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1. 发明专利

MX148189A 未知
公开(公告)号：MX148189A
公开(公告)日：1983-03-24
申请号：MX17706079
申请日：1979-03-27
申请人： BENJAMIN GONZALEZ NAJAR
发明人： NAJAR BENJAMIN GONZALEZ
IPC分类号： A61H33/06

2. 发明授权

US07745195B2 Method for the preparation of an evolved microorganism for the creation or the modification of metabolic pathways 有权
标题翻译：制备用于产生或修饰代谢途径的进化微生物的方法
公开(公告)号：US07745195B2
公开(公告)日：2010-06-29
申请号：US10781499
申请日：2004-02-18
申请人： Michel Chateau , Benjamin Gonzalez , Isabelle Meynial-Salles , Philippe Noel Paul Soucaille , Olivier Zink
发明人： Michel Chateau , Benjamin Gonzalez , Isabelle Meynial-Salles , Philippe Noel Paul Soucaille , Olivier Zink
IPC分类号： C12N1/00 , C12N1/36
CPC分类号： C12N15/1058 , C12N9/0036 , C12N15/01 , C12P7/18 , C12P7/20 , C12P7/42 , C12P7/52 , C12P13/12 , C12P33/00
摘要： The present invention is directed to a method for the preparation of evolved microorganisms permitting the creation or modification of metabolic pathways. Strains of evolved microorganisms and evolved genes obtained by the method are also provided. The invention is also directed to the use of evolved microorganisms, genes or proteins in a biotransformation process.
摘要翻译：本发明涉及一种用于制备允许创建或修饰代谢途径的进化微生物的方法。还提供了通过该方法获得的进化微生物和进化基因的菌株。本发明还涉及在生物转化过程中使用进化微生物，基因或蛋白质。

3. 发明申请

US20060270013A1 Method for the production of evolved microorganisms which permit the generation or modification of metabolic pathways 审中-公开
标题翻译：用于生产允许产生或修饰代谢途径的进化微生物的方法
公开(公告)号：US20060270013A1
公开(公告)日：2006-11-30
申请号：US10546139
申请日：2004-02-17
申请人： Michel Chateau , Benjamin Gonzalez , Isabelle Meynial-Salles , Philippe Soucailles , Olivier Zink
发明人： Michel Chateau , Benjamin Gonzalez , Isabelle Meynial-Salles , Philippe Soucailles , Olivier Zink
IPC分类号： C12N15/74 , C12N9/10 , C12N1/21
CPC分类号： C12N15/1058 , C12N9/0036 , C12N15/01 , C12P7/18 , C12P7/20 , C12P7/42 , C12P7/52 , C12P13/12 , C12P33/00
摘要： The invention relates to a method for the preparation of evolved microorganisms which permit a modification of metabolic pathways, comprising the following steps: a) production of a modified microorganism by genetic modification of initial microorganism cells such as to inhibit the production of or the consumption of a metabolite when the microorganism is cultivated in a defined medium which also affects the capacity of the microorganism for growth, b) culture of the modified microorganisms to induce evolution in said cells, c) selection of the cells of modified microorganisms which are capable of developing in the defined medium. The invention also relates to the strains of evolved microorganisms, the genes evolved which code for evolved proteins and the use of said evolved microorganisms, genes or proteins in a biotransformation method.
摘要翻译：本发明涉及一种用于制备能够修饰代谢途径的进化微生物的方法，包括以下步骤：a）通过初始微生物细胞的遗传修饰来产生经修饰的微生物，例如抑制或抑制微生物在限定培养基中培养的代谢物，其也影响微生物生长的能力，b）培养经修饰的微生物以诱导所述细胞中的进化，c）选择能够发育的修饰的微生物细胞在定义的介质中。本发明还涉及进化微生物菌株，进化型编码进化蛋白质的基因以及所述进化微生物，基因或蛋白质在生物转化方法中的应用。

