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1. 发明专利

GB959100A Coupling nipple for pipe or hose 未知
公开(公告)号：GB959100A
公开(公告)日：1964-05-27
申请号：GB843561
申请日：1961-03-08
申请人： EINAR BJORN CHRISTENSEN
IPC分类号： F16L33/22
摘要： 959,100. Pipe couplings. E. B. CHRISTENSEN. March 8, 1961, No. 8435/61. Heading F2G. A coupling nipple for a pipe or hose comprises a coupling part 1 having a threaded portion 5 and a tapered plug 6 with an outwardly projecting beading 9, a shell 2 having an internally threaded part 12 and a conical part 13 and a split ring 3 of flexible material having an outer conical surface 3 11 and an oblique slot therethrough. The end of the pipe or hose is received in the hollow space 7 and is clamped to the nipple on threaded engagement of the part 1 with the shell 2 by the ring 3 which is pressed into the wall of the pipe or hose between the surface 5 1 and the beading 9 by the action of the conical surfaces 13, 311 and the abutment of the end of the ring 3 with the surface 5 1 .

2. 发明申请

US20060168393A1 Apparatus and method for dependency tracking and register file bypass controls using a scannable register file 审中-公开
标题翻译：使用可扫描寄存器文件的依赖关系跟踪和寄存器文件旁路控制的装置和方法
公开(公告)号：US20060168393A1
公开(公告)日：2006-07-27
申请号：US11044567
申请日：2005-01-27
申请人： Bjorn Christensen , Peter Klim , Dung Nguyen , Raymond Yeung
发明人： Bjorn Christensen , Peter Klim , Dung Nguyen , Raymond Yeung
IPC分类号： G06F12/14
CPC分类号： G06F9/30141 , G06F9/30134 , G06F9/3828 , G06F9/3838 , G06F9/3867
摘要： An apparatus and method for dependency tracking and register file bypass controls using a scannable register file are provided. With the apparatus and method, a scannable register file array is provided and used to track the stage of any instruction in the execution unit. Every entry in the target vector is updated every cycle to stay synchronized with the instructions in the execution unit. To keep the register file array synchronized with the instructions in the execution unit, a right shift of all the data in each entry of the register file array occurs every cycle. The scan port of the register file array cells is used as the shift function.
摘要翻译：提供了使用可扫描寄存器文件的依赖关系跟踪和寄存器文件旁路控制的装置和方法。利用该装置和方法，提供可扫描的寄存器文件阵列并用于跟踪执行单元中任何指令的阶段。每个周期更新目标向量中的每个条目，以与执行单元中的指令保持同步。为了使寄存器文件阵列与执行单元中的指令保持同步，每个周期都会发生寄存器文件阵列的每个条目中所有数据的右移。寄存器文件阵列单元的扫描端口用作移位功能。

3. 发明申请

US20050170355A1 Non-viral gene delivery system 审中-公开
标题翻译：非病毒基因传递系统
公开(公告)号：US20050170355A1
公开(公告)日：2005-08-04
申请号：US10513429
申请日：2003-05-02
申请人： Per Artursson , Bjorn Christensen , Magnus Koping-Hoggard , Kjell Varum
发明人： Per Artursson , Bjorn Christensen , Magnus Koping-Hoggard , Kjell Varum
IPC分类号： A61K47/36 , A61K31/7088 , A61K39/00 , A61K47/46 , A61K47/48 , A61K48/00 , A61P31/00 , A61P35/00 , A61P37/06 , C12N15/87 , C12Q1/68 , C07H21/02 , C08B37/08
CPC分类号： C12N15/87 , A61K9/0073 , A61K47/61 , A61K48/0041
摘要： The present invention concerns a composition comprising complexes of cationic chitosan oligomers derived from the cationic polysaccharide chitosan, wherein said cationic oligomers contain a weight fraction of less than 20% of oligomers with a Degree of Polymerization (DP) 50, and a nucleic acid. These compositions comprising well-defined cationic chitosan oligomers having a certain distribution of chain lengths, and nucleic acid are advantageous to achieve delivery of the nucleic acid into cells of a selected tissue, and to obtain in vivo expression of the desired molecules encoded for by the nucleic acid.
摘要翻译：本发明涉及一种组合物，其包含衍生自阳离子多糖壳聚糖的阳离子壳聚糖低聚物的复合物，其中所述阳离子低聚物除了重量分数外还含有小于20％聚合度（DP）<10的低聚物的重量分数小于20％，DP> 50，和核酸。包含具有一定分子量链长度的定义明确的阳离子壳聚糖低聚物的这些组合物和核酸有利于实现将核酸递送至选定组织的细胞中，并获得所编码的所需分子的体内表达核酸。

