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1. 发明申请

WO1993004713A1 METHOD FOR INTRAVENOUS DRUG INFUSION 审中-公开
标题翻译：用于静脉输注的方法
公开(公告)号：WO1993004713A1
公开(公告)日：1993-03-18
申请号：PCT/AU1992000485
申请日：1992-09-11
申请人： THE UNIVERSITY OF MELBOURNE , CRANKSHAW, David, Pilkington
发明人： THE UNIVERSITY OF MELBOURNE
IPC分类号： A61M05/168
CPC分类号： A61M5/172 , G06F19/00 , G06F19/3468 , Y10S128/13
摘要： A method and apparatus for the infusion of a drug into a patient involving: (i) Calculating a multiplicity of infusion rate profiles for a selected drug by monitoring drug efflux from the body of a group of patients for a corresponding multiplicity of target concentrations of the selected drug; (ii) determining the body size of the patient, such as their Lean Body Mass; (iii) selecting a target concentration of the drug to in turn cause selection from the multiplicity of infusion rate profiles an infusion rate profile substantially corresponding to the infusion rate profile for the selected target concentration; (iv) scaling the selected infusion rate profile by the determined body size or Lean Body Mass of the patient, and (v) administering the drug to the patient in accordance with the scaled profile by means of an infusion device which is controlled to deliver said drug at said scaled infusion rate profile. By using the method and system defined above, drugs which are non-linear in their effect on a patient are able to be delivered to the patient in a much more accurate manner thereby avoiding overdosing, and indeed underdosing, of the drug and the undesirable consequences thereof.
摘要翻译：一种用于将药物输注到患者中的方法和装置，其涉及：（i）通过监测来自一组患者的身体的药物流出来计算所选择的药物的多次输注速率曲线，以获得相应的多种目标浓度选药; （ii）确定患者的身体尺寸，例如他们的精瘦身体质量; （iii）选择药物的目标浓度，从而根据输注速率曲线的多次来选择基本对应于所选择的靶浓度的输注速率曲线的输注速率分布; （iv）通过所确定的身体尺寸或患者的身体质量缩小所选择的输注速率曲线，以及（v）通过输注装置根据缩放的轮廓向患者施用药物，所述输注装置被控制以输送所述药物以所述缩放灌注速率曲线。通过使用上述方法和系统，对患者的非线性药物能够以更准确的方式递送给患者，从而避免了药物的过量给药以及药物的不良后果它们。

2. 发明申请

WO1995020145A1 IMPROVEMENTS IN SYRINGE PUMPS 审中-公开
标题翻译：灌注泵的改进
公开(公告)号：WO1995020145A1
公开(公告)日：1995-07-27
申请号：PCT/AU1995000029
申请日：1995-01-20
申请人： THE UNIVERSITY OF MELBOURNE , CRANKSHAW, David, Pilkington
发明人： THE UNIVERSITY OF MELBOURNE
IPC分类号： G01L01/14
CPC分类号： A61M5/1456 , A61M5/1458 , A61M5/16831 , G01L1/142
摘要： A syringe pump having a drive head (1) mounted on a lead screw (2) which drives the drive head (1) to cause the plunger (P) of the syringe (S) to be advanced to deliver the contents of the syringe in a controlled manner. The drive head (1) supports a sensing module (3) having a cylindrical outer metallic body supporting a sensor disk (9) to which a sensing button (10) is attached. The disk (9) has a central insulating disk (15) supporting copper plates (16 and 17) and thin layers of dielectric (18, 19) separated from ground plates (20, 21) by an air gap (22) defining separate electrical capacitors each having a significantly different value of capacitance such that a large fall in capacitance occurs in the first capacitor while a large rise in capacitance occurs in the second capacitor. The capacitors are connected to an integrated circuit (23) which detects changes in capacitance caused by small forces applied to the button (10) to provide signals representative of contact with the button (10) and/or the force applied by the button (10) and the plunger (P). The drive head (1) also carries spring loaded pawls (26, 27) which engage behind the flange of the plunger (P) of the syringe (S) to prevent plunger movement caused by siphoning or other undesired movement of the plunger.
摘要翻译：一种注射器泵，其具有安装在导螺杆（2）上的驱动头（1），所述驱动头驱动所述驱动头（1）以使所述注射器（S）的柱塞（P）前进以将所述注射器的内容物输送到受控的方式。驱动头（1）支撑感测模块（3），该传感模块（3）具有支撑感测按钮（10）的传感器盘（9）的圆柱形外金属体。盘（9）具有支撑铜板（16和17）的中心绝缘盘（15）和由接地板（20,21）与接地板（20,21）分离的薄层电介质（18,19），该气隙限定分开的电气电容器各自具有明显不同的电容值，使得在第一电容器中出现大的电容下降，同时在第二电容器中出现大的电容上升。电容器连接到集成电路（23），该集成电路检测由施加到按钮（10）的小力引起的电容变化，以提供表示与按钮（10）接触的信号和/或由按钮（10）施加的力）和柱塞（P）。驱动头（1）还承载弹簧加载的棘爪（26,27），其接合在注射器（S）的柱塞（P）的后面，以防止柱塞由于虹吸或其他不期望的柱塞运动而引起的运动。