4. 发明授权

US08252579B2 Evolved micro-organisms for the production of 1,2-propanediol 有权
标题翻译：用于生产1,2-丙二醇的进化微生物
公开(公告)号：US08252579B2
公开(公告)日：2012-08-28
申请号：US10585040
申请日：2005-01-12
申请人： Isabelle Meynial-Salles , Benjamin Gonzalez , Philippe Soucaille
发明人： Isabelle Meynial-Salles , Benjamin Gonzalez , Philippe Soucaille
IPC分类号： C12Q1/68 , C12P7/02 , C12N1/20 , C12N9/00 , C12N9/02 , C12N9/04 , C12N15/00 , C07H21/04
CPC分类号： C12P7/18 , C12N9/0051 , C12N15/01 , C12P7/28
摘要： The present invention concerns a new method of preparation of a strain of evolved micro-organisms for the production of 1,2-propanediol by the metabolism of a simple carbon source, which method comprises the growth under selection pressure in an appropriate growth medium containing a simple carbon source of an initial bacterial strain that has undergone the deletion of the gene tpiA and the deletion of at least one gene involved in the conversion of methylglyoxal (propanal) into lactate, in order to cause, in said initial strain, the evolution of one or more genes involved in the biosynthesis pathway from DHAP to methylglyoxal and then to 1,2-propanediol towards evolved genes that possess an improved “1,2-propanediol synthase activity”, the resulting strain or strains of evolved micro-organisms possessing an improved “1,2-propanediol synthase activity” then being selected and isolated.The invention also concerns the initial micro-organisms and the evolved micro-organisms thus obtained, and a method for the preparation of 1,2-propanediol and possibly acetone by culture of said evolved micro-organisms.
摘要翻译：本发明涉及通过简单碳源的代谢来制备用于生产1,2-丙二醇的进化微生物菌株的新方法，该方法包括在选择压力下在合适的生长培养基中生长，所述合适的生长培养基含有已经经历基因tpiA缺失的初始细菌菌株的简单碳源和涉及将甲基乙二醛（丙醛）转化成乳酸盐的至少一个基因的缺失，以便在所述初始菌株中引起涉及从DHAP到甲基乙二醛然后到1,2-丙二醇的生物合成途径中的一个或多个基因转化为具有改进的“1,2-丙二醇合酶活性”的进化基因，所得的产生的菌株或进化微生物菌株具有然后选择和分离改进的“1,2-丙二醇合酶活性”。本发明还涉及由此获得的初始微生物和进化微生物，以及通过培养所述进化微生物制备1,2-丙二醇和可能的丙酮的方法。

5. 发明授权

US07402437B2 Method and device for analyzing the intracellular chemical state of living cells by nuclear magnetic resonance 有权
标题翻译：通过核磁共振分析活细胞的细胞内化学状态的方法和装置
公开(公告)号：US07402437B2
公开(公告)日：2008-07-22
申请号：US10398942
申请日：2001-10-12
申请人： Benjamin Gonzalez , Martial Piotto , J. Gaspard Huber
发明人： Benjamin Gonzalez , Martial Piotto , J. Gaspard Huber
IPC分类号： G01N24/00 , G01V3/00
CPC分类号： G01N1/42 , G01R33/465 , Y10T436/24
摘要： The invention concerns a method for analysing the intracellular chemical state of living cells by nuclear magnetic resonance (NMR). Said method comprises a step which consists in preparing the cell sample and a step which consists in an NMR analysis of the sample, both steps being carried out at very low temperature so as to freeze the biochemical state of the living cells to obtain specific and accurate reproducible measurements of the cellular functioning in given conditions. The invention also concerns the device coupled to the NMR spectrometer for implementing the method of analysis.
摘要翻译：本发明涉及通过核磁共振（NMR）分析活细胞的细胞内化学状态的方法。所述方法包括制备细胞样品的步骤和由样品的NMR分析组成的步骤，两个步骤在非常低的温度下进行，以冷冻活细胞的生化状态以获得特异且准确的在给定条件下细胞功能的可重复测量。本发明还涉及耦合到NMR光谱仪的装置，以实现分析方法。

