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1. 发明申请

WO2006063302A3 VARIANTS OF GLYCOGEN SYNTHASE KINASE 3 AND USES THEREOF 审中-公开
标题翻译： GLYCOGEN SYNTHASE KINASE 3的变体及其用途
公开(公告)号：WO2006063302A3
公开(公告)日：2007-02-22
申请号：PCT/US2005044762
申请日：2005-12-09
申请人： WYETH CORP , CAIN MICHAEL , YAWORSKY PAUL
发明人： CAIN MICHAEL , YAWORSKY PAUL
IPC分类号： C12N9/40 , A61K38/00 , C07K16/40 , C12N5/08 , C12N9/12 , C12P21/06
CPC分类号： C12N9/1205 , A61K38/00 , C12N9/12 , C12N2310/11 , C12N2310/14
摘要： The present invention provides GSK3ß variants, including splice variants expressed in bone or other tissues. These variants have a broad range of functional activity, from inhibiting the Wnt pathway to activating the pathway as dominant-negatives of the full-length GSK3ß. These variants, as well as their modulators, can be used to treat diseases that involve GSK3ß or its associated signaling pathways.
摘要翻译：本发明提供GSK3β变体，包括在骨或其他组织中表达的剪接变体。这些变体具有广泛的功能活性，从抑制Wnt途径激活途径作为全长GSK3β的显性阴性。这些变体及其调节剂可用于治疗涉及GSK3β或其相关信号通路的疾病。

2. 发明申请

WO2005103543A2 FLUID DISTRIBUTION SYSTEM 审中-公开
标题翻译：流体分配系统
公开(公告)号：WO2005103543A2
公开(公告)日：2005-11-03
申请号：PCT/US2005/002338
申请日：2005-01-24
申请人： INGERSOLL-RAND COMPANY , MATT, Gunter, Gray , COLLINS, James, Christopher , CAIN, Michael, Patrick , ADKINS, Paul, Harry
发明人： MATT, Gunter, Gray , COLLINS, James, Christopher , CAIN, Michael, Patrick , ADKINS, Paul, Harry
IPC分类号： F16L
CPC分类号： F16L21/08 , F16L25/0009
摘要： A fluid distribution system comprising a hollow pipe section having at least one bore extending longitudinally therethrough. At least one longitudinal boss extends along the pipe section. An end fitting comprises a body configured to be received in the bore and a shoulder extending radially from the body. At least one bolt hole extends through the shoulder and is configured to align with the at least one longitudinal boss. A secondary component is configured for connection to the end fitting. Alternatively, an outlet plate fitting is configured for attaching a secondary component to a fluid pipe section. The fluid pipe section includes opposed flanges that define a receiving groove. The outlet plate fitting comprises a main body and an engagement platform having a planar surface with a seal member. Rotation of the engagement platform within the receiving groove causes the planar surface and seal member into sealing engagement within the receiving groove.
摘要翻译：一种流体分配系统，包括具有至少一个纵向延伸穿过的孔的中空管段。至少一个纵向凸台沿管段延伸。端部配件包括构造成容纳在孔中的主体和从主体径向延伸的肩部。至少一个螺栓孔延伸穿过所述肩部并且构造成与所述至少一个纵向凸台对准。辅助部件配置为连接到端部接头。或者，出口板配件构造成用于将次要部件附接到流体管道部分。流体管部分包括限定接收槽的相对的凸缘。出口板配件包括主体和具有带有密封构件的平面的接合平台。接合平台在接收槽内的旋转导致平面和密封件在接收槽内形成密封接合。

3. 发明申请

WO2003069899A3 SYSTEM AND METHOD FOR PROVIDING VIDEO PROGRAM INFORMATION OR VIDEO PROGRAM CONTENT TO A USER 审中-公开
公开(公告)号：WO2003069899A3
公开(公告)日：2003-08-21
申请号：PCT/US2003/003857
申请日：2003-02-07
申请人： AT & T BROADBAND , BRENNER, Scott , CAIN, Michael, E. , HAMEL, Kenneth, L. , STALLER, Joshua, D.
发明人： BRENNER, Scott , CAIN, Michael, E. , HAMEL, Kenneth, L. , STALLER, Joshua, D.
IPC分类号： H04N5/445
摘要： In a system for broadcasting video programs to a user including a display, a system and method for providing program information or a copy of at least a portion of a program to the user. In one embodiment, a controller receives an input signal representing a request for summary information concerning a program, the program having a beginning and the input signal generated at a time during the broadcast. The controller provides via the display a summary of the program from the program beginning to the input signal time in response to the input signal. A controller may alternatively monitor a period of time during which the display is tuned to a broadcast of a program, the period starting during the broadcast. The controller is used to provide via the display a copy of at least a portion of the program when the period exceeds a predetermined threshold time.

