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1. 发明申请

WO2007137120A1 IN-SITU EQUILIBRIUM DIALYSIS 审中-公开
标题翻译：现场平衡透析
公开(公告)号：WO2007137120A1
公开(公告)日：2007-11-29
申请号：PCT/US2007/069150
申请日：2007-05-17
申请人： IDEXX LABORATORIES, INC. , CARPENTER, Charles, R. , FARACE, Giosi
发明人： CARPENTER, Charles, R. , FARACE, Giosi
IPC分类号： G01N33/53 , G01N33/541
CPC分类号： G01N33/541
摘要： A method for the determination of analytes in samples using a pre-precipitated antibody complex. The complex includes an anti-analyte antibody and a secondary binding molecule that results in the precipitation of the antibody. Labeled-anal yte analog competes for binding sites on the complex with analyte in the sample. The presence or amount of the analyte in the sample can is determined by detecting the amount of the label associated with the complex. The pre-precipitated antibody complex may be preloaded with labeled-analyte analog.
摘要翻译：使用预沉淀抗体复合物测定样品中分析物的方法。复合物包括抗分析物抗体和导致抗体沉淀的二级结合分子。标记肛门模拟物与样品中分析物的复合物上的结合位点竞争。通过检测与复合物相关的标签的量来确定样品中分析物的存在或量。预沉淀抗体复合物可以用标记的分析物类似物预加载。

2. 发明申请

WO2007011936A3 LATERAL FLOW ASSAY AND DEVICE USING MAGNETIC PARTICLES 审中-公开
公开(公告)号：WO2007011936A3
公开(公告)日：2007-01-25
申请号：PCT/US2006/027845
申请日：2006-07-18
申请人： IDEXX LABORATORIES, INC. , CARPENTER, Charles, R. , FARACE, Giosi , MACHENRY, Paul, Scott , FOSTER, Brian, John , ZIEBA, Mirolee, Blue
发明人： CARPENTER, Charles, R. , FARACE, Giosi , MACHENRY, Paul, Scott , FOSTER, Brian, John , ZIEBA, Mirolee, Blue
IPC分类号： G01N33/558 , G01N33/543 , G01N33/50 , H01F1/36 , B01L3/00
摘要： A complex including magnetic particle bound to a metal colloid. The complex may be part of a reagent for use in a method for determining analytes. The reagent may include a binding partner specific for an analyte. The reagent may further include a first label that is distinguishable from a second label that is used to detect the analyte. The reagent is used in kits and methods for detecting analytes in samples. The methods include immunoassay methods, including method where the first label is used to calibrate the assay.

3. 发明申请

WO2007011936A2 LATERAL FLOW ASSAY AND DEVICE USING MAGNETIC PARTICLES 审中-公开
标题翻译：横向流动测定和使用磁性颗粒的装置
公开(公告)号：WO2007011936A2
公开(公告)日：2007-01-25
申请号：PCT/US2006027845
申请日：2006-07-18
申请人： IDEXX LAB INC , CARPENTER CHARLES R , FARACE GIOSI , MACHENRY PAUL SCOTT , FOSTER BRIAN JOHN , ZIEBA MIROLEE BLUE
发明人： CARPENTER CHARLES R , FARACE GIOSI , MACHENRY PAUL SCOTT , FOSTER BRIAN JOHN , ZIEBA MIROLEE BLUE
IPC分类号： G01N33/50
CPC分类号： G01N33/54333 , G01N33/558 , H01F1/0054
摘要： A complex including magnetic particle bound to a metal colloid. The complex may be part of a reagent for use in a method for determining analytes. The reagent may include a binding partner specific for an analyte. The reagent may further include a first label that is distinguishable from a second label that is used to detect the analyte. The reagent is used in kits and methods for detecting analytes in samples. The methods include immunoassay methods, including method where the first label is used to calibrate the assay.
摘要翻译：包含结合到金属胶体上的磁性颗粒的复合物。该复合物可以是用于测定分析物的方法中的试剂的一部分。该试剂可以包括对分析物特异的结合配偶体。该试剂还可以包括与用于检测分析物的第二标签可区分的第一标签。该试剂用于检测样品中分析物的试剂盒和方法。这些方法包括免疫分析方法，包括使用第一个标记来校准分析的方法。

