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1. 发明授权

US06777405B2 Detection and treatment of duplex polynucleotide damage 有权
标题翻译：检测和处理双链多核苷酸损伤
公开(公告)号：US06777405B2
公开(公告)日：2004-08-17
申请号：US10235433
申请日：2002-09-03
申请人： Jacqueline K. Barton , Brian A. Jackson , Brian P. Hudson
发明人： Jacqueline K. Barton , Brian A. Jackson , Brian P. Hudson
IPC分类号： A61K31555
CPC分类号： C07F15/008
摘要： Duplex polynucleotides containing damage or errors are detected with hindered intercalating compounds which are capable of intercalating only in the presence of such damage or error. Conditions characterized by the presence of polynucleotide errors or damage are treated with such compounds that are capable of catalyzing polynucleotide cleavage with light. Suitable compound include compounds of the formula: Rh(R1)(R2)(R3)3+ where R1 and R2 are each independently aryl, heteroaryl, substituted aryl or substituted heteroaryl of 1 to 5 rings, and R3 is a group of the formula where x and z are each independently an integer from 1 to 4 and y is an integer from 1 to 2, and R4, R5, and R6 are each independently H—, halo, HO—, H2N—, CN—, O2N—, HS—, O3S—, O3SO—, —COOH, —CONH2, R, RO—, RNH—, RaRbN—, RO3S—, RO3SO—, —COOR, —CONHR, or —CONRaRb, where R, Ra and Rb are each independently lower alkyl, cycloalkyl, lower alkenyl, lower alkynyl, or phenyl, or two R4, R5, or R6 together form a fused aryl ring.
摘要翻译：含有损伤或错误的双链多核苷酸用受阻的插入化合物检测，只能在存在这种损伤或错误的情况下插入。以多核苷酸错误或损伤存在为特征的条件用能够用光催化多核苷酸切割的化合物处理。合适的化合物包括下式的化合物：其中R 1和R 2各自独立地为1至5个环的芳基，杂芳基，取代的芳基或取代的杂芳基，并且R 3是式的基团，x和z各自独立地为1至4的整数并且y是1-2的整数，R4，R5和R6分别独立地为H，卤素，HO-，H2N-，CN-，O2N-，HS-，O3S-，O3SO-，-COOH， - CONH2，R，RO-，RNH-，RaRbN-，RO3S-，RO3SO-，-COOR，-CONHR或-CONRaRb，其中R，Ra和Rb各自独立地为低级烷基，环烷基，低级烯基，低级炔基或苯基或两个R 4，R 5或R 6一起形成稠合的芳基环。

2. 发明授权

US6031098A Detection and treatment of duplex polynucleotide damage 有权
标题翻译：检测和处理双链多核苷酸损伤
公开(公告)号：US6031098A
公开(公告)日：2000-02-29
申请号：US132357
申请日：1998-08-11
申请人： Jacqueline K. Barton , Brian A. Jackson , Brian P. Hudson
发明人： Jacqueline K. Barton , Brian A. Jackson , Brian P. Hudson
IPC分类号： C07F15/00
CPC分类号： C07F15/008
摘要： Duplex polynucleotides containing damage or errors are detected with hindered intercalating compounds which are capable of intercalating only in the presence of such damage or error. Conditions characterized by the presence of polynucleotide errors or damage are treated with such compounds that are capable of catalyzing polynucleotide cleavage with light. Suitable compound include compounds of the formula:Rh(R.sub.1)(R.sub.2)(R.sub.3).sup.3+where R.sub.1 and R.sub.2 are each independently aryl, heteroaryl, substituted aryl or substituted heteroaryl of 1 to 5 rings, and R.sub.3 is a group of the formula ##STR1## where x and z are each independently an integer from 1 to 4 and y is an integer from 1 to 2, and R.sub.4, R.sub.5, and R.sub.6 are each independently H--, halo, HO--, H.sub.2 N--, CN--, O.sub.2 N--, HS--, O.sub.3 S--, O.sub.3 SO--, --COOH, --CONH.sub.2, R, RO--, RNH--, R.sub.a R.sub.b N--, RO.sub.3 S--, RO.sub.3 SO--, --COOR, --CONHR, or --CONR.sub.a R.sub.b, where R, R.sub.a and R.sub.b are each independently lower alkyl, cycloalkyl, lower alkenyl, lower alkynyl, or phenyl, or two R.sub.4, R.sub.5, or R.sub.6 together form a fused aryl ring.
摘要翻译：含有损伤或错误的双链多核苷酸用受阻的插入化合物检测，只能在存在这种损伤或错误的情况下插入。以多核苷酸错误或损伤存在为特征的条件用能够用光催化多核苷酸切割的化合物处理。合适的化合物包括下式的化合物：Rh（R 1）（R 2）（R 3）3 +，其中R 1和R 2各自独立地为1至5个环的芳基，杂芳基，取代的芳基或取代的杂芳基，R 3为式其中x和z各自独立地为1至4的整数，y为1至2的整数，R4，R5和R6各自独立地为H，卤素，HO-，H 2 N - ，CN-，O 2 N-， HS-，O3S-，O3SO-，-COOH，-CONH2，R，RO-，RNH-，RaRbN-，RO3S-，RO3SO-，-COOR，-CONHR或-CONRaRb，其中R，Ra和Rb各自独立地低级烷基，环烷基，低级烯基，低级炔基或苯基，或两个R 4，R 5或R 6一起形成稠合芳基环。

