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1. 发明授权

US06323206B1 Chemokine receptor antagonists and methods of use therefor 失效
标题翻译：趋化因子受体拮抗剂及其使用方法
公开(公告)号：US06323206B1
公开(公告)日：2001-11-27
申请号：US09010321
申请日：1998-01-21
申请人： Charles F. Schwender , Charles R. Mackay , Julia C. Pinto , Walter Newman
发明人： Charles F. Schwender , Charles R. Mackay , Julia C. Pinto , Walter Newman
IPC分类号： A61K314433
CPC分类号： C07D405/06 , A61K31/05 , A61K31/137 , A61K31/14 , A61K31/216 , A61K31/222 , A61K31/404 , A61K31/423 , A61K31/428 , A61K31/451 , A61K31/4535 , A61K31/454 , A61K31/495 , A61K31/496 , C07D211/52 , C07D409/06 , C07D493/04
摘要： Disclosed is a method of treating a subject with a disease associated with aberrant leukocyte recruitment and/or activation. The method comprises administering to the subject a therapeutically effective amount of a compound represented by the following structural formula: and physiologically acceptable salts thereof. Z is a cycloalkyl or non-aromatic heterocyclic ring group fused to one or more carbocyclic aromatic rings and/or heteroaromatic rings, wherein each ring in Z is independently substituted or unsubstituted; Y is a covalent bond, —O— or —CO—; n is an integer from one to about five; X is a covalent bond or —CO—; and M is >NR2, >CR1R2; R1 is —H, —OH, an aliphatic group, —O—(aliphatic group), —SH or —S—(aliphatic group); R2 is an aliphatic group, a substituted aliphatic group, an aromatic group, a substituted aromatic group, a benzylic group, a substituted benzylic group, a non-aromatic heterocyclic group or a substituted non-aromatic heterocyclic group.
摘要翻译：公开了一种用异常白细胞募集和/或激活相关疾病治疗受试者的方法。该方法包括向受试者施用治疗有效量的由以下结构式表示的化合物：及其生理上可接受的盐.Z是与一个或多个碳环芳族环和/或杂芳族稠合的环烷基或非芳族杂环基环，其中Z中的每个环独立地为取代或未取代的; Y为共价键，-O-或-CO-; n为1至约5的整数; X为共价键或-CO-; 并且M是> NR 2，> CR 1 R 2; R 1是-H，-OH，脂族基，-O-（脂族基），-SH或-S-（脂族基）; R 2是脂族基团，取代脂族基，芳香族基团，取代芳香族基团，苄基基团，取代的苄基基团，非芳族杂环基团或取代的非芳族杂环基团。

2. 发明授权

US4491308A Door finishing support structure 失效
标题翻译：门整理支撑结构
公开(公告)号：US4491308A
公开(公告)日：1985-01-01
申请号：US438911
申请日：1982-11-03
申请人： Robert N. Walton , Ralph C. Pinto
发明人： Robert N. Walton , Ralph C. Pinto
IPC分类号： B23Q3/10 , B23Q1/04
CPC分类号： B23Q3/10 , Y10S269/905
摘要： A pair of horizontally elongated support structures is provided for supporting a horizontal panel member from opposite marginal edges thereof. The support structures each include an elongated horizontal member defining a central area for abutting, extending along and removable anchoring to one marginal edge of an associated panel member and upper and lower opposite marginal edges disposed above and below the central area thereof and the opposite marginal edges define a ridge extending along one marginal edge and a groove or trough extending along the other marginal edge. Accordingly, when the support structures are used in pairs of support structures with each pair supporting a horizontal door or other panel between the central areas thereof the ridges and troughs of vertically stacked support structures may be engaged with each other in order to support the panel members in horizontal, vertically spaced and stacked relation. In addition, each of the central areas includes a horizontal shank portion centrally intermediate its opposite ends and a pair of stands are provided including lower ends for support from a horizontal support surface and upper ends defining journals from which the shank portions may be removably journalled.
摘要翻译：提供一对水平细长的支撑结构，用于从相对的边缘支撑水平面板构件。支撑结构各自包括细长的水平构件，其限定中心区域，用于邻接，延伸并且可移除地固定到相关联的面板构件的一个边缘边缘，以及设置在其中心区域上方和下方的上部和下部相对边缘，并且相对的边缘限定沿一个边缘延伸的脊和沿另一个边缘延伸的凹槽或槽。因此，当支撑结构以成对的支撑结构使用时，每对支撑结构在其中心区域之间支撑水平门或其他面板，则垂直堆叠的支撑结构的脊和槽可以彼此接合，以便支撑面板构件在水平，垂直间隔和堆叠的关系。此外，每个中心区域包括在其相对端部中间的水平柄部分，并且设置一对支架，其包括用于从水平支撑表面支撑的下端和限定轴颈的上端，所述柄部分可从该支架表面可拆卸地安装。

