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1. 发明申请

US20090130665A1 POLYMER COMPOSITIONS AND USES THEREOF 有权
标题翻译：聚合物组合物及其用途
公开(公告)号：US20090130665A1
公开(公告)日：2009-05-21
申请号：US11914721
申请日：2006-05-26
申请人： Hanadi Sleiman , Bingzhi Chen
发明人： Hanadi Sleiman , Bingzhi Chen
IPC分类号： C12Q1/68 , C08L67/00
CPC分类号： G01N33/54346 , C07B2200/11 , C07F15/0026 , C07F15/0053 , C07F15/0086 , C08F297/00 , C08G61/08 , C12Q1/6816 , G01N33/531 , G01N33/544 , C12Q2563/155
摘要： Block copolymers labelled with molecular recognition units and comprising a hydrophobic block and a luminescent block are presented. A method of detecting biomolecules using such block copolymers is also presented. More specifically, the block copolymers of the present invention have the following Formula (I): wherein “A” is a hydrophobic block; “B” is a luminescent block; “C” is a hydrophilic block; “D” is a molecular recognition unit; “n” and “m” are integers ranging from 1 to 75; “x” is either 0 or an integer ranging from 1 to 75; and “Y” is either 0 or 1.
摘要翻译：提出了用分子识别单元标记并包含疏水嵌段和发光嵌段的嵌段共聚物。还提出了使用这种嵌段共聚物检测生物分子的方法。更具体地，本发明的嵌段共聚物具有下式（I）：其中“A”是疏水性嵌段; “B”是发光块; “C”是亲水性嵌段; “D”是分子识别单元; “n”和“m”为1〜75的整数; “x”是0或整数范围从1到75; “Y”为0或1。

2. 发明申请

US20130122597A1 SIMULTANEOUS DETERMINATION OF MULTIPLE ANALYTES IN INDUSTRIAL WATER SYSTEM 有权
标题翻译：同时确定工业水系统中的多种分析仪
公开(公告)号：US20130122597A1
公开(公告)日：2013-05-16
申请号：US13059139
申请日：2010-08-03
申请人： Caibin Xiao , Bingzhi Chen , Chunbo Yu , Hong Xu
发明人： Caibin Xiao , Bingzhi Chen , Chunbo Yu , Hong Xu
IPC分类号： G01N31/22 , G01N33/18
CPC分类号： G01N31/22 , G01N21/78 , G01N21/80 , G01N31/221 , G01N33/18 , G01N33/182 , Y10T436/16 , Y10T436/193333
摘要： A multi-purpose reagent composition is used for simultaneously determining concentrations of at least two analytes in a water sample. The two analytes are selected from the group consisting of free chlorine, pH, anionic polymer, and phosphates. In one embodiment, the multi-purpose reagent composition is for simultaneously determining the concentration of free chlorine and pH and comprises a free chlorine sensitive dye and pH indicator. In another embodiment, the reagent composition is for simultaneously determining of free chlorine and anionic polymer and includes a free chlorine sensitive dye, a pH buffer, cationic dye, and organic co-solvent. Thus, the pairs of free chlorine and pH or free chlorine and anionic polymer are determined using a single reagent composition. The reagent composition can also be the main reagent for one analyte analysis when it is used alone and also function as an ancillary reagent when it is combined with a second reagent composition for the determination of another analyte.
摘要翻译：多用途试剂组合物用于同时测定水样中至少两种分析物的浓度。两种分析物选自游离氯，pH，阴离子聚合物和磷酸盐。在一个实施方案中，多用途试剂组合物用于同时测定游离氯和pH的浓度并且包含游离氯敏感染料和pH指示剂。在另一个实施方案中，试剂组合物用于同时测定游离氯和阴离子聚合物，并且包括游离氯敏感染料，pH缓冲剂，阳离子染料和有机共溶剂。因此，使用单一试剂组合物测定游离氯和pH或游离氯和阴离子聚合物对。当单独使用时，试剂组合物也可以是用于一种分析物分析的主要试剂，并且当它与用于测定另一种分析物的第二试剂组合物组合时，其也可用作辅助试剂。

