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1. 发明专利

JP2014029346A Method for automated tissue analysis 有权
标题翻译：自动组织分析方法
公开(公告)号：JP2014029346A
公开(公告)日：2014-02-13
申请号：JP2013226607
申请日：2013-10-31
申请人： Cellumen Inc , セルーメン、インコーポレイテッド
发明人： ALBERT H GOUGH , GIULIANO KENNETH A , LANSING TAYLOR D
IPC分类号： G01N33/53 , G01N21/27 , G01N21/78 , G01N33/48 , G01N33/532 , G01N33/574
CPC分类号： G01N33/533 , G01N15/1475 , G01N21/6428 , G01N21/6458 , G01N21/6486 , G06K9/00127 , G06T7/0012 , G06T2207/10056 , G06T2207/30024 , Y10S436/809
摘要： PROBLEM TO BE SOLVED: To provide a method for automated tissue analysis.SOLUTION: A method for producing a cellular systems biology profile of one or more tissue samples comprises: a) obtaining at least two sections from one or more tissue samples; b) labeling at least one section with a histological stain, thereby producing a histologically stained section; c) labeling at least one section with a panel of fluorescently labeled reagents, thereby producing a fluorescently labeled section, wherein each fluorescently labeled reagent is specific for a biomarker, and wherein the panel of fluorescently labeled reagents detects at least four different biomarkers, and wherein the detection of a biomarker is a read-out of one or more features of a cellular systems biology profile; d) imaging the histologically stained section with at least a first optical mode, wherein the imaging produces a first set of data; e) imaging the fluorescently labeled section with at least a second optical mode, wherein the imaging produces a second set of data; f) analyzing the first set of data and the second set of data to identify five or more features, wherein at least one feature is identified in each of the first set of data and the second set of data, and wherein the combination of the five or more features generates a cellular systems biology profile of the one or more tissue samples, thereby providing a method for producing a cellular systems biology profile of the one or more tissue samples.
摘要翻译：要解决的问题：提供自动组织分析的方法。解决方案：一种或多种组织样品的细胞系统生物学特征的制备方法包括：a）从一个或多个组织样品获得至少两个切片; b）用组织学染色标记至少一个部分，从而产生组织学染色的部分; c）用一组荧光标记的试剂标记至少一个部分，从而产生荧光标记的部分，其中每个荧光标记的试剂对生物标志物是特异性的，并且其中荧光标记的试剂组检测至少四种不同的生物标志物，其中生物标志物的检测是读出细胞系统生物学特征的一个或多个特征; d）用至少第一光学模式成像组织学染色的部分，其中所述成像产生第一组数据; e）用至少第二光学模式对所述荧光标记部分进行成像，其中所述成像产生第二组数据; f）分析第一组数据和第二组数据以识别五个或更多个特征，其中在第一组数据和第二组数据中的每一个中识别至少一个特征，并且其中五个或更多特征产生所述一个或多个组织样本的细胞系统生物学特征，从而提供用于产生所述一个或多个组织样本的细胞系统生物学特征的方法。

2. 发明专利

CA2652562C METHOD FOR AUTOMATED TISSUE ANALYSIS 未知
公开(公告)号：CA2652562C
公开(公告)日：2015-05-12
申请号：CA2652562
申请日：2007-05-17
申请人： CELLUMEN INC
发明人： GOUGH ALBERT H , GIULIANO KENNETH A , TAYLOR D LANSING
IPC分类号： G01N33/50 , C12Q1/68
摘要： The invention provides an improved method for identifying and interpreting tissue specimens and/or cells derived from tissue specimens. A panel of cell-based reagents provides a number of readouts of cellular states or biomarkers that together define a profile of a diversity of cellular states or biomarkers in a tissue specimen representing the 'systems" nature of biology. This cellular profile is interpreted using informatics tools, to identify similarities between specimens, in vivo medical conditions, and suggest options for treating medical conditions.

