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1. 发明申请

WO2008027322A1 IMPLANTABLE SHUNT OR CATHETER ENABLING GRADUAL DELIVERY OF THERAPEUTIC AGENTS 审中-公开
标题翻译：可植入分流器或导管使得治疗药物的分级递送
公开(公告)号：WO2008027322A1
公开(公告)日：2008-03-06
申请号：PCT/US2007/018796
申请日：2007-08-27
申请人： WYETH , DRAGOON, Deborah, L. , COHEN, Jonathan, Marc
发明人： DRAGOON, Deborah, L. , COHEN, Jonathan, Marc
IPC分类号： A61M27/00 , A61M31/00
CPC分类号： A61M27/006 , A61M27/00 , A61M27/008 , A61M31/00 , A61M31/002
摘要： An implantable catheter or shunt (24) for draining fluid from a body cavity. The catheter or shunt body has a wall structure (28) that carries one or more therapeutic agents (26) in a manner enabling release of the therapeutic agent from the wall structure in situ after surgical implantation of the catheter or shunt body. The therapeutic agent can be gradually released over time to prevent infection, inhibit tissue ingrowths, and/or provide some other desired medicinal purpose. As an example, the therapeutic agent can be rapamycin or an mTOR inhibitor. According to some contemplated embodiments of the present invention, the therapeutic agent carried by the catheter/shunt is rechargeable or refillable in situ so that the therapeutic agent can be gradually released from the catheter/shunt over the expected useful life of the catheter/shunt.
摘要翻译：用于从体腔排出流体的可植入导管或分路器（24）。导管或分流体具有壁结构（28），该壁结构承载一种或多种治疗剂（26），以使得能够在手术植入导管或分流体之后将治疗剂从壁结构释放。治疗剂可以随着时间逐渐释放以防止感染，抑制组织向内生长和/或提供一些其它期望的药物用途。作为实例，治疗剂可以是雷帕霉素或mTOR抑制剂。根据本发明的一些预期的实施例，由导管/分流器承载的治疗剂可以在现场进行可再充电或可再填充，使得治疗剂可以在导管/分流器的预期使用寿命期间从导管/分流器逐渐释放。

2. 发明申请

WO2004098643A1 COMPOSITIONS CONTAINING PIPERACILLIN AND TAZOBACTAM USEFUL FOR INJECTION 审中-公开
标题翻译：含有PIPERACILLIN和TAZOBACTAM的组合物可用于注射
公开(公告)号：WO2004098643A1
公开(公告)日：2004-11-18
申请号：PCT/US2003/011340
申请日：2003-04-14
申请人： WYETH HOLDINGS CORPORATION , COHEN, Jonathan, Marc , SHAH, Syed, Muzafar , OFSLAGER, Christian, Luther , FAWZI, Mahdi, Bakir
发明人： COHEN, Jonathan, Marc , SHAH, Syed, Muzafar , OFSLAGER, Christian, Luther , FAWZI, Mahdi, Bakir
IPC分类号： A61K47/18
CPC分类号： A61K9/0019 , A61K31/43 , A61K31/431 , A61K31/496 , A61K47/12 , A61K47/183 , A61K2300/00
摘要： An aminocarboxylic acid chelating agent, preferably EDTA, or a salt thereof has been found to be useful for inhibiting particulate formation in piperacillin/tazobactam compositions. The composition may also contain a buffer, preferably citrate, and optionally an aminoglycoside. The product may be in the form of a frozen composition that can be thawed for use. The product may also be in the form of a cryodesiccated powder that can be reconstituted by addition of an aqueous vehicle to reform a solution.
摘要翻译：已经发现氨基羧酸螯合剂，优选EDTA或其盐可用于抑制哌拉西林/他唑巴坦组合物中的颗粒形成。组合物还可含有缓冲液，优选柠檬酸盐，以及任选的氨基糖苷类。产品可以是可以解冻使用的冷冻组合物的形式。该产品还可以是可通过加入水性载体来重构溶液的冷冻消毒粉末的形式。

3. 发明申请

WO2004091666A1 COMPOSITIONS CONTAINING PIPERACILLIN AND TAZOBACTAM USEFUL FOR INJECTION 审中-公开
标题翻译：含有PIPERACILLIN和TAZOBACTAM的组合物可用于注射
公开(公告)号：WO2004091666A1
公开(公告)日：2004-10-28
申请号：PCT/US2004/010698
申请日：2004-04-06
申请人： WYETH HOLDINGS CORPORATION , COHEN, Jonathan, Marc , SHAH, Syed, Muzafar , OFSLAGER, Christian, Luther , FAWZI, Mahdi, Bakir
发明人： COHEN, Jonathan, Marc , SHAH, Syed, Muzafar , OFSLAGER, Christian, Luther , FAWZI, Mahdi, Bakir
IPC分类号： A61K47/18
CPC分类号： A61K9/0019 , A61K31/43 , A61K31/431 , A61K31/496 , A61K47/183 , A61K2300/00
摘要： An aminocarboxylic acid chelating agent, preferably EDTA, or a salt thereof has been found to be useful for inhibiting particulate formation in piperacillin/tazobactam parenteral combinations. The composition may also contain a buffer, preferably citrate, and optionally an aminoglycoside. The product may be in the form of a frozen composition that can be thawed for use. The product may also be in the form of a cryodesiccated powder that can be reconstituted by addition of an aqueous vehicle to reform a solution.
摘要翻译：已经发现氨基羧酸螯合剂，优选EDTA或其盐可用于抑制哌拉西林/他唑巴坦肠胃外组合中的颗粒形成。组合物还可以含有缓冲液，优选柠檬酸盐，和任选的氨基糖苷类。产品可以是可以解冻使用的冷冻组合物的形式。该产品还可以是可以通过加入水性载体来重构溶液的冷冻消毒粉末的形式。

