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1. 发明授权

US07695899B2 Methods of identifying and using chemotherapeutic agents 有权
标题翻译：识别和使用化疗药物的方法
公开(公告)号：US07695899B2
公开(公告)日：2010-04-13
申请号：US10978206
申请日：2004-10-29
申请人： Tin Tin Su , Burnley R. Jaklevic
发明人： Tin Tin Su , Burnley R. Jaklevic
IPC分类号： C12Q1/00
CPC分类号： C12N9/12 , A01K2217/075 , A01K2227/706 , A01K2267/03 , G01N33/5011 , G01N33/5085
摘要： The disclosure includes methods for the identification of chemotherapeutic agents that selectively reduce the growth or the survival of genotoxically stressed DNA damage checkpoint deficient tissue, such as irradiated cancerous tissue. The methods involve the use of genotoxically-stressed tissue(s) that are deficient in one or more DNA damage checkpoints. The disclosure also provides kits for performing the disclosed methods. The disclosure also includes chemotherapeutic agents that selectively reduce the growth or the survival of genotoxically stressed DNA damage checkpoint deficient tissue, such as irradiated cancerous tissue. The disclosure also includes methods of treatment or management of cancer, tumor formation, other conditions involving abnormal proliferation, or cell-cycle diseases or disorders.
摘要翻译：本公开包括用于鉴定化学治疗剂的方法，所述化学治疗剂选择性地降低基因毒素应激的DNA损伤检查点缺陷组织如辐照的癌组织的生长或存活。这些方法涉及使用缺乏一个或多个DNA损伤检查点的基因毒素应激组织。本公开还提供了用于执行所公开的方法的套件。本公开还包括选择性地降低基因毒素应激的DNA损伤检查点缺陷组织如辐照的癌组织的生长或存活的化学治疗剂。本公开还包括治疗或治疗癌症，肿瘤形成，涉及异常增殖的其它病症或细胞周期疾病或病症的方法。

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