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1. 发明专利

GB9519219D0 Beverage compounds 未知
公开(公告)号：GB9519219D0
公开(公告)日：1995-11-22
申请号：GB9519219
申请日：1995-09-20
申请人： CLARKE MICHAEL F
IPC分类号： A23F3/30 , A23F5/14 , A23F5/24 , A23F5/40 , A23L2/395 , B65D81/00 , B65D85/804

2. 发明专利

GB9418880D0 Coffee lumps 未知
公开(公告)号：GB9418880D0
公开(公告)日：1994-11-09
申请号：GB9418880
申请日：1994-09-20
申请人： CLARKE MICHAEL F
IPC分类号： A23F3/30 , A23F5/14 , A23F5/24 , A23F5/40 , A23L2/395 , B65D81/00 , B65D85/804

3. 发明申请

WO2010085498A1 SINGLE CELL GENE EXPRESSION FOR DIAGNOSIS, PROGNOSIS AND IDENTIFICATION OF DRUG TARGETS 审中-公开
标题翻译：单细胞基因表达用于诊断，预防和鉴定药物目标
公开(公告)号：WO2010085498A1
公开(公告)日：2010-07-29
申请号：PCT/US2010/021525
申请日：2010-01-20
申请人： THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY , CLARKE, Michael F. , QUAKE, Stephen, R. , DALERBA, Piero, D. , LIU, Huiping , LEYRAT, Anne , KALISKY, Tomer , DIEHN, Maximillian
发明人： CLARKE, Michael F. , QUAKE, Stephen, R. , DALERBA, Piero, D. , LIU, Huiping , LEYRAT, Anne , KALISKY, Tomer , DIEHN, Maximillian
IPC分类号： C12Q1/68 , G01N33/53
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/118 , C12Q2600/136 , C12Q2600/158 , C12Q2600/178 , G01N33/5023 , G01N33/57484 , G01N2800/52
摘要： Methods are provided for diagnosis and prognosis of disease by analyzing expression of a set of genes obtained from single cell analysis. Classification allows optimization of treatment, and determination of whether on whether to proceed with a specific therapy, and how to optimize dose, choice of treatment, and the like. Single cell analysis also provides for the identification and development of therapies which target mutations and/or pathways in disease-state cells.
摘要翻译：通过分析从单细胞分析获得的一组基因的表达，为疾病的诊断和预后提供方法。分类允许优化治疗，确定是否进行特定治疗，以及如何优化剂量，治疗选择等。单细胞分析还提供了鉴定和开发针对疾病状态细胞中的突变和/或途径的疗法。

4. 发明申请

WO2006135886A3 COMPOSITIONS AND METHODS FOR TREATING AND DIAGNOSING CANCER 审中-公开
标题翻译：用于治疗和诊断癌症的组合物和方法
公开(公告)号：WO2006135886A3
公开(公告)日：2009-04-23
申请号：PCT/US2006023002
申请日：2006-06-13
申请人： UNIV MICHIGAN , CLARKE MICHAEL F , WANG XINHAO , LEWICKI JOHN A , GURNEY AUSTIN L
发明人： CLARKE MICHAEL F , WANG XINHAO , LEWICKI JOHN A , GURNEY AUSTIN L
IPC分类号： C12Q1/68 , C07H21/02 , C07K1/00 , C07K16/00 , G01N33/53 , G01N33/574
CPC分类号： G01N33/57415 , C12Q1/6837 , C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/118 , C12Q2600/136 , G01N33/57484
摘要： The present invention relates to compositions and methods for treating, characterizing, and diagnosing cancer. In particular, the present invention provides gene expression profiles associated with solid tumor stem cells, as well as novel stem cell cancer gene signatures useful for the diagnosis, characterization, prognosis and treatment of solid tumor stem cells.
摘要翻译：本发明涉及用于治疗，表征和诊断癌症的组合物和方法。特别地，本发明提供了与实体肿瘤干细胞相关的基因表达谱，以及用于实体瘤干细胞的诊断，表征，预后和治疗的新型干细胞癌基因特征。

5. 发明申请

WO2008092002A3 COMPOSITIONS AND METHODS FOR TREATING AND DIAGNOSING PANCREATIC CANCER 审中-公开
标题翻译：用于治疗和诊断胰腺癌的组合物和方法
公开(公告)号：WO2008092002A3
公开(公告)日：2008-11-13
申请号：PCT/US2008051910
申请日：2008-01-24
申请人： UNIV MICHIGAN , WICHA MAX S , CLARKE MICHAEL F , SIMEONE DIANE M
发明人： WICHA MAX S , CLARKE MICHAEL F , SIMEONE DIANE M
IPC分类号： C12N5/00 , C12N5/02 , C12N5/095 , G01N33/53
CPC分类号： C12N5/0695 , A01K2267/0331
摘要： The present invention relates to the field of oncology and provides novel compositions and methods for diagnosing and treating pancreatic cancer. In particular, the present invention provides pancreatic cancer stem cells useful for the study, diagnosis, and treatment of solid tumors.
摘要翻译：本发明涉及肿瘤学领域，并提供用于诊断和治疗胰腺癌的新型组合物和方法。特别地，本发明提供了可用于实体瘤的研究，诊断和治疗的胰腺癌干细胞。

