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1. 发明授权

US09377115B2 Check valve for spray nozzle and nozzle tube 有权
标题翻译：止回阀用于喷嘴和喷嘴管
公开(公告)号：US09377115B2
公开(公告)日：2016-06-28
申请号：US13479391
申请日：2012-05-24
申请人： Juergen Frick , Boris Schmidt , Albert Fecht
发明人： Juergen Frick , Boris Schmidt , Albert Fecht
IPC分类号： B05B1/30 , F16K15/08 , F16K15/12 , F16K17/04 , B05B15/00
CPC分类号： F16K15/08 , B05B1/3006 , B05B15/40 , F16K15/12 , F16K17/0493
摘要： A check valve for a spray nozzle including a tubular valve body, a shut-off member and a valve seat, wherein the shut-off member is mounted for movement at least in a longitudinal direction of the tubular valve body. The shut-off member is connected to the valve body by a corrugated tube disposed parallel to the longitudinal direction, wherein the shut-off member is biased toward the valve seat due to the spring effect of the corrugated tube. The check valve is suitable for use in, for example, descaling nozzles.
摘要翻译：一种用于喷嘴的止回阀，包括管状阀体，切断构件和阀座，其中所述切断构件安装成至少在管状阀体的纵向方向上移动。关闭构件通过与纵向方向平行设置的波纹管连接到阀体，其中由于波纹管的弹簧效应，切断构件被朝向阀座偏压。止回阀适用于例如除垢喷嘴。

2. 发明授权

US08835392B2 Mimetic peptides and the use thereof in the form of 20S, 26S and immunoproteasome inhibitors 有权
标题翻译：模拟肽及其在20S，26S和免疫蛋白酶体抑制剂形式中的用途
公开(公告)号：US08835392B2
公开(公告)日：2014-09-16
申请号：US11817628
申请日：2006-03-03
申请人： Boris Schmidt , Sumaira Umbreen , Hannes Braun , Peter-Michael Kloetzel , Ulrike Kuckelkorn
发明人： Boris Schmidt , Sumaira Umbreen , Hannes Braun , Peter-Michael Kloetzel , Ulrike Kuckelkorn
IPC分类号： A61K38/00 , A61P43/00 , C07K5/083 , C07K5/062
CPC分类号： C07K5/0808 , A61K38/00 , C07K5/06043
摘要： The present invention relates to peptide-mimetic compounds, the synthesis and use thereof fort he inhibition of proteasomes and the induction of apoptosis in tumor cells. The present invention furthermore relates to pharmaceutical compositions comprising the compounds and the use of the compounds for a treatment of diseases, in particular cancer and neurodegenerative diseases.
摘要翻译：本发明涉及肽模拟化合物，其抑制蛋白酶体的合成和用途以及肿瘤细胞凋亡的诱导。本发明还涉及包含该化合物的药物组合物和该化合物用于治疗疾病，特别是癌症和神经变性疾病的用途。

3. 发明申请

US20130287700A1 COMPOUNDS FOR THE DIAGNOSIS OF NEURODEGENERATIVE DISORDERS ON THE OLFACTORY EPITHELIUM 审中-公开
标题翻译：用于诊断上消化道上皮神经损伤的疾病的化合物
公开(公告)号：US20130287700A1
公开(公告)日：2013-10-31
申请号：US13825186
申请日：2011-09-20
申请人： Boris Schmidt , Daniel Kieser , Alexander Boländer , Jochen Herms , Roland Heyny-Von Haussen , Jiamin Gu
发明人： Boris Schmidt , Daniel Kieser , Alexander Boländer , Jochen Herms , Roland Heyny-Von Haussen , Jiamin Gu
IPC分类号： A61K49/00 , G01N21/64
CPC分类号： A61K49/0021 , A61K31/426 , A61K31/428 , A61K31/4965 , A61K31/505 , A61K49/0039 , C07D403/00 , C07D403/02 , C07D403/14 , C07D417/00 , C07D417/02 , G01N21/6428 , G01N33/6896 , G01N2800/28
摘要： Subject of the present invention are compounds with high affinity for the Aβ protein, α-synuclein or for Tau-PHF aggregates, which are suitable as preferably fluorescent probes for the in vivo diagnosis of neurodegenerative disorders like e.g. Alzheimer's disease and Parkinson's disease. The compounds are characterized by suitable physicochemical properties (excitation wavelength, emission wavelength, Stokes shift, extinction) as well as a high affinity and selectivity for the target proteins.
摘要翻译：本发明的主题是对Abeta蛋白，α-突触核蛋白或Tau-PHF聚集体具有高亲和力的化合物，其适合作为用于体内诊断神经变性疾病的荧光探针。阿尔茨海默病和帕金森病。化合物的特征在于适合的物理化学性质（激发波长，发射波长，斯托克斯位移，消光）以及靶蛋白的高亲和性和选择性。