4. 发明申请

WO0058730A9 METHOD AND DEVICE FOR DETECTING ANALYTES IN FLUIDS 审中-公开
标题翻译：用于检测流体分析仪的方法和装置
公开(公告)号：WO0058730A9
公开(公告)日：2002-07-11
申请号：PCT/US0007965
申请日：2000-03-24
申请人： IDEXX LAB INC , CARPENTER CHARLES R
发明人： CARPENTER CHARLES R
IPC分类号： G01N33/543 , C12M1/34 , C12Q1/25 , G01N21/78 , G01N33/483 , G01N33/533 , G01N33/536 , G01N33/558 , G01N33/577
CPC分类号： G01N33/558 , Y10S435/81 , Y10S435/91
摘要： A disposable, dry chemistry analytical system is disclosed which is broadly useful for the detection of a variety of analytes present in biological fluids such as whole blood, serum, plasma, urine and cerebral spinal fluid. The invention discloses the use of the reaction interface that forms between two liquids converging from opposite directions within a bibulous material. The discovery comprises a significant improvement over prior art disposable, analytical reagent systems in that the detectable reactant zone is visually distinct and separate from the unreacted reagents allowing for the use of reaction indicators exhibiting only minor changes as well as extremely high concentrations of reactants. In addition, staged, multiple reagents can be incorporated. Whole blood can be used as a sample without the need for separate cell separating materials. Finally, the invention is useful for the detection of analytes in a broad variety of materials such as milk, environmental samples, and other samples containing target analytes.
摘要翻译：公开了一次性干燥化学分析系统，其广泛用于检测生物流体如全血，血清，血浆，尿液和脑脊液中存在的各种分析物。本发明公开了在吸水材料内从两相反方向汇合的两种液体之间形成的反应界面的应用。该发现包括相对于现有技术的一次性分析试剂系统的显着改进，因为可检测的反应物区域在视觉上是不同的并且与未反应的试剂分离，允许使用仅显示微小变化的反应指示剂以及极高浓度的反应物。此外，可以并入分阶段的多种试剂。全血可用作样品，不需要单独的细胞分离材料。最后，本发明可用于检测多种材料中的分析物，例如牛奶，环境样品和含有目标分析物的其它样品。

5. 发明申请

WO2007078754A1 DUAL STANDARD CURVE IMMUNOASSAY 审中-公开
标题翻译：双标准曲线免疫
公开(公告)号：WO2007078754A1
公开(公告)日：2007-07-12
申请号：PCT/US2006/047488
申请日：2006-12-12
申请人： IDEXX LABORATORIES, INC. , CARPENTER, Charles, R. , FARACE, Giosi , MACHENRY, Paul, Scott , FOSTER, Brian, John , ZIEBA, Mirolee, Blue , D'ANGELO, Michael, Ryan
发明人： CARPENTER, Charles, R. , FARACE, Giosi , MACHENRY, Paul, Scott , FOSTER, Brian, John , ZIEBA, Mirolee, Blue , D'ANGELO, Michael, Ryan
IPC分类号： G01N33/58
CPC分类号： G01N33/58 , G01N2333/635
摘要： A method and a kit for determining the presence or amount of analytes in samples over a broad potential concentration range or samples. The method and kit incorporate chemiluminescent and fluorescent labels conjugated to a specific binding partner for the analyte for sandwich assays, or to the analyte or an analog of the analyte for competitive assays. The conjugates are mixed with the sample and the labels are detected simultaneously or sequentially.
摘要翻译：用于确定样品中广泛潜在浓度范围或样品中分析物的存在或数量的方法和试剂盒。该方法和试剂盒包含化学发光和荧光标记，其结合到用于夹心测定的分析物的特异性结合配偶体，或用于竞争性测定的分析物或分析物的类似物。将缀合物与样品混合，同时或依次检测标记物。

6. 发明申请

WO2003106696A2 METHODS AND DEVICES FOR THE DETECTION OF PATHOGENIC MICROORGANISMS AND THEIR ANTIMICROBIAL SUSCEPTILBILITY 审中-公开
标题翻译：检测病原微生物的方法和装置及其抗微生物的可疑性
公开(公告)号：WO2003106696A2
公开(公告)日：2003-12-24
申请号：PCT/US2003/000655
申请日：2003-01-09
申请人： IDEXX LABORATORIES, INC. , CHEN, Chun-Ming , CARPENTER, Charles, R. , GU, Haoyi , NAQUI, Ali , MADSEN, Gary , O'CONNOR, Thomas, P., Jr. , ESTY, Katherine, Jean
发明人： CHEN, Chun-Ming , CARPENTER, Charles, R. , GU, Haoyi , NAQUI, Ali , MADSEN, Gary , O'CONNOR, Thomas, P., Jr. , ESTY, Katherine, Jean
IPC分类号： C12Q
CPC分类号： B01L3/50853 , B01L2300/045 , B01L2300/0809 , C12Q1/04 , C12Q1/18
摘要： The present invention provides devices and methods for determining the presence or absence of pathogens in a biological sample and for the concurrent determination of the antimicrobial susceptibility of pathogens present. The devices and methods of the present invention are able to make the determinations without pre-selection of target bacteria. Instead, all organisms from the sample are applied to the device. In wells where one or more antimicrobial agents are present only pathogens resistant to the antimicrobial agent grow. This allows the user to determine the presence of target pathogens and concurrently determine the resistance patterns of the organisms without the need to subculture the organisms. The present invention also provides methods of performing a business service of performing the determinations described above, and kits containing the devices and descriptions of the methods.
摘要翻译：本发明提供用于确定生物样品中病原体的存在或不存在以及同时测定存在的病原体的抗微生物易感性的装置和方法。本发明的装置和方法能够在不预先选择目标细菌的情况下进行测定。相反，将来自样品的所有生物体施加到装置上。在存在一种或多种抗微生物剂的孔中，只有抗微生物剂抗性的病原体生长。这允许用户确定目标病原体的存在并且同时确定生物体的抗性模式，而不需要传代培养生物体。本发明还提供了执行上述确定的业务服务的方法，以及包含所述设备的方法和所述方法的描述的套件的方法。

