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1. 发明申请

WO2009092027A9 GASTROINTESTINAL ELECTRICAL STIMULATION FOR THE TREATMENT OF PANCREATITIS 审中-公开
公开(公告)号：WO2009092027A9
公开(公告)日：2009-07-23
申请号：PCT/US2009/031317
申请日：2009-01-16
申请人： BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM , PASRICHA, Pankaj , CHEN, Jiande
发明人： PASRICHA, Pankaj , CHEN, Jiande
IPC分类号： A61B18/18 , A61M37/00

2. 发明申请

WO2010101877A1 ELECTRICAL STIMULATION THERAPY TO PROMOTE GASTRIC DISTENTION FOR OBESITY MANAGEMENT 审中-公开
标题翻译：电刺激治疗促进胃肥力的治疗
公开(公告)号：WO2010101877A1
公开(公告)日：2010-09-10
申请号：PCT/US2010/025863
申请日：2010-03-02
申请人： MEDTRONIC, INC. , STARKEBAUM, Warren L. , CHEN, Jiande , FIRESTONE, Elizabeth D. , MAUDE-GRIFFIN, Roland C.
发明人： STARKEBAUM, Warren L. , CHEN, Jiande , FIRESTONE, Elizabeth D. , MAUDE-GRIFFIN, Roland C.
IPC分类号： A61N1/36
CPC分类号： A61F5/0026 , A61N1/36007
摘要： The disclosure is directed to techniques for delivering electrical stimulation therapy to support obesity management. The electrical stimulation therapy is configured to cause at least partial gastric distention. Gastric distention tends to induce a sensation of fullness and thereby discourages excessive food intake by the patient. The electrical stimulation therapy may be delivered to the gastrointestinal tract of the patient by electrodes deployed by one or more implantable leads coupled to an electrical stimulator. The electrical stimulator delivers stimulation pulses having a pulse width in a range found to be effective in causing gastric distention.
摘要翻译：本公开涉及用于递送电刺激治疗以支持肥胖症管理的技术。电刺激治疗被配置为引起至少部分胃膨胀。胃膨胀往往会引起丰满感，从而阻止患者摄取过量食物。电刺激治疗可以通过由耦合到电刺激器的一个或多个可植入引线部署的电极递送到患者的胃肠道。电刺激器传送刺激脉冲，其脉冲宽度在发现有效引起胃膨胀的范围内。

3. 发明申请

WO2009097542A9 ILEAL ELECTRICAL STIMULATION 审中-公开
公开(公告)号：WO2009097542A9
公开(公告)日：2009-08-06
申请号：PCT/US2009/032662
申请日：2009-01-30
申请人： BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM , CHEN, Jiande , PASRICHA, Pankaj
发明人： CHEN, Jiande , PASRICHA, Pankaj
IPC分类号： A61N1/36 , A61N1/32 , A61N1/18

4. 发明申请

WO2008070585A3 GASTROINTESTINAL ELECTRICAL STIMULATION FOR THE TREATMENT OF VISCERAL PAIN 审中-公开
公开(公告)号：WO2008070585A3
公开(公告)日：2008-06-12
申请号：PCT/US2007/086190
申请日：2007-11-30
申请人： BOARD OF REGENTS, UNIV OF TEXAS SYSTEM , CHEN, Jiande , PASRICHA, Pankaj Jay
发明人： CHEN, Jiande , PASRICHA, Pankaj Jay
IPC分类号： A61N1/00
摘要： The invention is a method of treatment for reducing visceral pain by administering in an individual in need thereof gastrointestinal electrical stimulation in repetitive trains of short pulses, where the administration of gastrointestinal electrical stimulation reduces visceral pain in the individual. Also, provided is a method of treating gastrointestinal sensory dysfunction. Further, this invention provides methods for modulating sympathetic nervous system for the treatment of visceral pain by administering in an individual in need thereof repetitive trains of short pulse electrical stimulation of the sympathetic nerves, where the electrical stimulation provided is effective in reducing visceral pain.

5. 发明申请

WO2006010025A3 TREATMENT OF THE AUTONOMIC NERVOUS SYSTEM 审中-公开
标题翻译：自主神经系统的治疗
公开(公告)号：WO2006010025A3
公开(公告)日：2007-02-22
申请号：PCT/US2005024326
申请日：2005-07-07
申请人： TRANSNEURONIX INC , CIGAINA VALERIO , CHEN JIANDE
发明人： CIGAINA VALERIO , CHEN JIANDE
IPC分类号： A61N1/36
CPC分类号： A61N1/36139 , A61B5/02405 , A61B5/0456 , A61B5/4035 , A61N1/36085
摘要： Systems and methods are provided for modulating the autonomic nervous system by the electrical stimulation of the neuro-muscular system of a patient, and include an implantable electrical system for gastrointestinal stimulation which incorporates a heart rate sensor to indicate the neurovegetative patient condition, to initiate and terminate stimulation at specific locations, and an algorithm to automatically control electrical stimulation frequency, interval, amplitude, or a combination of such parameters for adaptive treatment of obesity, anorexia, other eating disorders, diseases related with the so called "metabolic syndrome" (e.g., impaired glucose tolerance and diabetes type 2, GERD, systemic hypertension, early arterovascular degeneration, early senility, and the like), and disorders related to a pathologic inbalance of the autonomic nervous system.
摘要翻译：提供了系统和方法，用于通过对患者的神经 - 肌肉系统的电刺激来调节自主神经系统，并且包括用于胃肠刺激的可植入电气系统，其包括心率传感器以指示神经递质患者状况，以启动和在特定位置终止刺激，以及自动控制电刺激频率，间隔，幅度或这些参数的组合的算法，用于适应性治疗肥胖症，厌食症，其他进食障碍，与所谓的“代谢综合征”相关的疾病（例如，，糖耐量异常和2型糖尿病，GERD，全身高血压，早期动脉血管变性，早衰等），以及与自主神经系统的病理性失衡相关的疾病。

