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1. 发明授权

US07968650B2 Polymeric compositions comprising at least one volume excluding polymer 有权
标题翻译：包含除聚合物之外的至少一个体积的聚合物组合物
公开(公告)号：US07968650B2
公开(公告)日：2011-06-28
申请号：US11925207
申请日：2007-10-26
申请人： Brian J. Tighe , Muriel Nasso , Beverley Benning , Frank F. Molock, Jr.
发明人： Brian J. Tighe , Muriel Nasso , Beverley Benning , Frank F. Molock, Jr.
IPC分类号： C08F126/06
CPC分类号： A61K9/0051 , C08F283/00 , C08F283/12 , G02B1/043
摘要： The present invention relates to compositions comprising a polymeric substrate comprising at least one volume excluding polymer. In one embodiment, the present invention provides polymeric articles that are capable of acting as osmotic drivers. The articles are capable of maintaining a desired water balance by moving water in or out of a substrate to maintain cation concentration equilibrium between the substrate and its environment.
摘要翻译：本发明涉及包含聚合物基质的组合物，其包含除聚合物之外的至少一种体积。在一个实施方案中，本发明提供能够作为渗透驱动剂的聚合物制品。制品能够通过将水移入或移出基底来维持所需的水平衡，以维持基底与其环境之间的阳离子浓度平衡。

2. 发明授权

US4430458A Hydrogel-forming polymeric materials 失效
标题翻译：水凝胶形成聚合材料
公开(公告)号：US4430458A
公开(公告)日：1984-02-07
申请号：US309688
申请日：1981-10-08
申请人： Brian J. Tighe , Howard J. Gee
发明人： Brian J. Tighe , Howard J. Gee
IPC分类号： C08F226/06 , G02B1/04 , C08F220/20 , C08F226/10 , C08L31/02 , G02C7/04
CPC分类号： G02B1/043 , C08F226/06
摘要： Polymeric materials suitable for bio-medical applications, particularly in making contact lenses, are formed by copolymerization and crosslinking of: (1) an amide of an unsaturated carboxylic acid such as acrylamide or methacrylamide; (2) an N-vinyl lactam, such as N-vinyl pyrrolidone; (3) an ester of an unsaturated carboxylic acid, such as a hydroxy-substituted ester of acrylic or methacrylic acid; (4) an unsaturated carboxylic acid, such as acrylic or methacrylic acid; and (5) a polymerizable hydrophobic vinyl monomer, such as styrene; crosslinking with a crosslinking agent either being carried out during copolymerization or subsequently. The resulting polymeric materials may be machined to produce a contact lens form and then hydrated to form a hydrogel which is suitable for use as an extended wear contact lens.
摘要翻译：适用于生物医学应用，特别是制造隐形眼镜的聚合物材料是通过共聚和交联形成的：（1）不饱和羧酸的酰胺如丙烯酰胺或甲基丙烯酰胺; （2）N-乙烯基内酰胺，例如N-乙烯基吡咯烷酮; （3）不饱和羧酸的酯，例如丙烯酸或甲基丙烯酸的羟基取代的酯; （4）不饱和羧酸，如丙烯酸或甲基丙烯酸; 和（5）可聚合的疏水乙烯基单体，例如苯乙烯; 与交联剂交联或者在共聚合或随后进行交联。所得到的聚合物材料可以被加工以产生隐形眼镜形式，然后水合以形成适合用作延长磨损隐形眼镜的水凝胶。

3. 发明授权

US08501832B2 Polymeric compositions comprising at least one volume excluding polymer 有权
标题翻译：包含除聚合物之外的至少一个体积的聚合物组合物
公开(公告)号：US08501832B2
公开(公告)日：2013-08-06
申请号：US13096340
申请日：2011-04-28
申请人： Brian J. Tighe , Muriel Nasso , Beverley Benning , Frank F. Molock, Jr.
发明人： Brian J. Tighe , Muriel Nasso , Beverley Benning , Frank F. Molock, Jr.
IPC分类号： G02C7/04 , G02B1/04
CPC分类号： A61K9/0051 , C08F283/00 , C08F283/12 , G02B1/043
摘要： The present invention relates to compositions comprising a polymeric substrate comprising at least one volume excluding polymer. In one embodiment, the present invention provides polymeric articles that are capable of acting as osmotic drivers. The articles are capable of maintaining a desired water balance by moving water in or out of a substrate to maintain cation concentration equilibrium between the substrate and its environment.
摘要翻译：本发明涉及包含聚合物基质的组合物，其包含除聚合物之外的至少一种体积。在一个实施方案中，本发明提供能够作为渗透驱动剂的聚合物制品。制品能够通过将水移入或移出基底来维持所需的水平衡，以维持基底与其环境之间的阳离子浓度平衡。