3. 发明授权

US10772666B2 Bone plate locking cannula and drill guide assembly 有权
公开(公告)号：US10772666B2
公开(公告)日：2020-09-15
申请号：US16056923
申请日：2018-08-07
申请人： Thomas S. Johnston, Jr. , Jennifer C. Pinto
发明人： Thomas S. Johnston, Jr. , Jennifer C. Pinto
IPC分类号： A61B17/80 , A61B17/17 , A61B17/86
摘要： A bone plate locking cannula and drill guide assembly having a locking cannula detachably mountable onto screw-receiving apertures of a bone plate and a drill guide received within the locking cannula such that pilot holes are drilled through the apertures into bone at the proper angle to receive bone screws. The screw receiving apertures have a proximal bore of greater diameter than a distal bore, and the proximal bore is provided with internal threading to mate with external threading located on the distal end of the locking cannula. The bone screws are inserted through the locking cannula after removal of the drill guide and fastened into the bone to secure the bone plate in position without having to remove the locking cannulas from the bone plate, the internal diameter of the locking cannula bore being greater than the maximum diameter of the screw heads. The locking cannula is detached from the bone plate after the bone plate has been secured in place on the bone.

4. 发明申请

US20160235451A1 Bone Plate Locking Cannula and Drill Guide Assembly 审中-公开
标题翻译：骨板锁定插管和钻孔导向装置
公开(公告)号：US20160235451A1
公开(公告)日：2016-08-18
申请号：US14880337
申请日：2015-10-12
申请人： Thomas S. Johnston, JR. , Jennifer C. Pinto
发明人： Thomas S. Johnston, JR. , Jennifer C. Pinto
IPC分类号： A61B17/80 , A61B17/86 , A61B17/17
CPC分类号： A61B17/808 , A61B17/1728 , A61B17/80 , A61B17/8047 , A61B17/8052 , A61B17/8057 , A61B17/8085 , A61B17/8605
摘要： A bone plate locking cannula and drill guide assembly having a locking cannula detachably mountable onto screw-receiving apertures of a bone plate and a drill guide received within the locking cannula such that pilot holes are drilled through the apertures into bone at the proper angle to receive bone screws. The screw receiving apertures have a proximal bore of greater diameter than a distal bore, and the proximal bore is provided with internal threading to mate with external threading located on the distal end of the locking cannula. The bone screws are inserted through the locking cannula after removal of the drill guide and fastened into the bone to secure the bone plate in position without having to remove the locking cannulas from the bone plate, the internal diameter of the locking cannula bore being greater than the maximum diameter of the screw heads. The locking cannula is detached from the bone plate after the bone plate has been secured in place on the bone.
摘要翻译：骨板锁定套管和钻子引导器组件，其具有可拆卸地安装到骨板的螺钉接收孔和接收在锁定插管内的钻子引导件的锁定套管，使得导向孔以适当的角度钻孔穿过骨头以接收骨螺钉螺钉接收孔具有比远端孔更大的直径的近端孔，并且近端孔设置有内螺纹，以与位于锁定插管的远端上的外部螺纹配合。将骨螺钉插入穿过锁定插管后，取下钻子引导器并固定在骨头中，以将骨板固定在适当的位置，而不必从骨板上移除锁定插管，锁定套管孔的内径大于螺钉头的最大直径。在骨板已经固定在骨上的适当位置之后，将锁定插管与骨板分离。

