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1. 发明申请

US20090131705A1 Practical, Cost-Effective Synthesis of Ubiquinones 审中-公开
标题翻译：实用，经济有效的泛醌的合成
公开(公告)号：US20090131705A1
公开(公告)日：2009-05-21
申请号：US12096372
申请日：2006-12-12
申请人： Bruce H. Lipshutz , Volker Berl , Karin Schein , Frank Wetterich
发明人： Bruce H. Lipshutz , Volker Berl , Karin Schein , Frank Wetterich
IPC分类号： C07F5/06 , C07C49/403
CPC分类号： C07C17/263 , C07C5/333 , C07C17/16 , C07C46/00 , C07C46/08 , C07C2531/14 , C07F5/062 , C07C15/46 , C07C21/04 , C07C25/24 , C07C50/28 , C07C50/38
摘要： The present invention provides a convergent method for the synthesis of ubiquinones and ubiquinone analogues. Also provided are precursors of ubiquinones and their analogues that are useful in the methods of the invention. The invention further provides an improved method for the carboalumination of alkyne substrates.
摘要翻译：本发明提供了一种用于合成泛醌和泛醌类似物的收敛方法。还提供了可用于本发明方法的泛醌及其类似物的前体。本发明进一步提供了一种用于炔底物的碳照射的改进方法。

2. 发明授权

US5072010A Transmetalations from zirconium to copper intermediates 失效
标题翻译：从ZIRCONIUM到铜中间体的传输
公开(公告)号：US5072010A
公开(公告)日：1991-12-10
申请号：US504370
申请日：1990-04-04
申请人： Bruce H. Lipshutz , Edmund L. Ellsworth
发明人： Bruce H. Lipshutz , Edmund L. Ellsworth
IPC分类号： C07C405/00 , C07F1/08
CPC分类号： C07C405/00 , C07F1/08
摘要： Higher order cuprate complexes are prepared by means of a transmetalation from a corresponding zirconate intermediate. This process is particularly valuable with respect to the preparation of vinylic side chains such as are present in prostaglandins, as it is possible in accordance with the present invention to proceed directly from the acetylenic precursors via the reactive cuprates to the desired final products in a one-pot operation without isolation of intermediates and in high yields. Sequential additions to zirconium intermediates of components which together comprise the cuprate involved in transmetalation with the zirconium intermediate are disclosed as alternative procedures.
摘要翻译：通过来自相应锆酸盐中间体的转化金属制备高级铜酸盐络合物。该方法对于制备乙烯基侧链（例如存在于前列腺素中）是特别有价值的，因为根据本发明可能通过反应性铜酸盐从炔属前体直接进行到所需的最终产物 - 不分离中间体并以高产率进行操作。作为替代方法公开了一起组合的锆中间体的顺序添加，其一起包括与锆中间体转铁合金的铜盐。

3. 发明申请

US20160339418A1 NANO-TO-NANO FE/PPM Pd CATALYSIS OF CROSS-COUPLING REACTIONS IN WATER 审中-公开
标题翻译： NANO-TO-NANO FE / PPM Pd在水中的交联反应的催化
公开(公告)号：US20160339418A1
公开(公告)日：2016-11-24
申请号：US15158238
申请日：2016-05-18
申请人： Bruce H. Lipshutz , Sachin Handa
发明人： Bruce H. Lipshutz , Sachin Handa
IPC分类号： B01J31/24 , C07C45/68 , C07F9/12 , C07D317/46 , C07C201/12 , C07D317/22 , C07D213/64 , C07D239/26 , C07D213/30 , C07D241/18 , C07D215/06 , C07D471/04 , C07D333/60 , C07D239/54 , C07D211/70 , C07D409/04 , C07D403/04 , C07D401/04 , C07D405/14 , C07D405/04 , B01J31/22 , B01J35/00 , B01J35/12 , C07C41/30
CPC分类号： B01J31/2404 , B01J23/8906 , B01J31/0202 , B01J31/0209 , B01J31/068 , B01J31/22 , B01J35/0013 , B01J35/10 , B01J35/12 , B01J37/16 , B01J2231/4211 , B01J2231/4227 , B01J2231/4266 , B01J2231/64 , B01J2531/004 , B01J2531/007 , B01J2531/824 , B01J2531/842 , B01J2531/96 , B01J2531/985 , C07B37/04 , C07C37/18 , C07C41/30 , C07C45/68 , C07C201/12 , C07C205/12 , C07C209/325 , C07C209/68 , C07C211/45 , C07C269/06 , C07C269/08 , C07C319/20 , C07C2603/24 , C07D211/70 , C07D213/30 , C07D213/64 , C07D215/06 , C07D239/26 , C07D239/54 , C07D241/18 , C07D317/22 , C07D317/46 , C07D333/60 , C07D401/04 , C07D403/04 , C07D405/04 , C07D405/14 , C07D409/04 , C07D471/04 , C07F9/12 , C07C271/28 , C07C321/28 , C07C43/215 , C07C43/205 , C07C43/2055 , C07C47/546 , C07C47/575 , C07C39/21
摘要： In one embodiment, the present application discloses a catalyst composition comprising: a) a reaction solvent or a reaction medium; b) organometallic nanoparticles comprising: i) a nanoparticle (NP) catalyst, prepared by a reduction of an iron salt in an organic solvent, wherein the catalyst comprises at least one other metal selected from the group consisting of Pd, Pt, Au, Ni, Co, Cu, Mn, Rh, Jr, Ru and Os or mixtures thereof; c) a ligand; and d) a surfactant; wherein the metal or mixtures thereof is present in less than or equal to 50,000 ppm relative to the iron salt.
摘要翻译：在一个实施方案中，本申请公开了一种催化剂组合物，其包含：a）反应溶剂或反应介质; b）有机金属纳米颗粒，其包含：i）通过在有机溶剂中还原铁盐制备的纳米颗粒（NP）催化剂，其中所述催化剂包含至少一种选自Pd，Pt，Au，Ni ，Co，Cu，Mn，Rh，Jr，Ru和Os或其混合物; c）配体; 和d）表面活性剂; 其中所述金属或其混合物相对于所述铁盐以小于或等于50,000ppm的量存在。

