulation to be dispensed, a discharge mechanism and a discharge channel from the container for discharge of the drug formulation to the outlet; connecting to the container, a container collar connected to the discharge device; connecting to the container collar and moveable with respect thereto along the longitudinal axis of the drug discharge device; connecting to the container collar and moveable with respect thereto along the longitudinal axis of the drug discharge device, a transfer element including an actuating portion; provided to the housing, at least one finger operable member moveable to apply an actuating force to the actuating portion of the transfer element to move the transfer element from an initial position along the longitudinal axis in a first direction; provided to the container collar, a pre-load mechanism to prevent transfer of the actuating force to the container collar to move the drug discharge device along the longitudinal axis in the first direction to actuate the discharge mechanism until a pre-determined threshold force is overcome; and connecting the container collar with the transfer element, a biasing return mechanism acting to bias the transfer element along the longitudinal axis in a second direction to return the transfer element to its initial position.
摘要翻译：一方面提供了一种药物分配器装置，其包括壳体; 从所述壳体延伸出用于插入患者体腔的出口; 提供给壳体并相对于其可移动的药物排出装置，具有纵向轴线并包括用于储存待分配的药物制剂的容器，排出机构和来自容器的排出通道，用于将药物制剂排出到出口 ; 连接到容器，连接到排放装置的容器套环; 连接到所述容器套环并且沿着所述药物排出装置的纵向轴线可相对于所述容器套环移动; 连接到所述容器套环并且沿着所述药物排出装置的纵向轴线可相对于所述容器轴环移动，所述传递元件包括致动部分; 提供给所述壳体的至少一个手指可操作构件可移动以将致动力施加到所述传递元件的致动部分，以沿着所述纵向轴线沿第一方向从所述初始位置移动所述传递元件; 提供到容器套环的预加载机构，用于防止致动力转移到容器套环以沿着第一方向沿着纵向轴线移动药物排出装置，以致驱动排放机构，直到克服预定阈值力 ; 以及将所述容器套环与所述传递元件连接的偏置返回机构，用于沿所述纵向轴线沿第二方向偏置所述传递元件以使所述传递元件返回到其初始位置。

9. 发明申请

WO2008023018A1 ACTUATOR FOR AN INHALER 审中-公开
标题翻译：吸入器的执行器
公开(公告)号：WO2008023018A1
公开(公告)日：2008-02-28
申请号：PCT/EP2007/058678
申请日：2007-08-21
申请人： GLAXO GROUP LIMITED , ANDERSON, Gregor, John, McLennan , BURGESS, Penelope, Ann , CROSBY, Gary, Thomas , FAIRBROTHER, Tristan , FARR, Philip William
发明人： ANDERSON, Gregor, John, McLennan , BURGESS, Penelope, Ann , CROSBY, Gary, Thomas , FAIRBROTHER, Tristan , FARR, Philip William
IPC分类号： A61M15/00
CPC分类号： A61M15/009 , A61M15/0025 , A61M15/0086 , A61M2206/10 , A61M2209/06
摘要： An actuator for an inhaler for delivering drug by inhalation, comprising: a housing (11; 111 ) for receiving a canister (5; 106) which comprises a body (7; 107) which includes a base and a head and defines a chamber for containing drug, and a valve stem (8; 108) which extends from the body (7; 107) and from which drug is in use delivered on actuation of the canister (5; 106); an outlet (13; 105) through which a user in use inhales; and a nozzle assembly (4; 104) which provides for delivery of drug through the outlet (13; 105), wherein the nozzle assembly (4; 104) comprises a nozzle block (17; 127) for receiving the valve stem (8; 108) of the canister (5; 106) and, as a separately-formed component, a nozzle outlet (19; 121 ) which is fluidly connected to the nozzle block (17; 127) and includes an outlet orifice (41; 123) from which drug is in use delivered.
摘要翻译：一种用于通过吸入输送药物的吸入器的致动器，包括：用于容纳罐（5; 106）的壳体（11; 111），所述壳体包括主体（7; 107），所述主体包括基部和头部，并且限定用于以及从所述主体（7; 107）延伸并且在所述罐（5; 106）的致动下使用所述药物的药剂的阀杆（8; 108）; 使用者吸入的出口（13; 105）; 和喷嘴组件（4; 104），其提供通过所述出口（13; 105）输送药物，其中所述喷嘴组件（4; 104）包括用于接收所述阀杆（8; 108;和作为单独形成的部件的喷嘴出口（19; 121），其流体地连接到喷嘴块（17; 127）并且包括出口孔（41; 123）从哪个药物正在使用中。

10. 发明申请

WO2008023013A1 ACTUATOR FOR AN INHALER 审中-公开
标题翻译：吸入器的执行器
公开(公告)号：WO2008023013A1
公开(公告)日：2008-02-28
申请号：PCT/EP2007/058669
申请日：2007-08-21
申请人： GLAXO GROUP LIMITED , ANDERSON, Gregor, John, McLennan , BURGESS, Penelope, Ann , CROSBY, Gary, Thomas , FAIRBROTHER, Tristan , FARR, Philip, William
发明人： ANDERSON, Gregor, John, McLennan , BURGESS, Penelope, Ann , CROSBY, Gary, Thomas , FAIRBROTHER, Tristan , FARR, Philip, William
IPC分类号： A61M15/00
CPC分类号： A61M15/009 , A61M15/0025 , A61M2206/10 , A61M2210/0618
摘要： An actuator for an inhaler for delivering drug by inhalation, comprising: a housing (11; 111 ) for receiving a canister (5; 106) which comprises a body (7; 107) which includes a base and a head and defines a chamber for containing drug, and a valve stem (8; 108) which extends from the body (7; 107) and from which drug is in use delivered on actuation of the canister (5; 106); an outlet (13; 105) through which a user in use inhales; and a nozzle (4; 104) which provides for delivery of drug through the outlet (13; 105); wherein at least a rear section of the outlet (13; 105) has an increasing internal dimension in a direction away from the nozzle (4; 104).
摘要翻译：一种用于通过吸入输送药物的吸入器的致动器，包括：用于容纳罐（5; 106）的壳体（11; 111），所述壳体包括主体（7; 107），所述主体包括基部和头部，并且限定用于以及从所述主体（7; 107）延伸并且在所述罐（5; 106）的致动下使用所述药物的药剂的阀杆（8; 108）; 使用者吸入的出口（13; 105）; 和提供药物通过出口（13; 105）输送的喷嘴（4; 104）; 其中所述出口（13; 105）的至少后部具有沿远离所述喷嘴（4; 104）的方向增加的内部尺寸。

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