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1. 发明申请

US20090105334A1 Carbamate compounds for use in preventing or treating neuropathic pain and cluster and migraine headache-associated pain 审中-公开
标题翻译：用于预防或治疗神经性疼痛和集束型和偏头痛头痛相关疼痛的氨基甲酸酯化合物
公开(公告)号：US20090105334A1
公开(公告)日：2009-04-23
申请号：US11442445
申请日：2006-05-26
申请人： Ellen C. Codd , Carlos R. Plata-Salaman , Boyu Zhao
发明人： Ellen C. Codd , Carlos R. Plata-Salaman , Boyu Zhao
IPC分类号： A61K31/27 , A61P25/06
CPC分类号： A61K31/27
摘要： This invention is directed to a method for preventing or treating neuropathic pain and cluster and migraine headache-associated pain comprising administering to a subject in need thereof a therapeutically effective amount of a compound of Formula (I): wherein phenyl is substituted at X with one to five halogen atoms independently selected from the group consisting of fluorine, chlorine, bromine and iodine; and; R1, R2, R3 and R4 are independently selected from the group consisting of hydrogen and C1-C4 alkyl; wherein C1-C4 alkyl is optionally substituted with phenyl (wherein phenyl is optionally substituted with substituents independently selected from the group consisting of hydrogen, halogen, C1-C4 alkyl, C1-C4 alkoxy, amino, nitro and cyano).
摘要翻译：本发明涉及一种预防或治疗神经性疼痛和集束型和偏头痛性头痛相关疼痛的方法，包括向有需要的受试者施用治疗有效量的式（I）化合物：其中苯基在X被一个至五个独立地选自氟，氯，溴和碘的卤素原子; 和; R 1，R 2，R 3和R 4独立地选自氢和C 1 -C 4烷基; 其中C 1 -C 4烷基任选被苯基取代（其中苯基任选被独立地选自氢，卤素，C 1 -C 4烷基，C 1 -C 4烷氧基，氨基，硝基和氰基的取代基取代）。

2. 发明授权

US07375123B2 1,2,4-thiadiazole derivatives as melanocortin receptor modulators 失效
标题翻译：作为黑皮质素受体调节剂的1,2,4-噻二唑衍生物
公开(公告)号：US07375123B2
公开(公告)日：2008-05-20
申请号：US11344772
申请日：2006-02-01
申请人： Magdalena Eisinger , Louis J. Fitzpatrick , Daniel H. Lee , Kevin Pan , Carlos Plata-Salaman , Allen B. Reitz , Virginia L. Smith-Swintosky , Boyu Zhao
发明人： Magdalena Eisinger , Louis J. Fitzpatrick , Daniel H. Lee , Kevin Pan , Carlos Plata-Salaman , Allen B. Reitz , Virginia L. Smith-Swintosky , Boyu Zhao
IPC分类号： A61K31/433 , C07D285/08
CPC分类号： C07D285/08 , A61K8/49 , A61Q5/006 , A61Q19/00 , A61Q19/007 , C07D417/12
摘要： The present invention is directed to novel 1,2,4-thiadiazole derivatives useful as agonists or antagonists of the melanocortin receptor. More particularly, the compounds of the present invention are useful for the treatment of metabolic, CNS and dermatological disorders such as obesity, impaired oral glucose tolerance, elevated blood glucose levels, type II diabetes, Syndrome X, diabetic retinopathy, spinal cord injury, nerve injury, acute neurodegenerative disorders, chronic neurodegenerative disorders, plexopathies, male erectile dysfunction, dry eyes, acne, dry skin, aged skin, seborrheic dermatitis, rosacea, excessive ear wax, meibomian gland disorder, pseudofolliculitis, yeast infections, dandruff, hidradenitis suppurativa, ocular rosacea and eccrine gland disorder.
摘要翻译：本发明涉及可用作黑皮质素受体的激动剂或拮抗剂的新颖的1,2,4-噻二唑衍生物。更具体地，本发明的化合物可用于治疗代谢，CNS和皮肤病学障碍，例如肥胖症，口服葡萄糖耐量降低，血糖水平升高，II型糖尿病，X综合征，糖尿病性视网膜病变，脊髓损伤，神经伤口，急性神经退行性疾病，慢性神经退行性疾病，性欲症，男性勃起功能障碍，干眼症，痤疮，干性皮肤，老年皮肤，脂溢性皮炎，酒渣鼻，过度耳垢，睑板腺疾病，假性结石炎，酵母菌感染，头皮屑，眼红斑痤疮和外分泌腺疾病。

