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1. 发明公开

EP1773265A2 NANO-PARTICLE PRODUCTION 审中-公开
标题翻译：纳米粒子的生产
公开(公告)号：EP1773265A2
公开(公告)日：2007-04-18
申请号：EP05858030.9
申请日：2005-07-08
申请人： Chen, Tzer-fen D.
发明人： Chen, Tzer-fen D.
IPC分类号： A61F13/00 , A61K9/14
CPC分类号： A61K9/145 , A61K9/0019
摘要： Larger particles (e.g., larger than 100 μm) of a material are processed to generate smaller particles having dimensions smaller than 200 nm. At least a portion of the processing is performed under a cryogenic condition and based on at least a physical property of the material under the cryogenic condition.

2. 发明申请

WO1991011670A1 INTERFACE FLUID HEAT TRANSFER SYSTEM 审中-公开
标题翻译：接口流体传热系统
公开(公告)号：WO1991011670A1
公开(公告)日：1991-08-08
申请号：PCT/US1990000554
申请日：1990-01-30
申请人： CHAO, James, C. , CHEN, Tzer-Fen
IPC分类号： F28B03/02
CPC分类号： F28B3/02 , B01D5/0027 , B01D5/0087
摘要： A process for condensing vapor or mist material onto a thin first liquid film surface (14), which liquid film (14) is generated and supported on the outer surface (12) of a porous structure (10). A moving condensable vapor (20) contacts the thin liquid film (14) and is condensed onto the liquid surface (14). The condensed vapor (21) drains by gravity action into a collection zone (22), together with a portion of the liquid film material being entrained therein. The vapor or mist material can be either substantially immiscible or miscible in the liquid film. The first liquid (16) is preferably provided in a closed system and is recycled at near ambient temperature and a pressure condition sufficient to produce the thin liquid film (14) external to the porous structure (10), which has a porosity of 20-80 %. A handling system for condensing an upflowing condensable vapor is disclosed.
摘要翻译：一种将蒸气或雾材料冷凝到薄的第一液膜表面（14）上的过程，该薄膜第一液膜表面（14）被产生并支撑在多孔结构（10）的外表面（12）上。移动的可冷凝蒸汽（20）接触薄液膜（14）并被冷凝到液体表面（14）上。冷凝的蒸气（21）通过重力作用排入收集区（22）中，一部分液膜材料被夹带在其中。蒸气或烟雾材料可以与液膜基本上是不混溶的或可混溶的。第一液体（16）优选地设置在封闭系统中，并且在接近环境温度和足以产生多孔结构（10）外部的薄液体膜（14）的压力条件下再循环，所述多孔结构（10）的孔隙率为20- 80％。公开了用于冷凝可向上流动的可冷凝蒸汽的处理系统。

3. 发明专利

IL182856A Method for stabilizing an enveloped virus for storage in aqueous solution 未知
公开(公告)号：IL182856A
公开(公告)日：2015-03-31
申请号：IL18285607
申请日：2007-04-29
申请人： WELLSTAT BIOLOGICS CORP , CHEN TZER-FEN , JANG JOUHN-WERN , MILLER JEFFREY ALLEN
发明人： CHEN TZER-FEN , JANG JOUHN-WERN , MILLER JEFFREY ALLEN
摘要： Envelope viruses (e.g. Newcastle disease virus (NDV)) are formulated for storage at moderately cold temperatures (e.g. −20° C.). The formulation is an aqueous solution containing the enveloped virus at a concentration of from 106 PFU/mL to 1012 PFU/mL; and a non-reducing saccharide (e.g. sucrose). When the non-reducing saccharide is a disaccharide it is present in the solution at a concentration of from 5% (w/v) to 50% (w/v), and when it is a monosaccharide it is present in the solution at a concentration of from 2.5% (w/v) to 25% (w/v). The solution has an osmotic pressure of about 250 mOs or higher, and has a pH of from 5 to 10.