3. 发明专利

CA2652562A1 METHOD FOR AUTOMATED TISSUE ANALYSIS 未知
公开(公告)号：CA2652562A1
公开(公告)日：2007-11-29
申请号：CA2652562
申请日：2007-05-17
申请人： CELLUMEN INC
发明人： GOUGH ALBERT H , TAYLOR D LANSING , GIULIANO KENNETH A
IPC分类号： G01N33/50 , C12Q1/68
摘要： The invention provides an improved method for identifying and interpretin g tissue specimens and/or cells derived from tissue specimens. A panel of ce ll-based reagents provides a number of readouts of cellular states or biomar kers that together define a profile of a diversity of cellular states or bio markers in a tissue specimen representing the 'systems" nature of biology. T his cellular profile is interpreted using informatics tools, to identify sim ilarities between specimens, in vivo medical conditions, and suggest options for treating medical conditions.

4. 发明申请

WO2008018905A3 METHOD FOR PREDICTING BIOLOGICAL SYSTEMS RESPONSES 审中-公开
公开(公告)号：WO2008018905A3
公开(公告)日：2008-02-14
申请号：PCT/US2007/001217
申请日：2007-01-17
申请人： CELLUMEN, INC. , GIULIANO, Kenneth , GOUGH, Albert , JOHNSTON, Patricia , TAYLOR, D. Lansing
发明人： GIULIANO, Kenneth , GOUGH, Albert , JOHNSTON, Patricia , TAYLOR, D. Lansing
IPC分类号： G01N33/50
摘要： The inventive method employs a "systems biology" approach to predicting biological responses resulting from exposure to the test substance. In one embodiment, the invention provides an automated method for predicting the biological systems effects of a test substance. In another embodiment, the invention provides a method for constructing a knowledgebase (or database) of response profiles for reference substances with known biological systems effects. In another embodiment, the invention provides a set of protocols and software tools used to carry out the profiling. Another embodiment of the invention is a panel of reagents and protocols required for generating response profiles, either to create an knowledgebase, or to use with an existing knowledgebase and informatics software to profile substance physiological effects. Another embodiment of the invention is a database of physiological profiles.

5. 发明申请

WO2007139895A2 METHOD FOR MODELING A DISEASE 审中-公开
标题翻译：建模疾病的方法
公开(公告)号：WO2007139895A2
公开(公告)日：2007-12-06
申请号：PCT/US2007/012406
申请日：2007-05-24
申请人： CELLUMEN, INC. , GOUGH, Albert, H. , JOHNSTON, Patricia , GIULIANO, Kenneth, A. , TAYLOR, D., Lansing
发明人： GOUGH, Albert, H. , JOHNSTON, Patricia , GIULIANO, Kenneth, A. , TAYLOR, D., Lansing
CPC分类号： G01N33/5023
摘要： The invention described herein provides for methods of profiling cellular models of disease. Cellular systems biology is the investigation of the integrated and interacting networks of genes, proteins, and metabolites that are responsible for normal and abnormal cell functions. Methods and reagents for the profiling a disease state, the treatment of a disease state and assaying of treatments of a disease state are provided.
摘要翻译：本文描述的本发明提供了分析疾病细胞模型的方法。细胞系统生物学是对负责正常和异常细胞功能的基因，蛋白质和代谢物的整合和相互作用的网络的研究。提供了用于分析疾病状态的方法和试剂，疾病状态的治疗和疾病状态治疗的测定。