6. 发明申请

WO2006138275A3 COMPOSITIONS AND METHODS FOR TREATING AND DIAGNOSING CANCER 审中-公开
公开(公告)号：WO2006138275A3
公开(公告)日：2006-12-28
申请号：PCT/US2006/022934
申请日：2006-06-13
申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN , WANG, Xinhao , LEWICKI, John, A. , GURNEY, Austin, L. , CLARKE, Michael, F.
发明人： WANG, Xinhao , LEWICKI, John, A. , GURNEY, Austin, L. , CLARKE, Michael, F.
IPC分类号： G01N33/574 , G01N33/53 , C07K16/00
摘要： The present invention relates to compositions and methods for treating, characterizing, and diagnosing cancer. In particular, the present invention provides gene expression profiles and signatures associated with solid tumor stem cells, as well as novel stem cell cancer markers useful for the diagnosis, characterization, prognosis and treatment of solid tumor stem cells. More particularly, the present invention identifies two profiles of cancer stem cells useful for the diagnosis, characterization, and treatment of cancer and cancer metastases. The invention also provides a variety of reagents such as stem cell gene signatures for use in the diagnosis and management of cancer.

7. 发明申请

WO2003050502A3 PROSPECTIVE IDENTIFICATION AND CHARACTERIZATION OF BREAST CANCER STEM CELLS 审中-公开
公开(公告)号：WO2003050502A3
公开(公告)日：2003-06-19
申请号：PCT/US2002/039191
申请日：2002-12-06
申请人： REGENTS OF THE UNIVERSITY OF MICHIGAN , CLARKE, Michael, F. , WICHA, Max, S. , AL-HAJJ, Mohammad
发明人： CLARKE, Michael, F. , WICHA, Max, S. , AL-HAJJ, Mohammad
IPC分类号： A61K31/00
摘要： Human breast tumors contain heterogeneous cancer cells. Using an animal xenograft model in which human breast cancer cells were grown in immunocompromised mice, we found that only a small minority of breast cancer cells had the capacity to form new tumors. The ability to form new tumors was not a stochastic property, rather certain populations of cancer cells were depleted for the ability to form new tumors, while other populations were enriched for the ability to form new tumors. Tumorigenic cells could be distinguished from non-tumorigenic cancer cells based on surface marker expression. We prospectively identified and isolated the tumorigenic cells as CD44?+¿CD24?-/lo¿LINEAGE?-¿. As few as 100 cells from this population were able to form tumors the animal xenograft model, while tens of thousands of cells from non-tumorigenic populations failed to form tumors. The tumorigenic cells could be serially passaged, each time generating new tumors containing an expanded numbers of CD44?+¿CD24?-/low¿Lineage?-¿tumorigenic cells as well as phenotypically mixed populations of non-tumorigenic cancer cells. This is reminiscentof the ability of normal stem cells to self-renew and differentiate. The expression of potential therapeutic targets also differed between the tumorigenic and non-tumorigenic populations. Notch activation promoted the survival of the tumorigenic cells, and a blocking antibody against Notch4 induced tumorigenic breast cancer cells to undergo apoptosis.