4. 发明申请

US20070036864A1 Hygeine product for mouth 审中-公开
标题翻译： Hygeine产品为口
公开(公告)号：US20070036864A1
公开(公告)日：2007-02-15
申请号：US10577306
申请日：2004-10-27
申请人： Knut Börsheim , Simon Ballance , Bjorn Christensen , Olav Smidsrod
发明人： Knut Börsheim , Simon Ballance , Bjorn Christensen , Olav Smidsrod
IPC分类号： A61K9/14
CPC分类号： A61K8/97 , A61Q11/00
摘要： An oral hygiene product, such as tooth paste, is described. A methos for controlling undesirable bacterial flora in the oral cavity, as well as the use of the plant Sphagnum, are also described.
摘要翻译：描述了诸如牙膏的口腔卫生产品。还描述了用于控制口腔中不期望的细菌菌群的方法以及植物Sphagnum的使用。

5. 发明申请

US20050153397A1 Methods for producing polypeptides in Aspergillus mutant cells 有权
标题翻译：在曲霉突变体细胞中产生多肽的方法
公开(公告)号：US20050153397A1
公开(公告)日：2005-07-14
申请号：US10973973
申请日：2004-10-26
申请人： Bjorn Christensen , Henrik Mollgaard , Svend Kaasgaard , Jan Lehmbeck
发明人： Bjorn Christensen , Henrik Mollgaard , Svend Kaasgaard , Jan Lehmbeck
IPC分类号： C12N9/00 , C12N9/10 , C12N9/20 , C12N9/24 , C12N15/80 , C12P21/02 , C12N1/16 , C12N9/08 , C12N15/74
CPC分类号： C12N9/1085 , C12N9/00 , C12N9/10 , C12N9/20 , C12N9/248 , C12N9/2482 , C12N9/88 , C12N15/80 , C12P21/02 , C12R1/69 , C12Y302/01008
摘要： The present invention relates to methods for producing a polypeptide of interest by (a) cultivating a mutant of a parent Aspergillus cell, wherein (i) the mutant comprises a first nucleic acid sequence encoding the polypeptide and a second nucleic acid sequence comprising a modification of at least one of the genes responsible for the biosynthesis or secretion of at least one toxin, and (ii) the mutant produces less of the toxin than the parent Aspergillus cell when cultured under the same conditions; and (b) isolating the polypeptide from the culture medium. Also, mutants of Aspergillus cells are provided, as well as methods for obtaining the mutant cells.
摘要翻译：本发明涉及通过（a）培养母体曲霉细胞的突变体来产生感兴趣多肽的方法，其中（i）突变体包含编码多肽的第一核酸序列和包含修饰的第二核酸序列负责至少一种毒素的生物合成或分泌的基因中的至少一个，和（ii）当在相同条件下培养时，突变体产生比母体曲霉细胞少的毒素; 和（b）从培养基中分离多肽。此外，提供了曲霉菌细胞的突变体，以及获得突变细胞的方法。

6. 发明申请

US20080085242A1 NON-VIRAL GENE DELIVERY SYSTEM 审中-公开
标题翻译：非基因组递送系统
公开(公告)号：US20080085242A1
公开(公告)日：2008-04-10
申请号：US11848399
申请日：2007-08-31
申请人： Per Artursson , Bjorn Christensen , Magnus Koping-Hoggard , Kjell Varum , Kristoffer Tommeraas
发明人： Per Artursson , Bjorn Christensen , Magnus Koping-Hoggard , Kjell Varum , Kristoffer Tommeraas
IPC分类号： A61K31/7088 , A61K49/00 , A61P31/00 , A61P35/00
CPC分类号： A61K9/08 , A61K9/0073 , A61K47/61 , A61K48/0041 , C12N15/87
摘要： The present invention concerns a novel composition comprising a nucleic acid; and a chitosan containing branching groups covalently linked to the amino groups wherein said branches are selected from the following groups; alkyl with 2 or more carbon atoms, monosaccharides, oligosaccharides or polysaccharides. The composition is particularly useful as a non-viral gene delivery system. The composition facilitates the introduction of the nucleic acid into the cells to which it is administrated, as well as the expression of the function of the nucleic acid.
摘要翻译：本发明涉及包含核酸的新型组合物; 和含有与氨基共价连接的支链基团的壳聚糖，其中所述分支选自以下基团; 具有2个或更多碳原子的烷基，单糖，寡糖或多糖。该组合物特别可用作非病毒基因递送系统。该组合物促进将核酸引入其所施用的细胞中，以及核酸的功能的表达。