3. 发明授权

US08343771B2 Methods of using cyanine dyes for the detection of analytes 失效
标题翻译：使用花青染料检测分析物的方法
公开(公告)号：US08343771B2
公开(公告)日：2013-01-01
申请号：US13005134
申请日：2011-01-12
申请人： Bingzhi Chen , Caibin Xiao , Hong Xu , Alan M. Agree , Chunbo Yu
发明人： Bingzhi Chen , Caibin Xiao , Hong Xu , Alan M. Agree , Chunbo Yu
IPC分类号： G01N21/77 , G01N33/20
CPC分类号： G01N31/22 , G01N21/274 , G01N21/77 , G01N21/78 , G01N21/80 , G01N33/18 , G01N2021/7786 , Y10T436/193333
摘要： Measuring the concentration of an analyte in an aqueous solution by obtaining an aqueous solution containing an analyte, providing a cyanine indicator, placing the aqueous solution in fluid communication with the cyanine indicator, measuring a detectable property change of the cyanine indicator, and comparing the detectable property change of the cyanine indicator with a calibration curve of the detectable property change of samples containing known concentrations of the analyte. The concentration of the analyte is determined using the detectable property change that is proportional to the concentration of the analyte in the aqueous solution.
摘要翻译：通过获得含有分析物的水溶液来测量水溶液中的分析物的浓度，提供花青指示剂，将水溶液与花青指示剂流体连通，测量花青指示剂的可检测的性质变化，并比较可检测的花青指示剂的性质变化与含有已知浓度分析物的样品的可检测性质变化的校准曲线。使用与水溶液中分析物的浓度成比例的可检测的性质变化来确定分析物的浓度。

4. 发明申请

US20120178171A1 METHODS OF USING CYANINE DYES FOR THE DETECTION OF ANALYTES 失效
标题翻译：使用氰胺染料检测分析物的方法
公开(公告)号：US20120178171A1
公开(公告)日：2012-07-12
申请号：US13005134
申请日：2011-01-12
申请人： Bingzhi Chen , Caibin Xiao , Hong Xu , Alan M. Agree , Chunbo Yu
发明人： Bingzhi Chen , Caibin Xiao , Hong Xu , Alan M. Agree , Chunbo Yu
IPC分类号： G01N31/22 , G01N27/26 , G01N21/78
CPC分类号： G01N31/22 , G01N21/274 , G01N21/77 , G01N21/78 , G01N21/80 , G01N33/18 , G01N2021/7786 , Y10T436/193333
摘要： The present invention concerns a method of measuring the concentration of an analyte in an aqueous solution that comprises the steps of: obtaining an aqueous solution containing an analyte, providing a cyanine indicator, placing the aqueous solution in fluid communication with the cyanine indicator, measuring a detectable property change of the cyanine indicator, and comparing the detectable property change of the cyanine indicator with a calibration curve of the detectable property change of samples containing known concentrations of the analyte to determine the concentration of the analyte, wherein the detectable property change is proportional to the concentration of the analyte in said aqueous solution.
摘要翻译：本发明涉及一种测量水溶液中分析物浓度的方法，包括以下步骤：获得含有分析物的水溶液，提供花青指示剂，将水溶液与花青指示剂流体连通，测量并且将花青指示剂的可检测性质变化与含有已知浓度分析物的样品的可检测性质变化的校准曲线进行比较以确定分析物的浓度，其中可检测的性质变化是成比例的与所述水溶液中分析物的浓度。

5. 发明申请

US20120164739A1 DUAL HEAT STABILIZED POLYMER SENSOR FILMS 审中-公开
标题翻译：双热稳定聚合物传感器膜
公开(公告)号：US20120164739A1
公开(公告)日：2012-06-28
申请号：US12977558
申请日：2010-12-23
申请人： Bingzhi Chen , Scott Martell Boyette , Janine Clemens , Vidyasankar Sundaresan , Hong Xu
发明人： Bingzhi Chen , Scott Martell Boyette , Janine Clemens , Vidyasankar Sundaresan , Hong Xu
IPC分类号： G01N33/20
CPC分类号： G01N31/22
摘要： Methods are provided for improving the stability and shelf life of film sensors. The film sensors include a combination of polymeric matrix film material, analyte indicator, and solvent which has been heated in a first heat treatment application to volatilize most of the solvent and to solidify the analyte indicator to form the film sensor. The improvement comprises subjecting the film sensor to a second heat treatment to set the film and improve stability and shelf life.
摘要翻译：提供了用于提高薄膜传感器的稳定性和保质期的方法。膜传感器包括聚合物基质膜材料，分析物指示剂和溶剂的组合，其在第一热处理应用中被加热以挥发大部分溶剂并固化分析物指示剂以形成膜传感器。改进之处在于使薄膜传感器进行第二次热处理以设置薄膜并提高稳定性和保质期。

