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1. 发明公开

EP2632448A1 CIS 3,4-DIHYDROXY-2-(3-METHYLBUTANOYL)-5-(-3-METHYLBUTYL)-4-(4-METHYLPENTANOYL)CYCLOPENT-2-EN-1-ONE DERIVATIVES, SUBSTANTIALLY ENANTIOMERICALLY PURE COMPOSITIONS AND METHODS 审中-公开
标题翻译：顺式-3,4-二羟基-2-（3-甲基丁酰基）-5-（3-甲基丁基 - ） - 4-（4- METHYLPENTANOYL-）环戊-2-烯-1-酮衍生物，基本上对映体纯的组合物和方法 ENSURE
公开(公告)号：EP2632448A1
公开(公告)日：2013-09-04
申请号：EP11837235.8
申请日：2011-10-28
申请人： KinDex Therapeutics, LLC , Carroll, Brian , Darland, Gary , Desai, Anuradha , Konda, Veera , Dahlberg, Clinton J. , Urban, Jan
发明人： CARROLL, Brian , DARLAND, Gary , DESAI, Anuradha , KONDA, Veera , DAHLBERG, Clinton, J. , URBAN, Jan
IPC分类号： A61K31/122
摘要： The present application provides cis 3,4-dihydroxy-2-(3-methylbutanoyl)-5-(3-methylbutyl)-4-(4-methylpentanoyl)cyclopent-2-en-1-one derivatives and substantially enantiomerically pure compositions thereof. These derivatives include (+)-(4S,5R)-3,4-dihydroxy-2-(3-methylbutanoyl)-5-(3-methylbutyl)-4-(4-methylpentanoyl)cyclopent-2-en-1-one, (−)-(4R,5S)-3,4-dihydroxy-2-(3-methylbutanoyl)-5-(3-methylbutyl)-4-(4-methylpentanoyl)cyclopent-2-en-1-one, and salts and crystals thereof. The application further provides methods of using the disclosed compounds and compositions to activate PPARγ, activate GPR120, inhibit inflammation, and treat conditions responsive to PPARγ modulation, conditions responsive to GPR120 modulation, and metabolic disturbances such as diabetes.

2. 发明公开

EP2632448A4 CIS 3,4-DIHYDROXY-2-(3-METHYLBUTANOYL)-5-(-3-METHYLBUTYL)-4-(4-METHYLPENTANOYL)CYCLOPENT-2-EN-1-ONE DERIVATIVES, SUBSTANTIALLY ENANTIOMERICALLY PURE COMPOSITIONS AND METHODS 审中-公开
标题翻译：顺式-3,4-二羟基-2-（3-甲基丁酰基）-5-（3-甲基丁基 - ） - 4-（4- METHYLPENTANOYL-）环戊-2-烯-1-酮衍生物，基本上对映体纯的组合物和方法 ENSURE
公开(公告)号：EP2632448A4
公开(公告)日：2014-03-19
申请号：EP11837235
申请日：2011-10-28
申请人： KINDEX THERAPEUTICS LLC , CARROLL BRIAN , DARLAND GARY , DESAI ANURADHA , KONDA VEERA , DAHLBERG CLINTON J , URBAN JAN
发明人： CARROLL BRIAN , DARLAND GARY , DESAI ANURADHA , KONDA VEERA , DAHLBERG CLINTON J , URBAN JAN
IPC分类号： A61K31/122
CPC分类号： A61K31/122 , C07B2200/13 , C07C49/707
摘要： The present application provides cis 3,4-dihydroxy-2-(3-methylbutanoyl)-5-(3-methylbutyl)-4-(4-methylpentanoyl)cyclopent-2-en-1-one derivatives and substantially enantiomerically pure compositions thereof. These derivatives include (+)-(4S,5R)-3,4-dihydroxy-2-(3-methylbutanoyl)-5-(3-methylbutyl)-4-(4-methylpentanoyl)cyclopent-2-en-1-one, (−)-(4R,5S)-3,4-dihydroxy-2-(3-methylbutanoyl)-5-(3-methylbutyl)-4-(4-methylpentanoyl)cyclopent-2-en-1-one, and salts and crystals thereof. The application further provides methods of using the disclosed compounds and compositions to activate PPARγ, activate GPR120, inhibit inflammation, and treat conditions responsive to PPARγ modulation, conditions responsive to GPR120 modulation, and metabolic disturbances such as diabetes.

