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1. 发明专利

IL184984D0 PYRIMIDINE COMPOUND CRYSTAL OR AMORPHOUS FORM AND PROCESS FOR PRODUCING THE SAME 未知
公开(公告)号：IL184984D0
公开(公告)日：2007-12-03
申请号：IL18498407
申请日：2007-08-01
申请人： EISAI R&D MAN CO LTD , HARADA HITOSHI , ISHIHARA HIROSHI , SATO YOSHIAKI , CHIBA HIROYUKI , KOMATSU YUKI , INOUE SUSUMU , OZEKI NAOKI
IPC分类号： C07D20100101
摘要： Process to make 5-[2-amino-4-(2-furyl)pyrimidin-5-yl]-1-methylpyridin-2(1 H )-one.

2. 发明专利

IL209568D0 PYRIMIDINE COMPOUND CRYSTAL OR AMORPHOUS FORM AND PROCESS FOR PRODUCING THE SAME 未知
公开(公告)号：IL209568D0
公开(公告)日：2011-01-31
申请号：IL20956810
申请日：2010-11-25
申请人： EISAI R&D MAN CO LTD , HARADA HITOSHI , ISHIHARA HIROSHI , SATO YOSHIAKI , CHIBA HIROYUKI , KOMATSU YUKI , INOUE SUSUMU , OZEKI NAOKI
IPC分类号： C07D20060101
摘要： Process to make 5-[2-amino-4-(2-furyl)pyrimidin-5-yl]-1-methylpyridin-2(1 H )-one.

3. 发明专利

IL184983D0 CRYSTAL OF 5-[2-AMINO-4-(2-FURYL)PYRIMIDIN-5-YL]-1 -METHYLPYRIDIN-2(1H)-ONE AND PROCESSES FOR PRODUCING THE SAME 未知
公开(公告)号：IL184983D0
公开(公告)日：2007-12-03
申请号：IL18498307
申请日：2007-08-01
申请人： EISAI R&D MAN CO LTD , HARADA HITOSHI , ISHIHARA HIROSHI , SATO YOSHIAKI , CHIBA HIROYUKI , TAKIGAWA TEIJI
IPC分类号： C07D20100101
摘要： Process to make 5-[2-amino-4-(2-furyl)pyrimidin-5-yl]-1-methylpyridin-2(1 H )-one.

4. 发明专利

IL184983A CRYSTAL OF 5-[2-AMINO-4-(2-FURYL)PYRIMIDIN-5-YL]-1-METHYLPYRIDIN-2(1H)-ONE AND PROCESSES FOR PRODUCING THE SAME 未知
公开(公告)号：IL184983A
公开(公告)日：2011-12-29
申请号：IL18498307
申请日：2007-08-01
申请人： EISAI R&D MAN CO LTD , HARADA HITOSHI , ISHIHARA HIROSHI , SATO YOSHIAKI , CHIBA HIROYUKI , TAKIGAWA TEIJI
发明人： HARADA HITOSHI , ISHIHARA HIROSHI , SATO YOSHIAKI , CHIBA HIROYUKI , TAKIGAWA TEIJI
摘要： Process to make 5-[2-amino-4-(2-furyl)pyrimidin-5-yl]-1-methylpyridin-2(1 H )-one.

5. 发明专利

IL209568A PROCESS FOR PREPARING 5-[2-AMINO-4-(2-FURYL)PYRIMIDIN-5-YL]-1-METHYLPYRIDIN-2(1H)-ONE AND DERIVATIVES THEREOF 未知
公开(公告)号：IL209568A
公开(公告)日：2011-11-30
申请号：IL20956810
申请日：2010-11-25
申请人： EISAI R&D MAN CO LTD , HARADA HITOSHI , ISHIHARA HIROSHI , SATO YOSHIAKI , CHIBA HIROYUKI , KOMATSU YUKI , INOUE SUSUMU , OZEKI NAOKI
发明人： HARADA HITOSHI , ISHIHARA HIROSHI , SATO YOSHIAKI , CHIBA HIROYUKI , KOMATSU YUKI , INOUE SUSUMU , OZEKI NAOKI
摘要： Process to make 5-[2-amino-4-(2-furyl)pyrimidin-5-yl]-1-methylpyridin-2(1 H )-one.

