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1. 发明申请

WO2005086872A2 PTPN22 POLYMORPHISMS IN DIAGNOSIS AND THERAPY 审中-公开
标题翻译： PTPN22多态性在诊断和治疗中的应用
公开(公告)号：WO2005086872A2
公开(公告)日：2005-09-22
申请号：PCT/US2005/007800
申请日：2005-03-08
申请人： CELERA, AN APPLERA CORPORATION BUSINESS , BRODER, Samuel E. , BOOTH, Robert F.
发明人： BRODER, Samuel E. , BOOTH, Robert F.
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q1/6886 , C12Q2600/106 , C12Q2600/172
摘要： The invention provides 1) methods and compositions for detecting polymorphisms of the PTPN22 genomic DNA; 2) methods for associating polymorphisms of the PTPN22 gene with the occurrence of an immune disorder, inflammatory disorder or cell proliferation disorder; 3) methods for identifying subjects at risk of an immune disorder, inflammatory disorder or cell proliferation disorder by determining if they have a polymorphism of the PTPN22 gene and treating such subjects with a tyrosine kinase inhibitor to prevent or delay the progression of such diseases; 4) methods for identifying subjects having an immune disorder, inflammatory disorder or cell proliferation disorder who are promising candidates for therapy with a tyrosine kinase inhibitor by determining if such subjects have a polymorphism of the PTPN22 gene; and 5) methods of treating subjects having an immune disorder, inflammatory disorder or cell proliferation disorder mediated by a polymorphism of the PTPN22 gene by administering to such subjects a tyrosine kinase inhibitor.
摘要翻译：本发明提供1）用于检测PTPN22基因组DNA多态性的方法和组合物; 2）将PTPN22基因的多态性与免疫疾病，炎性疾病或细胞增殖紊乱的发生相关联的方法; 3）通过确定它们是否具有PTPN22基因的多态性并用酪氨酸激酶抑制剂治疗这些受试者以预防或延缓这些疾病的进展来识别患有免疫疾病，炎性障碍或细胞增殖病症风险的受试者的方法; 4）通过确定这些受试者是否具有PTPN22基因的多态性来鉴定具有免疫障碍，炎症性疾病或细胞增殖病症的受试者的方法，所述受试者是有希望用酪氨酸激酶抑制剂治疗的候选药物; 和5）通过向这些受试者施用酪氨酸激酶抑制剂来治疗由PTPN22基因的多态性介导的免疫疾病，炎性病症或细胞增殖病症的受试者的方法。

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