4. 发明授权

US4190579A Synthesis of beta-lactams from azetidine carboxylic acid esters 失效
标题翻译：从氮杂环丁烷羧酸酯合成β-内酰胺
公开(公告)号：US4190579A
公开(公告)日：1980-02-26
申请号：US865593
申请日：1977-12-29
申请人： Harry H. Wasserman , Bruce H. Lipshutz , James S. Wu
发明人： Harry H. Wasserman , Bruce H. Lipshutz , James S. Wu
IPC分类号： C07D205/08 , C07F7/12 , C07D403/06 , C07D407/06 , C07D409/06
CPC分类号： C07F7/12 , C07D205/08
摘要： Azetidine carboxylic acid esters are converted into enol silyl ethers which, as enamino ketene acetals, undergo ready oxidative cleavage of the ethylenically unsaturated double bond, e.g. by dye-sensitized photo-oxygenation, to form beta-lactams. The beta-lactams and substitution products thereof are useful intermediates in the synthesis of biologically active lactams.
摘要翻译：氮杂环丁烷羧酸酯转化成烯醇甲硅烷基醚，其作为烯氨基乙烯酮缩醛进行烯属不饱和双键的即时氧化裂解，通过染料敏化光氧化，形成β-内酰胺。 β-内酰胺及其取代产物是合成生物活性内酰胺的有用中间体。

5. 发明授权

US06545184B1 Practical, cost-effective synthesis of COQ10 失效
标题翻译： COQ10的实用，经济有效的合成
公开(公告)号：US06545184B1
公开(公告)日：2003-04-08
申请号：US09639223
申请日：2000-08-15
申请人： Bruce H. Lipshutz
发明人： Bruce H. Lipshutz
IPC分类号： C07C31500
CPC分类号： C07C47/575 , B01J31/1616 , B01J31/2243 , B01J31/2404 , B01J2231/4205 , B01J2531/0252 , B01J2531/845 , B01J2531/847 , C07C43/23 , C07C46/00 , C07C46/06 , C07C46/08 , C07C309/73 , C07F5/062 , C07C50/28
摘要： The present invention provides a convergent method for the synthesis of ubiquinones and ubiquinone analogues. Also provided are precursors of ubiquinones and their analogues that are useful in the methods of the invention.
摘要翻译：本发明提供了一种用于合成泛醌和泛醌类似物的收敛方法。还提供了可用于本发明方法的泛醌及其类似物的前体。

