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1. 发明专利

IL210843A Certain kynurenine-3-monooxygenase inhibitors and pharmaceutical compositions comprising same 未知
公开(公告)号：IL210843A
公开(公告)日：2014-05-28
申请号：IL21084311
申请日：2011-01-24
申请人： CHDI FOUNDATION INC , WITYAK JOHN , TOLEDO-SHERMAN LETICIA M , LEEDS JANET , DOMINGUEZ CELLA , YARNOLD CHRISTOPHER JOHN , PENA PAULA CRISTINA DE AGUIAR , SCHEEL ANDREAS , WINKLER DIRK , COURTNEY STEPHEN MARTIN
发明人： WITYAK JOHN , TOLEDO-SHERMAN LETICIA M , LEEDS JANET , DOMINGUEZ CELLA , YARNOLD CHRISTOPHER JOHN , PENA PAULA CRISTINA DE AGUIAR , SCHEEL ANDREAS , WINKLER DIRK , COURTNEY STEPHEN MARTIN
摘要： Certain chemical entities are provided herein. Also provided are pharmaceutical compositions comprising at least one chemical entity and one or more pharmaceutically acceptable vehicle. Methods of treating patients suffering from certain diseases and disorders responsive to the inhibition of KMO activity are described, which comprise administering to such patients an amount of at least one chemical entity effective to reduce signs or symptoms of the disease or disorder are disclosed. These diseases include neurodegenerative disorders such as Huntington's disease. Also described are methods of treatment include administering at least one chemical entity as a single active agent or administering at least one chemical entity in combination with one or more other therapeutic agents. Also provided are methods for screening compounds capable of inhibiting KMO activity.

2. 发明专利

IL187562D0 DIRT AND DUST CYCLONIC SEPARATING APPARATUS 未知
公开(公告)号：IL187562D0
公开(公告)日：2008-03-20
申请号：IL18756207
申请日：2007-11-22
申请人： DYSON TECHNOLOGY LTD , COURTNEY STEPHEN BENJAMIN , DYSON JAMES , GOMICIAGA PEREDA RICARDO
IPC分类号： A47L20100101 , A47L9/16 , B01D45/16 , B04C5/26 , B04C5/28
摘要： A cyclonic separating apparatus includes a first cyclonic separating unit including at least one first cyclone, a second cyclonic separating unit located downstream of the first cyclonic separating unit and including at least one second cyclone, and a third cyclonic separating unit located downstream of the second cyclonic separating unit and including at least one third cyclone. The separation efficiency of the second cyclonic separating unit is substantially the same as the separation efficiency of either the first cyclonic separating unit or the third separating unit, providing an apparatus which achieves a higher separation efficiency than known separation apparatus.

3. 发明专利

GB201001208D0 Safety recoil strap 未知
公开(公告)号：GB201001208D0
公开(公告)日：2010-03-10
申请号：GB201001208
申请日：2010-01-26
申请人： COURTNEY STEPHEN

4. 发明专利

IL187561D0 CYCLONIC SEPARATING APPARATUS 未知
公开(公告)号：IL187561D0
公开(公告)日：2008-03-20
申请号：IL18756107
申请日：2007-11-22
申请人： DYSON TECHNOLOGY LTD , COURTNEY STEPHEN BENJAMIN , DYSON JAMES , GOMICIAGA PEREDA RICARDO
IPC分类号： A47L20100101 , A47L9/16 , B04C5/24 , B04C5/26
摘要： A cyclonic separating apparatus includes a first cyclonic separating unit including at least one first cyclone and an annular dust collecting chamber, a second cyclonic separating unit located downstream of the first cyclonic separating unit and including at least one second cyclone and a dust collecting chamber, and a third cyclonic separating unit located downstream of the second cyclonic separating unit and including a plurality of third cyclones arranged in parallel and a dust collecting chamber. The number of third cyclones is higher than the number of second cyclones, and the dust collecting chambers of the second and third cyclonic separating units are located inside of the annular dust collecting chamber of the first cyclonic separating unit.

