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1. 发明申请

WO2005075679A3 ANTIGENIC HIV-1 PEPTIDES 审中-公开
标题翻译：抗原性HIV-1肽
公开(公告)号：WO2005075679A3
公开(公告)日：2005-12-08
申请号：PCT/IT2005000058
申请日：2005-02-08
申请人： UNIV ROMA , UNI DEGLI STUDI DI PALERMO 20 , CONSIGLIO NAZ DELLE RICERCHE 1 , AMICOSANTE MASSIMO , CAPPELLI GIULIA , COLIZZI VITTORIO , D ARRIGO ROBERTA , DIELI FRANCESCO , PERNO CARLO FEDERICO , SACCHI ALESSANDRA , SALERNO ALFREDO , MONTAGNER LUC , CHENAL HENRI , TONI THOMAS , SIMPORE JACQUES
发明人： AMICOSANTE MASSIMO , CAPPELLI GIULIA , COLIZZI VITTORIO , D ARRIGO ROBERTA , DIELI FRANCESCO , PERNO CARLO FEDERICO , SACCHI ALESSANDRA , SALERNO ALFREDO , MONTAGNER LUC , CHENAL HENRI , TONI THOMAS , SIMPORE JACQUES
IPC分类号： A61K39/00 , C07K14/16 , C12Q1/68 , C07K7/00
CPC分类号： C07K14/005 , A61K2039/55 , C12N2740/16222 , C12N2740/16322
摘要： The invention refers to a method of antigenic peptide identification and to the relative use for the preparation of a specific vaccine against HIV-1 for the populations of sub-Saharan Africa.
摘要翻译：本发明涉及抗原肽鉴定的方法以及针对撒哈拉以南非洲人群制备用于HIV-1的特定疫苗的相对用途。

2. 发明申请

WO2012011144A2 USE OF AMINO ACID SEQUENCES FROM MYCOBACTERIUM TUBERCULOSIS OR CORRESPONDING NUCLEIC ACIDS FOR DIAGNOSIS AND PREVENTION OF TUBERCULAR INFECTION, DIAGNOSTIC KIT AND VACCINE THEREFROM. 审中-公开
标题翻译：使用来自MYCOBACTERIUM TUBCCOSOSIS或相关核酸的氨基酸序列用于诊断和预防管腔感染，诊断试剂盒和疫苗。
公开(公告)号：WO2012011144A2
公开(公告)日：2012-01-26
申请号：PCT/IT2011/000266
申请日：2011-07-25
申请人： AMICOSANTE, Massimo , MARIANI, Francesca , COLIZZI, Vittorio , SALTINI, Cesare , 4ROMAPEPTIDI s.r.l.
发明人： AMICOSANTE, Massimo , MARIANI, Francesca , COLIZZI, Vittorio , SALTINI, Cesare
IPC分类号： A61K38/16 , C07K14/35 , C07K16/12 , C12N5/00 , C12Q1/68 , G01N33/569
CPC分类号： G01N33/56972 , A61K38/10 , A61K38/164 , C07K7/08 , C07K14/35 , G01N33/5695 , G01N33/6866 , G01N2333/35 , G01N2333/57
摘要： The present invention refers to the use of gene sequences or portions thereof characterized in that the same belong to the classes of in vitro and ex vivo induced, repressed or conserved genes in Mycobacterium tuberculosis currently infected human macrophages and to corresponding peptides or consensus peptides or proteins for the preparation of specific bio-markers for the diagnosis and prevention of active or latent disease.
摘要翻译：本发明涉及基因序列或其部分的用途，其特征在于它们属于目前感染的人巨噬细胞的结核分枝杆菌中的体外和离体诱导，抑制或保守基因类型以及相应的肽或共有肽或蛋白质用于制备用于诊断和预防活动性或潜伏性疾病的特异性生物标志物。

3. 发明申请

WO2007099117A1 THIOPYROPHOSPHATE ORGANIC COMPOUNDS, METHOD FOR PREPARING THEREOF AND COMPOSITIONS CONTAINING THEM 审中-公开
标题翻译：硫代磷酸酯有机化合物，其制备方法及其组合物
公开(公告)号：WO2007099117A1
公开(公告)日：2007-09-07
申请号：PCT/EP2007/051896
申请日：2007-02-28
申请人： C4T S.C. a r.l. , BRECCIA, Perla , ANGELI, Francesca , COLIZZI, Vittorio , PINZA, Mario , POCCIA, Fabrizio , TOPAI, Alessandra
发明人： BRECCIA, Perla , ANGELI, Francesca , COLIZZI, Vittorio , PINZA, Mario , POCCIA, Fabrizio , TOPAI, Alessandra
IPC分类号： C07F9/165 , A61K31/6615 , A61P35/00 , A61P29/00 , A61P37/00
CPC分类号： C07F9/1658
摘要： Compound of general formula (I), where R, X and n have the meanings mentioned in the specification. The invention also relates to a method for preparing the compound of general formula (I) and a pharmaceutical composition containing the same.
摘要翻译：通式（I）的化合物，其中R，X和n具有说明书中提及的含义。本发明还涉及制备通式（I）化合物的方法和含有该通式（I）的药物组合物。

