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1. 发明申请

WO2007050978A2 METHODS FOR THE ELIMINATION OF PATHOGENS AND OTHER PARTICULATE AGENTS 审中-公开
标题翻译：消除病原体和其他颗粒剂的方法
公开(公告)号：WO2007050978A2
公开(公告)日：2007-05-03
申请号：PCT/US2006/042204
申请日：2006-10-30
申请人： UNIVERSITY OF CONNECTICUT , CHANDAWARKAR, Rajiv, Y.
发明人： CHANDAWARKAR, Rajiv, Y.
CPC分类号： A61K39/39 , A61K38/1709 , A61K2039/6043
摘要： Disclosed herein are methods of treating infections, wounds, and exposure to particulate agents, comprising administering a heat shock protein (HSP) such as HSP70. The HSP may be uncomplexed to an antigenic peptide. Uncomplexed HSPs have been shown to activate phagocytosis by macrophages, and are thus particularly useful for the rapid clearance of harmful particulate agents including pathogenic organisms and particulate agents such as particulate pollutants.
摘要翻译：本文公开了治疗感染，伤口和暴露于颗粒剂的方法，包括施用热休克蛋白（HSP）如HSP70。 HSP可以与抗原肽不复合。已经显示未复合的HSP激活巨噬细胞的吞噬作用，因此特别可用于快速清除包括病原生物和颗粒物质如颗粒污染物在内的有害颗粒剂。

2. 发明申请

WO2001017554A1 METHODS AND COMPOSITIONS FOR THE TREATMENT AND PREVENTION OF GRAFT REJECTION USING HEAT SHOCK PROTEINS 审中-公开
标题翻译：治疗和预防使用热休克蛋白抑制剂的方法和组合物
公开(公告)号：WO2001017554A1
公开(公告)日：2001-03-15
申请号：PCT/US2000/024711
申请日：2000-09-08
申请人： FORDHAM UNIVERSITY , SRIVASTAVA, Pramod, K. , CHANDAWARKAR, Rajiv, Y.
发明人： SRIVASTAVA, Pramod, K. , CHANDAWARKAR, Rajiv, Y.
IPC分类号： A61K39/385
CPC分类号： A61K39/001 , A61K2039/6043 , A61K2039/622
摘要： Methods for treatment and prevention of graft rejection, e.g., in response to tissue or organ transplantation, are disclosed. The disclosed methods comprise administration of compositions of complexes of heat shock/stress protein (hsps) including, but not limited to, hsp70, hsp90, and gp96, either alone or in combination with each other, noncovalently bound to antigenic molecules, to suppress the immune response to the grafted tissue or organ. In addition, administration of compositions containing un-complexed stress proteins (i.e., free of antigenic molecules) to suppress the immune response to the grafted tissue or organ are also disclosed. The invention encompasses administration of heat shock proteins before, after, or both before and after transplantation or grafting. In addition, the invention encompasses administration of donor tissue sample prior to administration of heat shock protein and subsequent transplantation or grafting.
摘要翻译：公开了用于治疗和预防移植排斥反应的方法，例如响应于组织或器官移植。所公开的方法包括非共价结合抗原分子的单独或彼此组合的包括但不限于hsp70，hsp90和gp96的热休克/应激蛋白（hsps）复合物的组合物，以抑制对移植组织或器官的免疫应答。此外，还公开了含有非复合应激蛋白（即，不含抗原性分子）的组合物的给药以抑制对移植组织或器官的免疫应答。本发明包括在移植或移植之前，之后或之前施用热休克蛋白。此外，本发明包括在给予热休克蛋白之前施用供体组织样品，随后进行移植或移植。

3. 发明申请

WO2007050978A3 METHODS FOR THE ELIMINATION OF PATHOGENS AND OTHER PARTICULATE AGENTS 审中-公开
标题翻译：消除病原体和其他微粒剂的方法
公开(公告)号：WO2007050978A3
公开(公告)日：2007-08-30
申请号：PCT/US2006042204
申请日：2006-10-30
申请人： UNIV CONNECTICUT , CHANDAWARKAR RAJIV Y
发明人： CHANDAWARKAR RAJIV Y
IPC分类号： A61K38/17 , A61P31/00 , A61P33/00 , A61P37/04 , A61P39/00
CPC分类号： A61K39/39 , A61K38/1709 , A61K2039/6043
摘要： Disclosed herein are methods of treating infections, wounds, and exposure to particulate agents, comprising administering a heat shock protein (HSP) such as HSP70. The HSP may be uncomplexed to an antigenic peptide. Uncomplexed HSPs have been shown to activate phagocytosis by macrophages, and are thus particularly useful for the rapid clearance of harmful particulate agents including pathogenic organisms and particulate agents such as particulate pollutants.
摘要翻译：本文公开了治疗感染，伤口和暴露于颗粒剂的方法，其包括施用热休克蛋白（HSP）例如HSP70。 HSP可能不与抗原肽复合。已显示未复合的HSP通过巨噬细胞激活吞噬作用，因此特别适用于快速清除有害微粒剂，包括致病微生物和颗粒剂如颗粒污染物。

4. 发明申请

WO0117554A9 METHODS AND COMPOSITIONS FOR THE TREATMENT AND PREVENTION OF GRAFT REJECTION USING HEAT SHOCK PROTEINS 审中-公开
标题翻译：治疗和预防使用热休克蛋白抑制剂的方法和组合物
公开(公告)号：WO0117554A9
公开(公告)日：2002-09-26
申请号：PCT/US0024711
申请日：2000-09-08
申请人： UNIV FORDHAM , SRIVASTAVA PRAMOD K , CHANDAWARKAR RAJIV Y
发明人： SRIVASTAVA PRAMOD K , CHANDAWARKAR RAJIV Y
IPC分类号： A61K39/00 , A61P37/06 , A61K39/385 , A01N37/18 , A61K45/00 , C07K1/00 , C07K2/00
CPC分类号： A61K39/001 , A61K2039/6043 , A61K2039/622
摘要： Methods for treatment and prevention of graft rejection, e.g., in response to tissue or organ transplantation, are disclosed. The disclosed methods comprise administration of compositions of complexes of heat shock/stress protein (hsps) including, but not limited to, hsp70, hsp90, and gp96, either alone or in combination with each other, noncovalently bound to antigenic molecules, to suppress the immune response to the grafted tissue or organ. In addition, administration of compositions containing un-complexed stress proteins (i.e., free of antigenic molecules) to suppress the immune response to the grafted tissue or organ are also disclosed. The invention encompasses administration of heat shock proteins before, after, or both before and after transplantation or grafting. In addition, the invention encompasses administration of donor tissue sample prior to administration of heat shock protein and subsequent transplantation or grafting.
摘要翻译：公开了用于治疗和预防移植排斥反应的方法，例如响应于组织或器官移植。所公开的方法包括非共价结合抗原分子的单独或彼此组合的包括但不限于hsp70，hsp90和gp96的热休克/应激蛋白（hsps）复合物的组合物，以抑制对移植组织或器官的免疫应答。此外，还公开了含有非复合应激蛋白（即，不含抗原性分子）的组合物的给药以抑制对移植组织或器官的免疫应答。本发明包括在移植或移植之前，之后或之前施用热休克蛋白。此外，本发明包括在给予热休克蛋白之前施用供体组织样品，随后进行移植或移植。

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