4. 发明专利

ES2829388T3 Derivados de cis 3,4-dihidroxi-2-(3-metilbutanoil)-5-(-3-metilbutil)-4-(4-metilpentanoil)cyclopent-2-en-1-ona, composiciones sustancialmente puras enantioméricamente y métodos 未知
公开(公告)号：ES2829388T3
公开(公告)日：2021-05-31
申请号：ES11837235
申请日：2011-10-28
申请人： KINDEX THERAPEUTICS LLC , CARROLL BRIAN , DARLAND GARY , DESAI ANURADHA , KONDA VEERA , DAHLBERG CLINTON J , URBAN JAN
发明人： CARROLL BRIAN , DARLAND GARY , DESAI ANURADHA , KONDA VEERA , DAHLBERG CLINTON , URBAN JAN
IPC分类号： A61K31/122 , A61P3/10 , A61P29/00 , C07C49/707
摘要： (+)-(4S,5R)-3,4-dihidroxi-2-(3-metilbutanoil)-5-(3 -metilbutil)-4-(4-metilpentanoil)ciclopent-2-en-1-ona que tiene la estructura: **(Ver fórmula)** o una sal o cristal de esta, para su uso en el tratamiento de la diabetes en un sujeto.

5. 发明专利

AU2002223974A1 A SYSTEM FOR THE UNOBTRUSIVE INTERCEPTION OF DATA TRANSMISSIONS 未知
公开(公告)号：AU2002223974A1
公开(公告)日：2003-06-10
申请号：AU2002223974
申请日：2001-11-15
申请人： CARROLL BRIAN ANTHONY
发明人： CARROLL BRIAN ANTHONY
IPC分类号： H04L29/06 , H04M3/22 , H04M7/00 , H04W12/02 , H04Q7/38
摘要： An interceptor system (10) for lawful interception in a communications network overcomes the problem of requiring servers of considerable processing capacity by using a traffic interceptor (9) which is a hardware component such as a traffic analyser port (9) which intercepts the data and duplicates it sending one set of data to network filters (21). There is provided a management system which handles legal warrants for interception and through service filters (22) and a database (17) ensures that data which has a target identifier is transmitted onwards and the remainder is destroyed in a secure manner.

6. 发明专利

CA2853974C CIS 3,4-DIHYDROXY-2-(3-METHYLBUTANOYL)-5-(3-METHYLBUTYL)-4-(4-METHYLPENTANOYL)CYCLOPENT-2-EN-1-ONE DERIVATIVES, SUBSTANTIALLY ENANTIOMERICALLY PURE COMPOSITIONS AND METHODS 未知
公开(公告)号：CA2853974C
公开(公告)日：2020-11-10
申请号：CA2853974
申请日：2011-10-28
申请人： KINDEX THERAPEUTICS LLC , CARROLL BRIAN , DARLAND GARY , DESAI ANURADHA , KONDA VEERA , DAHLBERG CLINTON J , URBAN JAN
发明人： CARROLL BRIAN , DARLAND GARY , DESAI ANURADHA , KONDA VEERA , DAHLBERG CLINTON J , URBAN JAN
IPC分类号： C07C49/707 , A61K31/122 , A61P3/04 , A61P3/10
摘要： The present application provides cis 3,4-dihydroxy-2-(3-methylbutanoyl)-5-(3- methylbutyl)-4-(4-methylpentanoyl)cyclopent-2-en-1-one derivatives and substantially enantiomerically pure compositions thereof. These derivatives include (+)-(4S,5R)- 3,4- dihydroxy-2-(3-methylbutanoyl)-5-(3-methylbutyl)-4-(4-methylpentanoyl)cyclopent-2-en-1-one, (-)-(4R,5S)-3,4-dihydroxy-2-(3-methylbutanoyl)-5-(3-methylbutyl)-4-(4- methylpentanoyl)cyclopent-2-en-1-one, and salts and crystals thereof. The application further provides methods of using the disclosed compounds and compositions to activate PPAR?, activate GPR120, inhibit inflammation, and treat conditions responsive to PPAR? modulation, conditions responsive to GPR120 modulation, and metabolic disturbances such as diabetes.