3. 发明授权

US07087643B2 Carbamate compounds for use in preventing or treating neuropathic pain and cluster and migraine headache-associated pain 失效
标题翻译：用于预防或治疗神经性疼痛和集束型和偏头痛头痛相关疼痛的氨基甲酸酯化合物
公开(公告)号：US07087643B2
公开(公告)日：2006-08-08
申请号：US10869406
申请日：2004-06-16
申请人： Ellen C. Codd , Carlos R. Plata-Salaman , Boyu Zhao
发明人： Ellen C. Codd , Carlos R. Plata-Salaman , Boyu Zhao
IPC分类号： A00N47/10 , A61K31/27
CPC分类号： A61K31/27
摘要： This invention is directed to a method for preventing or treating neuropathic pain and cluster and migraine headache-associated pain comprising administering to a subject in need thereof a therapeutically effective amount of a compound of Formula (I): wherein phenyl is substituted at X with one to five halogen atoms independently selected from the group consisting of fluorine, chlorine, bromine and iodine; and; R1, R2, R3 and R4 are independently selected from the group consisting of hydrogen and C1–C4 alkyl; wherein C1–C4 alkyl is optionally substituted with phenyl (wherein phenyl is optionally substituted with substituents independently selected from the group consisting of hydrogen, halogen, C1–C4 alkyl, C1–C4 alkoxy, amino, nitro and cyano).
摘要翻译：本发明涉及一种预防或治疗神经性疼痛和集束型和偏头痛性头痛相关疼痛的方法，包括向有需要的受试者施用治疗有效量的式（I）化合物：其中苯基在X被一个至五个独立地选自氟，氯，溴和碘的卤素原子; 和; R 1，R 2，R 3和R 4各自独立地选自氢和C 1个C 1 -C 4烷基; 其中C 1 -C 4烷基任选被苯基取代（其中苯基任选被独立地选自氢，卤素，C 1〜 C 1 -C 4烷基，C 1 -C 4烷氧基，氨基，硝基和氰基）。

4. 发明授权

US06544976B1 Neurotrophic 2-azetidinecarboxylic acid derivatives, and related compositions and methods 有权
标题翻译：神经营养性2-氮杂环丁烷羧酸衍生物及相关组合物和方法
公开(公告)号：US06544976B1
公开(公告)日：2003-04-08
申请号：US09592531
申请日：2000-06-12
申请人： James C. Lanter , Suying Zhang , Boyu Zhao
发明人： James C. Lanter , Suying Zhang , Boyu Zhao
IPC分类号： A01N4300
CPC分类号： C07D401/12 , C07D205/04 , C07D401/14 , C07D409/06
摘要： This invention provides compounds having the following general structure: This invention also provides pharmaceutical compositions comprising same and methods of using these compositions to treat and prevent disorders characterized by neuronal damage.
摘要翻译：本发明提供具有以下一般结构的化合物：本发明还提供包含其的药物组合物和使用这些组合物治疗和预防以神经元损伤为特征的疾病的方法。