6. 发明申请

US20070087403A1 Optimised micro-organism strains for nadph-consuming biosynthetic pathways 有权
标题翻译：优化的微生物菌株用于消耗生物合成途径
公开(公告)号：US20070087403A1
公开(公告)日：2007-04-19
申请号：US10577084
申请日：2004-11-05
申请人： Gwénaëlle Bestel-Corre , Cedric Boisart , Michel Chateau , Benjamin Gonzalez , Philippe Soucaille , Rainer Figge , Olivier Zink
发明人： Gwénaëlle Bestel-Corre , Cedric Boisart , Michel Chateau , Benjamin Gonzalez , Philippe Soucaille , Rainer Figge , Olivier Zink
IPC分类号： C12P33/00 , C12P19/62 , C12P13/04 , C12P17/00 , C12P7/64 , C12P7/40 , C12N15/74 , C12N1/21 , C12N1/18
CPC分类号： C12N9/0036 , C12N9/92 , C12P7/18 , C12P13/005 , C12P13/04 , C12P33/16
摘要： The invention relates to optimised micro-organism strains for the biotransformation production of molecules having NADPH-consuming biosynthetic pathways. The inventive strains can be used in NADPH-consuming biotransformation methods. Said strains are characterised in that one or more NADPH-oxidising activities are limited.
摘要翻译：本发明涉及用于生物转化产生具有NADPH消耗生物合成途径的分子的优化的微生物菌株。本发明的菌株可用于NADPH消费的生物转化方法中。所述菌株的特征在于一个或多个NADPH氧化活性受到限制。

7. 发明申请

US20070072279A1 Evolved micro-organisms for the production of 1,2-propanediol 有权
标题翻译：用于生产1,2-丙二醇的进化微生物
公开(公告)号：US20070072279A1
公开(公告)日：2007-03-29
申请号：US10585040
申请日：2005-01-12
申请人： Isabelle Meynial-Salles , Benjamin Gonzalez , Philippe Soucaille
发明人： Isabelle Meynial-Salles , Benjamin Gonzalez , Philippe Soucaille
IPC分类号： C12P7/18 , C12N15/74 , C12N1/21
CPC分类号： C12P7/18 , C12N9/0051 , C12N15/01 , C12P7/28
摘要： The present invention concerns a new method of preparation of a strain of evolved micro-organisms for the production of 1,2-propanediol by the metabolism of a simple carbon source, which method comprises the growth under selection pressure in an appropriate growth medium containing a simple carbon source of an initial bacterial strain that has undergone the deletion of the gene tpiA and the deletion of at least one gene involved in the conversion of methylglyoxal (propanal) into lactate, in order to cause, in said initial strain, the evolution of one or more genes involved in the biosynthesis pathway from DHAP to methylglyoxal and then to 1,2-propanediol towards evolved genes that possess an improved “1,2-propanediol synthase activity”, the resulting strain or strains of evolved micro-organisms possessing an improved “1,2-propanediol synthase activity” then being selected and isolated. The invention also concerns the initial micro-organisms and the evolved micro-organisms thus obtained, and a method for the preparation of 1,2-propanediol and possibly acetone by culture of said evolved micro-organisms.
摘要翻译：本发明涉及通过简单碳源的代谢来制备用于生产1,2-丙二醇的进化微生物菌株的新方法，该方法包括在选择压力下在合适的生长培养基中生长，所述合适的生长培养基含有已经经历基因tpiA缺失的初始细菌菌株的简单碳源和涉及将甲基乙二醛（丙醛）转化成乳酸盐的至少一个基因的缺失，以便在所述初始菌株中引起涉及从DHAP到甲基乙二醛然后到1,2-丙二醇的生物合成途径中的一个或多个基因转化为具有改进的“1,2-丙二醇合酶活性”的进化基因，所得的产生的菌株或进化微生物菌株具有然后选择和分离改进的“1,2-丙二醇合酶活性”。本发明还涉及由此获得的初始微生物和进化微生物，以及通过培养所述进化微生物制备1,2-丙二醇和可能的丙酮的方法。

