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1. 发明申请

US20120234394A1 LIQUID AERATOR 审中-公开
标题翻译：液体电动机
公开(公告)号：US20120234394A1
公开(公告)日：2012-09-20
申请号：US13395721
申请日：2010-09-04
申请人： Jurl Seletzky , Joerg Kauling , Björn Frahm , Helmut Brod , Marc Jenne , Franz Schmitt
发明人： Jurl Seletzky , Joerg Kauling , Björn Frahm , Helmut Brod , Marc Jenne , Franz Schmitt
IPC分类号： B01F3/04 , B01F5/04
CPC分类号： C12M29/06 , B01F3/04248 , B01F2003/0417 , B01F2003/04297 , B01F2003/04333 , B01F2003/04368 , Y10T137/0329
摘要： The invention relates to a sparger for introducing a gas or gas mixture into a liquid and to a method for sparging liquids. The sparger according to the invention comprises a cavity, a gas inlet for routing a gas into the cavity and two or more faces, which are or can be pressed onto one another in a positive fashion such that a gas pressed into the cavity through the gas inlet escapes through the gaps occurring between the pressed together faces.
摘要翻译：本发明涉及一种用于将气体或气体混合物引入液体的喷射器和用于喷射液体的方法。根据本发明的分布器包括空腔，用于将气体引导到空腔中的气体入口和两个或更多个面，这两个或更多个面可以或可以以积极的方式彼此压紧，使得通过气体压入空腔中的气体入口通过压制在一起的面之间的间隙逸出。

2. 发明申请

US20120052578A1 GASSING SYSTEM 审中-公开
标题翻译：加气系统
公开(公告)号：US20120052578A1
公开(公告)日：2012-03-01
申请号：US13145823
申请日：2010-01-13
申请人： Joerg Kauling , Björn Frahm , Andre Pütz , Markus Schindler
发明人： Joerg Kauling , Björn Frahm , Andre Pütz , Markus Schindler
IPC分类号： C12N5/07 , C12N1/00 , C12N5/04 , C12M1/00 , C12M1/04
CPC分类号： A61K38/12 , B01F3/04517 , B01F3/04539 , B01F7/1675 , B01F7/18 , B01F11/0002 , C12M29/06
摘要： A gas-introduction system useful, for example, in biotechnology for supplying cells or microorganisms with oxygen. The gas-introduction system has a bubble column and a distributor. In the vessel there is situated a liquid medium which is to be supplied with gas. A vector is used as transport medium for the gas. The gas is introduced into the bubble column and here taken up by the vector. The vector is applied to the liquid surface via the distributor in droplet form, falls downward in the medium and releases to the medium some of the gas that has been taken up. At the bottom of the vessel is situated a collecting device in which the vector droplets coalesce and pass back into the bubble column. Disclosed are a bioreactor comprising the gas-introduction system and a method for introducing gas into a liquid medium, preferably an aqueous suspension containing cells or microorganisms.
摘要翻译：气体导入系统，例如在用于向氧气供应细胞或微生物的生物技术中有用。气体引入系统具有气泡塔和分配器。在容器中设有要供应气体的液体介质。载体用作气体的输送介质。将气体引入气泡塔中，并将其从载体中吸收。载体通过液滴形式的分配器施加到液体表面，在介质中向下落下，并向介质中释放出已经被吸收的一些气体。在容器的底部设有收集装置，其中矢量液滴聚结并传回到气泡塔中。公开了一种生物反应器，其包括气体引入系统和将气体引入液体介质，优选含有细胞或微生物的含水悬浮液的方法。

3. 发明申请

US20110165677A1 METHOD FOR REDUCING DEPOSITS DURING THE CULTIVATION OF ORGANISMS 审中-公开
标题翻译：用于在有机体生长过程中减少沉积物的方法
公开(公告)号：US20110165677A1
公开(公告)日：2011-07-07
申请号：US13062556
申请日：2009-09-17
申请人： Helmut Brod , Björn Frahm , Joerg Kauling
发明人： Helmut Brod , Björn Frahm , Joerg Kauling
IPC分类号： C12N5/02 , C12M3/02
CPC分类号： B01F3/04269 , B01F11/0088 , B01F2003/04319 , B01F2003/04404 , C12M23/24 , C12M27/04 , C12M29/04 , C12M39/00
摘要： The invention relates to a process for reducing the amount of deposits during the culture of organisms, and in particular of cell cultures, where these have a tendency towards agglomeration or adhesion to the bioreactor and to its elements, or where these are readily susceptible to agglomeration or adhesion of cell debris or of substances.
摘要翻译：本发明涉及一种减少生物体培养期间沉积物量的方法，特别是细胞培养物，其中这些沉积物具有聚集或粘附到生物反应器及其元件的趋势，或者其中容易易于聚集的方法或细胞碎片或物质的粘附。