8. 发明申请

WO2003050502A2 PROSPECTIVE IDENTIFICATION AND CHARACTERIZATION OF BREAST CANCER STEM CELLS 审中-公开
标题翻译：乳腺癌干细胞的前瞻性鉴定和表征
公开(公告)号：WO2003050502A2
公开(公告)日：2003-06-19
申请号：PCT/US2002/039191
申请日：2002-12-06
申请人： REGENTS OF THE UNIVERSITY OF MICHIGAN , CLARKE, Michael, F. , WICHA, Max, S. , AL-HAJJ, Mohammad
发明人： CLARKE, Michael, F. , WICHA, Max, S. , AL-HAJJ, Mohammad
IPC分类号： G01N
CPC分类号： C07K16/28 , A61K38/1703 , A61K47/6897 , A61K47/6901 , A61K2039/505 , B82Y5/00 , C07K16/3015 , C12N5/0695
摘要： Human breast tumors contain heterogeneous cancer cells. Using an animal xenograft model in which human breast cancer cells were grown in immunocompromised mice, we found that only a small minority of breast cancer cells had the capacity to form new tumors. The ability to form new tumors was not a stochastic property, rather certain populations of cancer cells were depleted for the ability to form new tumors, while other populations were enriched for the ability to form new tumors. Tumorigenic cells could be distinguished from non-tumorigenic cancer cells based on surface marker expression. We prospectively identified and isolated the tumorigenic cells as CD44 + CD24 -/lo LINEAGE - . As few as 100 cells from this population were able to form tumors the animal xenograft model, while tens of thousands of cells from non-tumorigenic populations failed to form tumors. The tumorigenic cells could be serially passaged, each time generating new tumors containing an expanded numbers of CD44 + CD24 -/low Lineage?- ¿tumorigenic cells as well as phenotypically mixed populations of non-tumorigenic cancer cells. This is reminiscentof the ability of normal stem cells to self-renew and differentiate. The expression of potential therapeutic targets also differed between the tumorigenic and non-tumorigenic populations. Notch activation promoted the survival of the tumorigenic cells, and a blocking antibody against Notch4 induced tumorigenic breast cancer cells to undergo apoptosis.
摘要翻译：人乳腺肿瘤包含异质癌细胞。使用动物异种移植模型，其中人乳腺癌细胞在免疫受损小鼠中生长，我们发现只有少数乳腺癌细胞具有形成新肿瘤的能力。形成新肿瘤的能力不是随机性质，而是癌细胞的某些群体耗尽形成新肿瘤的能力，而其他群体则富集形成新肿瘤的能力。基于表面标志物表达，致瘤细胞可以与非致瘤性癌细胞区分开。我们前瞻性地将致瘤细胞鉴定并分离为CD44 + CD24 < - / lo> LINEAGE - 。来自该群体的少至100个细胞能够形成肿瘤动物异种移植模型，而来自非致瘤基因群的数万个细胞未能形成肿瘤。致瘤细胞可以连续传代，每次产生含有扩增数量的CD44 + CD24 - / low> Lineage - 致瘤细胞的新肿瘤以及非致瘤性癌细胞的表型混合群体。这让人想起正常干细胞自我更新和分化的能力。潜在的治疗靶点的表达也在致瘤性和非致瘤性群体之间不同。 Notch活化促进致瘤细胞的存活，并且阻断Notch4诱导的致瘤性乳腺癌细胞进行细胞凋亡的抗体。

9. 发明申请

WO2007053648A2 COMPOSITIONS AND METHODS FOR TREATING AND DIAGNOSING CANCER 审中-公开
标题翻译：用于治疗和诊断癌症的组合物和方法
公开(公告)号：WO2007053648A2
公开(公告)日：2007-05-10
申请号：PCT/US2006/042561
申请日：2006-10-31
申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN , CLARKE, Michael, F. , HOEY, Tim , WANG, Xinhao , DYLLA, Scott , GURNEY, Austin , DALERBA, Pierro , CHEN, Grace , PRINCE, Mark
发明人： CLARKE, Michael, F. , HOEY, Tim , WANG, Xinhao , DYLLA, Scott , GURNEY, Austin , DALERBA, Pierro , CHEN, Grace , PRINCE, Mark
IPC分类号： C12N5/08
CPC分类号： C12N5/0695 , C12N5/0093 , Y10S435/968 , Y10S435/971
摘要： The present invention relates to compositions and methods for characterizing, treating and diagnosing cancer. In particular, the present invention provides a cancer stem cell profile, as well as novel stem cell cancer markers useful for the diagnosis, characterization, prognosis and treatment of cancer and in particular the targeting of solid tumor stem cells.
摘要翻译：本发明涉及用于表征，治疗和诊断癌症的组合物和方法。特别地，本发明提供癌症干细胞概况，以及用于癌症的诊断，表征，预后和治疗的新型干细胞癌标记物，特别是固体肿瘤干细胞的靶向。

10. 发明申请

WO2005005601A3 Compositions and methods for treating and diagnosing cancer 审中-公开
标题翻译：用于治疗和诊断癌症的组合物和方法
公开(公告)号：WO2005005601A3
公开(公告)日：2006-04-27
申请号：PCT/US2004018266
申请日：2004-06-09
申请人： CLARKE MICHAEL F , LIU RUI , UNIV MICHIGAN
发明人： CLARKE MICHAEL F , LIU RUI
IPC分类号： C12N20060101 , C12N5/095 , C12Q1/68 , G01N33/574 , C12N5/08
CPC分类号： G01N33/6893 , C12N5/0695 , C12Q1/6886 , C12Q2600/106 , C12Q2600/136 , C12Q2600/158 , G01N33/574 , G01N33/57496
摘要： The present invention relates to compositions and methods for treating, characterizing, and diagnosing cancer. In particular, the present invention provides gene expression profiles associated with solid tumor stem cells, as well as novel stem cell cancer markers useful for the diagnosis, characterization, and treatment of solid tumor stem cells.

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