7. 发明专利

CA2853974A1 CIS 3,4-DIHYDROXY-2-(3-METHYLBUTANOYL)-5-(-3-METHYLBUTYL)-4-(4-METHYLPENTANOYL)CYCLOPENT-2-EN-1-ONE DERIVATIVES, SUBSTANTIALLY ENANTIOMERICALLY PURE COMPOSITIONS AND METHODS 未知
公开(公告)号：CA2853974A1
公开(公告)日：2012-05-03
申请号：CA2853974
申请日：2011-10-28
申请人： KINDEX THERAPEUTICS LLC , CARROLL BRIAN , DARLAND GARY , DESAI ANURADHA , KONDA VEERA , DAHLBERG CLINTON J , URBAN JAN
发明人： CARROLL BRIAN , DARLAND GARY , DESAI ANURADHA , KONDA VEERA , DAHLBERG CLINTON J , URBAN JAN
IPC分类号： C07C49/707 , A61K31/122 , A61P3/04 , A61P3/10
摘要： The present application provides cis 3,4-dihydroxy-2-(3-methylbutanoyl)-5-(3- methylbutyl)-4-(4-methylpentanoyl)cyclopent-2-en-1-one derivatives and substantially enantiomerically pure compositions thereof. These derivatives include (+)-(4S,5R)- 3,4- dihydroxy-2-(3-methylbutanoyl)-5-(3-methylbutyl)-4-(4-methylpentanoyl)cyclopent-2-en-1-one, (-)-(4R,5S)-3,4-dihydroxy-2-(3-methylbutanoyl)-5-(3-methylbutyl)-4-(4- methylpentanoyl)cyclopent-2-en-1-one, and salts and crystals thereof. The application further provides methods of using the disclosed compounds and compositions to activate PPAR?, activate GPR120, inhibit inflammation, and treat conditions responsive to PPAR? modulation, conditions responsive to GPR120 modulation, and metabolic disturbances such as diabetes.

8. 发明申请

WO2012058649A1 CIS 3,4-DIHYDROXY-2-(3-METHYLBUTANOYL)-5-(-3-METHYLBUTYL)-4-(4-METHYLPENTANOYL)CYCLOPENT-2-EN-1-ONE DERIVATIVES, SUBSTANTIALLY ENANTIOMERICALLY PURE COMPOSITIONS AND METHODS 审中-公开
标题翻译：（3,4-二羟基-2-（3-甲基丁基）-5-（3-甲基丁基）-4-（4-甲基戊基）环戊-2-烯-1-酮衍生物，主要是纯的组合物和方法
公开(公告)号：WO2012058649A1
公开(公告)日：2012-05-03
申请号：PCT/US2011/058477
申请日：2011-10-28
申请人： KINDEX THERAPEUTICS, LLC , CARROLL, Brian , DARLAND, Gary , DESAI, Anuradha , KONDA, Veera , DAHLBERG, Clinton, J. , URBAN, Jan
发明人： CARROLL, Brian , DARLAND, Gary , DESAI, Anuradha , KONDA, Veera , DAHLBERG, Clinton, J. , URBAN, Jan
IPC分类号： A61K31/122
CPC分类号： A61K31/122 , C07B2200/13 , C07C49/707
摘要： The present application provides cis 3,4-dihydroxy-2-(3-methylbutanoyl)-5-(3- methylbutyl)-4-(4-methylpentanoyl)cyclopent-2-en-1-one derivatives and substantially enantiomerically pure compositions thereof. These derivatives include (+)-( 4S,5R )- 3,4- dihydroxy-2-(3-methylbutanoyl)-5-(3-methylbutyl)-4-(4-methylpentanoyl)cyclopent-2-en-1-one, (-)-(4 R,5S )-3,4-dihydroxy-2-(3-methylbutanoyl)-5-(3-methylbutyl)-4-(4- methylpentanoyl)cyclopent-2-en-1-one, and salts and crystals thereof. The application further provides methods of using the disclosed compounds and compositions to activate PPAR Ƴ , activate GPR120, inhibit inflammation, and treat conditions responsive to PPAR Ƴ modulation, conditions responsive to GPR120 modulation, and metabolic disturbances such as diabetes.
摘要翻译：本申请提供了顺式3,4-二羟基-2-（3-甲基丁酰基）-5-（3-甲基丁基）-4-（4-甲基戊酰基）环戊-2-烯-1-酮衍生物及其基本上对映体纯的组合物。这些衍生物包括（+） - （4S，5R）-3,4-二羟基-2-（3-甲基丁酰基）-5-（3-甲基丁基）-4-（4-甲基戊酰基）环戊-2-烯-1-酮（ - ） - （4R，5S）-3,4-二羟基-2-（3-甲基丁酰基）-5-（3-甲基丁基）-4-（4-甲基戊酰基）环戊-2-烯-1-酮，及其盐和晶体。本申请还提供了使用所公开的化合物和组合物来激活PPARα，激活GPR120，抑制炎症和治疗对PPARα有反应的病症的方法。调节，响应于GPR120调节的病症，以及诸如糖尿病的代谢紊乱。