4. 发明申请

US20120298780A1 CHECK VALVE FOR SPRAY NOZZLE AND NOZZLE TUBE 有权
标题翻译：检查阀用于喷雾喷嘴和喷嘴管
公开(公告)号：US20120298780A1
公开(公告)日：2012-11-29
申请号：US13479391
申请日：2012-05-24
申请人： Juergen Frick , Boris Schmidt , Albert Fecht
发明人： Juergen Frick , Boris Schmidt , Albert Fecht
IPC分类号： B05B1/00 , B05B1/34
CPC分类号： F16K15/08 , B05B1/3006 , B05B15/40 , F16K15/12 , F16K17/0493
摘要： A check valve for a spray nozzle including a tubular valve body, a shut-off member and a valve seat, wherein the shut-off member is mounted for movement at least in a longitudinal direction of the tubular valve body. The shut-off member is connected to the valve body by a corrugated tube disposed parallel to the longitudinal direction, wherein the shut-off member is biased toward the valve seat due to the spring effect of the corrugated tube. The check valve is suitable for use in, for example, descaling nozzles.
摘要翻译：一种用于喷嘴的止回阀，包括管状阀体，切断构件和阀座，其中所述切断构件安装成至少在管状阀体的纵向方向上移动。关闭构件通过与纵向方向平行设置的波纹管连接到阀体，其中由于波纹管的弹簧效应，切断构件被朝向阀座偏压。止回阀适用于例如除垢喷嘴。

5. 发明申请

US20100151064A1 THIAZOLHYDRAZIDES FOR TREATMENT OF NEURODEGENERATIVE DISEASES 失效
标题翻译：用于治疗神经损伤性疾病的噻唑烷
公开(公告)号：US20100151064A1
公开(公告)日：2010-06-17
申请号：US12513480
申请日：2007-11-05
申请人： Eckhard Mandelkow , Eva-Maria Mandelkow , Markus Pickhardt , Jacek Biernat , David George Lloyd , Boris Schmidt , Gregor Larbig
发明人： Eckhard Mandelkow , Eva-Maria Mandelkow , Markus Pickhardt , Jacek Biernat , David George Lloyd , Boris Schmidt , Gregor Larbig
IPC分类号： A61K36/16 , A61K31/55 , A61K31/444 , A61K31/435 , A61K31/445 , A61K31/4439 , A61K31/428 , C07D417/12 , A61P25/28 , A61P25/16 , A61P27/02 , A61P25/14 , A61P25/00 , A61K31/4433
CPC分类号： C07D417/12 , C07D277/50 , C07D417/04
摘要： Described are compounds having a thiazolhydrazide scaffold, pharmaceutically acceptable salts of these compounds and pharmaceutical compositions containing at least one of these compounds together with pharmaceutically acceptable carrier, excipient and/or diluents. Said thiazolhydrazide compounds can be used for prophylaxis and/or treatment of neurodegenerative diseases and conditions.
摘要翻译：描述了具有噻唑酰肼支架的化合物，这些化合物的药学上可接受的盐和包含这些化合物中的至少一种以及药学上可接受的载体，赋形剂和/或稀释剂的药物组合物。所述噻唑酰肼化合物可用于预防和/或治疗神经变性疾病和病症。