4. 发明专利

IL182856D0 STABLE AND FILTERABLE ENVELOPED VIRUS FORMULATIONS 未知
公开(公告)号：IL182856D0
公开(公告)日：2007-08-19
申请号：IL18285607
申请日：2007-04-29
申请人： WELLSTAT BIOLOGICS CORP , CHEN TZER FEN , JANG JOUHN WERN , MILLER JEFFREY A
IPC分类号： C12N20100101
摘要： Envelope viruses (e.g. Newcastle disease virus (NDV)) are formulated for storage at moderately cold temperatures (e.g. −20° C.). The formulation is an aqueous solution containing the enveloped virus at a concentration of from 106 PFU/mL to 1012 PFU/mL; and a non-reducing saccharide (e.g. sucrose). When the non-reducing saccharide is a disaccharide it is present in the solution at a concentration of from 5% (w/v) to 50% (w/v), and when it is a monosaccharide it is present in the solution at a concentration of from 2.5% (w/v) to 25% (w/v). The solution has an osmotic pressure of about 250 mOs or higher, and has a pH of from 5 to 10.

5. 发明申请

WO2006135373A2 NANO-PARTICLE PRODUCTION 审中-公开
标题翻译：纳米颗粒生产
公开(公告)号：WO2006135373A2
公开(公告)日：2006-12-21
申请号：PCT/US2005024501
申请日：2005-07-08
申请人： CHEN TZER-FEN D
发明人： CHEN TZER-FEN D
IPC分类号： A61F13/00 , A61K9/14
CPC分类号： A61K9/145 , A61K9/0019
摘要： Larger particles (e.g., larger than 100 µm) of a material are processed to generate smaller particles having dimensions smaller than 200 nm. At least a portion of the processing is performed under a cryogenic condition and based on at least a physical property of the material under the cryogenic condition.
摘要翻译：对材料的较大颗粒（例如，大于100μm）进行处理以产生尺寸小于200nm的较小颗粒。处理的至少一部分在低温条件下进行，并且至少基于在低温条件下材料的物理性质。

6. 发明申请

WO2006052813A3 STABLE AND FILTERABLE ENVELOPED VIRUS FORMULATIONS 审中-公开
标题翻译：稳定和可过滤的包膜病毒制剂
公开(公告)号：WO2006052813A3
公开(公告)日：2006-09-14
申请号：PCT/US2005040149
申请日：2005-11-04
申请人： WELLSTAT BIOLOGICS CORP , CHEN TZER-FEN , JANG JOUHN-WERN , MILLER JEFFREY A
发明人： CHEN TZER-FEN , JANG JOUHN-WERN , MILLER JEFFREY A
IPC分类号： C12N7/02
CPC分类号： A61K9/0019 , A61K47/26 , C12N7/00 , C12N2760/18151
摘要： Envelope viruses (e.g. Newcastle disease virus (NDV)) are formulated for storage at moderately cold temperatures (e.g. -20 °C). The formulation is an aqueous solution containing the enveloped virus at a concentration of from 10 6 PFU/mL to 10 12 PFU/mL; and a non-reducing saccharide (e.g. sucrose). When the non-reducing saccharide is a disaccharide it is present in the solution at a concentration of from 5% (w/v) to 50% (w/v), and when it is a monosaccharide it is present in the solution at a concentration of from 2.5% (w/v) to 25% (w/v). The solution has an osmotic pressure of about 250 mOs or higher, and has a pH of from 5 to 10.
摘要翻译：包膜病毒（例如新城疫病毒（NDV））被配制用于在适度的低温（例如-20℃）下储存。制剂是含有浓度为10 6 PFU / mL至10 12 PFU / mL的包膜病毒的水溶液; 和非还原性糖（例如蔗糖）。当非还原性糖是二糖时，以5％（w / v）至50％（w / v）的浓度存在于溶液中，当其为单糖时，其存在于溶液中浓度为2.5％（w / v）至25％（w / v）。该溶液的渗透压为约250mOs以上，pH为5〜10。

