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    • 7. 发明授权
    • Aviadenovirus
    • 禽流感病毒
    • US06241991B1
    • 2001-06-05
    • US09257485
    • 1999-02-25
    • Guntram PaulMichael Bernhard Hess
    • Guntram PaulMichael Bernhard Hess
    • A61K39235
    • C12N7/00A61K2039/522A61K2039/523A61K2039/5254A61K2039/5256C12N2710/10221Y10S424/816
    • The invention relates to a new aviadenovirus which was isolated from a pigeon. The aviadenovirus according to the present invention comprises group-I specific antigen and cannot be neutralized by antiserum against any of the FAV serotypes 1-12. The present invention also relates to an antibody or antiserum immunoreactive with a fibre of the new aviadenovirus, a fibre thereof as well as a vaccin against PiAV related diseases comprising a chemically or physically inactivated virus an attenuated virus, a fibre or fragment thereof, a host cell transformed with a nucleic acid sequence encoding an amino acid sequence comprising an immunogenic determent or a functional variant thereof of a fibre of the aviadenovirus according to the present invention, together with a pharmaceutical carrier.
    • 本发明涉及一种从鸽子中分离的新型禽流感病毒。 根据本发明的禽链球菌属病毒包含I组特异性抗原,并且不能被抗血清中和任何FAV血清型1-12中和。 本发明还涉及与新型禽流感病毒纤维,其纤维以及针对PiAV相关疾病的疫苗免疫反应的抗体或抗血清,其包含化学或物理灭活的病毒,其为减毒病毒,纤维或其片段,宿主 用编码包含根据本发明的aviadenovirus纤维的免疫原性抑制剂或其功能变体的氨基酸序列的核酸序列与药物载体一起转化。