6. 发明申请

WO2005097254A2 SENSOR BASED GASTROINTESTINAL ELECTRICAL SIMULATION FOR THE TREATMENT OF OBESITY OR MOTILITY DISORDER 审中-公开
标题翻译：用于治疗肥胖或动物疾病的基于传感器的胃肠电图模拟
公开(公告)号：WO2005097254A2
公开(公告)日：2005-10-20
申请号：PCT/US2005010795
申请日：2005-03-30
申请人： TRANSNEURONIX INC , FOLEY STEVE , CHEN JIANDE
发明人： FOLEY STEVE , CHEN JIANDE
IPC分类号： A61N1/18 , A61N1/36
CPC分类号： A61N1/36007
摘要： A method for treatment of obesity, especially morbid obesity, gastroparesis and other syndromes related to motor disorders of the stomach. The method of this invention utilizes a sensor to detect food entering the patient's stomach, thereby the sensor communicates with and activates at least one electrical stimulation device attached to either the stomach or the small intestine.
摘要翻译：一种治疗与胃运动障碍相关的肥胖症，特别是病态肥胖，胃轻瘫等综合征的方法。本发明的方法利用传感器来检测进入患者胃部的食物，由此传感器与附着在胃或小肠上的至少一个电刺激装置通信并激活。

7. 发明申请

WO2004011085A1 IMPROVED PROCESS FOR ELECTROSTIMULATION TREATMENT OF MORBID OBESITY 审中-公开
标题翻译：改善治疗肥胖症的改善方法
公开(公告)号：WO2004011085A1
公开(公告)日：2004-02-05
申请号：PCT/US2003/023374
申请日：2003-07-25
申请人： TRANSNEURONIX, INC. , CHEN, Jiande
发明人： CHEN, Jiande
IPC分类号： A61N1/18
CPC分类号： A61N1/32
摘要： An improved process using electrostimulation for treating obesity, especially morbid obesity, is provided. The method provides electrostimulation on or along the small intestines, preferably on or along the duodenum (30) and/or jejunum (40), which provides improved control of obesity. In one embodiment, the process employs stimulation of the lesser curvature (34) at a rate of about 2 to 30 pulses/minute with each pulse lasting about 0.1 to 4 seconds such that there is a pause of about 3 to 30 seconds between the pulses. More preferably, the pulse rate is about 12 to 14 pulses/minute with each pulse lasting about 0.1 to 0.5 seconds with a pause of about 4.5 to 5 seconds between pulses. Preferably, the pulse amplitude is about 0.5 to 12 milliamps. More preferable, each pulse consists of a train of microbursts with a frequency of about 5 to 100 Hz.
摘要翻译：提供了使用电刺激治疗肥胖症，特别是病态肥胖的改进方法。该方法在小肠上或沿着小肠优选在十二指肠（30）和/或空肠（40）上或沿着其提供电刺激，其提供改善的肥胖控制。在一个实施例中，该过程以约2至30个脉冲/分钟的速率刺激较小曲率（34），每个脉冲持续约0.1至4秒，使得在脉冲之间存在约3至30秒的暂停。更优选地，脉冲速率为约12至14脉冲/分钟，每个脉冲持续约0.1至0.5秒，脉冲之间的停留时间为约4.5至5秒。优选地，脉冲振幅为约0.5至12毫安。更优选地，每个脉冲由具有约5至100Hz的频率的微爆发列组成。