6. 发明公开

EP1413574A1 PYRROLIDINE DERIVATIVES AND METHOD OF SYNTHESIZING THESE 审中-公开
标题翻译：吡咯烷衍生物及其合成方法
公开(公告)号：EP1413574A1
公开(公告)日：2004-04-28
申请号：EP02743893.6
申请日：2002-07-09
申请人： Eizai Co., Ltd. , Chiba, Hiroyuki , Nakamura, Taiju
发明人： TAGAMI, Katsuya , CHIBA, H., Room 1202, Fujiwa-city-homes-bunkyo-ot , NAKAMURA, T., Room 204, Grand-chariot 2bankan , KUBOTA, Manabu , MATSUI, Makoto, Room 305 , KAYANO, Akio , MIYAZAWA, Mamoru , ABE, Taichi
IPC分类号： C07D207/12
CPC分类号： C07D207/12 , Y02P20/55
摘要： The object of the invention is to provide a process for efficient, inexpensive and stereoselective production of (2S,4S)-2-[[(3R)-pyrrolidin-3-yl-(R)-hydroxy] methyl] pyrrolidin-4-thiol dihydrochloride useful as an intermediate in production of novel carbapenem, and the intermediate is produced via a novel crystallizable intermediate (2S,4R)-N-t-butoxycarbonyl-2-[[(3R)-N-t-butoxycarbonyl pyrrolidin-3-yl-(R)-hydroxy]methyl]-4-hydroxypyrrolidine from a (2S,4R)-4-alkylsilyloxy-N-t-butoxycarbonylpyridine-2-carbal dehyde derivative by aldol reaction using an asymmetric assistant such as amino-alcohol.
摘要翻译：本发明的目的是提供一种用于（2S，4S）-2 - [[（3R） - 吡咯烷-3-基 - （R） - 羟基]甲基]吡咯烷-4-酮的有效，廉价和立体选择性生产的方法，（2S，4R）-N-叔丁氧基羰基-2 - [[（3R）-N-叔丁氧基羰基吡咯烷-3-基 - （（2S，4R）-4-烷基甲硅烷氧基-N-叔丁氧基羰基吡啶-2-甲醛衍生物通过使用不对称助剂如氨基醇进行醛醇缩合反应来制备（R） - 羟基]甲基] -4-羟基吡咯烷。

7. 发明公开

EP1413574A4 PYRROLIDINE DERIVATIVES AND METHOD OF SYNTHESIZING THESE 审中-公开
标题翻译：吡咯烷合成和方法
公开(公告)号：EP1413574A4
公开(公告)日：2004-12-08
申请号：EP02743893
申请日：2002-07-09
申请人： EIZAI CO LTD , CHIBA HIROYUKI , NAKAMURA TAIJU
发明人： TAGAMI KATSUYA , CHIBA H , NAKAMURA T , KUBOTA MANABU , MATSUI MAKOTO , KAYANO AKIO , MIYAZAWA MAMORU , ABE TAICHI
IPC分类号： C07D207/12 , C07M7/00
CPC分类号： C07D207/12 , Y02P20/55
摘要： A process for efficiently, inexpensively, and stereoselectively producing (2S,4S)-2-[[(3R)-pyrrolidin-3-yl-(R)-hydroxy]methyl]pyrrolidine-4-thiol dihydrochloride, which is useful as an intermediate for the production of a novel carbapenem; and the novel intermediate. The intermediate is produced from a (2S,4R)-4-alkylsilyloxy-N-t-butoxycarbonylpyrrolidine-2-carbaldehyde derivative through an aldol reaction using an asymmetric synthesis aid such as an amino alcohol or via (2S,4R)-N-t-butoxycarbonyl-2-[[(3R)-N-t-butoxycarbonylpyrrolidin-3-yl-(R)-hydroxy]methyl]-4-hydroxypyrrolidine, which is a novel intermediate having crystallinity.

8. 发明申请

WO2012147900A1 MICROREACTOR PROCESS FOR HALICHONDRIN B ANALOG SYNTHESIS 审中-公开
标题翻译： HALICHONDRIN B类似物合成的MICROREACTOR过程
公开(公告)号：WO2012147900A1
公开(公告)日：2012-11-01
申请号：PCT/JP2012/061307
申请日：2012-04-20
申请人： EISAI R&D MANAGEMENT CO., LTD. , CHIBA, Hiroyuki , FUKUYAMA, Takashi , TAKIGAWA, Teiji , KOMATSU, Yuki
发明人： CHIBA, Hiroyuki , FUKUYAMA, Takashi , TAKIGAWA, Teiji , KOMATSU, Yuki
IPC分类号： C07D493/04 , C07D493/22
CPC分类号： C07D493/22 , C07D493/04
摘要： The present invention provides methods for producing eribulin, intermediates useful for the synthesis of eribulin, or pharmaceutically acceptable salts thereof, e.g., eribulin mesylate using microreactors.
摘要翻译：本发明提供了生产可用于合成干燥蛋白的中间体或其药学上可接受的盐，例如使用微反应器的甲磺酸艾美林的方法。