8. 发明申请

US20050164964A1 Non-viral gene delivery system 审中-公开
标题翻译：非病毒基因传递系统
公开(公告)号：US20050164964A1
公开(公告)日：2005-07-28
申请号：US10513311
申请日：2003-05-02
申请人： Per Artursson , Bjorn Christensen , Magnus Koping-Hoggard , Kjell Varum , Kristoffer Tommeraas
发明人： Per Artursson , Bjorn Christensen , Magnus Koping-Hoggard , Kjell Varum , Kristoffer Tommeraas
IPC分类号： G01N33/50 , A61K9/08 , A61K31/7088 , A61K47/36 , A61K47/48 , A61K48/00 , A61P7/00 , A61P31/00 , A61P37/06 , A61P43/00 , C12N15/09 , C12N15/87 , C12Q1/68 , C07H21/04 , C08B37/08
CPC分类号： A61K9/08 , A61K9/0073 , A61K47/61 , A61K48/0041 , C12N15/87
摘要： The present invention concerns a novel composition comprising a nucleic acid; and a chitosan containing branching groups covalently linked to the amino groups wherein said branches are selected from the following groups; alkyl with 2 or more carbon atoms, monosaccharides, oligosaccharides or polysaccharides. The composition is particularly useful as a non-viral gene delivery system. The composition facilitates the introduction of the nucleic acid into the cells to which it is administrated, as well as the expression of the function of the nucleic acid.
摘要翻译：本发明涉及包含核酸的新型组合物; 和含有与氨基共价连接的支链基团的壳聚糖，其中所述分支选自以下基团; 具有2个或更多碳原子的烷基，单糖，寡糖或多糖。该组合物特别可用作非病毒基因递送系统。该组合物促进将核酸引入其所施用的细胞中，以及核酸的功能的表达。

9. 发明授权

US07753238B2 Volume measurement and/or metering device and method for operating a volume measurement and/or metering device 有权
标题翻译：用于操作体积测量和/或计量装置的体积测量和/或计量装置和方法
公开(公告)号：US07753238B2
公开(公告)日：2010-07-13
申请号：US11674460
申请日：2007-02-13
申请人： Peter Kirschenbuhler , Bjorn Christensen
发明人： Peter Kirschenbuhler , Bjorn Christensen
IPC分类号： B67D7/58
CPC分类号： G01F11/028
摘要： A volume measurement and/or metering device includes a cylinder/piston and cock system for sucking in and/or discharging liquids in a defined way, the piston being movable in relation to the cylinder for sucking in or discharging the liquid. The cylinder is mounted, together with the cylinder bottom, rotatably with respect to the cock system about an axis of rotation parallel to the cylinder longitudinal axis. The cylinder bottom bears with a sealing seat against a cock element of the cock system, the cock element having at least one duct orifice. These orifices are arranged in such a way that the at least one orifice in the cylinder bottom can be brought into congruence with the orifices of the cock element when the cylinder and the cylinder bottom are rotated. Further, the cock element is brought into a sealing closing position for simultaneously closing of all the orifices of the cylinder bottom are provided.
摘要翻译：容积测量和/或计量装置包括用于以限定的方式吸入和/或排出液体的气缸/活塞和旋塞系统，活塞可相对于气缸移动以吸入或排出液体。气缸与气缸底部一起相对于旋塞系统围绕平行于气缸纵向轴线的旋转轴线可旋转地安装。气缸底部具有抵靠旋塞系统的旋塞元件的密封座，所述旋塞元件具有至少一个管道孔口。这些孔被布置成使得当气缸和气缸底部旋转时，气缸底部中的至少一个孔口可以与旋塞元件的孔口一致。此外，提供旋塞元件进入密封关闭位置，以同时关闭气缸底部的所有孔。

10. 发明申请

US20070298048A1 Non-viral gene delivery system 有权
标题翻译：非病毒基因传递系统
公开(公告)号：US20070298048A1
公开(公告)日：2007-12-27
申请号：US11809816
申请日：2007-06-01
申请人： Per Artursson , Bjorn Christensen , Magnus Koping-Hoggard , Kjell Varum
发明人： Per Artursson , Bjorn Christensen , Magnus Koping-Hoggard , Kjell Varum
IPC分类号： A61K47/48 , A61K39/395 , A61K48/00 , A61P31/00 , A61P37/00 , C08B37/08
CPC分类号： C12N15/87 , A61K9/0073 , A61K47/61 , A61K48/0041
摘要： The present invention concerns a composition comprising complexes of cationic chitosan oligomers derived from the cationic polysaccharide chitosan, wherein said cationic oligomers contain a weight fraction of less than 20% of oligomers with a Degree of Polymerization (DP) 50, and a nucleic acid. These compositions comprising well-defined cationic chitosan oligomers having a certain distribution of chain lengths, and nucleic acid are advantageous to achieve delivery of the nucleic acid into cells of a selected tissue, and to obtain in vivo expression of the desired molecules encoded for by the nucleic acid.
摘要翻译：本发明涉及一种组合物，其包含衍生自阳离子多糖壳聚糖的阳离子壳聚糖低聚物的复合物，其中所述阳离子低聚物除了重量分数外还含有小于20％聚合度（DP）<10的低聚物的重量分数小于20％，DP> 50，和核酸。包含具有一定分子量链长度的定义明确的阳离子壳聚糖低聚物的这些组合物和核酸有利于实现将核酸递送至选定组织的细胞中，并获得由所述组合编码的所需分子的体内表达核酸。

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