5. 发明授权

US08834521B2 Suturing construct with spliced tails 有权
标题翻译：缝合结构与拼接尾巴
公开(公告)号：US08834521B2
公开(公告)日：2014-09-16
申请号：US12646786
申请日：2009-12-23
申请人： Mark C. Pinto , Peter J. Dreyfuss
发明人： Mark C. Pinto , Peter J. Dreyfuss
IPC分类号： A61B17/04 , A61B17/06 , A61F2/08
CPC分类号： A61B17/06166 , A61B17/0401 , A61B17/0469 , A61B2017/0414 , A61B2017/0618 , A61F2/0805 , A61F2/0811 , A61F2002/0858 , A61F2002/0888
摘要： A surgical construct having a flexible strand with a middle region and at least two opposing tail regions that are spliced to form a single tail. The middle region has a first diameter and the opposing tail regions have a second diameter, which is smaller than the first diameter. The tail regions may have similar or different diameters. Because of the thin spliced tail regions, the suturing construct of the present invention can be easily inserted into suture/tape passing and retrieving instruments and passed through soft tissue (such as a rotator cuff). Once the suturing construct has been passed through tissue, the splice may be cut to allow the suture/tape to have again individual tails.
摘要翻译：具有柔性股线的中间区域和至少两个相对的尾部区域的外科手术结构，所述至少两个相对的尾部区域被拼接以形成单个尾部。中间区域具有第一直径，并且相对的尾部区域具有小于第一直径的第二直径。尾部区域可以具有相似或不同的直径。由于薄的接合尾部区域，本发明的缝合构造可以容易地插入到缝合线/带通过和取回器具中并通过软组织（例如肩袖）。一旦缝合结构通过组织，则可以切割接头以允许缝合线/带再次具有单独的尾部。

6. 发明授权

US07388572B2 Backplanes for electro-optic displays 有权
标题翻译：电光显示器背板
公开(公告)号：US07388572B2
公开(公告)日：2008-06-17
申请号：US10906585
申请日：2005-02-25
申请人： Gregg M. Duthaler , Guy M. Danner , Jason C. Pinto , Justin J. Abramson , David Miller , John Atkinson , Alain Bouchard
发明人： Gregg M. Duthaler , Guy M. Danner , Jason C. Pinto , Justin J. Abramson , David Miller , John Atkinson , Alain Bouchard
IPC分类号： G09G3/34 , G02B26/00
CPC分类号： G02F1/167 , G02B26/026 , G02F1/1334 , G02F1/133707 , G02F1/1508 , G02F2202/28
摘要： A backplane for an electro-optic display comprises a plurality of pixel electrodes, and an adhesive layer disposed adjacent the backplane, the adhesive layer comprising a plurality of pixel regions disposed adjacent the pixel electrodes of the backplane, and at least one inter-pixel region disposed between two pixels of the backplane, the at least one inter-pixel region having at least one of a lower dielectric constant and a higher volume resistivity than the pixel regions of the adhesive layer.
摘要翻译：用于电光显示器的背板包括多个像素电极和邻近背板设置的粘合剂层，所述粘合剂层包括邻近背板的像素电极设置的多个像素区域，以及至少一个像素间区域设置在背板的两个像素之间，所述至少一个像素间区域具有比粘合剂层的像素区域更低介电常数和更高体积电阻率中的至少一个。

7. 发明授权

US06281212B1 Chemokine receptor antagonists and methods of use therefor 失效
标题翻译：趋化因子受体拮抗剂及其使用方法
公开(公告)号：US06281212B1
公开(公告)日：2001-08-28
申请号：US08891518
申请日：1997-07-11
申请人： Charles F. Schwender , Charles R. Mackay , Julia C. Pinto , Walter Newman
发明人： Charles F. Schwender , Charles R. Mackay , Julia C. Pinto , Walter Newman
IPC分类号： A61K31495
CPC分类号： A61K31/496 , A61K31/05 , A61K31/137 , A61K31/14 , A61K31/216 , A61K31/222 , A61K31/404 , A61K31/423 , A61K31/428 , A61K31/451 , A61K31/4535 , A61K31/454 , A61K31/495
摘要： Disclosed is a method of treating a subject with a disease associated with aberrant leukocyte recruitment and/or activation. The method comprises administering to the subject a therapeutically effective amount of a compound represented by the following structural formula: and physiologically acceptable salts thereof. Z is a substituted or unsubstitured aromatic group. Y is a covalent bond, —O— or —CO—. n is an integer from one to about five. X is a covalent bond or —CO—. Ra is an aliphatic or a substituted aliphatic group; Rb is an aliphatic group substituted with an aromatic group or substituted aromatic group; and, taken together with the nitrogen atom bonded to Ra and Rb, can form a substituted or unsubstituted non-aromatic heterocyclic ring.
摘要翻译：公开了一种用异常白细胞募集和/或激活相关疾病治疗受试者的方法。该方法包括向受试者施用治疗有效量的由以下结构式表示的化合物及其生理学上可接受的盐.Z是取代或未取代的芳族基团.Y是共价键，-O-或-CO-。 n是1至约5的整数.X是共价键或-CO-.R a是脂族或取代的脂族基团; Rb是被芳基或取代芳基取代的脂族基; 并且与与R a和R b结合的氮原子一起可以形成取代或未取代的非芳族杂环。

