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    • 4. 发明申请
    • BENZOYLUREA DERIVATIVES AND ANTINEOPLASTIC COMPOSITIONS CONTAINING THEM
    • 苯甲酰衍生物和含有它们的抗生素组合物
    • WO1995025096A1
    • 1995-09-21
    • PCT/KR1995000021
    • 1995-03-15
    • KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGYHWANG, Ki-JunPARK, Kyung-HoLEE, Chong, OckCHOI, Sang, Un
    • KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY
    • C07D239/34
    • C07D231/26C07D231/22
    • The present invention concerns benzoylurea derivatives represented by formula (I), wherein R and R are the same or different, and each represents hydrogen; one or more halogen atoms selected from the group consisting of fluorine, chlorine and bromine; straight or branch chained alkoxy group having 1 to 6 carbon atoms; haloalkyl group or nitro group; R represents hydrogen; straight or branch chained alkyl group having 1 to 6 carbon atoms; W, X and Y are the same or different, and each represents hydrogen; one or more halogen atoms selected from the group consisting of fluorine, chlorine and bromine; straight or branch chained alkyl group having 1 to 6 carbon atoms; straight or branch chained haloalkyl group having 1 to 6 carbon atoms; or phenyl group, optionally substituted with halogen, alkyl group having 1 to 6 carbon atoms or haloalkyl group; and Z represents oxygen or sulfur atom, and pharmaceutically acceptable salts thereof.
    • 本发明涉及由式(I)表示的苯甲酰基脲衍生物,其中R和R 2相同或不同,各自表示氢; 一个或多个选自氟,氯和溴的卤素原子; 具有1至6个碳原子的直链或支链烷氧基; 卤代烷基或硝基; R 1表示氢; 具有1-6个碳原子的直链或支链烷基; W,X和Y相同或不同,各自表示氢; 一个或多个选自氟,氯和溴的卤素原子; 具有1-6个碳原子的直链或支链烷基; 具有1至6个碳原子的直链或支链的卤代烷基; 或苯基,任选被卤素取代,具有1至6个碳原子的烷基或卤代烷基; Z表示氧或硫原子,及其药学上可接受的盐。