4. 发明申请

US20110118379A1 INTERVERTEBRAL DISC AND INTRAOCULAR LENS 审中-公开
标题翻译：椎间盘和内镜
公开(公告)号：US20110118379A1
公开(公告)日：2011-05-19
申请号：US12736540
申请日：2009-04-20
申请人： Brian J. Tighe , Valerie Franklin , Fiona Jane Lydon , Sally Roberts , Jocelyn P.G. Urban , Sarit Sivan
发明人： Brian J. Tighe , Valerie Franklin , Fiona Jane Lydon , Sally Roberts , Jocelyn P.G. Urban , Sarit Sivan
IPC分类号： A61L27/50 , A61M5/00
CPC分类号： A61L27/52 , A61L27/16 , C08L43/00
摘要： The invention relates to the use of an aqueous gel in the repair of or prevention of damage to soft tissue, the gel comprising an aqueous gel obtainable by polymerizing one or more olefinically unsaturated monomers comprising one or more phosphate, phosphonate, borate, sulphate and/or sulphonate groups. This is preferably used for intervertebral discs or a lens of an eye. Kits and syringes containing the components are also provided.
摘要翻译：本发明涉及水性凝胶在修复或防止对软组织的损害中的用途，该凝胶包含通过聚合一种或多种包含一种或多种磷酸盐，膦酸盐，硼酸盐，硫酸盐和/或磷酸盐的烯属不饱和单体获得的水凝胶，或磺酸基团。这优选用于椎间盘或眼睛的晶状体。还提供了包含组件的试剂盒和注射器。

5. 发明申请

US20080114123A1 POLYMERIC COMPOSITIONS COMPRISING AT LEAST ONE VOLUME EXCLUDING POLYMER 有权
标题翻译：包含至少一个体积的聚合物的聚合物组合物不包括聚合物
公开(公告)号：US20080114123A1
公开(公告)日：2008-05-15
申请号：US11925207
申请日：2007-10-26
申请人： Brian J. Tighe , Mariel Nasso , Beverly Benning , Frank F. Molock
发明人： Brian J. Tighe , Mariel Nasso , Beverly Benning , Frank F. Molock
IPC分类号： C08L23/00
CPC分类号： A61K9/0051 , C08F283/00 , C08F283/12 , G02B1/043
摘要： The present invention relates to compositions comprising a polymeric substrate comprising at least one volume excluding polymer. In one embodiment, the present invention provides polymeric articles that are capable of acting as osmotic drivers. The articles are capable of maintaining a desired water balance by moving water in or out of a substrate to maintain cation concentration equilibrium between the substrate and its environment.
摘要翻译：本发明涉及包含聚合物基质的组合物，其包含除聚合物之外的至少一种体积。在一个实施方案中，本发明提供能够作为渗透驱动剂的聚合物制品。制品能够通过将水移入或移出基底来维持所需的水平衡，以维持基底与其环境之间的阳离子浓度平衡。

6. 发明授权

US4493910A Fluorine-containing hydrogel-forming polymeric materials 失效
标题翻译：含氟水凝胶聚合物
公开(公告)号：US4493910A
公开(公告)日：1985-01-15
申请号：US507729
申请日：1983-06-24
申请人： Brian J. Tighe , Howard J. Gee
发明人： Brian J. Tighe , Howard J. Gee
IPC分类号： C08F8/20 , C08F220/54 , C08F226/06 , G02B1/04 , C08F214/18 , G02C7/04
CPC分类号： G02B1/043 , C08F220/54 , C08F226/06 , C08F8/20
摘要： Polymeric materials suitable for bio-medical applications, particularly in making contact lenses, are derived by reaction of the following:(1) 20 to 40 mole % of a polymerizable amide which is an unsubstituted or substituted amide of a carboxylic acid containing olefinic unsaturation,(2) 25 to 55 mole % of an N-vinyl lactam,(3) 5 to 20 mole % of a polymerizable ester which is an ester of a carboxylic acid containing olefinic unsaturation,(4) 1 to 10 mole % of a polymerizable carboxylic acid containing olefinic unsaturation, and(5) 3 to 10 mole % of a hydrophobic monomer component comprising:(a) a fluorine-containing polymerizable monomer having a fluoroaliphatic side chain, or a polymerizable monomer having an esterifiable group, and(b) a non-fluorine-containing polymerizable hydrophobic vinyl monomer;and subsequently esterifying any esterifiable groups provided by monomer (5a) using a fluorine-containing aliphatic acid or derivative thereof, the amounts of the monomers (1) to (5) totalling 100 mole %, and either the copolymerization is carried out in the presence of a cross linking agent or the resulting copolymer is subsequently cross linked.The polymeric material of the present invention may be machined to form contact lenses and subsequently hydrated to form a hydrogel which is suitable for use as an extended wear contact lens.