8. 发明申请

US20080186842A1 DETECT-AND-MULTIPLEX TECHNIQUE FOR SPECTRUM SHARING 审中-公开
标题翻译：用于光谱共享的检测和多重技术
公开(公告)号：US20080186842A1
公开(公告)日：2008-08-07
申请号：US12019547
申请日：2008-01-24
申请人： Chia-Chin Chong , Pedro C. Pinto , Moe Z. Win , Fujio Watanabe , Hiroshi Inamura
发明人： Chia-Chin Chong , Pedro C. Pinto , Moe Z. Win , Fujio Watanabe , Hiroshi Inamura
IPC分类号： H04J9/00
CPC分类号： H04W16/14
摘要： A wireless communication system and a detect-and-multiplex (DAM) spectrum sharing technique eliminate contention by secondary spectrum users by multiplexing multiple access methods. Suitable multiple access methods include time division multiple access (TDMA), frequency division multiple access (FDMA), code division multiple access (CDMA), space division multiple access (SDMA), orthogonal frequency division multiple access (OFDMA), spectral nulling (SN) or a hybrid scheme (HS) based on a combination of two or more of the above techniques. Unlike, detect-and-avoid (DAA) multiple access methods, the DAM method increases spectrum usage efficiency, and allows more users to share the same region of the spectrum.
摘要翻译：无线通信系统和检测与复用（DAM）频谱共享技术通过复用多种接入方式消除了二级频谱用户的争用。合适的多址方法包括时分多址（TDMA），频分多址（FDMA），码分多址（CDMA），空分多址（SDMA），正交频分多址（OFDMA），频谱归零）或基于两种或更多种上述技术的组合的混合方案（HS）。与DAA方法不同的是，DAM方法提高了频谱使用效率，并且允许更多用户共享频谱的相同区域。

9. 发明申请

US20060048937A1 Perforation method and apparatus 审中-公开
标题翻译：穿孔方法和装置
公开(公告)号：US20060048937A1
公开(公告)日：2006-03-09
申请号：US10937649
申请日：2004-09-09
申请人： C. Pinto , Stephen Thompson , David Johnson
发明人： C. Pinto , Stephen Thompson , David Johnson
IPC分类号： E21B43/117 , E21B47/09
CPC分类号： E21B43/119 , E21B47/024
摘要： A signature element is attached to a downhole cable or other protected equipment and the signal from a signature position detector is used, at least in part, to control the orientation of a directed perforating device or other directional device. Signal emitting sources can include a radioactive material added to an encapsulating composition of a downhole cable.
摘要翻译：签名元件附接到井下电缆或其他受保护设备，并且使用来自签名位置检测器的信号，至少部分地用于控制定向穿孔设备或其他定向设备的定向。信号发射源可以包括添加到井下电缆的封装组合物中的放射性物质。

10. 发明申请

US20180338784A1 Bone Plate Locking Cannula and Drill Guide Assembly 审中-公开
公开(公告)号：US20180338784A1
公开(公告)日：2018-11-29
申请号：US16056923
申请日：2018-08-07
申请人： Thomas S. Johnston, JR. , Jennifer C. Pinto
发明人： Thomas S. Johnston, JR. , Jennifer C. Pinto
IPC分类号： A61B17/80 , A61B17/17 , A61B17/86
CPC分类号： A61B17/808 , A61B17/1728 , A61B17/80 , A61B17/8047 , A61B17/8052 , A61B17/8057 , A61B17/8085 , A61B17/8605
摘要： A bone plate locking cannula and drill guide assembly having a locking cannula detachably mountable onto screw-receiving apertures of a bone plate and a drill guide received within the locking cannula such that pilot holes are drilled through the apertures into bone at the proper angle to receive bone screws. The screw receiving apertures have a proximal bore of greater diameter than a distal bore, and the proximal bore is provided with internal threading to mate with external threading located on the distal end of the locking cannula. The bone screws are inserted through the locking cannula after removal of the drill guide and fastened into the bone to secure the bone plate in position without having to remove the locking cannulas from the bone plate, the internal diameter of the locking cannula bore being greater than the maximum diameter of the screw heads. The locking cannula is detached from the bone plate after the bone plate has been secured in place on the bone.

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