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1. 发明专利

AU3613001A Production method of recombinant rotavirus structural proteins and vaccine composition 未知
公开(公告)号：AU3613001A
公开(公告)日：2001-08-20
申请号：AU3613001
申请日：2001-02-12
申请人： KIM WON YONG , CHUNG IN SIK
发明人： KIM WON-YONG , CHUNG IN-SIK , LEE YOUN-HYUNG , KIM HONG-JOONG
IPC分类号： A61K39/00 , C07K14/14 , C12N15/82 , C12N5/00
摘要： The present invention relates to a method for producing recombinant rotavirus structural proteins by culturing a transformed plant cell, and to a vaccine composition comprising the same as an effective component. More specifically, the method comprises the steps of preparing the expression vector comprising cDNA fragments encoding rotavirus structural proteins; transforming a plant cell with the expression vector; and recovering the vaccine composition, including rotavirus antigens, from the cell culture. The method for producing the recombinant rotavirus structural proteins is advantageous in that higher yields of more than 0.3 mg/L are obtained, as well as a lower cost and a lower contamination hazard than those of eukaryotic expression systems such as baculovirus and animal cell. Furthermore, the method can be used to produce a edible vaccine. The invention also proves that the rotavirus structural protein can be produced with a high aspect rotary vessel reactor.

2. 发明授权

KR100863351B1 COOLING APPARATUS 有权
标题翻译：冷却装置
公开(公告)号：KR100863351B1
公开(公告)日：2008-10-15
申请号：KR20080017535
申请日：2008-02-26
申请人： CHUNG IN SIK
发明人： CHUNG IN SIK
IPC分类号： F25B40/02 , F25B43/00
摘要： A freezing apparatus is provided to effectively cool off refrigerant supplied to an evaporator using evaporation heat generated when liquid refrigerant is evaporated in an accumulator. A freezing apparatus(10) comprises a compressor(11), a condenser(13) connected to the compressor through a first connection pipe(12), a crossing shaft part, an evaporator(16) connected to the crossing shaft part, an accumulator(18) installed on a third connection pipe(17), and a heat exchanger(19) for preliminarily cooling refrigerant introduced from the accumulator to the evaporator. The crossing shaft part communicates with a second connection pipe(14) extending from the condenser. The third connection pipe interconnects the evaporator and the compressor.
摘要翻译：提供一种冷冻装置，用于在液体制冷剂在蓄压器中蒸发时产生的蒸发热量，有效地冷却供给蒸发器的制冷剂。冷冻装置（10）包括压缩机（11），通过第一连接管（12）连接到压缩机的冷凝器（13），交叉轴部分，连接到交叉轴部分的蒸发器（16），蓄能器（18），以及热交换器（19），用于预先将从蓄能器引入蒸发器的制冷剂冷却。交叉轴部分与从冷凝器延伸的第二连接管（14）连通。第三连接管将蒸发器和压缩机互连。