4. 发明申请

WO2005021790A3 USE OF GENE SEQUENCES SPECIFIC FOR MYCOBACTERIUM TUBERCULOSIS AND THEIR RELATED PROTEINS FOR DIAGNOSIS AND PREVENTION OF TUBERCULAR INFECTION 审中-公开
标题翻译：结核分枝杆菌特异性基因序列及其相关蛋白在诊断和预防结核感染中的应用
公开(公告)号：WO2005021790A3
公开(公告)日：2005-05-06
申请号：PCT/IT2004000471
申请日：2004-08-25
申请人： CONSIGLIO NAZIONALE RICERCHE , CAPPELLI GIULIA , MARIANI FRANCESCA , COLIZZI VITTORIO
发明人： CAPPELLI GIULIA , MARIANI FRANCESCA , COLIZZI VITTORIO
IPC分类号： C12Q1/68
CPC分类号： C12Q1/689 , C12Q1/6883
摘要： The present invention relates to the use of gene sequences specific Mycobacterium tuberculosis and their corresponding proteins for the diagnosis and the prevention of the tubercular infection.
摘要翻译：本发明涉及基因序列特异性结核分枝杆菌及其相应蛋白用于诊断和预防结核感染的用途。

5. 发明申请

WO2003045365A3 SPHINGOSINE DERIVATIVE AS AN IMMUNOREGULATOR COMPOUND 审中-公开
公开(公告)号：WO2003045365A3
公开(公告)日：2003-06-05
申请号：PCT/IT2002/000740
申请日：2002-11-21
申请人： UNIVERSITA DEGLI STUDI DI ROMA "TOR VERGATA" , FRAZIANO, Maurizio , GARG, Sanjay, Kumar , CIARAMELLA, Antonio , AURICCHIO, Giovanni , VOLPE, Elisabetta , MARTINO, Angelo , BALDINI, Morena , DE VITO, Paolo , GALATI, Domenico , COLIZZI, Vittorio
发明人： FRAZIANO, Maurizio , GARG, Sanjay, Kumar , CIARAMELLA, Antonio , AURICCHIO, Giovanni , VOLPE, Elisabetta , MARTINO, Angelo , BALDINI, Morena , DE VITO, Paolo , GALATI, Domenico , COLIZZI, Vittorio
IPC分类号： A61K31/045
摘要： The invention relates to sphingosine derivative compounds, like D-erythro-sphingosine 1-phosphate (S1P), to be used as immunomodulators in a microbicidal treatment of infections derived from bacteria and specifically Mycobacterium tuberculosis . Such compounds are characterized in that they stimulate macrophagic Phospholipase D (PLD) (Figure 1). The invention further relates to pharmaceutical compositions containing sphingosine derivative compounds and diagnostic methods for the preparation thereof. Further objects of the invention are methods of inducing or restoring the microbicidal activity in vitro of macrophages for monitoring the efficiency of phagocytosis and degradation processes performed by the same and assay methods suitable to evaluate therapeutic effectiveness of candidate microbicides.