5. 发明专利

GB0709320D0 Shutter pull device 未知
公开(公告)号：GB0709320D0
公开(公告)日：2007-06-20
申请号：GB0709320
申请日：2007-05-15
申请人： COURTNEY STEPHEN

6. 发明专利

IL210843D0 CERTAIN KYNURENINE-3-MONOOXYGENASE INHIBITORS, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE THEREOF 未知
公开(公告)号：IL210843D0
公开(公告)日：2011-04-28
申请号：IL21084311
申请日：2011-01-24
申请人： CHDI INC , WITYAK JOHN , TOLEDO SHERMAN LETICIA M , LEEDS JANET , DOMINGUEZ CELLA , YARNOLD CHRISTOPHER JOHN , AGUIAR PENA PAULA CRISTINA DE , SCHEEL ANDREAS , WINKLER DIRK , COURTNEY STEPHEN MARTIN
IPC分类号： A61K20060101
摘要： Certain chemical entities are provided herein. Also provided are pharmaceutical compositions comprising at least one chemical entity and one or more pharmaceutically acceptable vehicle. Methods of treating patients suffering from certain diseases and disorders responsive to the inhibition of KMO activity are described, which comprise administering to such patients an amount of at least one chemical entity effective to reduce signs or symptoms of the disease or disorder are disclosed. These diseases include neurodegenerative disorders such as Huntington's disease. Also described are methods of treatment include administering at least one chemical entity as a single active agent or administering at least one chemical entity in combination with one or more other therapeutic agents. Also provided are methods for screening compounds capable of inhibiting KMO activity.

7. 发明申请

WO2013024253A3 A HAND DRYER 审中-公开
标题翻译：手提干衣机
公开(公告)号：WO2013024253A3
公开(公告)日：2013-11-21
申请号：PCT/GB2012051830
申请日：2012-07-27
申请人： DYSON TECHNOLOGY LTD , RYAN LEIGH , GAMMACK PETER , COURTNEY STEPHEN
发明人： RYAN LEIGH , GAMMACK PETER , COURTNEY STEPHEN
IPC分类号： A47K10/48
CPC分类号： A47K10/48 , F26B25/06
摘要： A hand dryer having a left-hand nozzle section which, in normal use, is used to dry a user's left hand and a right-hand nozzle section which, in normal use, is used separately to dry the user's right hand, the left-hand nozzle section being arranged to emit drying air along a first direction - outwardly to the left of the dryer - and the right-hand nozzle section being arranged to emit drying air in a second direction - outwardly to the right of the dryer - said first and second directions having a downward and/or forward component.
摘要翻译：一种具有左侧喷嘴部分的手动干燥器，其在正常使用中用于干燥用户的左手和右侧喷嘴部分，其在正常使用中被单独使用以干燥用户的右手，手动喷嘴部分被布置成沿着第一方向（向外到干燥器的左侧）发射干燥空气，并且右侧喷嘴部分被布置成沿第二方向（在干燥器的右侧）向外发射干燥空气 - 所述第一和具有向下和/或向前分量的第二方向。

8. 发明申请

WO2013064919A1 QUINAZOLINE DERIVATIVES WITH HSP90 INHIBITORY ACTIVITY 审中-公开
标题翻译：喹诺酮衍生物与HSP90抑制活性
公开(公告)号：WO2013064919A1
公开(公告)日：2013-05-10
申请号：PCT/IB2012/054649
申请日：2012-09-07
申请人： DAC SRL , AMICI, Raffaella , COLOMBO, Andrea , COURTNEY, Stephen Martin , MERCURIO, Ciro , MONTALBETTI, Christian Aldo Georges Napoleon , MORTONI, Annalisa , VARASI, Mario
发明人： AMICI, Raffaella , COLOMBO, Andrea , COURTNEY, Stephen Martin , MERCURIO, Ciro , MONTALBETTI, Christian Aldo Georges Napoleon , MORTONI, Annalisa , VARASI, Mario
IPC分类号： C07D401/10 , C07D401/14 , C07D451/06 , A61K31/517 , A61P35/00
CPC分类号： C07D401/10 , C07D401/14 , C07D451/06
摘要： Compounds of general formula (I): or a stereoisomer, tautomer, polymorph, hydrate, solvate, or a pharmaceutically acceptable salt thereof, wherein R is as defined herein, are useful for the treatment of diseases and conditions which are mediated by excessive or inappropriate Hsp90 activity such as proliferative diseases, e.g. cancers, viral and fungal infections, neurodegenerative or inflammatory diseases or conditions. The invention also relates to the preparation of these compounds as well as to pharmaceutical compositions comprising them.
摘要翻译：通式（I）的化合物或其立体异构体，互变异构体，多晶型物，水合物，溶剂合物或其药学上可接受的盐，其中R如本文所定义，可用于治疗由过度或不适当的介导的疾病和病症 Hsp90活性如增殖性疾病，例如癌症，病毒和真菌感染，神经变性或炎性疾病或病症。本发明还涉及这些化合物的制备以及包含它们的药物组合物。