4. 发明申请

US20090180933A1 REACTOR 失效
标题翻译：反应堆
公开(公告)号：US20090180933A1
公开(公告)日：2009-07-16
申请号：US12297987
申请日：2007-04-23
申请人： Jörg Kauling , Helmut Brod , Sebastian Schmidt , Martin Poggel , Björn Frahm , Reinhold Rose
发明人： Jörg Kauling , Helmut Brod , Sebastian Schmidt , Martin Poggel , Björn Frahm , Reinhold Rose
IPC分类号： G01N21/64 , B01J19/00 , C12M1/00 , B01J19/12
CPC分类号： B01J19/28 , B01F3/04269 , B01F11/0002 , B01F11/0008 , B01F13/0018 , B01F13/0032 , B01F15/00733 , B01F15/0085 , B01F15/00915 , B01F15/065 , B01F15/066 , B01F2003/04361 , B01J19/123 , B01J19/285 , B01J2219/0025 , B01J2219/00761 , B01J2219/185 , B01J2219/192 , C12M23/14 , C12M23/28 , C12M27/02 , C12M27/10
摘要： The invention relates to a reactor driven in an oscillatory-rotary manner about its fixed, preferably vertical, axis, for preferably biotechnological and pharmaceutical applications. By means of its process-intensifying properties for mixing, suspension, gaseous material transport, heat transfer, irradiation and particle retention, the applicability on the industrial scale is ensured. The reactor which succeeds without a shaft seal permits particularly robust production with respect to sterile technique with avoidance of cleaning and cleaning validation required when the reactor is constructed as a single-use reactor.
摘要翻译：本发明涉及一种围绕其固定的，优选垂直的轴以振荡旋转方式驱动的反应器，优选用于生物技术和制药应用。通过其混合，悬浮，气态物质运输，传热，照射和颗粒保留的工艺增强性能，确保了工业规模的适用性。没有轴封成功的反应器相对于无菌技术可以特别稳定的生产，避免了当反应器被构造为一次性反应器时所需的清洁和清洁验证。

5. 发明授权

US08602636B2 Eccentrically-rotating reactor 失效
标题翻译：偏心反应堆
公开(公告)号：US08602636B2
公开(公告)日：2013-12-10
申请号：US12297987
申请日：2007-04-23
申请人： Jörg Kauling , Helmut Brod , Sebastian Schmidt , Martin Poggel , Björn Frahm , Reinhold Rose
发明人： Jörg Kauling , Helmut Brod , Sebastian Schmidt , Martin Poggel , Björn Frahm , Reinhold Rose
IPC分类号： B01F11/00
CPC分类号： B01J19/28 , B01F3/04269 , B01F11/0002 , B01F11/0008 , B01F13/0018 , B01F13/0032 , B01F15/00733 , B01F15/0085 , B01F15/00915 , B01F15/065 , B01F15/066 , B01F2003/04361 , B01J19/123 , B01J19/285 , B01J2219/0025 , B01J2219/00761 , B01J2219/185 , B01J2219/192 , C12M23/14 , C12M23/28 , C12M27/02 , C12M27/10
摘要： The invention relates to a reactor driven in an oscillatory-rotary manner about its fixed, preferably vertical, axis, for preferably biotechnological and pharmaceutical applications. By means of its process-intensifying properties for mixing, suspension, gaseous material transport, heat transfer, irradiation and particle retention, the applicability on the industrial scale is ensured. The reactor which succeeds without a shaft seal permits particularly robust production with respect to sterile technique with avoidance of cleaning and cleaning validation required when the reactor is constructed as a single-use reactor.
摘要翻译：本发明涉及一种围绕其固定的，优选垂直的轴以振荡旋转方式驱动的反应器，优选用于生物技术和制药应用。通过其混合，悬浮，气态物质运输，传热，照射和颗粒保留的工艺增强性能，确保了工业规模的适用性。没有轴封成功的反应器相对于无菌技术可以特别稳定的生产，避免了当反应器被构造为一次性反应器时所需的清洁和清洁验证。

6. 发明申请

US20110097800A1 METHOD AND APPARATUS FOR RETAINING AND RECIRCULATING CELLS 审中-公开
标题翻译：用于保留和再循环细胞的方法和装置
公开(公告)号：US20110097800A1
公开(公告)日：2011-04-28
申请号：US12997281
申请日：2009-06-10
申请人： Joerg Kauling , Björn Frahm , Marc Jenne , Helmut Brod , Stephan Kirchner , Arndt Braun
发明人： Joerg Kauling , Björn Frahm , Marc Jenne , Helmut Brod , Stephan Kirchner , Arndt Braun
IPC分类号： C12N5/07 , C12M3/02 , B29C53/58 , B32B7/08
CPC分类号： C12M23/06 , C12M23/26 , C12M29/08 , C12M33/22
摘要： The invention relates to a device and a method for retaining and recirculating cells in a vessel through which flow passes continuously or batchwise.In addition, the invention relates to a method of producing a device by which cells can be retained and recirculated in a vessel through which flow passes continuously or batchwise.
摘要翻译：本发明涉及一种用于保持和再循环在容器中的细胞的装置和方法，血液通过该细胞连续或间歇地流过。此外，本发明涉及一种生产装置的方法，通过该装置可以将细胞保持和再循环在流过连续或间歇流过的容器中。

7. 发明申请

US20110256624A1 BIOREACTOR 审中-公开
公开(公告)号：US20110256624A1
公开(公告)日：2011-10-20
申请号：US13140464
申请日：2009-12-08
申请人： Marc Jenne , Björn Frahm , Joerg Kauling , Helmut Brod
发明人： Marc Jenne , Björn Frahm , Joerg Kauling , Helmut Brod
IPC分类号： C12M1/04 , C12N5/071 , C12N1/00 , C12N5/07 , C12N5/04
CPC分类号： C12M29/08
摘要： The invention relates to a bioreactor, to the use of the bioreactor for culturing microorganisms or cell cultures, and also to a method for culturing microorganisms or cell cultures.
摘要翻译：本发明涉及使用生物反应器培养微生物或细胞培养物的生物反应器，以及培养微生物或细胞培养物的方法。

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