4. 发明申请

WO2012023113A2 DESIGNER OSTEOGENIC PROTEINS 审中-公开
标题翻译：设计者蛋白质蛋白
公开(公告)号：WO2012023113A2
公开(公告)日：2012-02-23
申请号：PCT/IB2011/053638
申请日：2011-08-17
申请人： WYETH LLC , BERASI, Stephen Peter , BROWN, Christopher Todd , CAIN, Michael John , CALABRO, Valerie Perrine , JUO, Zong Sean , MARTINEZ, Robert Vincent Paul , SEEHERMAN, Howard Joel , WOZNEY, John Martin
发明人： BERASI, Stephen Peter , BROWN, Christopher Todd , CAIN, Michael John , CALABRO, Valerie Perrine , JUO, Zong Sean , MARTINEZ, Robert Vincent Paul , SEEHERMAN, Howard Joel , WOZNEY, John Martin
IPC分类号： A61K38/18
CPC分类号： C07K14/51 , A61K38/00
摘要： The invention relates to novel designer osteogenic proteins having altered affinity for a cognate receptor, nucleic acids encoding the same, and methods of use therefor. More preferably, the novel designer osteogenic proteins are designer BMPs and have altered affinity for a cognate BMP receptor. The designer BMPs demonstrate altered biological characteristics and provide potential useful novel therapeutics.
摘要翻译：本发明涉及对同型受体具有改变的亲和力的新型设计者成骨蛋白质，及其编码的核酸及其使用方法。更优选地，新设计的成骨蛋白是设计者BMP并且对同源BMP受体具有改变的亲和力。设计者BMPs展示了改变的生物学特征，并提供潜在的有用的新型治疗。

5. 发明申请

WO2009005813A1 MODULATORS OF AXL FOR USE IN TREATING BONE DISORDERS 审中-公开
标题翻译： AXL调制器用于治疗骨质疏松症
公开(公告)号：WO2009005813A1
公开(公告)日：2009-01-08
申请号：PCT/US2008/008220
申请日：2008-07-02
申请人： WYETH , YAWORSKY, Paul , SMITH, Erica , CAIN, Michael , ROBINSON, John A.
发明人： YAWORSKY, Paul , SMITH, Erica , CAIN, Michael , ROBINSON, John A.
IPC分类号： A61K45/06 , A61K38/18 , A61K39/395 , A61K31/7105 , A61K31/435 , A61P19/08 , C12N15/11 , G01N33/50
CPC分类号： A61K31/435 , A61K31/66 , A61K31/7088 , A61K31/7105 , A61K38/00 , A61K38/1875 , A61K45/06 , C07K14/705 , C07K2319/30 , C12N15/1136 , C12N15/1138 , C12N2310/14 , C12Q1/485 , G01N33/5008 , G01N2333/91205 , G01N2500/02 , G01N2800/108 , A61K2300/00
摘要： The invention provides methods for treating or preventing bone and cartilage disorders comprising administering to a mammal an inhibitor of Axl gene expression or an inhibitor of Axl protein activity.
摘要翻译：本发明提供了治疗或预防骨和软骨疾病的方法，包括向哺乳动物施用Axl基因表达抑制剂或Ax1蛋白活性抑制剂。