9. 发明申请

WO2007112230A2 WIRE MOLD SPACER, WIRE CONNECTION KIT, WIRE FABRICATION METHOD AND WIRE 审中-公开
标题翻译：导线模制间隔器，导线连接套件，导线制造方法和导线
公开(公告)号：WO2007112230A2
公开(公告)日：2007-10-04
申请号：PCT/US2007/064369
申请日：2007-03-20
申请人： 3M INNOVATIVE PROPERTIES COMPANY , CHIBA, Hiroyuki
发明人： CHIBA, Hiroyuki
CPC分类号： H02G15/003 , H02G15/18
摘要： This invention provides a mold spacer for a wire, a wire connection kit, a wire fabrication method and a wire capable of improving the connection reliability of a joined portion. When forming an insulative wire covering by molding resin on a joint (6) of wire (1), a resin filling space to be filled in with a liquid resin (15) is formed between the joint (6) and mold case (10). Liquid resin (15) is poured in the resin filling space and solidified to form a wire mold spacer constituting an insulative covering (7) of predetermined thickness. The spacer comprises a cylindrical spacer body mounted on or adjacent to joint (6), and a multiplicity of pins projected radially outward from the outer surface of the spacer body with at least a plurality of projection ends adapted to contact the inner wall surface of the mold case (10).
摘要翻译：本发明提供了一种用于导线的模制间隔件，导线连接套件，导线制造方法和导线，其能够提高接合部分的连接可靠性。当通过在导线（1）的接头（6）上模制树脂形成绝缘导线覆盖物时，在接头（6）和模具外壳（10）之间形成用液体树脂（15）填充的树脂填充空间，。将液态树脂（15）倒入树脂填充空间并固化以形成构成预定厚度的绝缘覆盖物（7）的线模垫片。隔离件包括安装在接头（6）上或附近的圆柱形隔离件主体，以及从隔离件主体的外表面径向向外突出的多个销，至少多个突出端适于接触接头（6）的内壁表面模具盒（10）。

10. 发明申请

WO2008085692A1 CABLE CLAMPING HARDWARE AND CABLE CONNECTION BOX HAVING SAME 审中-公开
标题翻译：电缆夹紧硬件和具有相同功能的电缆连接盒
公开(公告)号：WO2008085692A1
公开(公告)日：2008-07-17
申请号：PCT/US2007/088324
申请日：2007-12-20
申请人： 3M INNOVATIVE PROPERTIES COMPANY , CHIBA, Hiroyuki , ONO, Shinichi , REBERS, Kenneth, D.
发明人： CHIBA, Hiroyuki , ONO, Shinichi , REBERS, Kenneth, D.
IPC分类号： H02G15/10
CPC分类号： H02G15/182
摘要： The present invention provides cable clamping hardware able to reduce the space for clamping cables and thereby able to flexibly handle any increase in the number of cables and a cable connection box having the same. Cable clamping hardware (15) provided with, inside a cable closure protecting a splice 4c of cables 2, a plate-shaped base (16) having a support plate (19) supporting cables and fastened to the cable closure and clamps (17) provided at the support plate (19) and clamping the cables (2) with the support plate (19), each clamp (17) provided with a support point supported at the support plate (19) in a pivotable state, a working part clamping a cable (2) with the support plate (19) at an opposite side from the support point, and an action point functioning as a fulcrum and receiving external force for making the working part operate.
摘要翻译：本发明提供了一种电缆固定硬件，其能够减少用于夹紧电缆的空间，从而能够灵活地处理电缆数量的增加以及具有该电缆的电缆连接盒。电缆夹紧件（15）在保护电缆2的接头4c的电缆封套内设有一个板状基座（16），该基座具有一个支撑电缆并支撑电缆的支撑板（19），并固定在电缆封闭件和夹具（17）上在支撑板（19）上并且用支撑板（19）夹住电缆（2），每个夹具（17）设置有在可枢转状态下支撑在支撑板（19）处的支撑点，夹紧电缆（2）与支撑板（19）在与支撑点相反的一侧，以及作为支点的作用点并且接收用于使作业部件工作的外力。

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