5. 发明授权

US07786311B2 1,2,4-thiadiazolium derivatives as melanocortin receptor modulators 有权
标题翻译：作为黑皮质素受体调节剂的1,2,4-噻二唑衍生物
公开(公告)号：US07786311B2
公开(公告)日：2010-08-31
申请号：US12221900
申请日：2008-08-05
申请人： Magdalena Eisinger , Louis J. Fitzpatrick , Daniel H. Lee , Kevin Pan , Carlos Plata-Salaman , Allen B. Reitz , Virginia L. Smith-Swintosky , Boyu Zhao
发明人： Magdalena Eisinger , Louis J. Fitzpatrick , Daniel H. Lee , Kevin Pan , Carlos Plata-Salaman , Allen B. Reitz , Virginia L. Smith-Swintosky , Boyu Zhao
IPC分类号： C07D285/08
CPC分类号： C07D285/08 , A61K8/49 , A61Q5/006 , A61Q19/00 , A61Q19/007 , C07D333/16 , C07D417/12 , C07F9/4018
摘要： The present invention is directed to novel 1,2,4-thiadiazol-2-ium derivatives useful as agonists or antagonists of the melanocortin receptor. More particularly, the compounds of the present invention are useful for the treatment of metabolic, CNS and dermatological disorders such as obesity, impaired oral glucose tolerance, elevated blood glucose levels, type II diabetes, Syndrome X, diabetic retinopathy, spinal cord injury, nerve injury, acute neurodegenerative disorders, chronic neurodegenerative disorders, plexopathies, male erectile dysfunction, dry eyes, acne, dry skin, aged skin, seborrheic dermatitis, rosacea, excessive ear wax, meibomian gland disorder, pseudofolliculitis, yeast infections, dandruff, hidradenitis suppurativa, ocular rosacea and eccrine gland disorder.
摘要翻译：本发明涉及可用作黑皮质素受体的激动剂或拮抗剂的新颖的1,2,4-噻二唑-2-基衍生物。更具体地，本发明的化合物可用于治疗代谢，CNS和皮肤病学障碍，例如肥胖症，口服葡萄糖耐量降低，血糖水平升高，II型糖尿病，X综合征，糖尿病性视网膜病变，脊髓损伤，神经伤口，急性神经退行性疾病，慢性神经退行性疾病，性欲症，男性勃起功能障碍，干眼症，痤疮，干性皮肤，老年皮肤，脂溢性皮炎，酒渣鼻，过度耳垢，睑板腺疾病，假性结石炎，酵母菌感染，头皮屑，眼红斑痤疮和外分泌腺疾病。

6. 发明申请

US20090281179A1 CARBAMATE COMPOUNDS FOR USE IN PREVENTING OR TREATING NEUROPATHIC PAIN AND CLUSTER AND MIGRAINE HEADACHE ASSOCIATED PAIN 审中-公开
标题翻译：用于预防或治疗神经病性疼痛和聚集体和血小板相关性疼痛的碳酸盐化合物
公开(公告)号：US20090281179A1
公开(公告)日：2009-11-12
申请号：US12505765
申请日：2009-07-20
申请人： Ellen E. CODD , Richard P. Shank , Katherine E. Rogers , Carlos R. Plata-Salaman , Boyu Zhao
发明人： Ellen E. CODD , Richard P. Shank , Katherine E. Rogers , Carlos R. Plata-Salaman , Boyu Zhao
IPC分类号： A61K31/27 , A61P25/00
CPC分类号： A61K31/27
摘要： This invention is directed to a method for preventing or treating neuropathic pain and cluster and migraine headache-associated pain comprising administering to a subject in need thereof a therapeutically effective amount of an enantiomer of Formula (I) substantially free of other enantiomers or an enantiomeric mixture wherein an enantiomer of Formula (I) predominates: wherein phenyl is substituted at X with one to five halogen atoms independently selected from the group consisting of fluorine, chlorine, bromine and iodine; and; R1 and R2 are independently selected from the group consisting of hydrogen and C1-C4 alkyl; wherein C1-C4 alkyl is optionally substituted with phenyl (wherein phenyl is optionally substituted with substituents independently selected from the group consisting of hydrogen, halogen, C1-C4 alkyl, C1-C4 alkoxy, amino, nitro and cyano).
摘要翻译：本发明涉及一种用于预防或治疗神经性疼痛和集束型和偏头痛性头痛相关疼痛的方法，包括向有需要的受试者施用治疗有效量的基本上不含其它对映异构体或对映体混合物的式（I）对映异构体其中式（I）的对映异构体占主导地位：其中苯基在X上被一至五个独立地选自氟，氯，溴和碘的卤素原子取代; 和; R 1和R 2独立地选自氢和C 1 -C 4烷基; 其中C 1 -C 4烷基任选被苯基取代（其中苯基任选被独立地选自氢，卤素，C 1 -C 4烷基，C 1 -C 4烷氧基，氨基，硝基和氰基的取代基取代）。