6. 发明申请

WO2007068667A1 METHOD AND APPARATUS FOR ANALYZING THE EFFECT OF DIFFERENT EXECUTION PARAMETERS ON THE PERFORMANCE OF A DATABASE QUERY 审中-公开
标题翻译：分析不同执行参数对数据库查询性能的影响的方法和装置
公开(公告)号：WO2007068667A1
公开(公告)日：2007-06-21
申请号：PCT/EP2006/069535
申请日：2006-12-11
申请人： INTERNATIONAL BUSINESS MACHINES CORPORATION , IBM UNITED KINGDOM LIMITED , BESTGEN, Robert Joseph , CAIN, Michael , KETHIREDDY, Shantan , PFEIFER, Michael Donald
发明人： BESTGEN, Robert Joseph , CAIN, Michael , KETHIREDDY, Shantan , PFEIFER, Michael Donald
IPC分类号： G06F17/30
CPC分类号： G06F17/30306 , G06F17/30433 , G06F17/30471
摘要： A database application re-uses one or more query execution strategies for a given logical query, and saves historical data concerning query execution performance under differing execution parameters. The historical data is analyzed to identify environmental variables and/or imported variables which significantly affect execution performance. Preferably, an auxiliary data structure includes, for each of multiple execution strategies, a respective set of imported and environmental variables and respective average cost measure, such as execution time. An analytical tool compares multiple different strategies to identify imported and/or environmental variables which caused a different strategy to be used, and resultant average cost. Preferably, the tool can also compare variation within the same strategy.
摘要翻译：数据库应用程序重新使用给定逻辑查询的一个或多个查询执行策略，并在不同的执行参数下保存有关查询执行性能的历史数据。分析历史数据，以识别显着影响执行绩效的环境变量和/或导入变量。优选地，对于多个执行策略中的每一个，辅助数据结构包括相应的一组导入和环境变量以及相应的平均成本度量，诸如执行时间。分析工具比较了多种不同的策略来识别导致使用不同策略的进口和/或环境变量，从而导致平均成本。优选地，该工具还可以比较相同策略中的变化。

7. 发明申请

WO2005103543A3 FLUID DISTRIBUTION SYSTEM 审中-公开
标题翻译：流体分配系统
公开(公告)号：WO2005103543A3
公开(公告)日：2006-01-19
申请号：PCT/US2005002338
申请日：2005-01-24
申请人： INGERSOLL RAND CO , MATT GUNTER GRAY , COLLINS JAMES CHRISTOPHER , CAIN MICHAEL PATRICK , ADKINS PAUL HARRY
发明人： MATT GUNTER GRAY , COLLINS JAMES CHRISTOPHER , CAIN MICHAEL PATRICK , ADKINS PAUL HARRY
IPC分类号： F16L21/08 , F16L25/00
CPC分类号： F16L21/08 , F16L25/0009
摘要： A fluid distribution system (10) comprising a hollow pipe section (20) having at least one bore (24) extending longitudinally therethrough. At least one longitudinal boss (26) extends along the pipe section (20). An end fitting (30) comprises a body (32) configured to be received in the bore (24) and a shoulder (34) extending radially from the body (32). At least one bolt hole (35) extends through the shoulder (34) and is configured to align with the at least one longitudinal boss (26). A secondary component is configured for connection to the end fitting (30). Alternatively, an outlet plate fitting (80) is configured for attaching a secondary component to a fluid pipe section (20). The fluid pipe section (20) includes opposed flanges (28) that define a receiving groove (29). The outlet plate fitting (80) comprises a main body and an engagement platform (92) having a planar surface with a seal member. Rotation of the engagement platform (92) within the receiving groove (29) causes the planar surface and seal member into sealing engagement within the receiving groove (29).
摘要翻译：一种流体分配系统（10），包括具有至少一个纵向穿过其中延伸的孔（24）的中空管段（20）。至少一个纵向凸台（26）沿管段（20）延伸。端部配件（30）包括构造成容纳在孔（24）中的主体（32）和从主体（32）径向延伸的肩部（34）。至少一个螺栓孔（35）延伸穿过所述肩部（34）并且构造成与所述至少一个纵向凸台（26）对准。辅助部件构造成用于连接到端部配件（30）。或者，出口板配件（80）构造成用于将次要部件附接到流体管道部分（20）。流体管道部分（20）包括限定接收槽（29）的相对的凸缘（28）。出口板配件（80）包括主体和具有带有密封构件的平面的接合平台（92）。接合平台（92）在接收槽（29）内的旋转导致平面和密封件在接收槽（29）内密封接合。