8. 发明申请

WO2009092027A2 GASTROINTESTINAL ELECTRICAL STIMULATION FOR THE TREATMENT OF PANCREATITIS 审中-公开
标题翻译：用于治疗胰腺炎的胃肠电刺激
公开(公告)号：WO2009092027A2
公开(公告)日：2009-07-23
申请号：PCT/US2009031317
申请日：2009-01-16
申请人： UNIV TEXAS , PASRICHA PANKAJ , CHEN JIANDE
发明人： PASRICHA PANKAJ , CHEN JIANDE
IPC分类号： A61B18/18 , A61M37/00
CPC分类号： A61N1/36007
摘要： A method of preventing acute pancreatitis comprising positioning stimulatory electrodes in the stomach of an individual in need thereof; and administering repetitive trains of short pulse gastrointestinal electrical stimulation effective for suppressing the inflammatory response in the pancreas is provided herein. The electrodes are placed by laproscopic, endoscopic or surgical means. The gastrointestinal stimulation activates vagal reflexes. The activation of the vagal reflexes is via the gastric and pancreatic afferents. The gastrointestinal stimulation also activates the axonal reflexes. The activation of the axonal reflexes is via the dichotomous branches of the spinal nerves. The electrical stimulation is administered concurrently with an endoscopic procedure or immediately following an endoscopic procedure. Also, provided herein is a method of preventing inflammation of a visceral organ comprising positioning a stimulatory electrode in proximity of descending efferents in the vagus, innervating the visceral organ, of an individual in need thereof, and administering repetitive trains of short pulse electrical stimulation effective in activating nicotinic receptors.
摘要翻译：一种预防急性胰腺炎的方法，包括在有需要的个体的胃中定位刺激电极; 并且提供了有效抑制胰腺炎症反应的短脉冲胃肠电刺激重复列车。电极通过腹腔镜，内窥镜或外科手段放置。胃肠道刺激激活迷走神经反射。迷走神经反射的激活是通过胃和胰腺传入的。胃肠道刺激也激活轴突反射。轴突反射的激活是通过脊神经的二分支。电刺激与内窥镜手术同时进行或立即进行内镜手术。此外，本文提供了一种防止内脏器官炎症的方法，包括将刺激电极定位在迷走神经中的下降传出物附近，有意义的个体的内脏器官，并施用有效的短脉冲电刺激重复训练在激活烟碱受体。

9. 发明申请

WO2008157452A1 HEPATIC ELECTRICAL STIMULATION 审中-公开
标题翻译： HEPATIC电刺激
公开(公告)号：WO2008157452A1
公开(公告)日：2008-12-24
申请号：PCT/US2008/067047
申请日：2008-06-14
申请人： BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM , PASRICHA, Pankaj , CHEN, Jiande
发明人： PASRICHA, Pankaj , CHEN, Jiande
IPC分类号： A61N1/00
CPC分类号： A61N1/36007 , A61N1/36014 , A61N1/362
摘要： The present invention relates to a method of providing electrical stimulation to a liver of a subject which includes providing one or more stimulatory electrodes to the liver of the subject and providing electrical stimulation to the liver of the subject. The invention further relates to methods of reducing risk factors of metabolic syndrome, treating diabetes, treating a subject having eating disorders and reducing glucose levels of a subject using methods of the present invention.
摘要翻译：本发明涉及向受试者的肝脏提供电刺激的方法，其包括向受试者的肝脏提供一个或多个刺激电极并且向受试者的肝脏提供电刺激。本发明还涉及使用本发明的方法降低代谢综合征的危险因素，治疗糖尿病，治疗患有进食障碍的受试者并降低受试者的葡萄糖水平的方法。

10. 发明申请

WO2009097542A2 ILEAL ELECTRICAL STIMULATION 审中-公开
标题翻译： ILEAL电刺激
公开(公告)号：WO2009097542A2
公开(公告)日：2009-08-06
申请号：PCT/US2009032662
申请日：2009-01-30
申请人： UNIV TEXAS , CHEN JIANDE , PASRICHA PANKAJ
发明人： CHEN JIANDE , PASRICHA PANKAJ
IPC分类号： A61N1/36 , A61N1/18 , A61N1/32
CPC分类号： A61N1/36007
摘要： The invention is a method of treatment for obesity, in an individual in need thereof comprising positioning stimulatory electrodes in the distal small intestines or ileum, and administering electrical stimulation in trains of pulses or repetitive pulses, where the electrical stimulation is effective, at least in part in, stimulating the vagal afferent and efferent activity, of the distal small intestines or ileum, in the individual. The stimulation of the vagal afferent and efferent activity leads to the regulation of the ileal brake. Specifically, the electrical stimulation is provided in trains of pulses. Also, described is a method of treatment for functional gastrointestinal disease by ileal electrical stimulation. Further this invention provides a method of treatment for an eating disorder comprising administering ileal electrical stimulation effective, at least in part, in stimulating the vagal and sympathetic pathways. The stimulatory electrodes are placed by laparoscopic, endoscopic or surgical means.
摘要翻译：本发明是一种在有需要的个体中治疗肥胖症的方法，其包括将远端小肠或回肠中的刺激电极定位，并且在电刺激有效的脉冲或重复脉冲列中给予电刺激，至少在部分地，刺激远端小肠或回肠的迷走神经传入和传出活动。迷走神经传入和传出活动的刺激导致回肠制动器的调节。具体地说，在脉冲串中提供电刺激。此外，描述了通过回肠电刺激治疗功能性胃肠道疾病的方法。此外，本发明提供了一种饮食障碍的治疗方法，包括给予至少部分刺激迷走神经和交感神经通路有效的回肠电刺激。刺激电极通过腹腔镜，内窥镜或外科手段放置。

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