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2. 发明申请

WO0238183A3 DELIVERY DEVICES 审中-公开
标题翻译：递送设备
公开(公告)号：WO0238183A3
公开(公告)日：2003-01-23
申请号：PCT/GB0104982
申请日：2001-11-09
申请人： UNIV CAMBRIDGE TECH , CAMERON RUTH ELIZABETH , DICKERS KIRSTEN JOANNE , MILROY GEORGINA EMILY , HUATAN HIEP
发明人： CAMERON RUTH ELIZABETH , DICKERS KIRSTEN JOANNE , MILROY GEORGINA EMILY , HUATAN HIEP
IPC分类号： A61K9/00 , A61K9/20 , A61K9/22 , A61K47/34
CPC分类号： A61K9/0024 , A61K9/204
摘要： A process is provided for impregnating a substantial homopolymer of glycolic acid selected form substantial homopolymers of glycolic acid and block copolymers comprising at least 40 mol. % glycolic acid monomer as blocks which are substantial homopolymers of glycolic acid with a pharmaceutically active compound, the process comprising dissolving the pharmaceutically active compound in a solvent to form a solution of pharmaceutically active compound, contacting the solution with the polymer and allowing the solution to penetrate the polymer, characterised in that the solvent is liquid at atmospheric pressure and 20 DEG C and is capable of penetrating the polymer and is not capable of dissolving the polymer. The solvent may be for instance water or an organic solvent having solubility parameter S of from 18.5 to 28.0 Mpa . The product may be used for implantation in a human or other animal subject. Also provided is a product suitable for implantation in the body of a human or other animal subject comprising a pharmaceutically active compound encapsulated by a casing which forms a barrier between the pharmaceutically active compound and the environment, wherein at least part of the barrier is formed from a membrane of glycolic acid polymer selected from substantial homopolymers of glycolic acid and block copolymers comprising at least 40 mol. % glycolic acid monomer as blocks which are substantial homopolymers of glycolic acid.
摘要翻译：提供一种方法，用于浸渍基本上选自乙醇酸均聚物的乙醇酸均聚物和包含至少40mol的乙烯酸的嵌段共聚物。乙醇酸单体作为基本上是乙醇酸均聚物与药物活性化合物的嵌段，该方法包括将药学活性化合物溶解在溶剂中以形成药物活性化合物的溶液，使溶液与聚合物接触，并使溶液渗透聚合物，其特征在于溶剂在大气压和20℃下为液体，并且能够渗透聚合物并且不能溶解聚合物。溶剂可以是例如水或溶解度参数S为18.5至28.0Mpa 1/2的有机溶剂。该产品可用于植入人或其他动物受试者。还提供了适于植入人或其他动物受试者体内的产品，其包含由在药学活性化合物和环境之间形成屏障的外壳包封的药学活性化合物，其中至少部分屏障是由选自乙醇酸的基本均聚物的乙醇酸聚合物的膜和包含至少40mol的乙烯酸的嵌段共聚物。％乙醇酸单体作为基本上是乙醇酸均聚物的嵌段。

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