3. 发明申请

WO2011136506A9 METHOD FOR PRODUCING RECOMBINANT COMPLEX ANTIGENS USING NANOPARTICLES OF HUMAN ROTAVIRUS 审中-公开
标题翻译：使用人类脊髓损伤的纳米颗粒生产重组复合抗原的方法
公开(公告)号：WO2011136506A9
公开(公告)日：2012-03-01
申请号：PCT/KR2011002937
申请日：2011-04-22
申请人： UNIV CHUNG ANG IND , KIM WON YONG , CHUNG IN SIK , KIM JONG-BUM , SHON DONG-HWA , THAN VAN THAI , YOON JANG WON , PARK JOO HYOUNG , BAEK IN-HYUK
发明人： KIM WON YONG , CHUNG IN SIK , KIM JONG-BUM , SHON DONG-HWA , THAN VAN THAI , YOON JANG WON , PARK JOO HYOUNG , BAEK IN-HYUK
IPC分类号： C12N15/46 , C07K19/00 , C12N15/51 , C12N15/866
CPC分类号： A61K39/29 , A61K39/12 , A61K39/15 , A61K2039/5256 , A61K2039/5258 , A61K2039/55566 , A61K2039/627 , A61K2039/64 , C07K14/005 , C07K2319/00 , C12N2710/14143 , C12N2720/12322 , C12N2720/12334 , C12N2770/32234 , C12N2770/32422 , C12N2770/32434 , G01N33/56983 , G01N2333/14
摘要： The present invention relates to a construct for expressing rotavirus complex antigens having heterologous virus antigen epitopes, to a vaccine composition comprising the rotavirus complex antigens, to rotavirus-like particles comprising the rotavirus complex antigens, and to a vaccine composition comprising the rotavirus-like particles. According to the present invention, complex antigens comprising both the rotavirus antigens and epitopes of heterologous viruses different from the rotaviruses, and rotavirus-like particles comprising the complex antigens can be mass-produced at low costs. The method of the present invention can be applied to the study and development of novel complex vaccines against rotaviruses and heterologous viruses.
摘要翻译：本发明涉及将含有异源病毒抗原表位的轮状病毒复合抗原，包含轮状病毒复合抗原的疫苗组合物，包含轮状病毒复合物抗原的轮状病毒样颗粒，以及包含轮状病毒样颗粒的疫苗组合物。根据本发明，可以以低成本批量生产包含轮状病毒抗原和不同于轮状病毒的异源病毒的表位的复合抗原和包含复合抗原的轮状病毒样颗粒。本发明的方法可用于研究和开发抗轮状病毒和异源病毒的新型复合疫苗。

4. 发明申请

WO2009131423A3 NOVEL HEPATITIS A VIRUS ANTIGEN GENE AND TRANSFORMED PLANTS WITH THE GENE 审中-公开
标题翻译：新型乙型肝炎病毒抗原基因和转基因植物与基因
公开(公告)号：WO2009131423A3
公开(公告)日：2009-12-23
申请号：PCT/KR2009002173
申请日：2009-04-24
申请人： UNIV KYUNG HEE UNIV IND COOP GROUP , MEDIKAN INC , CHUNG IN SIK , KIM KYUNG IL , LEE JONG MIN , LEE HYUN HO , SHON DONG HWA , KIM WON YONG , LEE HEEYOUNG , CHUNG HO YONG , CHUNG HA YOUNG , HWANG BO JEON , YOO KI HYUN , KIM JONG BUM
发明人： CHUNG IN SIK , KIM KYUNG IL , LEE JONG MIN , LEE HYUN HO , SHON DONG HWA , KIM WON YONG , LEE HEEYOUNG , CHUNG HO YONG , CHUNG HA YOUNG , HWANG BO JEON , YOO KI HYUN
IPC分类号： C12N15/33 , C12N15/63
CPC分类号： C12N15/8258
摘要： The present invention relates to a novel hepatitis A virus antigen gene and transformed plants with the gene, more particularly to a novel hepatitis A virus antigen gene synthesized by optimization of a genetic code, a recombinant vector containing the gene and plants transformed with the recombinant vector. According to the invention, the use of a synthesized antigen gene of hepatitis A virus makes it possible to prepare recombinant hepatitis A virus vaccine materials at a high efficiency, and transformed plants expressing a hepatitis A virus antigen are useful as functional food materials and orally administrated vaccine materials.
摘要翻译：本发明涉及一种新型甲型肝炎病毒抗原基因和具有该基因的转化植物，更具体地涉及通过优化遗传密码合成的新型甲型肝炎病毒抗原基因，含有该基因的重组载体和用该重组载体转化的植物。根据本发明，甲型肝炎病毒合成抗原基因的使用使得能够以高效率制备重组甲型肝炎病毒疫苗材料，表达甲型肝炎病毒抗原的转化植物可用作功能性食品材料并经口服疫苗材料。