9. 发明申请

WO2008141397A1 APPARATUS FOR DISPENSING PACKETS OF GOODS 审中-公开
标题翻译：用于分配商品包的装置
公开(公告)号：WO2008141397A1
公开(公告)日：2008-11-27
申请号：PCT/AU2008/000734
申请日：2008-05-23
申请人： THE HOT CHIPS COMPANY , CARROLL, Brian
发明人： CARROLL, Brian
IPC分类号： B65G59/06
CPC分类号： B65G59/067
摘要： An apparatus (2) for dispensing packets (12) of goods comprises a feed mechanism (4) having a dispensing opening (8) in which is provided a platform (6) for engaging a packet (12) to be dispensed. A striking member (14) is rotated about the platform (6) at a position to strike and subsequently push the packet (12) supported by the platform (6) from the platform (6) thereby dispensing the packet (12) from the opening (8). After the striking member (14) passes across the platform (6) the feed mechanism (4) sequentially feeds a next packet (12) to the opening (8) where it is supported on the platform (6). This dispensing process can be repeated to dispense the packet (12) now supported on the platform (6). In this way each of the packets (12) held in the feed mechanism (4) can be sequentially dispensed.
摘要翻译：用于分配货物包装（12）的装置（2）包括具有分配开口（8）的进给机构（4），其中设置有用于接合要分配的包装（12）的平台（6）。打击构件（14）围绕平台（6）在打击的位置旋转，并且随后将平台（6）支撑的包（12）从平台（6）推动，从而从开口分配包（12）（8）。在冲击构件（14）穿过平台（6）之后，进给机构（4）顺序地将下一个包（12）馈送到其被支撑在平台（6）上的开口（8）。可以重复该分配过程以分配现在支持在平台（6）上的分组（12）。以这种方式，可以顺序地分配保持在进给机构（4）中的每个包（12）。

10. 发明申请

WO2008141393A2 COOKING APPARATUS 审中-公开
标题翻译：烹饪设备
公开(公告)号：WO2008141393A2
公开(公告)日：2008-11-27
申请号：PCT/AU2008/000730
申请日：2008-05-23
申请人： THE HOT CHIPS COMPANY , CARROLL, Brian
发明人： CARROLL, Brian
CPC分类号： A47J37/1214 , A47J37/1228
摘要： A cooking apparatus (10) comprises a container (12) for holding a volume of a cooking liquid (14), a guide (16) and a transport system (18). The guide (16) is disposed in the container (12) and has a first portion (20) submerged in the cooking liquid (14) and an inclined portion (22) extending from the first portion (20) to an outlet (24) of the apparatus (10). The transport system (18) transports a foodstuff (26) such as potato cuts or chips along the guide (16) through the first portion (20), and thus through the cooking liquid (14), up the inclined portion (22) and to the outlet (24).
摘要翻译：烹饪设备（10）包括用于容纳烹饪液体（14）的容积的容器（12），引导件（16）和输送系统（18）。引导件（16）设置在容器（12）中并且具有浸没在烹饪液体（14）中的第一部分（20）和从第一部分（20）延伸到出口（24）的倾斜部分（22）的装置（10）。运输系统（18）通过第一部分（20）沿着引导件（16）输送诸如马铃薯切片或碎屑的食品（26），从而通过烹饪液体（14）向上倾斜倾斜部分（22）和到出口（24）。

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