6. 发明申请

WO2008115420A3 METHODS FOR DETECTING MOLECULAR INTERACTIONS WITHIN CELLS USING COMBINATION OF INDUCIBLE PROMOTERS AND BIOSENSORS 审中-公开
标题翻译：使用可溶性促进剂和生物传感器组合检测细胞中分子相互作用的方法
公开(公告)号：WO2008115420A3
公开(公告)日：2008-11-13
申请号：PCT/US2008003401
申请日：2008-03-14
申请人： CELLUMEN INC , DELFINO FRANK J , STROCK CHRISTOPHER J , GIULIANO KENNETH A , TAYLOR D LANSING , PREMKUMAR DAVID R
发明人： DELFINO FRANK J , STROCK CHRISTOPHER J , GIULIANO KENNETH A , TAYLOR D LANSING , PREMKUMAR DAVID R
IPC分类号： C12Q1/68 , G01N33/50 , G01N33/68
CPC分类号： C12Q1/6897 , G01N33/5041 , G01N33/6845
摘要： The invention provides methods and reagents for identifying an agent, such as by screening a library of agents, that modulates the interaction of s an endogenous polypeptide and a biosensor polypeptide comprising a binding domain, a localization domain and a reporter domain all of which are operably linked to an inducible promoter.
摘要翻译：本发明提供用于鉴定试剂的方法和试剂，例如通过筛选调节内源性多肽与包含结合结构域，定位结构域和报告分子结构域的生物传感器多肽的相互作用的试剂文库，所有这些都可操作地与诱导型启动子连接。

7. 发明申请

WO2008115420A2 METHODS FOR DETECTING MOLECULAR INTERACTIONS WITHIN CELLS USING COMBINATION OF INDUCIBLE PROMOTERS AND BIOSENSORS 审中-公开
标题翻译：使用诱导型启动子和生物传感器组合检测细胞内分子相互作用的方法
公开(公告)号：WO2008115420A2
公开(公告)日：2008-09-25
申请号：PCT/US2008/003401
申请日：2008-03-14
申请人： CELLUMEN, INC. , DELFINO, Frank, J. , STROCK, Christopher, J. , GIULIANO, Kenneth, A. , TAYLOR, D., Lansing , PREMKUMAR, David, R.
发明人： DELFINO, Frank, J. , STROCK, Christopher, J. , GIULIANO, Kenneth, A. , TAYLOR, D., Lansing , PREMKUMAR, David, R.
IPC分类号： C12Q1/68 , G01N33/50 , G01N33/68
CPC分类号： C12Q1/6897 , G01N33/5041 , G01N33/6845
摘要： The invention provides methods and reagents for identifying an agent, such as by screening a library of agents, that modulates the interaction of s an endogenous polypeptide and a biosensor polypeptide comprising a binding domain, a localization domain and a reporter domain all of which are operably linked to an inducible promoter.
摘要翻译：本发明提供了用于鉴定试剂的方法和试剂，例如通过筛选试剂库来调节内源多肽与生物传感器多肽的相互作用，所述内源多肽与生物传感器多肽包含结合结构域，定位结构域和所有这些报道结构域都可操作地连接到诱导型启动子上。

8. 发明申请

WO2008060483A2 PROTEIN-PROTEIN INTERACTION BIOSENSORS AND METHODS OF USE THEREOF 审中-公开
标题翻译：蛋白质 - 蛋白质相互作用生物传感器及其使用方法
公开(公告)号：WO2008060483A2
公开(公告)日：2008-05-22
申请号：PCT/US2007/023678
申请日：2007-11-09
申请人： CELLUMEN, INC. , TAYLOR, Lansing, D. , GIULIANO, Kenneth, A. , PREMKUMAR, Daniel, Rajadavid
发明人： TAYLOR, Lansing, D. , GIULIANO, Kenneth, A. , PREMKUMAR, Daniel, Rajadavid
CPC分类号： G01N33/5035 , C07K14/4738 , C07K2319/01 , C12N15/1055 , G01N2500/02
摘要： The invention provides methods and reagents for identifying an agent, such as by screening a library of agents, that modulates the interaction of two or more polypeptides. The invention also provides methods and reagents for identifying the binding domains of one or more polypeptides.
摘要翻译：本发明提供用于鉴定试剂的方法和试剂，例如通过筛选调节两种或多种多肽相互作用的试剂文库。本发明还提供了用于鉴定一种或多种多肽的结合结构域的方法和试剂。