5. 发明申请

WO2011136506A3 METHOD FOR PRODUCING RECOMBINANT COMPLEX ANTIGENS USING NANOPARTICLES OF HUMAN ROTAVIRUS 审中-公开
标题翻译：使用人轮状病毒纳米颗粒生产重组复合抗原的方法
公开(公告)号：WO2011136506A3
公开(公告)日：2012-04-19
申请号：PCT/KR2011002937
申请日：2011-04-22
申请人： UNIV CHUNG ANG IND , KIM WON YONG , CHUNG IN SIK , KIM JONG-BUM , SHON DONG-HWA , THAN VAN THAI , YOON JANG WON , PARK JOO HYOUNG , BAEK IN-HYUK
发明人： KIM WON YONG , CHUNG IN SIK , KIM JONG-BUM , SHON DONG-HWA , THAN VAN THAI , YOON JANG WON , PARK JOO HYOUNG , BAEK IN-HYUK
IPC分类号： C12N15/46 , C07K19/00 , C12N15/51 , C12N15/866
CPC分类号： A61K39/29 , A61K39/12 , A61K39/15 , A61K2039/5256 , A61K2039/5258 , A61K2039/55566 , A61K2039/627 , A61K2039/64 , C07K14/005 , C07K2319/00 , C12N2710/14143 , C12N2720/12322 , C12N2720/12334 , C12N2770/32234 , C12N2770/32422 , C12N2770/32434 , G01N33/56983 , G01N2333/14
摘要： The present invention relates to a construct for expressing rotavirus complex antigens having heterologous virus antigen epitopes, to a vaccine composition comprising the rotavirus complex antigens, to rotavirus-like particles comprising the rotavirus complex antigens, and to a vaccine composition comprising the rotavirus-like particles. According to the present invention, complex antigens comprising both the rotavirus antigens and epitopes of heterologous viruses different from the rotaviruses, and rotavirus-like particles comprising the complex antigens can be mass-produced at low costs. The method of the present invention can be applied to the study and development of novel complex vaccines against rotaviruses and heterologous viruses.
摘要翻译：本发明涉及用于表达具有异源病毒抗原表位的轮状病毒复合抗原，包含轮状病毒复合抗原的疫苗组合物，包含轮状病毒复合抗原的轮状病毒样颗粒的构建体，以及包含轮状病毒样颗粒。根据本发明，包含轮状病毒抗原和不同于轮状病毒的异源病毒表位的复合抗原和包含复合抗原的轮状病毒样颗粒可以以低成本大量生产。本发明的方法可以应用于研究和开发针对轮状病毒和异源病毒的新型复合疫苗。

6. 发明申请

WO2008069598A1 METHOD FOR PREPARING ANTIGEN OF HEPATITIS A VIRUS USING TRANSFORMED INSECT CELLS 审中-公开
标题翻译：使用转化的细胞株制备乙型肝炎病毒的方法
公开(公告)号：WO2008069598A1
公开(公告)日：2008-06-12
申请号：PCT/KR2007/006322
申请日：2007-12-06
申请人： MEDIKAN INC. , CHUNG, In Sik , KIM, Wonyong , LEE, Heeyoung
发明人： CHUNG, In Sik , KIM, Wonyong , LEE, Heeyoung
IPC分类号： C12N15/85
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K39/125 , A61K2039/5256 , A61K2039/542 , A61K2039/55544 , A61K2039/55566 , C12N7/00 , C12N2710/14043 , C12N2770/32421 , C12N2770/32422 , C12N2770/32434 , Y02A50/464
摘要： The present invention relates to a method for stably preparing the VPl or VP2 antigen protein of hepatitis A virus using insect cells transformed with a recombinant vector containing the antigen gene of hepatitis A virus. When the transformed insect cells expressing the antigen gene of hepatitis A virus is used, a recombinant hepatitis A virus antigen can be stably prepared, and it can be used as a vaccine.
摘要翻译：本发明涉及使用含有甲型肝炎病毒抗原基因的重组载体转化的昆虫细胞，稳定地制备甲型肝炎病毒的VP1或VP2抗原蛋白的方法。当使用表达甲型肝炎病毒的抗原基因的转化的昆虫细胞时，可以稳定地制备重组甲型肝炎病毒抗原，可以用作疫苗。

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