7. 发明申请

US20090203751A1 Novel 1,2,4-thiadiazolium derivatives as melanocortin receptor modulators 有权
标题翻译：新型1,2,4-噻二唑衍生物作为黑皮质素受体调节剂
公开(公告)号：US20090203751A1
公开(公告)日：2009-08-13
申请号：US12221900
申请日：2008-08-05
申请人： Magdalena Eisinger Eisinger , Louis J. Fitzpatrick , Daniel H. Lee , Kevin Pan , Carlos Plata-Salaman , Allen B. Reitz , Virginia L. Smith-Swintosky , Boyu Zhao
发明人： Magdalena Eisinger Eisinger , Louis J. Fitzpatrick , Daniel H. Lee , Kevin Pan , Carlos Plata-Salaman , Allen B. Reitz , Virginia L. Smith-Swintosky , Boyu Zhao
IPC分类号： A61K31/433 , A61P3/00 , A61P17/00 , C07C335/04
CPC分类号： C07D285/08 , A61K8/49 , A61Q5/006 , A61Q19/00 , A61Q19/007 , C07D333/16 , C07D417/12 , C07F9/4018
摘要： The present invention is directed to novel 1,2,4-thiadiazol-2-ium derivatives useful as agonists or antagonists of the melanocortin receptor. More particularly, the compounds of the present invention are useful for the treatment of metabolic, CNS and dermatological disorders such as obesity, impaired oral glucose tolerance, elevated blood glucose levels, type II diabetes, Syndrome X, diabetic retinopathy, spinal cord injury, nerve injury, acute neurodegenerative disorders, chronic neurodegenerative disorders, plexopathies, male erectile dysfunction, dry eyes, acne, dry skin, aged skin, seborrheic dermatitis, rosacea, excessive ear wax, meibomian gland disorder, pseudofolliculitis, yeast infections, dandruff, hidradenitis suppurativa, ocular rosacea and eccrine gland disorder.
摘要翻译：本发明涉及可用作黑皮质素受体的激动剂或拮抗剂的新颖的1,2,4-噻二唑-2-基衍生物。更具体地，本发明的化合物可用于治疗代谢，CNS和皮肤病学障碍，例如肥胖症，口服葡萄糖耐量降低，血糖水平升高，II型糖尿病，X综合征，糖尿病性视网膜病变，脊髓损伤，神经伤口，急性神经退行性疾病，慢性神经退行性疾病，性欲症，男性勃起功能障碍，干眼症，痤疮，干性皮肤，老年皮肤，脂溢性皮炎，酒渣鼻，过度耳垢，睑板腺疾病，假性结石炎，酵母菌感染，头皮屑，眼红斑痤疮和外分泌腺疾病。

8. 发明申请

US20060293383A1 Carbamate compounds for use in preventing or treating neuropathic pain and cluster and migraine headache-associated pain 审中-公开
公开(公告)号：US20060293383A1
公开(公告)日：2006-12-28
申请号：US11194875
申请日：2006-03-30
申请人： Ellen Codd , Carlos Plata-Salaman , Boyu Zhao
发明人： Ellen Codd , Carlos Plata-Salaman , Boyu Zhao
IPC分类号： A61K31/325
CPC分类号： A61K31/325 , A61K31/27
摘要： This invention is directed to a method for preventing or treating neuropathic pain and cluster and migraine headache-associated pain comprising administering to a subject in need thereof a therapeutically effective amount of an enantiomer of Formula (I) substantially free of other enantiomers or an enantiomeric mixture wherein an enantiomer of Formula (I) predominates: wherein phenyl is substituted at X with one to five halogen atoms independently selected from the group consisting of fluorine, chlorine, bromine and iodine; and; R1 and R2 are independently selected from the group consisting of hydrogen and C1-C4 alkyl; wherein C1-C4 alkyl is optionally substituted with phenyl (wherein phenyl is optionally substituted with substituents independently selected from the group consisting of hydrogen, halogen, C1-C4 alkyl, C1-C4 alkoxy, amino, nitro and cyano).