6. 发明授权

US5405981A Copper catalyzed coupling reactions 失效
标题翻译：铜催化偶联反应
公开(公告)号：US5405981A
公开(公告)日：1995-04-11
申请号：US37947
申请日：1993-03-26
申请人： Bruce H. Lipshutz
发明人： Bruce H. Lipshutz
IPC分类号： C07C45/69 , C07F1/08 , C07F7/18
CPC分类号： C07F7/1892 , C07C403/02 , C07C45/69 , C07C2101/14
摘要： A general method for sequential addition of two substituents to an .alpha.,.beta.-unsaturated ketone (enone), involving 1,4-conjugate addition of a desired substituent group to the enone to form an intermediate enolate, followed by electrophilic trapping of the enolate, wherein catalytic amounts of copper are employed in combination with another organometallic compound to effect the conjugate addition via a reactive cuprate reagent and yet provide an intermediate enolate species based on the other organometallic compound which is amenable to trapping by a suitable electrophile. Pursuant to this method, a true three-component coupling reaction can be effected starting from an alkyne, an enone, and an electrophile.
摘要翻译：用于向α，β-不饱和酮（烯酮）中顺序添加两个取代基的一般方法，其涉及将所需取代基加成到所述烯酮中以形成中间体烯醇化物，然后亲和性捕获烯醇化物，其中催化量的铜与另一种有机金属化合物组合使用以通过反应性铜酸盐试剂进行共轭加成，并提供基于其它有机金属化合物的中间体烯醇化物，所述其它有机金属化合物适于通过合适的亲电试剂捕获。根据该方法，可以从炔烃，烯酮和亲电子试剂开始进行真正的三组分偶联反应。

7. 发明授权

US5286889A Transmetalations from zirconium to copper intermediates 失效
标题翻译：从锆到铜中间体的转化
公开(公告)号：US5286889A
公开(公告)日：1994-02-15
申请号：US20492
申请日：1993-02-22
申请人： Bruce H. Lipshutz , Edmund L. Ellsworth
发明人： Bruce H. Lipshutz , Edmund L. Ellsworth
IPC分类号： C07C405/00 , C07F1/08 , C07D309/00
CPC分类号： C07F1/08 , C07C405/00
摘要： Higher order cuprate complexes are prepared by means of a transmetalation from a corresponding zirconate intermediate. This process is particularly valuable with respect to the preparation of vinylic side chains such as are present in prostaglandins, as it is possible in accordance with the present invention to proceed directly from the acetylenic precursors via the reactive cuprates to the desired final products in a one-pot operation without isolation of intermediates and in high yields. Sequential additions to zirconium intermediates of components which together comprise the cuprate involved in transmetalation with the zirconium intermediate are disclosed as alternative procedures.
摘要翻译：通过来自相应锆酸盐中间体的转化金属制备高级铜酸盐络合物。该方法对于制备乙烯基侧链（例如存在于前列腺素中）是特别有价值的，因为根据本发明可能通过反应性铜酸盐从炔属前体直接进行到所需的最终产物 - 不分离中间体并以高产率进行操作。作为替代方法公开了一起组合的锆中间体的顺序添加，其一起包括与锆中间体转铁合金的铜盐。

8. 发明申请

US20170173569A1 Fe-ppm Pd, Cu and/or Ni Nanoparticle-Catalyzed Reactions in Water 审中-公开
公开(公告)号：US20170173569A1
公开(公告)日：2017-06-22
申请号：US15379986
申请日：2016-12-15
申请人： Bruce H. Lipshutz , Sachin Handa
发明人： Bruce H. Lipshutz , Sachin Handa
IPC分类号： B01J23/89 , C07B31/00 , B01J37/00 , B01J23/745 , B01J35/00
CPC分类号： B01J23/8906 , B01J23/72 , B01J23/745 , B01J23/755 , B01J31/0202 , B01J31/0209 , B01J31/0225 , B01J31/04 , B01J31/068 , B01J31/2404 , B01J35/0013 , B01J37/009 , B01J37/16 , B01J2231/327 , B01J2231/4211 , B01J2231/4266 , B01J2231/64 , B01J2531/824 , B01J2531/842 , B01J2531/96 , C07B31/00 , C07B37/04 , C07C209/325 , C07C213/02 , C07C221/00 , C07C227/04 , C07C231/12 , C07C253/30 , C07C319/20 , C07C2601/14 , C07D209/12 , C07D211/90 , C07D213/30 , C07D213/61 , C07D215/40 , C07D235/18 , C07D249/04 , C07D249/06 , C07D277/48 , C07D295/192 , C07D401/04 , C07D405/04 , C07D405/14 , C07D409/12 , C07D471/04 , C07J41/0055 , C07C211/52 , C07C229/60 , C07C233/55 , C07C217/84 , C07C211/58 , C07C217/86 , C07C215/76 , C07C211/45 , C07C237/30 , C07C237/36 , C07C215/70 , C07C217/60 , C07C229/42 , C07C229/08 , C07C255/58 , C07C255/59 , C07C223/06 , C07C225/22 , C07C323/36
摘要： In one embodiment, the application discloses a composition for the reduction of an organic compound comprising a nitro group to form an organic compound comprising an amine group, the composition comprising: a) a transition metal salt; b) an iron salt; and c) a reducing agent; and methods for the use of such compositions, including Click chemistry and cross coupling reactions.