6. 发明申请

US20080283635A1 High pressure nozzle and method for the manufacture of a high pressure nozzle 有权
标题翻译：高压喷嘴及制造高压喷嘴的方法
公开(公告)号：US20080283635A1
公开(公告)日：2008-11-20
申请号：US12152362
申请日：2008-05-14
申请人： Albert FECHT , Juergen FRICK , Boris SCHMIDT
发明人： Albert FECHT , Juergen FRICK , Boris SCHMIDT
IPC分类号： B05B1/02 , B22F3/00 , B23P15/00
CPC分类号： B05B1/042 , B05B1/04 , B05B1/3402 , B05B15/40 , B21B45/0233 , B21B45/08 , B22F3/225 , B22F5/106 , B22F7/062 , Y10T29/49433
摘要： 1. High pressure nozzle and method for the manufacture of a high pressure nozzle.2.1. The invention relates to a high pressure nozzle with a jet director within a supply channel to a discharge opening.2.2 According to the invention in an area directly surrounding the supply channel median longitudinal axis, the jet director has a free flow cross-section.2.3. Use e.g. for high pressure nozzles for descaling steel products.
摘要翻译： 1.高压喷嘴及制造高压喷嘴的方法。 2.1。本发明涉及一种在喷射口的供应通道内具有喷射导管的高压喷嘴。 2.2根据本发明在直接围绕供应通道中纵轴的区域中，喷射导管具有自由流动横截面。 2.3。使用例如用于高压喷嘴用于除锈钢产品。

7. 发明授权

US07432293B2 Heterocyclic compounds useful as Nurr-1 activators 失效
标题翻译：用作Nurr-1激活剂的杂环化合物
公开(公告)号：US07432293B2
公开(公告)日：2008-10-07
申请号：US10545245
申请日：2004-02-13
申请人： Samuel Hintermann , Bastian Hengerer , Boris Schmidt
发明人： Samuel Hintermann , Bastian Hengerer , Boris Schmidt
IPC分类号： A61K31/42 , A61K31/4245 , C07D263/30 , C07D271/06
CPC分类号： C07D271/06 , C07D261/08 , C07D263/32 , C07D413/04
摘要： The present invention relates to compounds of formula (I): wherein R1 is hydroxy, C1-4 alkoxy, amino, C1-4 alkyl-amino, di C1-4alkylamino, benzyloxy or C2-C7 alkanoyl, R2 is C1-4 alkyl, C1-4 alkoxy, C1-4 alkoxy C1-4alkoxy, CF3, halogen, C1-4alkylamino, di C1-4alkylamino, di C1-4 alkylamino C1-4 alkoxy or N—C1-4 alkoxy C1-4 alkyl-N—C1-4 alkylamino, N—C1-4 alkyl-piperazinyl, morpholinyl or pyrrolidinyl-C1-4 alkoxy, wherein the C1-4 alkyl radicals in R2 are optionally further substituted by C1-4 alkyl, halogen, cyano, amino, alkoxy or alkylthio, X is N or O, Y is N, O or CH, Z is N or CH, and W is N or CH, provided that (a) R1 is not hydroxy or C1-4 alkoxy when R2 is CF3, X is O, Y is CH, Z is N and W is CH, (b) R1 is not hydroxy or C1-4 alkoxy when R2 is CF3 or chloro, X is N, Y is O, Z is CH and W is CH, (c) R1 is not hydroxy when R2 is CF3, X is O, Y is N, Z is CH and W is CH and (d) X and Y are not simultaneously O, the salts thereof; their preparation, their use and pharmaceutical compositions containing them.
摘要翻译：本发明涉及式（I）的化合物：其中R 1是羟基，C 1-4烷氧基，氨基，C 1-4 烷基 - 氨基，二C 1-4烷基氨基，苄氧基或C 2 -C 7烷酰基，R 2 为C 1-4烷基，C 1-4烷氧基，C 1-4烷氧基C 1-4烷基烷氧基，CF 3，卤素，C 1-4烷基氨基，二C 1-4烷基氨基，二C 1-4 烷基氨基C 1-4烷氧基或NC 1-4烷氧基C 1-4烷基-NC 1-4 烷基氨基，NC 1-4烷基 - 哌嗪基，吗啉基或吡咯烷基-C 1-4烷氧基，其中C 1-4 - R 2中的烷基任选进一步被C 1-4烷基，卤素，氰基，氨基，烷氧基或烷硫基取代，X是N或O，Y是N ，O或CH，Z是N或CH，W是N或CH，条件是当R（R）不为羟基或C 1-4烷氧基时， 2是CF 3，X是O，Y是C H，Z是N，W是CH，（b）当R 2是CF时，R 1不是羟基或C 1-4烷氧基 3是或氯，X是N，Y是O，Z是CH，W是CH，（c）R 1不是羟基， SUB>是CF 3，X是O，Y是N，Z是CH，W是CH，（d）X和Y不同时为O，其盐; 它们的制备，它们的用途和含有它们的药物组合物。

