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1. 发明公开

EP0119269A1 ALCOHOL BREATH TESTER 失效
标题翻译：酒精ATEMTESTVORRICHTUNG。
公开(公告)号：EP0119269A1
公开(公告)日：1984-09-26
申请号：EP83903273.0
申请日：1983-09-22
申请人： CHILDS, Robert L. , CHILDS, Richard W.
发明人： CHILDS, Robert L. , CHILDS, Richard W.
IPC分类号： G01N33
CPC分类号： G01N33/98 , G01N33/4972
摘要： Appareil permettant de déterminer la teneur en alcool de l'haleine d'un sujet humain. Le dispositif comprend une cartouche transparente (30) possédant un sommet et un fond, une première soupape à sens unique (36) disposée sur le fond du récipient (30) et orientée de manière à permettre uniquement l'entrée dans le récipient (30). Une solution sensible à l'alcool (37) est disposée dans le récipient (30) et une telle solution (37) est composée de manière à changer de couleur en fonction de l'alcool combiné à la solution (37). Une embouchure (24) et un organe de corps (12) sont également prévus, un passage (14) reliant l'embouchure (24) à la soupape à sens unique (36) par laquelle, lorsque le sujet expire au travers de l'embouchure (24), l'haleine pénètre dans la solution (37) au travers de la soupape à sens unique (36) et s'écoule au travers de la solution (37). La couleur de la solution (37) varie alors en fonction de la quantité d'alcool présente dans l'haleine du sujet.

2. 发明专利

AU2080083A ALCOHOL BREATH TESTER 未知
公开(公告)号：AU2080083A
公开(公告)日：1984-04-04
申请号：AU2080083
申请日：1983-09-22
申请人： CHILDS ROBERT L , CHILDS RICHARD W
发明人： CHILDS ROBERT L , CHILDS RICHARD W
IPC分类号： G01N31/06

3. 发明专利

IL273979D0 Methods of producing modified natural killer cells and methods of use 未知
公开(公告)号：IL273979D0
公开(公告)日：2020-05-31
申请号：IL27397920
申请日：2020-04-16
申请人： US HEALTH , CHILDS RICHARD W , DAVID S J ALLAN
发明人： RICHARD W CHILDS , DAVID S J ALLAN
IPC分类号： A61P31/12 , A61K35/17 , A61P35/00 , C12N5/00 , C12N5/0783 , C12N15/867
摘要： Disclosed herein are method of producing NK cells that include one or more heterologous nucleic acids. The methods include culturing a population of isolated NK cells in the presence of one or more cytokines to produce a population of activated NK cells. The population of activated NK cells are transduced with a viral vector comprising the one or more heterologous nucleic acids, for example by contacting the activated NK cells with viral particles including the viral vector. The resulting transduced NK cells are then cultured in the presence of one or more cytokines, and optionally in the presence of irradiated feeder cells, to produce a population of expanded transduced NK cells. Also disclosed are methods of treating a subject with a disorder (such as a tumor or hyperproliferative disorder) by administering to the subject NK cells produced by the methods described herein.

4. 发明申请

WO1984001222A1 ALCOHOL BREATH TESTER 审中-公开
公开(公告)号：WO1984001222A1
公开(公告)日：1984-03-29
申请号：PCT/US1983001454
申请日：1983-09-22
申请人： CHILDS, Robert, L. , CHILDS, Richard, W.
IPC分类号： G01N31/06
CPC分类号： G01N33/98 , G01N33/4972
摘要： Apparatus for determining the alcohol content in the breath of a human subject. The apparatus comprises a clear cartridge (30) having a top and a bottom, a first oneway valve (36) disposed in the bottom of the container (30) and oriented to permit only ingress to the container (30). An alcohol - sensitive solution (37) is disposed in the container (30) and such solution (37) is formulated to change color in accordance with alcohol combined with the solution (37). A mouthpiece (24) and a body member (12) are also provided having a passageway (14) connecting the mouthpiece (24) to the oneway valve (36) whereby, when the subject exhales through the mouthpiece (24), the breath enters the solution (37) through the oneway valve (36) and flows through the solution (37). The color of the solution (37) then changes in accordance with the quantity of alcohol in the subject's breath.
摘要翻译：用于确定人类受试者呼吸中的酒精含量的装置。该设备包括具有顶部和底部的清洁盒（30），设置在容器（30）的底部中并定向成仅允许进入容器（30）的第一单向阀（36）。酒精敏感溶液（37）设置在容器（30）中，并且这种溶液（37）被配制为根据与溶液（37）组合的醇改变颜色。吸嘴（24）和本体构件（12）还设有具有将接口（24）连接到单向阀（36）的通道（14），由此当被检者通过接口管（24）呼出时，呼吸进入溶液（37）通过单向阀（36）并流过溶液（37）。然后溶液（37）的颜色根据受试者呼吸中的酒精量而变化。