6. 发明公开

EP3216869A1 NUTRACEUTICAL PLANT DERIVED MICRORNA ELEMENTS FOR TREATMENT OF CANCER 有权
标题翻译：微生态制剂衍生微量元素治疗癌症
公开(公告)号：EP3216869A1
公开(公告)日：2017-09-13
申请号：EP16020075.4
申请日：2016-03-09
申请人： Colizzi, Vittorio
发明人： CIRILLO, Marco , GALGANI, Andrea , DEL GALLO DI ROCCAGIOVINE, Flavia , KENZO, Maurice , MINUTOLO, Antonella , MONTESANO, Carla , MULEO, Rosario , PIRRÒ, Stefano , POTESTÀ, Marina
IPC分类号： C12N15/113 , A61K31/7088 , A61K31/713 , A61P35/00
摘要： The subject of the invention is a use of plant-derived miRNA molecule or its synthetic equivalent, selected from amongst plant-miR-20, plant-miR-27, plant-miR-34 or plant-miR-168a, for decreasing tumor proliferation by regulating expression of cancer-related proteins in humans. An isolated plant-functional microRNA or an extract containing said plant-functional microRNA, a preparation method therefore, and an application thereof are provided. More particularly, the invention concerns the use of an water-soluble extract of the Moninga oleifera plant seeds, as active principle, on its own or combined with at least another active principle, for preparing a nutraceutical composition used for treating or preventing cancer. The composition is easily absorbed in the cells, and has beneficial advantages selectively toxic for cancer but not normal cells. The invention therefore delivers a novel therapeutic method based on endogenous or synthetic plant-functional microRNAs capable of regulating mammalian SIRT-1 pathway associated non-plant target-genes and decreasing proliferation of human cancer cells.
摘要翻译：本发明的主题是选自植物miR-20，植物miR-27，植物miR-34或植物miR-168a的植物来源的miRNA分子或其合成等同物用于减少肿瘤增殖通过调节癌症相关蛋白在人体内的表达。提供了分离的植物功能性微RNA或含有所述植物功能性微RNA的提取物，其制备方法及其应用。更具体地说，本发明涉及Moninga oleifera植物种子的水溶性提取物作为活性成分单独使用或与至少另一种活性成分组合用于制备用于治疗或预防癌症的营养组合物的用途。该组合物易于在细胞中吸收，并具有对癌症有选择性毒性而不是正常细胞的有利优点。因此，本发明提供了基于能够调节哺乳动物SIRT-1途径相关的非植物靶基因并减少人癌细胞增殖的内源性或合成植物功能性微RNA的新型治疗方法。

7. 发明申请

WO2012011144A3 USE OF AMINO ACID SEQUENCES FROM MYCOBACTERIUM TUBERCULOSIS OR CORRESPONDING NUCLEIC ACIDS FOR DIAGNOSIS AND PREVENTION OF TUBERCULAR INFECTION, DIAGNOSTIC KIT AND VACCINE THEREFROM 审中-公开
标题翻译：使用来自MYCOBACTERIUM TUBCCOSOSIS或相关核酸的氨基酸序列用于诊断和预防管感染，诊断试剂盒和疫苗
公开(公告)号：WO2012011144A3
公开(公告)日：2012-04-12
申请号：PCT/IT2011000266
申请日：2011-07-25
申请人： 4ROMAPEPTIDI S R L , MARIANI FRANCESCA , AMICOSANTE MASSIMO , COLIZZI VITTORIO , SALTINI CESARE
发明人： MARIANI FRANCESCA , AMICOSANTE MASSIMO , COLIZZI VITTORIO , SALTINI CESARE
IPC分类号： A61K38/16 , C07K14/35 , C07K16/12 , C12N5/00 , C12Q1/68 , G01N33/569
CPC分类号： G01N33/56972 , A61K38/10 , A61K38/164 , C07K7/08 , C07K14/35 , G01N33/5695 , G01N33/6866 , G01N2333/35 , G01N2333/57
摘要： The present invention refers to the use of gene sequences or portions thereof characterized in that the same belong to the classes of in vitro and ex vivo induced, repressed or conserved genes in Mycobacterium tuberculosis currently infected human macrophages and to corresponding peptides or consensus peptides or proteins for the preparation of specific bio-markers for the diagnosis and prevention of active or latent disease.
摘要翻译：本发明涉及基因序列或其部分的用途，其特征在于它们属于目前感染的人巨噬细胞的结核分枝杆菌中的体外和离体诱导，抑制或保守基因类型以及相应的肽或共有肽或蛋白质用于制备用于诊断和预防活动性或潜伏性疾病的特异性生物标志物。

8. 发明申请

WO2005075679A2 METHOD OF ANTIGENIC PEPTIDE IDENTIFICATION AND RELATIVE USE FOR THE PREPARATION OF A VACCINE ANTI HIV-1 审中-公开
标题翻译：抗生素鉴定方法及制备疫苗抗HIV-1的相关用途
公开(公告)号：WO2005075679A2
公开(公告)日：2005-08-18
申请号：PCT/IT2005/000058
申请日：2005-02-08
申请人： UNIVERSITA'DEGLI STUDI DI ROMA "TOR VERGATA" (70%) , UNIVERSITA'DEGLI STUDI DI PALERMO (20%) , CONSIGLIO NAZIONALE DELLE RICERCHE (10%) , AMICOSANTE, Massimo , CAPPELLI, Giulia , COLIZZI, Vittorio , D'ARRIGO, Roberta , DIELI, Francesco , PERNO, Carlo Federico , SACCHI, Alessandra , SALERNO, Alfredo , MONTAGNER, Luc , CHENAL, Henri , TONI, Thomas , SIMPORE, Jacques
发明人： AMICOSANTE, Massimo , CAPPELLI, Giulia , COLIZZI, Vittorio , D'ARRIGO, Roberta , DIELI, Francesco , PERNO, Carlo Federico , SACCHI, Alessandra , SALERNO, Alfredo , MONTAGNER, Luc , CHENAL, Henri , TONI, Thomas , SIMPORE, Jacques
IPC分类号： C12Q1/68
CPC分类号： C07K14/005 , A61K2039/55 , C12N2740/16222 , C12N2740/16322
摘要： The invention refers anti to a method of antigenic peptide identification and to the relative use for the preparation of a specific vaccine against HIV-1 for the populations of sub-Saharan Africa.
摘要翻译：本发明涉及针对抗原肽鉴定的方法以及用于为撒哈拉以南非洲人群制备用于HIV-1的特异性疫苗的相对用途。