3. 发明授权

US06444661B1 Detection and treatment of duplex polynucleotide damage 失效
标题翻译：检测和处理双链多核苷酸损伤
公开(公告)号：US06444661B1
公开(公告)日：2002-09-03
申请号：US09448325
申请日：1999-11-23
申请人： Jacqueline K. Barton , Brian A. Jackson , Brian P. Hudson
发明人： Jacqueline K. Barton , Brian A. Jackson , Brian P. Hudson
IPC分类号： A61K31555
CPC分类号： C07F15/008
摘要： Duplex polynucleotides containing damage or errors are detected with hindered intercalating compounds which are capable of intercalating only in the presence of such damage or error. Conditions characterized by the presence of polynucleotide errors or damage are treated with such compounds that are capable of catalyzing polynucleotide cleavage with light. Suitable compound include compounds of the formula: Rh(R1)(R2)(R3)3+ where R1 and R2 are each independently aryl, heteroaryl, substituted aryl or substituted heteroaryl of 1 to 5 rings, and R3 is a group of the formula where x and z are each independently an integer from 1 to 4 and y is an integer from 1 to 2, and R4, R5, and R6 are each independently H—, halo, HO—, H2N—, CN—, O2N—, HS—, O3S—, O3SO—, —COOH, —CONH2, R, RO—, RNH—, RaRbN—, RO3S—, RO3SO—, —COOR, —CONHR, or —CONRaRb, where R, Ra and Rb are each independently lower alkyl, cycloalkyl, lower alkenyl, lower alkynyl, or phenyl, or two R4, R5, or R6 together form a fused aryl ring.
摘要翻译：含有损伤或错误的双链多核苷酸用受阻的插入化合物检测，只能在存在这种损伤或错误的情况下插入。以多核苷酸错误或损伤存在为特征的条件用能够用光催化多核苷酸切割的化合物处理。合适的化合物包括下式的化合物：其中R 1和R 2各自独立地为1至5个环的芳基，杂芳基，取代的芳基或取代的杂芳基，并且R 3是式的基团，x和z各自独立地为1至4的整数并且y是1-2的整数，R4，R5和R6分别独立地为H，卤素，HO-，H2N-，CN-，O2N-，HS-，O3S-，O3SO-，-COOH， - CONH2，R，RO-，RNH-，RaRbN-，RO3S-，RO3SO-，-COOR，-CONHR或-CONRaRb，其中R，Ra和Rb各自独立地为低级烷基，环烷基，低级烯基，低级炔基或苯基或两个R 4，R 5或R 6一起形成稠合的芳基环。

4. 发明授权

US06306601B1 Detection and treatment of duplex polynucleotide damage 有权
标题翻译：检测和处理双链多核苷酸损伤
公开(公告)号：US06306601B1
公开(公告)日：2001-10-23
申请号：US09447447
申请日：1999-11-22
申请人： Jacqueline K. Barton , Brian A. Jackson , Brian P. Hudson
发明人： Jacqueline K. Barton , Brian A. Jackson , Brian P. Hudson
IPC分类号： C12Q168
CPC分类号： C07F15/008
摘要： Duplex polynucleotides containing damage or errors are detected with hindered intercalating compounds which are capable of intercalating only in the presence of such damage or error. Conditions characterized by the presence of polynucleotide errors or damage are treated with such compounds that are capable of catalyzing polynucleotide cleavage with light. Suitable compound include compounds of the formula: Rh(R1)(R2)(R3)3+ where R1 and R2 are each indepenently aryl, heteroaryl, substituted aryl or substituted heteroaryl of 1 to 5 rings, and R3 is a group of the formula where x and z are each independently an interger from 1 to 4 and y is an interger from 1 to 2, and R4, R5, and R6 are independently H—, halo, HO—, H2N—, CN—, O2N—, HS—, O3S—, O3SO—, —COOH, —CONH2, R, RO—, RNH—, RaRbN—, RO3SO—, RO3SO—, —COOR, —CONHR, or —CONHRaRbwhere R, Ra and Rb are each independently lower alkyl, cycloalkyl, lower alkenyl, lower alkynyl, or phenyl, or two R4, R5, or R6 together form a fused aryl ring.
摘要翻译：含有损伤或错误的双链多核苷酸用受阻的插入化合物检测，只能在存在这种损伤或错误的情况下插入。以多核苷酸错误或损伤存在为特征的条件用能够用光催化多核苷酸切割的化合物处理。合适的化合物包括下式的化合物：其中R 1和R 2各自独立地为1至5个环的芳基，杂芳基，取代的芳基或取代的杂芳基，并且R 3是式的基团，x和z各自独立地为1至4的整数并且y是1至2的整数，R4，R5和R6独立地为H，卤素，HO-，H2N-，CN-，O2N-，HS-，O3S-，O3SO-，-COOH，-CONH2 ，R，RO-，RNH-，RaRbN-，RO3SO-，RO3SO-，-COOR，-CONHR或-CONHRaRb，其中R，Ra和Rb各自独立地为低级烷基，环烷基，低级烯基，低级炔基或苯基，或两个R 4，R 5或R 6一起形成稠合的芳基环。

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