3. 发明申请

WO1988010383A1 INFUSION PUMP AND DRIVE SYSTEMS THEREFORE 审中-公开
标题翻译：输液泵和驱动系统
公开(公告)号：WO1988010383A1
公开(公告)日：1988-12-29
申请号：PCT/AU1988000198
申请日：1988-06-20
申请人： THE UNIVERSITY OF MELBOURNE , CRANKSHAW, David, Pilkington
发明人： THE UNIVERSITY OF MELBOURNE
IPC分类号： F16H37/04
CPC分类号： A61M5/1456 , A61M5/1452 , A61M5/1458 , A61M5/16854 , Y10S128/01 , Y10S128/12
摘要： A drug infusion pump having a drive system including a drive motor (49), a worm gear (53) on the output shaft of said motor, a worm wheel (55) meshing with said worm gear (53) and constructed to drive an output reduction gear (60) and clutch means (62) associated with said output gear (60) for disengaging drive to a drive head (61) engaged by a drive belt (83) which is permanently connected to a syringe actuator (7) to cause controlled infusion of the contents of a syringe under the control of a central control system including a microprocessor (20) and programmable memory means (21 and 23) which determine the manner in which the infusion is performed. A syringe clamping arm (5) is associated with a potentiometer (24) which provides to the controller diameter information regarding the syringe. The programmable memory means (23) includes data relating to one or more standard syringe sizes to enable automatic operation on insertion of a standard syringe. In the event that a non-standard syringe is to be used, the infusion pump may be simply programmed to allow such non-standard syringes to be used.
摘要翻译：一种具有驱动系统的药液输注泵，包括驱动马达（49），在所述马达的输出轴上的蜗轮（53），与所述蜗轮（53）啮合的蜗轮（55），构成为驱动输出与所述输出齿轮（60）相关联的减速齿轮（60）和离合器装置（62），用于使驱动头与由永久连接到注射器致动器（7）的传动带（83）接合的驱动头（61）在包括微处理器（20）和可编程存储器装置（21和23）的中央控制系统的控制下控制注射器的内容物，该可编程存储器装置确定进行输液的方式。注射器夹持臂（5）与电位计（24）相关联，电位计（24）向控制器提供关于注射器的直径信息。可编程存储装置（23）包括与一个或多个标准注射器尺寸相关的数据，以便能够在插入标准注射器时进行自动操作。在使用非标准注射器的情况下，输注泵可以被简单地编程以允许使用这种非标准注射器。

4. 发明申请

WO1997021456A1 FIELD PROGRAMMABLE INTRAVENOUS INFUSION SYSTEM 审中-公开
标题翻译：现场可编程入侵输血系统
公开(公告)号：WO1997021456A1
公开(公告)日：1997-06-19
申请号：PCT/AU1996000801
申请日：1996-12-12
申请人： THE UNIVERSITY OF MELBOURNE , CRANKSHAW, David, Pilkington
发明人： THE UNIVERSITY OF MELBOURNE
IPC分类号： A61M05/142
CPC分类号： A61M5/172 , A61M2005/14208
摘要： A system for controlling the operation of an infusion pump including means for controlling the rate of infusion of a drug or other solution by the infusion pump into a patient, user programmable microprocessor means for defining a predetermined rate of infusion profile or pattern for a predetermined drug or solution, a user operable scaling means for programming the microprocessor means to control the overall size of the predetermined rate infusion profile or pattern and thereby determine the amount of drug or solution delivered to the patient, and user operable means for activating the infusion pump to cause infusion of the drug or solution according to the user programmed information.
摘要翻译：一种用于控制输注泵的操作的系统，包括用于控制通过输注泵将药物或其他溶液输注到患者体内的速率的装置，用户可编程微处理器装置，用于定义预定药物的预定速率的输注配置文件或图案或解决方案，用户可操作的缩放装置，用于对微处理器装置进行编程，以控制预定速率输注曲线或图案的总体尺寸，从而确定递送给患者的药物或溶液的量，以及用户可操作的装置，用于将输注泵激活到导致根据用户编程的信息输注药物或溶液。

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