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    • 6. 发明申请
    • A PROCESS OF SURFACE ACTIVATION OF BIOCOMPATIBLE AND BIOABSORBABLE ALIPHATIC POLYESTERS AND POLYESTERS THUS ACTIVATED
    • 生物成分和生物可吸收的脂肪族聚酯和活化的聚酯的表面活化过程
    • WO1997005193A1
    • 1997-02-13
    • PCT/IT1996000149
    • 1996-07-24
    • SANITARIA SCALIGERA SPAZUCCATO, AlessandroPEREGO, GabrieleCELLA, Gian, Domenico
    • SANITARIA SCALIGERA SPA
    • C08J07/12
    • C08J7/14A61L27/18C08J7/12C08J2367/04C08L67/04
    • A process of surface activation of a material based on one or more of the copolymers of lactic acid and epsilon -caprolactone is carried out on bioabsorbable and biocompatible aliphatic polyesters chosen from the group formed by homo- and copolymers derived from L-lactide, D-lactide, racemic D,L-lactide, meso D,L-lactide, epsilon -caprolactone, glycolide, delta -valerolactone, p-dioxanone, preferably copolymers of L-lactide, D-lactide, racemic D,L-lactide, meso D,L-lactide with epsilon -caprolactone; the process consists of performing at least one of the following treatments: acid or base hydrolysis, treatment by means of cold plasma, by chemical reactions or electromagnetic radiations. The process brings about a substantial increase in surface hydrophilicity and, consequently, a significant lowering of the wetting angle measured with water at 23 degrees Celsius in air. This can in many cases favour cellular adherence to bioabsorbable medical prostheses realised using these materials, and thus surface-activated, such as for example endothelialisation processes in vascular grafts.
    • 基于乳酸和ε-己内酯的一种或多种共聚物的材料的表面活化的方法在生物可吸收和生物相容的脂族聚酯上进行,所述脂族聚酯选自由衍生自L-丙交酯,D-丙交酯的均聚物和共聚物形成的基团, 丙交酯,外消旋D,L-丙交酯,内消旋D,L-丙交酯,ε-己内酯,乙交酯,δ-戊内酯,对二恶烷酮,优选L-丙交酯,D-丙交酯,外消旋D,L-丙交酯,内消旋D ,ε-己内酯的L-丙交酯; 该方法包括进行以下处理中的至少一种:酸或碱水解,通过冷等离子体处理,通过化学反应或电磁辐射。 该方法导致表面亲水性的显着增加,并因此导致在空气中在23摄氏度下用水测量的润湿角度的显着降低。 在许多情况下,这可以有利于细胞粘附到使用这些材料实现的生物可吸收的医用假体,并因此有利于表面活化,例如血管移植物中的内皮化过程。