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1. 发明申请

WO03011277A3 METHODS TO MOBILIZE PROGENITOR/STEM CELLS 审中-公开
标题翻译：移动原核细胞/干细胞的方法
公开(公告)号：WO03011277A3
公开(公告)日：2003-05-22
申请号：PCT/US0224212
申请日：2002-07-30
申请人： ANORMED INC , BRIDGER GARY J , ABRAMS MICHAEL J , HENSON GEOFFREY W , MACFARLAND RONALD TREVOR , CALANDRA GARY B
发明人： BRIDGER GARY J , ABRAMS MICHAEL J , HENSON GEOFFREY W , MACFARLAND RONALD TREVOR , CALANDRA GARY B
IPC分类号： A61K45/00 , A61K20060101 , A61K31/33 , A61K31/395 , A61K31/496 , A61K31/55 , A61K31/551 , A61K31/555 , A61K38/00 , A61K38/19 , A61P7/00 , A61P7/06 , A61P17/02 , A61P31/04 , A61P35/02 , A61P37/00 , A61P37/04
CPC分类号： A61K31/395 , A61K31/33 , A61K31/4427 , A61K31/496 , A61K31/55 , A61K31/551 , A61K31/555 , A61K35/28 , A61K38/193 , A61K38/195 , A61K2035/124 , C12N5/0647 , A61K2300/00
摘要： The present invention is directed to methods to elevate progenitor and stem cell counts in animal subjects using compounds which bind to the chemokine receptor CXCR4.
摘要翻译：本发明涉及使用结合趋化因子受体CXCR4的化合物来提高动物受试者中祖细胞和干细胞计数的方法。

2. 发明申请

WO2005000333A1 METHODS TO MOBILIZE PROGENITOR/STEM CELLS 审中-公开
标题翻译：移动原核细胞/干细胞的方法
公开(公告)号：WO2005000333A1
公开(公告)日：2005-01-06
申请号：PCT/US2004/016941
申请日：2004-05-27
申请人： ANORMED INC. , BRIDGER, Gary, J. , ABRAMS, Michael, J. , HENSON, Geoffrey, W. , MACFARLAND, Ronald, T. , CALANDRA, Gary, B.
发明人： BRIDGER, Gary, J. , ABRAMS, Michael, J. , HENSON, Geoffrey, W. , MACFARLAND, Ronald, T. , CALANDRA, Gary, B.
IPC分类号： A61K38/00
CPC分类号： A61K31/33 , A61K31/496 , A61K31/55 , A61K31/551 , A61K31/555 , A61K38/193 , A61K38/195 , A61K47/555 , A61K2300/00
摘要： Methods to elevate progenitor and stem cell counts in animal subjects using compounds which bind to the chemokine receptor CXCR4 are disclosed. Preferred embodiments of such compounds are of the formula (1): Z-linker-Z’ or pharmaceutically acceptable salt thereof wherein Z is of the formula (A) wherein A comprises a monocyclic or bicyclic fused ring system containing at least one N and B is H or an organic moiety of 1-20 atoms, Z’ is of the formula (I) : -Ar(Y) j ; wherein Ar is an aromatic or heteroaromatic moiety, and each Y is independently a non-interfering substituent and j is 0-3; and “linker” represents a bond, alkylene (1-6C) or may comprise aryl, fused aryl, oxygen atoms contained in an alkylene chain, or may contain keto groups or nitrogen or sulfur atoms.
摘要翻译：公开了使用结合趋化因子受体CXCR4的化合物来提高动物受试者祖细胞和干细胞计数的方法。这些化合物的优选实施方案是式（1）：Z-连接体-Z'或其药学上可接受的盐，其中Z具有式（A）的化合物，其中A包含含有至少一个N和B的单环或双环稠环体系是H或1-20个原子的有机部分，Z'具有式（I）：-Ar（Y）j; 其中Ar是芳族或杂芳族部分，并且每个Y独立地是非干扰性取代基，并且j是0-3; 和“接头”表示键，亚烷基（1-6C）或可包含芳基，稠合芳基，亚烷基链中所含的氧原子，或可含有酮基或氮或硫原子。

3. 发明申请

WO2003011277A2 METHODS TO MOBILIZE PROGENITOR/STEM CELLS 审中-公开
标题翻译：移动祖细胞/干细胞的方法
公开(公告)号：WO2003011277A2
公开(公告)日：2003-02-13
申请号：PCT/US2002/024212
申请日：2002-07-30
申请人： ANORMED INC. , BRIDGER, Gary, J. , ABRAMS, Michael, J. , HENSON, Geoffrey, W. , MACFARLAND, Ronald, Trevor , CALANDRA, Gary, B.
发明人： BRIDGER, Gary, J. , ABRAMS, Michael, J. , HENSON, Geoffrey, W. , MACFARLAND, Ronald, Trevor , CALANDRA, Gary, B.
IPC分类号： A61K31/33
CPC分类号： A61K31/395 , A61K31/33 , A61K31/4427 , A61K31/496 , A61K31/55 , A61K31/551 , A61K31/555 , A61K35/28 , A61K38/193 , A61K38/195 , A61K2035/124 , C12N5/0647 , A61K2300/00
摘要： Methods to elevate progenitor and stem cell counts in animal subjects using compounds which bind to the chemokine receptor CXCR4 are disclosed. Preferred embodiments of such compounds are of the formula Z-linker-Z' (1) or pharmaceutically acceptable salt thereof wherein Z is a cyclic polyamine containing 9-32 ring members of which 3-8 are nitrogen atoms, said nitrogen atoms separated from each other by at least 2 carbon atoms, and wherein said heterocycle may optionally contain additional heteroatoms besides nitrogen and/or may be fused to an additional ring system; or Z is of formula (a), wherein A comprises a monocyclic or bicyclic fused ring system containing at least one N and B is H or an organic moiety of 1-20 atoms, Z' may be embodied in a form as defined by Z above, or alternatively may be of the formula -N(R)-(CR 2 ) n -X wherein each R is independently H or straight, branched or cyclic alkyl (1-6C), n is 1 or 2, and X is an aromatic ring, including heteroaromatic rings, or is a mercaptan; "linker" represents a bond, alkylene (1-6C) or may comprise aryl, fused aryl, oxygen atoms contained in an alkylene chain, or may contain keto groups or nitrogen or sulfur atoms.
摘要翻译：公开了使用结合趋化因子受体CXCR4的化合物提高动物受试者的祖细胞和干细胞计数的方法。这些化合物的优选实施方案具有式Z-接头-Z'（1）或其药学上可接受的盐，其中Z为含有9-32个环成员的环多胺，其中3-8个为氮原子，所述氮原子与其它至少2个碳原子，并且其中所述杂环可以任选地包含除了氮之外的另外的杂原子和/或可以与另外的环系统稠合; 或Z具有式（a），其中A包含含有至少一个N的单环或双环稠合环体系，B是H或1-20个原子的有机部分，Z'可以以如Z 或可选地可以具有式-N（R） - （CR 2）n -X其中每个R独立地为H或直链，支链或环状的烷基（ n为1或2，并且X为芳环，包括杂芳环，或为硫醇; ＆QUOT;接头＆QUOT; 表示键，亚烷基（1-6C）或可包含亚烷基链中所含的芳基，稠合的芳基，氧原子，或可含有酮基或氮或硫原子。

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