5. 发明申请

WO2022098718A1 MODIFIED NK CELLS WITH REDUCED CCR5 EXPRESSION AND METHODS OF THEIR USE 审中-公开
公开(公告)号：WO2022098718A1
公开(公告)日：2022-05-12
申请号：PCT/US2021/057845
申请日：2021-11-03
申请人： THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES , CHILDS, Richard W. , LEVY, Emily R. , CLARA, Joseph
发明人： CHILDS, Richard W. , LEVY, Emily R. , CLARA, Joseph
IPC分类号： C12N5/0783
摘要： Modified NK cells with reduced expression of CCR5 are provided. Methods of treating a subject with cancer with the modified NK cells are also provided. In some examples, the modified NK cells also have reduced expression of one or more of CCR1, CXCR6, and CD38, increased expression of one or more of CXCR4, CCR7, and CXCR3, and/or express a chimeric antigen receptor.

6. 发明申请

WO2010129569A1 SELECTIVE ACCESS TO CRYOPRESERVED SAMPLES 审中-公开
标题翻译：选择性获得CRYOPRESERVED样品
公开(公告)号：WO2010129569A1
公开(公告)日：2010-11-11
申请号：PCT/US2010/033575
申请日：2010-05-04
申请人： THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES , AMERICAN FLUOROSEAL CORPORATION , CHILDS, Richard, W. , CULLIS, Herb , VASU, Sumithira , BROUSSARD, Phillippe, Jean , CLARK, Kevin, Douglas , HARTING, Eric, Kelsey
发明人： CHILDS, Richard, W. , CULLIS, Herb , VASU, Sumithira , BROUSSARD, Phillippe, Jean , CLARK, Kevin, Douglas , HARTING, Eric, Kelsey
IPC分类号： G01N1/28 , A01N1/02 , A01M1/02 , B29C65/00
CPC分类号： B65B17/00 , A01N1/0252 , A01N1/0257 , A61M1/0281 , B29C63/18 , B29C65/04 , B29C65/08 , B29C65/14 , B29C65/1412 , B29C65/18 , B29C65/224 , B29C65/228 , B29C65/743 , B29C65/7443 , B29C65/7841 , B29C66/0044 , B29C66/024 , B29C66/0242 , B29C66/1122 , B29C66/348 , B29C66/43 , B29C66/431 , B29C66/4312 , B29C66/43121 , B29C66/53262 , B29C66/7373 , B29C66/73921 , B29C66/8122 , B29C66/81261 , B29C66/81427 , B29C66/818 , B29C66/8181 , B29C66/81811 , B29C66/81821 , B29C66/81831 , B29C66/81871 , B29C66/8242 , B29C66/8322 , B29C66/91213 , B29C66/91221 , B29C66/91231 , B29C66/91421 , B29C66/91423 , B29C66/91441 , B29C66/91445 , B29C66/9161 , B29C66/91655 , B29C66/919 , B29C66/9221 , B29C66/9231 , B29C66/9241 , B29C66/92445 , B29C66/94 , B29C66/949 , B29C66/961 , B29C2035/0822 , B29C2793/0054 , B29L2031/7148 , G01N1/286 , Y10T83/041 , Y10T83/283 , B29C65/00 , B29K2827/18 , B29K2827/12 , B29K2909/02
摘要： Methods and apparatus for selectively accessing a portion of a sterile cryopreserved sample are disclosed. The apparatus may include a container configured to receive the cryopreserved sample and having a first portion and a second portion, a heat sink chamber surrounding the first portion of the container, and a heat source adjacent to the second portion of the container. The chamber may be configured to maintain a non-accessed portion of the sample in a cryopreserved state. The heat source may be configured to separating an accessed portion of the sample from the non-accessed portion of the sample while maintaining the viability of the accessed portion while the non-accessed portion is maintained in the cryopreserved state.
摘要翻译：公开了用于选择性访问无菌冷冻保存样品的一部分的方法和装置。该装置可以包括容纳构造成接收冷冻保存样品并具有第一部分和第二部分的容器，围绕容器的第一部分的散热室以及与容器的第二部分相邻的热源。腔室可以被配置为将样品的未被接近的部分保持在冷冻保存状态。热源可以被配置为将样本的被访问部分与样本的未访问部分分离，同时保持所访问部分的可行性，同时将未访问部分保持在冷冻保存状态。

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