9. 发明申请

WO2011071947A2 BIS-ACYLATED HYDROXYLAMINE DERIVATIVES 审中-公开
标题翻译：双官能羟基胺衍生物
公开(公告)号：WO2011071947A2
公开(公告)日：2011-06-16
申请号：PCT/US2010/059331
申请日：2010-12-07
申请人： JOHNS HOPKINS UNIVERSITY , CARDIOXYL PHARMACEUTICALS, INC. , TOSCANO, John P. , SUTTON, Art , KALISH, Vincent J. , BROOKFIELD, Frederick Arthur , COURTNEY, Stephen Martin , FROST, Lisa Marie
发明人： TOSCANO, John P. , SUTTON, Art , KALISH, Vincent J. , BROOKFIELD, Frederick Arthur , COURTNEY, Stephen Martin , FROST, Lisa Marie
IPC分类号： C07C311/48
CPC分类号： C07D333/34 , C07C233/01 , C07C233/64 , C07C259/06 , C07C259/10 , C07C271/08 , C07C311/51 , C07C311/53 , C07C317/14 , C07C317/28 , C07C317/32 , C07C2601/08 , C07C2601/14 , C07D207/16 , C07D213/40 , C07D213/71 , C07D295/205 , C07D295/215 , C07D307/82 , C07D309/12
摘要： The invention provides certain bis-acylated hydroxylamine derivative compounds, pharmaceutical compositions and kits comprising such compounds, and methods of using such compounds or pharmaceutical compositions. In particular, the invention provides methods of using such compounds or pharmaceutical compositions for treating, preventing, or delaying the onset and/or develop of a disease or condition. In some embodiments, the disease or condition is selected from cardiovascular diseases, ischemia, reperfusion injury, cancerous disease, pulmonary hypertension and conditions responsive to nitroxyl therapy.
摘要翻译：本发明提供某些双酰化羟胺衍生物化合物，包含这些化合物的药物组合物和试剂盒，以及使用这些化合物或药物组合物的方法。特别地，本发明提供了使用这些化合物或药物组合物治疗，预防或延缓疾病或病症发作和/或发展的方法。在一些实施方案中，疾病或病症选自心血管疾病，局部缺血，再灌注损伤，癌性疾病，肺动脉高压和对硝酰基治疗有反应的病症。

10. 发明申请

WO2010146382A1 A TOOL FOR A SURFACE TREATING APPLIANCE 审中-公开
标题翻译：表面处理用具的工具
公开(公告)号：WO2010146382A1
公开(公告)日：2010-12-23
申请号：PCT/GB2010/050864
申请日：2010-05-26
申请人： DYSON TECHNOLOGY LIMITED , GELL, Ian , ILES, Jean-Paul , ASHBEE, Giles , FOLLOWS, Thomas , COURTNEY, Stephen
发明人： GELL, Ian , ILES, Jean-Paul , ASHBEE, Giles , FOLLOWS, Thomas , COURTNEY, Stephen
IPC分类号： A47L9/06
CPC分类号： A47L9/0606 , A47L9/02 , A47L9/24
摘要： A tool (10) for a surface treating appliance comprises a main body (12) connected to a conduit (14). The main body (12) comprises a first suction channel (22) and a second suction channel (24) in fluid communication with the first suction channel (22) and located between the first suction channel (22) and an outlet from the main body (12). In use, a relatively low vacuum is generated in the first suction channel (22) which draws a first dirt-bearing fluid flow into the main body (12), and a relatively high vacuum is generated in the second suction channel (24), which draws a second dirt-bearing fluid flow into the main body (12) and receives the first dirt-bearing fluid flow from the first suction channel (22). To maintain the pressure differences between the suction channels (22, 24), the main body (12) comprises flexible surface engaging means (32, 34) located about the suction channels (22, 24), and between the first suction channel (22) and the second suction channel (24).
摘要翻译：用于表面处理设备的工具（10）包括连接到导管（14）的主体（12）。主体（12）包括与第一抽吸通道（22）流体连通并且位于第一抽吸通道（22）和来自主体的出口之间的第一抽吸通道（22）和第二抽吸通道（24）（12）。在使用中，在第一抽吸通道（22）中产生相对较低的真空，其将第一含尘流体流动流入主体（12），并且在第二抽吸通道（24）中产生相对高的真空度，其将第二含尘流体流动到主体（12）中并且接收来自第一吸入通道（22）的第一污物流体流。为了保持吸入通道（22,24）之间的压力差，主体（12）包括围绕抽吸通道（22,24）定位的柔性表面接合装置（32,34），以及位于第一吸入通道）和第二抽吸通道（24）。

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