9. 发明授权

US4178286A .beta.-Lactams, their production, intermediates thereto and derivatives thereof 失效
标题翻译： β-内酰胺，其生产，中间体及其衍生物
公开(公告)号：US4178286A
公开(公告)日：1979-12-11
申请号：US736343
申请日：1976-10-28
申请人： Harry H. Wasserman , Bruce H. Lipshutz
发明人： Harry H. Wasserman , Bruce H. Lipshutz
IPC分类号： C07D223/10 , C07D201/02 , C07D205/08 , C07D205/095 , C07D207/263 , C07D211/76 , C07D409/06 , C07D405/06
CPC分类号： C07D201/02 , C07D205/08 , C07D205/095
摘要： .gamma.-lactones are converted into both known and new azetidine carboxylic acids which can be transformed readily to the corresponding .beta.-lactams by oxidative decarboxylation. The .beta.-lactams and substitution products thereof are useful intermediates in the synthesis of biologically active lactams such as nocardicin.
摘要翻译： γ-内酯被转化为已知的和新的氮杂环丁烷羧酸，其可以通过氧化脱羧而容易地转化成相应的β-内酰胺。 β-内酰胺及其取代产物是合成生物活性内酰胺如诺卡霉素的有用中间体。

10. 发明授权

US09956551B2 Nano-to-nano Fe/ppm Pd catalysis of cross-coupling reactions in water 有权
公开(公告)号：US09956551B2
公开(公告)日：2018-05-01
申请号：US15158238
申请日：2016-05-18
申请人： Bruce H. Lipshutz , Sachin Handa
发明人： Bruce H. Lipshutz , Sachin Handa
IPC分类号： C07C45/68 , C07C41/30 , C07C209/32 , C07B37/04 , B01J31/06 , B01J35/00 , B01J35/12 , B01J31/02 , B01J23/89 , B01J37/16 , C07F9/12 , C07D471/04 , C07D409/04 , C07D405/14 , C07D405/04 , C07D403/04 , C07D401/04 , C07D333/60 , C07D317/22 , C07D317/46 , C07D241/18 , C07D239/26 , C07D239/54 , B01J31/24 , B01J31/22 , C07C201/12 , C07D211/70 , C07D213/30 , C07D213/64 , C07D215/06 , C07C269/08 , C07C209/68
CPC分类号： B01J31/2404 , B01J23/8906 , B01J31/0202 , B01J31/0209 , B01J31/068 , B01J31/22 , B01J35/0013 , B01J35/10 , B01J35/12 , B01J37/16 , B01J2231/4211 , B01J2231/4227 , B01J2231/4266 , B01J2231/64 , B01J2531/004 , B01J2531/007 , B01J2531/824 , B01J2531/842 , B01J2531/96 , B01J2531/985 , C07B37/04 , C07C37/18 , C07C41/30 , C07C45/68 , C07C201/12 , C07C205/12 , C07C209/325 , C07C209/68 , C07C211/45 , C07C269/06 , C07C269/08 , C07C319/20 , C07C2603/24 , C07D211/70 , C07D213/30 , C07D213/64 , C07D215/06 , C07D239/26 , C07D239/54 , C07D241/18 , C07D317/22 , C07D317/46 , C07D333/60 , C07D401/04 , C07D403/04 , C07D405/04 , C07D405/14 , C07D409/04 , C07D471/04 , C07F9/12 , C07C271/28 , C07C321/28 , C07C43/215 , C07C43/205 , C07C43/2055 , C07C47/546 , C07C47/575 , C07C39/21
摘要： In one embodiment, the present application discloses a catalyst composition comprising: a) a reaction solvent or a reaction medium; b) organometallic nanoparticles comprising: i) a nanoparticle (NP) catalyst, prepared by a reduction of an iron salt in an organic solvent, wherein the catalyst comprises at least one other metal selected from the group consisting of Pd, Pt, Au, Ni, Co, Cu, Mn, Rh, Ir, Ru and Os or mixtures thereof; c) a ligand; and d) a surfactant; wherein the metal or mixtures thereof is present in less than or equal to 50,000 ppm relative to the iron salt.

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