9. 发明申请

WO2005021790A2 USE OF GENE SEQUENCES SPECIFIC FOR MYCOBACTERIUM TUBERCULOSIS AND THEIR RELATED PROTEINS FOR DIAGNOSIS AND PREVENTION OF TUBERCULAR INFECTION 审中-公开
标题翻译：使用特异性基因序列进行MYCOBACTERIUM TUBCCOSOSIS及其相关蛋白质的诊断和预防管腔感染
公开(公告)号：WO2005021790A2
公开(公告)日：2005-03-10
申请号：PCT/IT2004/000471
申请日：2004-08-25
申请人： CONSIGLIO NAZIONALE DELLE RICERCHE , CAPPELLI, Giulia , MARIANI, Francesca , COLIZZI, Vittorio
发明人： CAPPELLI, Giulia , MARIANI, Francesca , COLIZZI, Vittorio
IPC分类号： C12Q1/68
CPC分类号： C12Q1/689 , C12Q1/6883
摘要： The present invention relates to the use of gene sequences specific Mycobacterium tuberculosis and their corresponding proteins for the diagnosis and the prevention of the tubercular infection.
摘要翻译：本发明涉及特异性结核分枝杆菌及其相应蛋白质的基因序列用于诊断和预防结核感染的用途。

10. 发明申请

WO2003045365A2 IMMUNOREGULATOR COMPOUNDS 审中-公开
标题翻译：免疫球蛋白化合物
公开(公告)号：WO2003045365A2
公开(公告)日：2003-06-05
申请号：PCT/IT2002/000740
申请日：2002-11-21
申请人： UNIVERSITA DEGLI STUDI DI ROMA "TOR VERGATA" , FRAZIANO, Maurizio , GARG, Sanjay, Kumar , CIARAMELLA, Antonio , AURICCHIO, Giovanni , VOLPE, Elisabetta , MARTINO, Angelo , BALDINI, Morena , DE VITO, Paolo , GALATI, Domenico , COLIZZI, Vittorio
发明人： FRAZIANO, Maurizio , GARG, Sanjay, Kumar , CIARAMELLA, Antonio , AURICCHIO, Giovanni , VOLPE, Elisabetta , MARTINO, Angelo , BALDINI, Morena , DE VITO, Paolo , GALATI, Domenico , COLIZZI, Vittorio
IPC分类号： A61K31/00
CPC分类号： A61K31/661 , A61K31/047 , A61K31/132
摘要： The invention relates to sphingosine derivative compounds, like D-erythro-sphingosine 1-phosphate (S1P), to be used as immunomodulators in a microbicidal treatment of infections derived from bacteria and specifically Mycobacterium tuberculosis . Such compounds are characterized in that they stimulate macrophagic Phospholipase D (PLD) (Figure 1). The invention further relates to pharmaceutical compositions containing sphingosine derivative compounds and diagnostic methods for the preparation thereof. Further objects of the invention are methods of inducing or restoring the microbicidal activity in vitro of macrophages for monitoring the efficiency of phagocytosis and degradation processes performed by the same and assay methods suitable to evaluate therapeutic effectiveness of candidate microbicides.
摘要翻译：本发明涉及鞘氨醇衍生物化合物，如D-赤式 - 鞘氨醇1-磷酸（S1P），用作在来自细菌，特别是结核分枝杆菌的感染的杀微生物治疗中作为免疫调节剂。这些化合物的特征在于它们刺激巨噬细胞磷脂酶D（PLD）（图1）。本发明还涉及含有鞘氨醇衍生物化合物的药物组合物及其制备方法。本发明的另外的目的是诱导或恢复巨噬细胞体外杀微生物活性的方法，用于监测通过相同方法进行的吞噬效率和降解过程的效率以及适于评价候选杀微生物剂治疗效果的测定方法。

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