8. 发明授权

US08088620B2 Optimised micro-organism strains for NADPH-consuming biosynthetic pathways 有权
标题翻译：用于NADPH消耗生物合成途径的优化微生物菌株
公开(公告)号：US08088620B2
公开(公告)日：2012-01-03
申请号：US10577084
申请日：2004-11-05
申请人： Gwénaëlle Bestel-Corre , Cédric Boisart , Michel Chateau , Benjamin Gonzalez , Philippe Soucaille , Rainer Figge , Olivier Zink
发明人： Gwénaëlle Bestel-Corre , Cédric Boisart , Michel Chateau , Benjamin Gonzalez , Philippe Soucaille , Rainer Figge , Olivier Zink
IPC分类号： C12N15/00 , C12N1/21 , C12N1/16 , C12P13/04 , C12P1/00
CPC分类号： C12N9/0036 , C12N9/92 , C12P7/18 , C12P13/005 , C12P13/04 , C12P33/16
摘要： The invention relates to optimised micro-organism strains for the biotransformation production of molecules having NADPH-consuming biosynthetic pathways. The inventive strains can be used in NADPH-consuming biotransformation methods. Said strains are characterized in that one or more NADPH-oxidizing activities are limited.
摘要翻译：本发明涉及用于生物转化产生具有NADPH消耗生物合成途径的分子的优化的微生物菌株。本发明的菌株可用于NADPH消费生物转化方法。所述菌株的特征在于限制了一种或多种NADPH氧化活性。

9. 发明申请

US20070271860A1 Waste tires foundation bags 审中-公开
标题翻译：废旧轮胎基础袋
公开(公告)号：US20070271860A1
公开(公告)日：2007-11-29
申请号：US11441738
申请日：2006-05-27
申请人： Benjamin Gonzalez , Javier Gonzalez , Juaquin Gonzalez
发明人： Benjamin Gonzalez , Javier Gonzalez , Juaquin Gonzalez
IPC分类号： E02D27/00
CPC分类号： E02D27/02 , E02D27/18
摘要： The present invention is a waste-tire foundation bag. Stackable bags suitable for containing soil are filled with 50% waste tire portions and 50% soil. The bag openings are closed to prevent the contents from falling out. The bags are stacked in piles in a building-foundation excavation pit. Concrete is poured over and between the piles, whereby the solidified concrete foundation rests on the piles of waste-tire bags.
摘要翻译：本发明是一种废旧轮胎基础袋。适用于容纳土壤的可叠放袋子填充有50％的废轮胎部分和50％的土壤。袋子开口关闭，以防止内容物脱落。袋子堆放在建筑物基础挖掘坑中的桩中。将混凝土浇注在桩之间和之间，由此固化的混凝土基础搁置在废旧轮胎袋的堆上。

10. 发明申请

US20050054060A1 Method for the preparation of an evolved microorganism for the creation or the modification of metabolic pathways 有权
标题翻译：制备用于产生或修饰代谢途径的进化微生物的方法
公开(公告)号：US20050054060A1
公开(公告)日：2005-03-10
申请号：US10781499
申请日：2004-02-18
申请人： Michel Chateau , Benjamin Gonzalez , Isabelle Meynial-Salles , Philippe Soucaille , Olivier Zink
发明人： Michel Chateau , Benjamin Gonzalez , Isabelle Meynial-Salles , Philippe Soucaille , Olivier Zink
IPC分类号： C12N1/21 , C12N9/10 , C12N9/88 , C12N15/01 , C12N15/10 , C12P11/00 , C12P13/12 , C12P13/04 , C12N9/08 , C12P13/08
CPC分类号： C12N15/1058 , C12N9/0036 , C12N15/01 , C12P7/18 , C12P7/20 , C12P7/42 , C12P7/52 , C12P13/12 , C12P33/00
摘要： The present invention is directed to a method for the preparation of evolved microorganisms permitting the creation or modification of metabolic pathways. Strains of evolved microorganisms and evolved genes obtained by the method are also provided. The invention is also directed to the use of evolved microorganisms, genes or proteins in a biotransformation process.
摘要翻译：本发明涉及一种用于制备允许创建或修饰代谢途径的进化微生物的方法。还提供了通过该方法获得的进化微生物和进化基因的菌株。本发明还涉及在生物转化过程中使用进化微生物，基因或蛋白质。

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