6. 发明授权

US09228986B2 Simultaneous determination of multiple analytes in industrial water system 有权
标题翻译：同时测定工业用水系统中的多种分析物
公开(公告)号：US09228986B2
公开(公告)日：2016-01-05
申请号：US13059139
申请日：2010-08-03
申请人： Caibin Xiao , Bingzhi Chen , Chunbo Yu , Hong Xu
发明人： Caibin Xiao , Bingzhi Chen , Chunbo Yu , Hong Xu
IPC分类号： G01N21/78 , G01N21/80 , G01N31/22 , G01N33/18
CPC分类号： G01N31/22 , G01N21/78 , G01N21/80 , G01N31/221 , G01N33/18 , G01N33/182 , Y10T436/16 , Y10T436/193333
摘要： A method using a multi-purpose reagent composition to simultaneously determine concentrations of at least two analytes in a water sample. In one embodiment, the multi-purpose reagent composition used is for simultaneously determining free chlorine concentration and pH and comprises a free chlorine sensitive dye and a pH indicator. In another embodiment, the reagent composition used is for simultaneously determining of free chlorine and anionic polymer and includes a free chlorine sensitive dye, a pH buffer, a cationic dye, and an organic co-solvent. Thus, the pairs of free chlorine and pH or free chlorine and anionic polymer are determined using a single reagent composition. The reagent composition can also be the main reagent for one analyte analysis when it is used alone and also function as an ancillary reagent when it is combined with a second reagent composition for the determination of another analyte.
摘要翻译：一种使用多用途试剂组合物同时测定水样中至少两种分析物的浓度的方法。在一个实施方案中，所用的多用途试剂组合物用于同时测定游离氯浓度和pH，并且包含游离氯敏感染料和pH指示剂。在另一个实施方案中，所用的试剂组合物用于同时测定游离氯和阴离子聚合物，并且包括游离氯敏感染料，pH缓冲剂，阳离子染料和有机共溶剂。因此，使用单一试剂组合物测定游离氯和pH或游离氯和阴离子聚合物对。当单独使用时，试剂组合物也可以是用于一种分析物分析的主要试剂，并且当它与用于测定另一种分析物的第二试剂组合物组合时，其也可用作辅助试剂。

7. 发明授权

US08324358B2 Polymer compositions and uses thereof 有权
标题翻译：聚合物组合物及其用途
公开(公告)号：US08324358B2
公开(公告)日：2012-12-04
申请号：US11914721
申请日：2006-05-26
申请人： Hanadi Sleiman , Bingzhi Chen , Kim Metera
发明人： Hanadi Sleiman , Bingzhi Chen , Kim Metera
IPC分类号： C07H21/00 , C07H21/02 , C12Q1/68
CPC分类号： G01N33/54346 , C07B2200/11 , C07F15/0026 , C07F15/0053 , C07F15/0086 , C08F297/00 , C08G61/08 , C12Q1/6816 , G01N33/531 , G01N33/544 , C12Q2563/155
摘要： Block copolymers labelled with molecular recognition units and comprising a hydrophobic block and a luminescent block are presented. A method of detecting biomolecules using such block copolymers is also presented. More specifically, the block copolymers of the present invention have the following Formula (I): wherein “A” is a hydrophobic block; “B” is a luminescent block; “C” is a hydrophilic block; “D” is a molecular recognition unit; “n” and “m” are integers ranging from 1 to 75; “x” is either 0 or an integer ranging from 1 to 75; and “Y” is either 0 or 1.
摘要翻译：提出了用分子识别单元标记并包含疏水嵌段和发光嵌段的嵌段共聚物。还提出了使用这种嵌段共聚物检测生物分子的方法。更具体地说，本发明的嵌段共聚物具有下式（I）：其中A是疏水嵌段; B是发光块; C是亲水性嵌段; D是分子识别单元; n和m是1至75的整数; x是0或整数范围从1到75; Y为0或1。