7. 发明专利

CA2573657A1 NANO-PARTICLE PRODUCTION 未知
公开(公告)号：CA2573657A1
公开(公告)日：2006-12-21
申请号：CA2573657
申请日：2005-07-08
申请人： CHEN TZER-FEN D
发明人： CHEN TZER-FEN D
IPC分类号： A61F13/00 , A61K9/14

8. 发明申请

WO2006135373A3 NANO-PARTICLE PRODUCTION 审中-公开
公开(公告)号：WO2006135373A3
公开(公告)日：2006-12-21
申请号：PCT/US2005/024501
申请日：2005-07-08
申请人： CHEN, Tzer-fen, D.
发明人： CHEN, Tzer-fen, D.
IPC分类号： B29B9/00 , A61K9/14
摘要： Larger particles (e.g., larger than 100 μm) of a material are processed to generate smaller particles having dimensions smaller than 200 nm. At least a portion of the processing is performed under a cryogenic condition and based on at least a physical property of the material under the cryogenic condition.

9. 发明申请

WO2006052813A2 STABLE AND FILTERABLE ENVELOPED VIRUS FORMULATIONS 审中-公开
标题翻译：稳定和可过滤的包膜病毒制剂
公开(公告)号：WO2006052813A2
公开(公告)日：2006-05-18
申请号：PCT/US2005/040149
申请日：2005-11-04
申请人： WELLSTAT BIOLOGICS CORPORATION , CHEN, Tzer-Fen , JANG, Jouhn-Wern , MILLER, Jeffrey, A.
发明人： CHEN, Tzer-Fen , JANG, Jouhn-Wern , MILLER, Jeffrey, A.
IPC分类号： C12Q1/70 , C12N7/00
CPC分类号： A61K9/0019 , A61K47/26 , C12N7/00 , C12N2760/18151
摘要： Envelope viruses (e.g. Newcastle disease virus (NDV)) are formulated for storage at moderately cold temperatures (e.g. -20 °C). The formulation is an aqueous solution containing the enveloped virus at a concentration of from 10 6 PFU/mL to 10 12 PFU/mL; and a non-reducing saccharide (e.g. sucrose). When the non-reducing saccharide is a disaccharide it is present in the solution at a concentration of from 5% (w/v) to 50% (w/v), and when it is a monosaccharide it is present in the solution at a concentration of from 2.5% (w/v) to 25% (w/v). The solution has an osmotic pressure of about 250 mOs or higher, and has a pH of from 5 to 10.
摘要翻译：包膜病毒（例如新城疫病毒（NDV））被配制用于在中等低温（例如-20℃）下储存。该制剂是含有浓度为10 6 PFU / mL至10 12 PFU / mL的包膜病毒的水溶液; 和非还原糖（例如蔗糖）。当非还原性糖为二糖时，其以5％（w / v）至50％（w / v）的浓度存在于溶液中，当其为单糖时，其在溶液中以浓度从2.5％（w / v）到25％（w / v）。该溶液具有约250mOs或更高的渗透压，并具有5至10的pH。

10. 发明专利

TW200610577A 奈米粒子之製造 NANO-PARTICLE PRODUCTION 审中-公开
简体标题：奈米粒子之制造 NANO-PARTICLE PRODUCTION
公开(公告)号：TW200610577A
公开(公告)日：2006-04-01
申请号：TW094123188
申请日：2005-07-08
申请人：陳澤風 CHEN, TZER-FEN D.
发明人：陳澤風 CHEN, TZER-FEN D.
IPC分类号： B02C
CPC分类号： A61K9/145 , A61K9/0019
摘要：一物質之較大粒子(例如大於100μm)經處理而產生較小粒子其維度小於200nm。此處理程序之至少一部份係於一低溫狀態下進行，且係基於此物質在低溫狀態下之至少一物理性質而進行。
简体摘要：一物质之较大粒子(例如大于100μm)经处理而产生较小粒子其维度小于200nm。此处理进程之至少一部份系于一低温状态下进行，且系基于此物质在低温状态下之至少一物理性质而进行。

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