9. 发明授权

US07078436B2 Carbamate compounds for use in preventing or treating anxiety disorders 失效
标题翻译：用于预防或治疗焦虑症的氨基甲酸酯化合物
公开(公告)号：US07078436B2
公开(公告)日：2006-07-18
申请号：US10081713
申请日：2002-02-21
申请人： Carlos R. Plata-Salaman , Boyu Zhao , Roy E. Twyman
发明人： Carlos R. Plata-Salaman , Boyu Zhao , Roy E. Twyman
IPC分类号： A61K31/27
CPC分类号： A61K31/27
摘要： This invention is directed to a method for preventing or treating anxiety disorders comprising administering to a subject in need thereof a therapeutically effective amount of a compound selected from the group consisting of Formula (I) and Formula (II): wherein phenyl is substituted at X with one to five halogen atoms selected from the group consisting of fluorine, chlorine, bromine and iodine; and, R1, R2, R3, R4, R5 and R6 are independently selected from the group consisting of hydrogen and C1-C4 alkyl; wherein C1-C4 alkyl is optionally substituted with phenyl (wherein phenyl is optionally substituted with substituents independently selected from the group consisting of halogen, C1-C4 alkyl, C1-C4 alkoxy, amino, nitro and cyano).
摘要翻译：本发明涉及一种预防或治疗焦虑症的方法，包括向有需要的受试者施用治疗有效量的选自式（I）和式（II）的化合物：其中苯基在X 具有选自氟，氯，溴和碘的一至五个卤素原子; 和R 1，R 2，R 3，R 4，R 5和/或和R 6和R 6独立地选自氢和C 1 -C 4烷基; 其中C 1 -C 4烷基任选被苯基取代（其中苯基任选被独立地选自卤素，C 1 -C 6烷基的取代基取代， C 1 -C 4烷基，C 1 -C 4烷氧基，氨基，硝基和氰基）。

10. 发明申请

US20050009905A1 Carbamate compounds for use in preventing or treating neuropathic pain and cluster and migraine headache-associated pain 审中-公开
标题翻译：用于预防或治疗神经性疼痛和集束型和偏头痛头痛相关疼痛的氨基甲酸酯化合物
公开(公告)号：US20050009905A1
公开(公告)日：2005-01-13
申请号：US10870103
申请日：2004-06-17
申请人： Ellen Codd , Carlos Plata-Salaman , Boyu Zhao
发明人： Ellen Codd , Carlos Plata-Salaman , Boyu Zhao
IPC分类号： A61P25/04 , A61K31/27 , A61K31/325
CPC分类号： A61K31/325 , A61K31/27
摘要： This invention is directed to a method for preventing or treating neuropathic pain and cluster and migraine headache-associated pain comprising administering to a subject in need thereof a therapeutically effective amount of an enantiomer of Formula (I) substantially free of other enantiomers or an enantiomeric mixture wherein an enantiomer of Formula (I) predominates: wherein phenyl is substituted at X with one to five halogen atoms independently selected from the group consisting of fluorine, chlorine, bromine and iodine; and; R1 and R2 are independently selected from the group consisting of hydrogen and C1-C4 alkyl; wherein C1-C4 alkyl is optionally substituted with phenyl (wherein phenyl is optionally substituted with substituents independently selected from the group consisting of hydrogen, halogen, C1-C4 alkyl, C1-C4 alkoxy, amino, nitro and cyano).
摘要翻译：本发明涉及一种用于预防或治疗神经性疼痛和集束型和偏头痛性头痛相关疼痛的方法，包括向有需要的受试者施用治疗有效量的基本上不含其它对映异构体或对映体混合物的式（I）对映异构体其中式（I）的对映异构体占主导地位：其中苯基在X上被一至五个独立地选自氟，氯，溴和碘的卤素原子取代; 和; R 1和R 2独立地选自氢和C 1 -C 4烷基; 其中C 1 -C 4烷基任选被苯基取代（其中苯基任选被独立地选自氢，卤素，C 1 -C 4烷基，C 1 -C 4烷氧基，氨基，硝基和氰基的取代基取代）。

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