8. 发明申请

US20110217213A1 METHOD AND APPARATUS FOR MEASURING pH OF LOW ALKALINITY SOLUTIONS 有权
标题翻译：用于测量低碱性溶液pH值的方法和装置
公开(公告)号：US20110217213A1
公开(公告)日：2011-09-08
申请号：US13110047
申请日：2011-05-18
申请人： Bingzhi Chen , Weiyi Cui , Li Zhang , Caibin Xiao
发明人： Bingzhi Chen , Weiyi Cui , Li Zhang , Caibin Xiao
IPC分类号： G01N21/80 , G01N21/75
CPC分类号： G01N21/80 , G01N21/274 , Y10T436/10
摘要： Systems and methods are described for measuring pH of low alkalinity samples. The present invention provides a sensor array comprising a plurality of pH indicators, each indicator having a different indicator concentration. A calibration function is generated by applying the sensor array to a sample solution having a known pH such that pH responses from each indicator are simultaneously recorded versus indicator concentration for each indicator. Once calibrated, the sensor array is applied to low alkalinity samples having unknown pH. Results from each pH indicator are then compared to the calibration function, and fitting functions are extrapolated to obtain the actual pH of the low alkalinity sample.
摘要翻译：描述了用于测量低碱度样品的pH的系统和方法。本发明提供一种包含多个pH指示剂的传感器阵列，每个指示剂具有不同的指示剂浓度。通过将传感器阵列应用于具有已知pH的样品溶液来产生校准功能，使得来自每个指示剂的pH响应同时记录，而每个指示剂的指示剂浓度。一旦校准，传感器阵列被施加到具有未知pH的低碱度样品。然后将每个pH指示剂的结果与校准函数进行比较，外推拟合函数以获得低碱度样品的实际pH。

9. 发明申请

US20080295581A1 Method for the determination of aqueous polymer concentration in water systems 审中-公开
标题翻译：测定水体系中聚合物浓度的方法
公开(公告)号：US20080295581A1
公开(公告)日：2008-12-04
申请号：US11809345
申请日：2007-05-31
申请人： Li Zhang , Caibin Xiao , Yinhua Long , Weiyi Cui , Bingzhi Chen , Zhixin Zheng
发明人： Li Zhang , Caibin Xiao , Yinhua Long , Weiyi Cui , Bingzhi Chen , Zhixin Zheng
IPC分类号： G01N33/00 , C08J5/22
CPC分类号： G01N31/22 , G01N21/78 , G01N33/182 , G01N2021/773 , G01N2021/7783
摘要： The concentration of an anionically charged polymer in an aqueous solution is determined with a thin solid film having a polymer matrix and a cationic dye. A sample of an aqueous solution containing at least one anionically charged polymer to be tested is applied to the film sensor. The absorbance of the film sensor is measured after the sample has been applied. The absorbance of the film sensor is then compared with a calibration curve of the absorbance of samples containing known concentrations of the anionically charged polymers to determine the concentration of anionically charged polymer in the sample.
摘要翻译：阴离子带电聚合物在水溶液中的浓度用具有聚合物基质和阳离子染料的薄固体膜测定。将含有至少一种带阴离子电荷的待测试聚合物的水溶液样品施加到膜传感器。在涂布样品后测量薄膜传感器的吸光度。然后将膜传感器的吸光度与含有已知浓度的阴离子电荷聚合物的样品的吸光度的校准曲线进行比较，以确定样品中阴离子带电聚合物的浓度。

10. 发明授权

US08148166B2 Method and apparatus for measuring pH of low alkalinity solutions 有权
标题翻译：测量低碱度溶液pH值的方法和装置
公开(公告)号：US08148166B2
公开(公告)日：2012-04-03
申请号：US13110047
申请日：2011-05-18
申请人： Bingzhi Chen , Weiyi Cui , Li Zhang , Caibin Xiao
发明人： Bingzhi Chen , Weiyi Cui , Li Zhang , Caibin Xiao
IPC分类号： G01N21/00
CPC分类号： G01N21/80 , G01N21/274 , Y10T436/10
摘要： Systems and methods are described for measuring pH of low alkalinity samples. The present invention provides a sensor array comprising a plurality of pH indicators, each indicator having a different indicator concentration. A calibration function is generated by applying the sensor array to a sample solution having a known pH such that pH responses from each indicator are simultaneously recorded versus indicator concentration for each indicator. Once calibrated, the sensor array is applied to low alkalinity samples having unknown pH. Results from each pH indicator are then compared to the calibration function, and fitting functions are extrapolated to obtain the actual pH of the low alkalinity sample.
摘要翻译：描述了用于测量低碱度样品的pH的系统和方法。本发明提供一种包含多个pH指示剂的传感器阵列，每个指示剂具有不同的指示剂浓度。通过将传感器阵列应用于具有已知pH的样品溶液来产生校准功能，使得来自每个指示剂的pH响应同时记录，而每个指示剂的指示剂浓度。一旦校准，传感器阵列被施加到具有未知pH的低碱度样品。然后将每个pH指示剂的结果与校准函数进行比较，外推拟合函数以获得低碱度样品的实际pH。

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