4. 发明申请

WO2011112816A1 ORAL FORMULATIONS AND LIPOPHILIC SALTS OF METHYLNALTREXONE 审中-公开
标题翻译：甲基溴的口服制剂和脂质体
公开(公告)号：WO2011112816A1
公开(公告)日：2011-09-15
申请号：PCT/US2011/027913
申请日：2011-03-10
申请人： WYETH, LLC , SHAH, Syed, M. , DIORIO, Christopher, Richard , EHRNSPERGER, Eric, C. , MENG, Xu , AL SHAREFFI, Kadum, A. , COHEN, Jonathan, Marc
发明人： SHAH, Syed, M. , DIORIO, Christopher, Richard , EHRNSPERGER, Eric, C. , MENG, Xu , AL SHAREFFI, Kadum, A. , COHEN, Jonathan, Marc
IPC分类号： C07D471/00
CPC分类号： A61K31/485 , A61K9/0053 , A61K9/2009 , A61K9/2013 , A61K9/2054 , A61K9/2077 , A61K9/28 , A61K47/12 , A61K47/20 , C07D489/08
摘要： The present invention provides compositions comprising methylnaltrexone or a salt thereof, and compositions and formulations thereof, for oral administration.
摘要翻译：本发明提供了包含甲基纳曲酮或其盐及其组合物和制剂用于口服给药的组合物。

5. 发明申请

WO2006044600A1 COMPOSITIONS CONTAINING PIPERACILLIN, TAZOBACTAM AND A AMINOCARBOXILIC ACID IN A SODIUM LACTATE DILUENT 审中-公开
标题翻译：包含哌醋嗪，TAZOBACTAM和氨基酸的组合物在乳清酸稀释液中
公开(公告)号：WO2006044600A1
公开(公告)日：2006-04-27
申请号：PCT/US2005/036938
申请日：2005-10-12
申请人： WYETH , COHEN, Jonathan, Marc , SHAH, Syed, M. , FAWZI, Mahdi
发明人： COHEN, Jonathan, Marc , SHAH, Syed, M. , FAWZI, Mahdi
IPC分类号： A61K31/43 , A61K31/431 , A61K31/496
CPC分类号： A61K9/0019 , A61K31/198 , A61K31/407 , A61K31/43 , A61K31/431 , A61K31/496 , A61K47/12 , A61K47/183 , A61K2300/00
摘要： The invention provides a pharmaceutical composition comprising piperacillin, tazobactam, an aminocarboxylic acid, and a buffer in a sodium lactate diluent. The invention further relates to a method of treating a bacterial infection and an LR condition in a human which comprises administering to said human an effective amount of a pharmaceutical composition comprising piperacillin, tazobactam, an aminocarboxylic acid, and a buffer in a sodium lactate diluent.
摘要翻译：本发明提供包含哌拉西林，他唑巴坦，氨基羧酸和乳酸钠稀释剂中的缓冲液的药物组合物。本发明还涉及一种治疗人的细菌感染和LR病症的方法，其包括向所述人施用有效量的包含哌拉西林，他唑巴坦，氨基羧酸和在乳酸钠稀释剂中的缓冲液的药物组合物。

6. 发明申请

WO2004091666A8 COMPOSITIONS CONTAINING PIPERACILLIN AND TAZOBACTAM USEFUL FOR INJECTION 审中-公开
标题翻译：含有PIPERACILLIN和TAZOBACTAM的组合物可用于注射
公开(公告)号：WO2004091666A8
公开(公告)日：2005-11-10
申请号：PCT/US2004010698
申请日：2004-04-07
申请人： WYETH CORP , COHEN JONATHAN MARC , SHAH SYED MUZAFAR , OFSLAGER CHRISTIAN LUTHER , FAWZI MAHDI BAKIR
发明人： COHEN JONATHAN MARC , SHAH SYED MUZAFAR , OFSLAGER CHRISTIAN LUTHER , FAWZI MAHDI BAKIR
IPC分类号： A61K31/43 , A61K31/431 , A61K31/496 , A61K47/18 , A61P31/04
CPC分类号： A61K9/0019 , A61K31/43 , A61K31/431 , A61K31/496 , A61K47/183 , A61K2300/00
摘要： An aminocarboxylic acid chelating agent, preferably EDTA, or a salt thereof has been found to be useful for inhibiting particulate formation in piperacillin/tazobactam parenteral combinations. The composition may also contain a buffer, preferably citrate, and optionally an aminoglycoside. The product may be in the form of a frozen composition that can be thawed for use. The product may also be in the form of a cryodesiccated powder that can be reconstituted by addition of an aqueous vehicle to reform a solution.
摘要翻译：已经发现氨基羧酸螯合剂，优选EDTA或其盐可用于抑制哌拉西林/他唑巴坦肠胃外组合中的颗粒形成。组合物还可以含有缓冲液，优选柠檬酸盐，和任选的氨基糖苷类。产品可以是可以解冻使用的冷冻组合物的形式。该产品还可以是可以通过加入水性载体来重构溶液的冷冻消毒粉末的形式。

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