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1. 发明申请

WO1995032198A1 IMIDAZOLE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF 审中-公开
标题翻译：咪唑衍生物及其制备方法
公开(公告)号：WO1995032198A1
公开(公告)日：1995-11-30
申请号：PCT/KR1995000058
申请日：1995-05-19
申请人： KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY , YOO, Sung, Eun , YI, Kyu, Yang , LEE, Sang, Hee , KIM, Hye, Ryung , SUH, Jee, Hee , KIM, Nak, Jeong , KIM, Seon, Ju , CHA, Ok, Ja , SHIN, Young, Ah , SHIN, Wha, Sup , LEE, Sung, Hou , JUNG, Yi, Sook , LEE, Byung, Ho , SEO, Ho, Won , LEE, Hye, Suk
发明人： KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY
IPC分类号： C07D403/14
CPC分类号： C07D401/14
摘要： Novel imidazole derivatives of formula (I) inhibit effectively the action of angiotensin II and have a superior antihypertensive activity, wherein A is a straight, branched or cyclic C1-C6 alkyl group, or OR1 wherein R1 is a hydrogen, or a straight, baranched or cyclic C1-C6 alkyl radical; B is a halogen, CF3 or CF2CF3; X is N or N-oxide; Y is -CH2-, -CH(OR1)- wherein R1 is the same as defined above or, -C(=O)-; n is 0 or an integer of 1 to 4; Z is a halogen, -OH, -OR1, -NR1R2, -N(=O)R3R4, -C(=O)R1, -C(=O)OR1, -CH(OR1)2 or -C(=O)NR1R2, wherein R1 is the same as defined above, R2 is, independently of R1, a hydrogen, or a straight, branched or cyclic C1-C6 alkyl radical, and R3 and R4 are independendtly a straight, branched or cyclic C1-C6 alkyl radical; and D is a hydrogen, or a straight, branched or cyclic C1-C6 alkyl radical.
摘要翻译：式（I）的新型咪唑衍生物有效地抑制血管紧张素II的作用并具有优异的抗高血压活性，其中A是直链，支链或环状的C 1 -C 6烷基或OR 1，其中R 1是氢或直链，或环状C 1 -C 6烷基; B是卤素，CF 3或CF 2 CF 3; X是N或N-氧化物; Y是-CH 2 - ， - CH（OR 1） - ，其中R 1与上述相同或者是-C（= O） - ; n为0或1〜4的整数， Z是卤素，-OH，-OR1，-NR1R2，-N（= O）R3R4，-C（= O）R1，-C（= O）OR1，-CH（OR1）2或-C ）NR1R2，其中R1与上述定义相同，R2独立地为R1，氢或直链，支链或环状的C1-C6烷基，R3和R4独立地为直链，支链或环状的C1-C6 烷基; 并且D是氢或直链，支链或环状的C 1 -C 6烷基。

2. 发明申请

WO1995034564A1 PIRYDYL IMIDAZOLE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF 审中-公开
标题翻译：吡啶基咪唑衍生物及其制备方法
公开(公告)号：WO1995034564A1
公开(公告)日：1995-12-21
申请号：PCT/KR1995000075
申请日：1995-06-07
申请人： KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY , YOO, Sung, Eun , YI, Kyu, Yang , LEE, Sang, Hee , KIM, Hye, Ryung , SUH, Jee, Hee , KIM, Nak, Jeong , KIM, Seon, Ju , CHA, Ok, Ja , SHIN, Young, Ah , SHIN, Wha, Sup , LEE, Sung, Hou , JUNG, Yi, Sook , LEE, Byung, Ho , SEO, Ho, Won , LEE, Hye, Suk
发明人： KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY
IPC分类号： C07D471/04
CPC分类号： C07D471/04
摘要： Novel pyridyl imidazole derivatives of formula (I) inhibit effectively the action of angiotensin II and have a superior antihypertensive activity, wherein A is a straight, branched or cyclic C1-C6 alkyl or alkenyl group, OR (wherein R is a hydrogen, or a straight, branched or cyclic C1-C6 alkyl or alkenyl radical), or NR R (wherein R and R are independently a hydrogen, or a straight, branched or cyclic C1-C6 alkyl radical); B is a group of formula (II); D is a hydrogen; a halogen; a straight, branched or cyclic C1-C6 alkyl, C2-C6 alkenyl or C2-C6 alkynyl group which is optionally substituted with OH, a C1-C4 alkoxy radical, CO2R , COR , CON(R )2 or N(R )2, wherein R is the same as defined above; tetrazol-5-yl; a perfluoro-C1-C4 alkyl group; or N(R )2, OR , CO2R or CON(R )2, wherein R is the same as defined above; E is a hydrogen; a halogen; a straight or branched C1-C6 alkyl, C2-C6 alkenyl or C2-C6 alkynyl group which is optionally substituted with OH, a C1-C4 alkoxy radical, CO2R , COR , CON(R )2 or N(R )2, wherein R is the same as defined above; a perfluoro-C1-C4 alkyl group; NO2; or N(R )2 or OR , wherein R is the same as defined above; and n is 0 or an integer of 1 to 4.
摘要翻译：式（I）的新型吡啶基咪唑衍生物有效地抑制血管紧张素II的作用并具有优异的抗高血压活性，其中A是直链，支链或环状的C 1 -C 6烷基或链烯基，OR 1（其中R 1，是氢或直链，支链或环状的C 1 -C 6烷基或链烯基）或NR 2 R 3（其中R 2和R 3独立地是氢或直链，支链或环状C 1 -C 6烷基）; B是式（II）的一组; D是氢; 卤素任选被OH，C 1 -C 4烷氧基，CO 2 R 1，COR 1，CON（R 1）取代的直链，支链或环状C 1 -C 6烷基，C 2 -C 6烯基或C 2 -C 6炔基 >）2或N（R 1）2，其中R 1与上述定义相同; 四唑-5-基; 全氟-C 1 -C 4烷基; 或N（R 1）2，OR 1，CO 2 R 1或CON（R 1）2，其中R 1与上述定义相同; E是氢; 卤素任选被OH，C 1 -C 4烷氧基，CO 2 R 1，COR 1，CON（R 1）烷基取代的直链或支链C 1 -C 6烷基，C 2 -C 6烯基或C 2 -C 6炔基， 2或N（R 1）2，其中R 1与上述定义相同; 全氟-C 1 -C 4烷基; NO2; 或N（R 1）2或OR 1，其中R 1与上述定义相同; n为0或1〜4的整数。

3. 发明申请

WO1995021838A1 PYRIDYL IMIDAZOLE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF 审中-公开
标题翻译：吡啶基咪唑衍生物及其制备方法
公开(公告)号：WO1995021838A1
公开(公告)日：1995-08-17
申请号：PCT/KR1995000009
申请日：1995-02-08
申请人： KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY , YOO, Sung, Eun , YI, Kyu, Yang , LEE, Sang, Hee , KIM, Hye, Ryung , SUH, Jee, Hee , KIM, Nak, Jeong , KIM, Seon, Ju , CHA, Ok, Ja , SHIN, Young, Ah , SHIN, Wha, Sup , LEE, Sung, Hou , JUNG, Yi, Sook , LEE, Byung, Ho , SEO, Ho, Won
发明人： KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY
IPC分类号： C07D471/04
CPC分类号： C07D471/04
摘要： Novel substituted pyridyl imidazole derivatives of formula (I) inhibit effectively the action of angiotensin II and have a superior antihypertensive activity.
摘要翻译：式（I）的新型取代的吡啶基咪唑衍生物有效抑制血管紧张素II的作用并具有优异的抗高血压活性。

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