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1. 发明申请

WO2006000562A1 PROCESS FOR THE PREPARATION OF GABAPENTIN 审中-公开
标题翻译：制备GABAPENTIN的方法
公开(公告)号：WO2006000562A1
公开(公告)日：2006-01-05
申请号：PCT/EP2005/052906
申请日：2005-06-22
申请人： ZAMBON GROUP S.P.A. , VILLA, Marco , PAIOCCHI, Maurizio , ARRIGHI, Katiuscia , CORCELLA, Francesco , CANNATA, Vincenzo , SORIATO, Giorgio , VERZINI, Massimo
发明人： VILLA, Marco , PAIOCCHI, Maurizio , ARRIGHI, Katiuscia , CORCELLA, Francesco , CANNATA, Vincenzo , SORIATO, Giorgio , VERZINI, Massimo
IPC分类号： C07C231/10
CPC分类号： C07C231/10 , C07D221/20 , C07C233/08
摘要： The present invention relates to a process for the preparation of gabapentin and, more in particular, to a method of synthesis of 1,1-cyclohexane acetic acid monoamide, an intermediate used in the preparation of gabapentin, comprising the basic hydrolysis reaction of α,¬-diaminocarbonyl-β,β-pentamethylene glutarimide.
摘要翻译：本发明涉及一种制备加巴喷丁的方法，更具体地涉及合成1,1-环己烷乙酸单酰胺的方法，该方法用于制备加巴喷丁，其包括a， α-二氨基羰基-β，β-戊二酰戊二酰亚胺。

2. 发明申请

WO2005044779A2 PROCESS FOR THE PREPARATION OF GABAPENTIN 审中-公开
标题翻译：加巴芬的制备方法
公开(公告)号：WO2005044779A2
公开(公告)日：2005-05-19
申请号：PCT/EP2004/052894
申请日：2004-11-09
申请人： ZAMBON GROUP S.P.A. , ARRIGHI, Katiuscia , CANNATA, Vincenzo , CORCELLA, Francesco , MARCHIORO, Gaetano , NICOLI, Andrea , PAIOCCHI, Maurizio , VILLA, Marco
发明人： ARRIGHI, Katiuscia , CANNATA, Vincenzo , CORCELLA, Francesco , MARCHIORO, Gaetano , NICOLI, Andrea , PAIOCCHI, Maurizio , VILLA, Marco
IPC分类号： C07C231/02
CPC分类号： C07C231/02 , C07C2601/14 , C07C233/08
摘要： The present invention relates to an improved process for the preparation of gabapentin and, more particularly, to an improvement of the preparation reaction of 1,1-cyclohexanediacetic acid monoamide, intermediate utilized in the preparation of gabapentin.
摘要翻译：本发明涉及制备加巴喷丁的改进方法，并且更具体地涉及用于制备加巴喷丁的1,1-环己烷二乙酸单酰胺中间体的制备反应的改进。

3. 发明申请

WO2005044779A3 PROCESS FOR THE PREPARATION OF GABAPENTIN 审中-公开
标题翻译：制备GABAPENTIN的方法
公开(公告)号：WO2005044779A3
公开(公告)日：2005-07-14
申请号：PCT/EP2004052894
申请日：2004-11-09
申请人： ZAMBON SPA , ARRIGHI KATIUSCIA , CANNATA VINCENZO , CORCELLA FRANCESCO , MARCHIORO GAETANO , NICOLI ANDREA , PAIOCCHI MAURIZIO , VILLA MARCO
发明人： ARRIGHI KATIUSCIA , CANNATA VINCENZO , CORCELLA FRANCESCO , MARCHIORO GAETANO , NICOLI ANDREA , PAIOCCHI MAURIZIO , VILLA MARCO
IPC分类号： C07C229/28 , C07C231/02 , C07C231/24 , C07C233/08
CPC分类号： C07C231/02 , C07C2601/14 , C07C233/08
摘要： The present invention relates to an improved process for the preparation of gabapentin and, more particularly, to an improvement of the preparation reaction of 1,1-cyclohexanediacetic acid monoamide, intermediate utilized in the preparation of gabapentin.
摘要翻译：本发明涉及一种用于制备加巴喷丁的改进方法，更具体地涉及改进用于制备加巴喷丁的中间体的1,1-环己烷二乙酸单酰胺的制备反应。

4. 发明申请

WO0230917A3 PROCESS FOR THE PRODUCTION OF RACEMIC THIOCTIC ACID 审中-公开
标题翻译：生产季铵盐酸的方法
公开(公告)号：WO0230917A3
公开(公告)日：2002-07-25
申请号：PCT/EP0111577
申请日：2001-10-08
申请人： LABORATORIO CHIMICO INT SPA , SALVI ANNIBALE , MAIORANA STEFANO , CORCELLA FRANCESCO
发明人： SALVI ANNIBALE , MAIORANA STEFANO , CORCELLA FRANCESCO
IPC分类号： C07D339/04 , C07C319/06
CPC分类号： C07D339/04
摘要： Process for the synthesis of racemic thiotic acid comprising the following stages: a) reaction of the alkyl ester of 6,8-di-halo-octanoic acid in an organic solvent with an aqueous solution of alkali disulfide in presence of a compound for phase transfer catalysis selected from the group consisting of quaternary ammonium or phosphonium salts having the following general formula: where: A is nitrogen of phosphorus, X is selected from the group consisting of Cl, Br, I, HSO4, and H2PO4 and the substitutents R1, R2, R3 and R4 are selection from the group consisting of linear or branched alkyl radicals having one to twenty carbon atoms (C1-C20), said substituents being identical or different one from the other, or only one of said substituents is selected from the group consisting of arylalkyl radicals having the following formula -(CH2)nC6H5 in which n=1-16; b) followed by the hydrolysis of the ester of racemic thiotic acid.
摘要翻译：包括以下步骤合成外消旋硫酸的方法：a）在相转移化合物存在下，6,8-二卤代辛酸的烷基酯在有机溶剂中与碱性二硫化物水溶液的反应选自具有以下通式的季铵或鏻盐的催化剂：其中：A是磷的氮，X选自Cl，Br，I，HSO 4和H 2 PO 4，取代基R1，R2 ，R3和R4选自具有1-20个碳原子的直链或支链烷基（C1-C20），所述取代基彼此相同或不同，或者只有一个所述取代基选自基团由具有下式的芳基烷基 - （CH 2）n C 6 H 5，其中n = 1-16; b）然后水解外消旋硫酸的酯。

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