9. 发明申请

WO2008018905A8 METHOD FOR PREDICTING BIOLOGICAL SYSTEMS RESPONSES 审中-公开
标题翻译：预测生物系统反应的方法
公开(公告)号：WO2008018905A8
公开(公告)日：2009-07-09
申请号：PCT/US2007001217
申请日：2007-01-17
申请人： CELLUMEN INC , GIULIANO KENNETH , GOUGH ALBERT , JOHNSTON PATRICIA , TAYLOR D LANSING
发明人： GIULIANO KENNETH , GOUGH ALBERT , JOHNSTON PATRICIA , TAYLOR D LANSING
IPC分类号： G01N33/50
CPC分类号： G01N33/5008
摘要： The inventive method employs a 'systems biology' approach to predicting biological responses resulting from exposure to the test substance. In one embodiment, the invention provides an automated method for predicting the biological systems effects of a test substance. In another embodiment, the invention provides a method for constructing a knowledgebase (or database) of response profiles for reference substances with known biological systems effects. In another embodiment, the invention provides a set of protocols and software tools used to carry out the profiling. Another embodiment of the invention is a panel of reagents and protocols required for generating response profiles, either to create an knowledgebase, or to use with an existing knowledgebase and informatics software to profile substance physiological effects. Another embodiment of the invention is a database of physiological profiles.
摘要翻译：本发明的方法采用“系统生物学”方法来预测暴露于测试物质所产生的生物反应。在一个实施方案中，本发明提供了一种用于预测测试物质的生物系统效应的自动化方法。在另一个实施例中，本发明提供了一种用于构建具有已知生物系统效应的参考物质的响应曲线的知识库（或数据库）的方法。在另一个实施例中，本发明提供了一组用于执行分析的协议和软件工具。本发明的另一个实施例是生成响应简档所需的试剂和协议的一组，用于创建知识库，或者与现有知识库和信息学软件一起使用以描绘物质生理效应。本发明的另一个实施例是生理特征的数据库。

10. 发明申请

WO2009002565A1 METHOD FOR PREDICTING BIOLOGICAL SYSTEMS RESPONSES IN HEPATOCYTES 审中-公开
标题翻译：预测生物系统响应的方法
公开(公告)号：WO2009002565A1
公开(公告)日：2008-12-31
申请号：PCT/US2008/008105
申请日：2008-06-26
申请人： CELLUMEN, INC. , IRWIN, William , VERNETTI, Lawrence , JOHNSTON, Patricia, A. , TAYLOR, D., Lansing
发明人： IRWIN, William , VERNETTI, Lawrence , JOHNSTON, Patricia, A. , TAYLOR, D., Lansing
IPC分类号： G01N33/50
CPC分类号： G01N33/5067
摘要： The inventive method employs a "systems biology" approach to predicting hepatotoxicity and other biological hepatocyte responses resulting from exposure to the test substance. In one embodiment, the invention provides an automated method for predicting the hepatocyte biological systems effect of a test substance. In another embodiment, the invention provides a method for constructing a knowledgebase (or database) of cellular systems biology response profiles for reference substances with known biological systems effects. In another embodiment, the invention provides a set of protocols and software tools used to carry out the profiling. Another embodiment of the invention is a panel of reagents. In another embodiment, the invention provides a set of protocols and software tools used to carry out the profiling. Another embodiment of the invention is a panel of reagents and protocols required for generating cellular systems biology response profiles, either to create a knowledgebase, or to use with an existing knowledgebase and informatics software to profile substance physiological effects. Another embodiment of the invention is a database of physiological profiles.
摘要翻译：本发明的方法采用“系统生物学”方法来预测由暴露于测试物质引起的肝毒性和其他生物肝细胞反应。在一个实施方案中，本发明提供了一种用于预测测试物质的肝细胞生物系统作用的自动化方法。在另一个实施方案中，本发明提供了用于构建具有已知生物系统效应的参考物质的细胞系统生物学应答谱的知识库（或数据库）的方法。在另一个实施例中，本发明提供了一组用于执行分析的协议和软件工具。本发明的另一个实施方案是一组试剂。在另一个实施例中，本发明提供了一组用于执行分析的协议和软件工具。本发明的另一个实施方案是生成细胞系统生物反应概况所需的一组试剂和方案，用于创建知识库，或与现有知识库和信息学软件一起使用以描绘物质生理效应。本发明的另一个实施例是生理特征的数据库。

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