7. 发明授权

US4433111A Fluorine-containing hydrogel-forming polymeric materials 失效
标题翻译：含氟水凝胶聚合物
公开(公告)号：US4433111A
公开(公告)日：1984-02-21
申请号：US309581
申请日：1981-10-08
申请人： Brian J. Tighe , Howard J. Gee
发明人： Brian J. Tighe , Howard J. Gee
IPC分类号： C08F8/20 , C08F220/54 , C08F226/06 , G02B1/04 , C08F214/18 , G02C7/04
CPC分类号： G02B1/043 , C08F220/54 , C08F226/06 , C08F8/20
摘要： Polymeric materials suitable for biomedical applications, particularly in making contact lenses, are formed by copolymerization and crosslinking of: (1) an amide of an unsaturated carboxylic acid such as acrylamide or methacrylamide; (2) an N-vinyl lactam such as N-vinyl pyrrolidone; (3) an ester of an unsaturated carboxylic acid such as a hydroxy-substituted ester of acrylic or methacrylic acid; (4) an unsaturated carboxylic acid such as acrylic or methacrylic acid; and (5) a hydrophobic monomer component comprising: (a) a fluorine-containing polymerizable monomer having a fluoroaliphatic side chain, such as fluoroalkyl acrylate or methacrylate, and (b) a non-fluorine-containing polymerizable hydrophobic vinyl monomer such as styrene; crosslinking with a crosslinking agent either being carried out during copolymerization or subsequently. The resulting polymeric materials may be machined to produce a contact lens form and then hydrated to form a hydrogel which is suitable for use as an extended wear contact lens.
摘要翻译：适用于生物医学应用的聚合材料，特别是制造隐形眼镜，是通过共聚和交联形成的：（1）不饱和羧酸的酰胺如丙烯酰胺或甲基丙烯酰胺; （2）N-乙烯基内酰胺如N-乙烯基吡咯烷酮; （3）不饱和羧酸的酯，例如丙烯酸或甲基丙烯酸的羟基取代的酯; （4）不饱和羧酸如丙烯酸或甲基丙烯酸; （5）疏水性单体成分，其含有：（a）具有氟脂肪族侧链的含氟聚合性单体，例如丙烯酸氟代烷基酯或甲基丙烯酸烷基酯，和（b）非氟可聚合疏水性乙烯基单体如苯乙烯; 与交联剂交联或者在共聚合或随后进行交联。所得到的聚合物材料可以被加工以产生隐形眼镜形式，然后水合以形成适合用作延长磨损隐形眼镜的水凝胶。

8. 发明申请

US20120212703A1 POLYMERIC COMPOSITIONS COMPRISING AT LEAST ONE VOLUME EXCLUDING POLYMER 有权
标题翻译：包含至少一个体积的聚合物的聚合物组合物不包括聚合物
公开(公告)号：US20120212703A1
公开(公告)日：2012-08-23
申请号：US13096340
申请日：2011-04-28
申请人： Brian J. Tighe , Muriel Nasso , Beverley Benning , Frank F. Molock, JR.
发明人： Brian J. Tighe , Muriel Nasso , Beverley Benning , Frank F. Molock, JR.
IPC分类号： G02C7/04 , C08L33/26
CPC分类号： A61K9/0051 , C08F283/00 , C08F283/12 , G02B1/043
摘要： The present invention relates to compositions comprising a polymeric substrate comprising at least one volume excluding polymer. In one embodiment, the present invention provides polymeric articles that are capable of acting as osmotic drivers. The articles are capable of maintaining a desired water balance by moving water in or out of a substrate to maintain cation concentration equilibrium between the substrate and its environment.
摘要翻译：本发明涉及包含聚合物基质的组合物，其包含除聚合物之外的至少一种体积。在一个实施方案中，本发明提供能够作为渗透驱动剂的聚合物制品。制品能够通过将水移入或移出基底来维持所需的水平衡，以维持基底与其环境之间的阳离子浓度平衡。

9. 发明授权

US06436905B1 Lipid-containing compositions and uses thereof 失效
标题翻译：含脂质的组合物及其用途
公开(公告)号：US06436905B1
公开(公告)日：2002-08-20
申请号：US09510223
申请日：2000-02-22
申请人： Stephen R Tonge , Brian J Tighe
发明人： Stephen R Tonge , Brian J Tighe
IPC分类号： A61K3170
CPC分类号： A61K9/0019 , A61K9/0082 , A61K9/1075 , A61K9/1271 , A61K47/24 , A61K47/32
摘要： Lipid-containing compositions are disclosed which provide surfactants and solubilizing agents useful in medicine, biochemistry and other industries.
摘要翻译：公开了含有脂质的组合物，其提供用于医药，生物化学和其它工业中的表面活性剂和增溶剂。

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