7. 发明申请

WO2003106696A3 METHODS AND DEVICES FOR THE DETECTION OF PATHOGENIC MICROORGANISMS AND THEIR ANTIMICROBIAL SUSCEPTILBILITY 审中-公开
公开(公告)号：WO2003106696A3
公开(公告)日：2003-12-24
申请号：PCT/US2003/000655
申请日：2003-01-09
申请人： IDEXX LABORATORIES, INC. , CHEN, Chun-Ming , CARPENTER, Charles, R. , GU, Haoyi , NAQUI, Ali , MADSEN, Gary , O'CONNOR, Thomas, P., Jr. , ESTY, Katherine, Jean
发明人： CHEN, Chun-Ming , CARPENTER, Charles, R. , GU, Haoyi , NAQUI, Ali , MADSEN, Gary , O'CONNOR, Thomas, P., Jr. , ESTY, Katherine, Jean
IPC分类号： A61K38/00
摘要： The present invention provides devices and methods for determining the presence or absence of pathogens in a biological sample and for the concurrent determination of the antimicrobial susceptibility of pathogens present. The devices and methods of the present invention are able to make the determinations without pre-selection of target bacteria. Instead, all organisms from the sample are applied to the device. In wells where one or more antimicrobial agents are present only pathogens resistant to the antimicrobial agent grow. This allows the user to determine the presence of target pathogens and concurrently determine the resistance patterns of the organisms without the need to subculture the organisms. The present invention also provides methods of performing a business service of performing the determinations described above, and kits containing the devices and descriptions of the methods.

8. 发明申请

WO0058730A8 METHOD AND DEVICE FOR DETECTING ANALYTES IN FLUIDS 审中-公开
标题翻译：用于检测流体分析仪的方法和装置
公开(公告)号：WO0058730A8
公开(公告)日：2001-07-19
申请号：PCT/US0007965
申请日：2000-03-24
申请人： IDEXX LAB INC , CARPENTER CHARLES R
发明人： CARPENTER CHARLES R
IPC分类号： G01N33/543 , C12M1/34 , C12Q1/25 , G01N21/78 , G01N33/483 , G01N33/533 , G01N33/536 , G01N33/558 , G01N33/577
CPC分类号： G01N33/558 , Y10S435/81 , Y10S435/91
摘要： A disposable, dry chemistry analytical system is disclosed which is broadly useful for the detection of a variety of analytes present in biological fluids such as whole blood, serum, plasma, urine and cerebral spinal fluid. The invention discloses the use of the reaction interface that forms between two liquids converging from opposite directions within a bibulous material. The discovery comprises a significant improvement over prior art disposable, analytical reagent systems in that the detectable reactant zone is visually distinct and separate from the unreacted reagents allowing for the use of reaction indicators exhibiting only minor changes as well as extremely high concentrations of reactants. In addition, staged, multiple reagents can be incorporated. Whole blood can be used as a sample without the need for separate cell separating materials. Finally, the invention is useful for the detection of analytes in a broad variety of materials such as milk, environmental samples, and other samples containing target analytes.
摘要翻译：公开了一次性干燥化学分析系统，其广泛用于检测生物流体如全血，血清，血浆，尿液和脑脊液中存在的各种分析物。本发明公开了使用在吸水材料内从相反方向汇合的两种液体之间形成的反应界面。该发现包括对现有技术的一次性分析试剂系统的显着改进，因为可检测的反应物区域在视觉上是不同的并且与未反应试剂分离，允许使用仅显示微小变化的反应指示剂以及极高浓度的反应物。此外，可以并入分阶段的多种试剂。全血可用作样品，不需要单独的细胞分离材料。最后，本发明可用于检测各种材料中的分析物，例如牛奶，环境样品和含有目标分析物的其它样品。

9. 发明授权

US2354848A Fish stringer and the like 失效
标题翻译：鱼inger等
公开(公告)号：US2354848A
公开(公告)日：1944-08-01
申请号：US41264941
申请日：1941-09-27
申请人： CARPENTER CHARLES R
发明人： CARPENTER CHARLES R
IPC分类号： A01K65/00
CPC分类号： A01K65/00 , Y10T24/465 , Y10T24/4668

10. 发明授权

US2628659A Convertible furniture article 失效
标题翻译：可转换家具用品
公开(公告)号：US2628659A
公开(公告)日：1953-02-17
申请号：US20645551
申请日：1951-01-17
申请人： CARPENTER CHARLES R
发明人： CARPENTER CHARLES R
IPC分类号： A47B83/02 , A47D3/00 , B65D6/18
CPC分类号： A47D3/005 , A47B83/02

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