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    • 4. 发明申请
    • CONTRAST AGENTS FOR MEDICAL IMAGING
    • 医学影像的对比剂
    • WO1994003210A1
    • 1994-02-17
    • PCT/GB1993001667
    • 1993-08-06
    • INSTITUTE OF CANCER RESEARCHROWLAND, Ian, JohnLEACH, Martin, OsmundCOLLINS, David, John
    • INSTITUTE OF CANCER RESEARCH
    • A61K49/00
    • A61K49/12
    • Contrast agent for medical diagnostic techniques comprising a polymer in which an NMR-visible nucleus is contained in at least one monomer unit within the polymer, and a medical diagnostic method for the human or animal body comprising the administration of this contrast agent and detection thereof by a spectroscopic or imaging technique. The polymer preferably contains two or more different NMR-visible nuclei and the images of the different nuclei are superimposed. Advantageously, the polymer contains fluorine and is, for example, a fluorinated organosilicon polymer, for example polymethyl-3,3,3-trifluoropropylsiloxane. Non-fluorinated and partially fluorinated polyethers are also mentioned. The method is especially suitable for imaging the gastrointestinal tract.
    • 用于医疗诊断技术的对比剂包括其中聚合物内的至少一个单体单元中含有NMR-可见核的聚合物,以及用于人或动物体的医学诊断方法,包括施用该造影剂并通过 光谱或成像技术。 聚合物优选含有两个或更多个不同的NMR可见核,并且叠加不同核的图像。 有利地,聚合物含有氟,并且是例如氟化有机硅聚合物,例如聚甲基-3,3,3-三氟丙基硅氧烷。 还提及了非氟化和部分氟化的聚醚。 该方法特别适用于胃肠道成像。
    • 6. 发明申请
    • HERBICIDES
    • 除草剂
    • WO1994013652A1
    • 1994-06-23
    • PCT/GB1993002350
    • 1993-11-16
    • ZENECA LIMITEDKAY, Ian, TrevorBARTON, John, Edward, DuncanCOLLINS, David, JohnKOWALCZYK, BogdanMITCHELL, GlynnSHRIBBS, John, MartinCOX, John, MichaelBARNES, Nigel, JohnSMITH, Stephen, Chrisopher
    • ZENECA LIMITED
    • C07D277/14
    • C07D207/273A01N47/18A01N47/24C07D211/76C07D231/08C07D233/38C07D233/40C07D237/04C07D239/10C07D241/08C07D261/04C07D263/18C07D265/02C07D265/32C07D277/14C07D279/12C07D285/16
    • A compound of formula (I), where E is oxygen or sulphur; A is CR or N where R is hydrogen or hydrocarbyl; D completes a 5 or 6-membered non-aromatic heterocyclic ring which optionally contains additional heteroatoms selected from oxygen nitrogen or sulphur and which is optionally substituted by an optionally substituted lower hydrocarbyl group, or an optionally substituted heteroaryl group; R and R are each independently hydrogen, optionally substituted lower hydrocarbyl, or optionally substituted heteroaryl, or R and R together with the nitrogen atom to which they are attached, form a heterocyclic ring; Z represents halogen, optionally substituted lower hydrocarbyl, optionally substituted lower hydrocarbyloxy, optionally substituted lower hydrocarbylthio, hydrocarbylsulphinyl, or hydrocarbylsulphonyl, cyano, nitro, CHO, NHOH, ONR7'R7'', SF5, CO (optionally substituted lower hydrocarbyl), acylamino, COOR , SO2NR R , CONR R , OR or NR R where R , R , R , R , R , R and R are independently H or lower hydrocarbyl; R is hydrogen, SO2 lower hydrocarbyl or COR ; R and R are independently lower hydrocarbyl, lower hydrocarbyloxy or a group R ; R is OR , NR R , hydrogen or lower hydrocarbyl; R is lower hydrocarbyl, R and R are independently hydrogen or lower hydrocarbyl provided that when there are two or more substituents Z, they may be the same or different; and m is 0 or an integer from 1 to 5.
    • 式(I)化合物,其中E为氧或硫; A是CR 3或N,其中R 3是氢或烃基; D完成5或6元非芳族杂环,其任选地含有选自氧氮或硫的另外的杂原子,其任选被任选取代的低级烃基或任选取代的杂芳基取代; R 1和R 2各自独立地为氢,任选取代的低级烃基或任选取代的杂芳基,或R 1和R 2与它们所连接的氮原子一起形成杂环; Z表示卤素,任选取代的低级烃基,任选取代的低级烃氧基,任选取代的低级烃基硫代,烃基亚磺酰基或烃基磺酰基,氰基,硝基,CHO,NHOH,ONR7'R7“,SF5,CO(任选取代的低级烃基) COOR 7,SO 2 NR 8 R 9,CONR 10 R 11,OR 12或NR 13 R 14,其中R 7,R 7',R“ R“,R 9,R 10和R 11独立地为H或低级烃基; R 12是氢,SO 2低级烃基或COR 15; R 13和R 14独立地为低级烃基,低级烃氧基或R 12基团; R 15是OR 16,NR 17 R 18,氢或低级烃基; R 16是低级烃基,R 17和R 18独立地是氢或低级烃基,条件是当有两个或更多个取代基Z时,它们可以相同或不同; m为0或1〜5的整数。