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1. 发明申请

WO2008076819A3 HUMAN GROWTH HORMONE FORMULATIONS 审中-公开
标题翻译：人类生长激素配方
公开(公告)号：WO2008076819A3
公开(公告)日：2009-03-26
申请号：PCT/US2007087417
申请日：2007-12-13
申请人： ALTUS PHARMACEUTICALS INC , CHUNG WEN-LI , BUSH LAWRENCE , PECHENOV SERGEY , BASU SUJIT K
发明人： CHUNG WEN-LI , BUSH LAWRENCE , PECHENOV SERGEY , BASU SUJIT K
IPC分类号： A61K9/10 , A61K38/27
CPC分类号： A61K9/0019 , A61K9/0021 , A61K38/27 , A61K47/34 , A61K47/645 , A61K47/6921 , C07K14/61
摘要： Formulations containing complexed human growth hormone crystals are described. Also described are needleless injection systems for crystalline proteins.
摘要翻译：描述了含有复合人生长激素晶体的制剂。还描述了用于结晶蛋白的无针注射系统。

2. 发明申请

WO1998028007A1 STABLE LIQUID INTERFERON FORMULATIONS 审中-公开
标题翻译：稳定液体干扰素制剂
公开(公告)号：WO1998028007A1
公开(公告)日：1998-07-02
申请号：PCT/US1997023817
申请日：1997-12-23
申请人： BIOGEN, INC. , DIBIASI, Mary, D. , STAPLES, Mark , CHUNG, Wen-Li , SCHARIN, Eric
发明人： BIOGEN, INC.
IPC分类号： A61K47/18
CPC分类号： A61K47/183 , A61K9/0019 , A61K38/215
摘要： Liquid interferon compositions having a pH between 4.0 and 7.2 are described. The compositions comprise interferon-beta and a stabilizing agent at between about 0.3 % and 5 % by weight which is an amino acid selected from the group consisting of acidic amino acids, arginine and glycine. If needed, salt is added to provide sufficient ionic strength. The liquid composition has not been previously lyophilized or previously cavitated. The liquid is preferably contained within a vessel having at least one surface in contact with the liquid that is coated with a material inert to adsorption of interferon-beta. A kit for parenteral administration of a liquid interferon formulation and a method for stabilizing liquid interferon compositions are also described.
摘要翻译：描述pH在4.0和7.2之间的液体干扰素组合物。所述组合物包含约0.3％至5％重量的干扰素-β和稳定剂，其为选自酸性氨基酸，精氨酸和甘氨酸的氨基酸。如果需要，加入盐以提供足够的离子强度。液体组合物以前没有冻干或先前被气蚀。液体优选包含在具有至少一个表面与液体接触的容器中，该表面涂覆有对吸附干扰素-β无惰性的物质。还描述了用于液体干扰素制剂的肠胃外给药的试剂盒和用于稳定液体干扰素组合物的方法。

3. 发明申请

WO2008076819A2 HUMAN GROWTH HORMONE FORMULATIONS 审中-公开
标题翻译：人类生长激素配方
公开(公告)号：WO2008076819A2
公开(公告)日：2008-06-26
申请号：PCT/US2007/087417
申请日：2007-12-13
申请人： ALTUS PHARMACEUTICALS INC. , CHUNG, Wen-Li , BUSH, Lawrence , PECHENOV, Sergey , BASU, Sujit K.
发明人： CHUNG, Wen-Li , BUSH, Lawrence , PECHENOV, Sergey , BASU, Sujit K.
IPC分类号： A61K9/10 , A61K38/27
CPC分类号： A61K9/0019 , A61K9/0021 , A61K38/27 , A61K47/34 , A61K47/645 , A61K47/6921 , C07K14/61
摘要： Formulations containing complexed human growth hormone crystals are described. Also described are needleless injection systems for crystalline proteins.
摘要翻译：描述了含有复合人生长激素晶体的制剂。还描述了用于结晶蛋白的无针注射系统。

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