8. 发明授权

US11583870B2 Injection nozzle for a spray device and spray device 有权
公开(公告)号：US11583870B2
公开(公告)日：2023-02-21
申请号：US17011153
申请日：2020-09-03
申请人： Boris Schmidt , Gabriele Beddies , Robert Heinkel , Hannes Knupfer
发明人： Boris Schmidt , Gabriele Beddies , Robert Heinkel , Hannes Knupfer
IPC分类号： B05B1/06 , F04F5/46 , B01F25/312
摘要： An injection nozzle for a spray device for drawing in a fluid suction medium by a fluid propellant which is under excess pressure and for spraying an admixture of the suction medium and the propellant. The injection nozzle has a nozzle housing, an injection chamber arranged in the nozzle housing, a jet nozzle which opens in the injection chamber for producing a propellant jet which is introduced into the injection chamber, and a fluid suction opening for the fluid suction medium. The fluid suction opening opens in an annular channel which has a flow connection to the injection chamber.

9. 发明申请

US20090272610A1 BRAKE DISK AND MODULAR SYSTEM 审中-公开
标题翻译：制动盘和模块化系统
公开(公告)号：US20090272610A1
公开(公告)日：2009-11-05
申请号：US12428508
申请日：2009-04-23
申请人： OLIVER MOESSINGER , BORIS SCHMIDT
发明人： OLIVER MOESSINGER , BORIS SCHMIDT
IPC分类号： F16D65/12 , B23P19/00
CPC分类号： F16D65/128 , F16D65/125 , F16D65/807 , F16D2065/1328 , F16D2200/0039 , Y10T29/53
摘要： A built brake disk for a wheel brake of a vehicle, in particular an automobile, has two friction rings, between which a plurality of spacers are arranged to form cooling ducts of an internal ventilation of the brake disk, and further has a nave, which is arranged coaxially with the friction rings and is firmly connected to the friction rings and/or to a plurality of spacers.
摘要翻译：用于车辆的车轮制动器，特别是汽车的内置制动盘具有两个摩擦环，多个间隔件之间布置有多个间隔件，以形成制动盘的内部通风的冷却管道，并且还具有一个教练座与摩擦环同轴布置并且牢固地连接到摩擦环和/或多个间隔件。

10. 发明申请

US20090012007A1 Mimetic Peptides and the Use Thereof in the Form of 20S, 26S and Immunoproteasome Inhitibors 有权
标题翻译：模拟肽及其用途为20S，26S和免疫蛋白酶体的生物体
公开(公告)号：US20090012007A1
公开(公告)日：2009-01-08
申请号：US11817628
申请日：2006-03-03
申请人： Boris Schmidt , Sumaira Umbreen , Hannes Braun , Peter-Michael Kloetzel , Ulrike Kuckelkorn
发明人： Boris Schmidt , Sumaira Umbreen , Hannes Braun , Peter-Michael Kloetzel , Ulrike Kuckelkorn
IPC分类号： A61K38/05 , C07C229/24 , C07C229/08 , C12N5/06
CPC分类号： C07K5/0808 , A61K38/00 , C07K5/06043
摘要： The present invention relates to peptide-mimetic compounds, the synthesis and use thereof fort he inhibition of proteasomes and the induction of apoptosis in tumour cells. The present invention furthermore relates to pharmaceutical compositions comprising the compounds and the use of the compounds for a treatment of diseases, in particular cancer and neurodegenerative diseases.
摘要翻译：本发明涉及肽模拟化合物，其抑制蛋白酶体的合成和用途以及肿瘤细胞凋亡的诱导。本发明还涉及包含该化合物的药物组合物和该化合物用于治疗疾病，特别是癌症和神经变性疾病的用途。

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