8. 发明申请

WO2003069899A2 SYSTEM AND METHOD FOR PROVIDING VIDEO PROGRAM INFORMATION OR VIDEO PROGRAM CONTENT TO A USER 审中-公开
标题翻译：向用户提供视频节目信息或视频节目内容的系统和方法
公开(公告)号：WO2003069899A2
公开(公告)日：2003-08-21
申请号：PCT/US2003/003857
申请日：2003-02-07
申请人： AT & T BROADBAND , BRENNER, Scott , CAIN, Michael, E. , HAMEL, Kenneth, L. , STALLER, Joshua, D.
发明人： BRENNER, Scott , CAIN, Michael, E. , HAMEL, Kenneth, L. , STALLER, Joshua, D.
IPC分类号： H04N5/445
CPC分类号： H04N21/44204 , H04N5/76 , H04N5/765 , H04N5/775 , H04N5/781 , H04N5/907 , H04N7/17318 , H04N21/2543 , H04N21/4316 , H04N21/4331 , H04N21/437 , H04N21/47202 , H04N21/6581 , H04N21/84 , H04N21/8549
摘要： In a system for broadcasting video programs to a user including a display, a system and method for providing program information or a copy of at least a portion of a program to the user. In one embodiment, a controller receives an input signal representing a request for summary information concerning a program, the program having a beginning and the input signal generated at a time during the broadcast. The controller provides via the display a summary of the program from the program beginning to the input signal time in response to the input signal. A controller may alternatively monitor a period of time during which the display is tuned to a broadcast of a program, the period starting during the broadcast. The controller is used to provide via the display a copy of at least a portion of the program when the period exceeds a predetermined threshold time.
摘要翻译：在用于向包括显示器的用户广播视频节目的系统中，用于向用户提供节目信息或至少一部分节目的副本的系统和方法。在一个实施例中，控制器接收表示关于节目的摘要信息的请求的输入信号，该节目具有在广播期间的一个时间产生的开始和输入信号。响应输入信号，控制器通过显示从程序开始到输入信号时间的程序摘要。控制器可以替代地监视将显示调谐到节目广播的时间段，即在广播期间开始的周期。当该周期超过预定阈值时间时，控制器用于经由显示器提供至少一部分程序的副本。

9. 发明申请

WO2012023113A3 DESIGNER OSTEOGENIC PROTEINS 审中-公开
标题翻译：设计者成骨蛋白
公开(公告)号：WO2012023113A3
公开(公告)日：2012-04-12
申请号：PCT/IB2011053638
申请日：2011-08-17
申请人： WYETH LLC , BERASI STEPHEN PETER , BROWN CHRISTOPHER TODD , CAIN MICHAEL JOHN , CALABRO VALERIE PERRINE , JUO ZONG SEAN , MARTINEZ ROBERT VINCENT PAUL , SEEHERMAN HOWARD JOEL , WOZNEY JOHN MARTIN
发明人： BERASI STEPHEN PETER , BROWN CHRISTOPHER TODD , CAIN MICHAEL JOHN , CALABRO VALERIE PERRINE , JUO ZONG SEAN , MARTINEZ ROBERT VINCENT PAUL , SEEHERMAN HOWARD JOEL , WOZNEY JOHN MARTIN
IPC分类号： A61K38/18 , C07K14/51
CPC分类号： C07K14/51 , A61K38/00
摘要： The invention relates to novel designer osteogenic proteins having altered affinity for a cognate receptor, nucleic acids encoding the same, and methods of use therefor. More preferably, the novel designer osteogenic proteins are designer BMPs and have altered affinity for a cognate BMP receptor. The designer BMPs demonstrate altered biological characteristics and provide potential useful novel therapeutics.
摘要翻译：本发明涉及对同源受体具有改变的亲和力的新型设计者成骨蛋白，编码其的核酸及其使用方法。更优选地，新型设计者成骨蛋白是经设计的BMP并且对同源BMP受体具有改变的亲和力。设计的BMP显示改变的生物学特性并提供潜在的有用的新型治疗剂。

10. 发明申请

WO2006063302A2 VARIANTS OF GLYCOGEN SYNTAHSE KINASE 3 AND USES THEREOF 审中-公开
标题翻译： GLYCOGEN SYNTAHSE KINASE 3的变体及其用途
公开(公告)号：WO2006063302A2
公开(公告)日：2006-06-15
申请号：PCT/US2005/044762
申请日：2005-12-09
申请人： WYETH , CAIN, Michael , YAWORSKY, Paul
发明人： CAIN, Michael , YAWORSKY, Paul
CPC分类号： C12N9/1205 , A61K38/00 , C12N9/12 , C12N2310/11 , C12N2310/14
摘要： The present invention provides GSK3β variants, including splice variants expressed in bone or other tissues. These variants have a broad range of functional activity, from inhibiting the Wnt pathway to activating the pathway as dominant-negatives of the full-length GSK3β. These variants, as well as their modulators, can be used to treat diseases that involve GSK3β or its associated signaling pathways.
摘要翻译：本发明提供GSK3β变体，包括在骨或其他组织中表达的剪接变体。这些变体具有广泛的功能活性，从抑制Wnt途径激活途径作为全长GSK3β的显性阴性。这些变体及其调节剂可用于治疗涉及GSK3β或其相关信号通路的疾病。

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