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1. 发明授权

US08859815B2 Sulphonylated diphenylethylenediamines, method for their preparation and use in transfer hydrogenation catalysis 有权
标题翻译：磺酰化二苯基乙二胺，其制备方法和用于转移氢化催化
公开(公告)号：US08859815B2
公开(公告)日：2014-10-14
申请号：US13313889
申请日：2011-12-07
申请人： Beatriz Dominguez , Antonio Zanotti-Gerosa , Gabriela Alexandra Grasa , Jonathan Alan Medlock
发明人： Beatriz Dominguez , Antonio Zanotti-Gerosa , Gabriela Alexandra Grasa , Jonathan Alan Medlock
IPC分类号： C07C311/13 , C07C311/14 , C07C311/16 , C07C33/20 , C07C33/22 , C07C33/46 , C07C303/38 , B01J31/18 , C07C29/143 , C07C311/18
CPC分类号： B01J31/1805 , B01J2231/643 , B01J2531/821 , B01J2531/822 , B01J2531/824 , B01J2531/827 , B01J2531/828 , B01J2531/842 , B01J2531/845 , B01J2531/847 , C07B2200/07 , C07C29/143 , C07C311/18 , C07C2602/10 , C07C33/46 , C07C33/22 , C07C35/32
摘要： A diamine of formula (I) is described in which A is hydrogen or a saturated or unsaturated C1-C20 alkyl group or an aryl group; B is a substituted or unsubstituted C1-C20 alkyl, cycloalkyl, alkaryl, alkaryl or aryl group or an alkylamino group and at least one of X1, X2, Y1, Y2 or Z is a C1-C10 alkyl, cycloalkyl, alkaryl, aralkyl or alkoxy substituting group. The chiral diamine may be used to prepare catalysts suitable for use in transfer hydrogenation reactions.
摘要翻译：描述了式（I）的二胺，其中A是氢或饱和或不饱和的C 1 -C 20烷基或芳基; B是取代或未取代的C 1 -C 20烷基，环烷基，烷芳基，烷芳基或芳基或烷基氨基，X 1，X 2，Y 1，Y 2或Z中的至少一个是C 1 -C 10烷基，环烷基，烷芳基，芳烷基或烷氧基取代基。手性二胺可用于制备适用于转移氢化反应的催化剂。

2. 发明授权

US08513414B2 Processes and intermediates for producing azaindoles 失效
公开(公告)号：US08513414B2
公开(公告)日：2013-08-20
申请号：US13541504
申请日：2012-07-03
申请人： Gerald J. Tanoury , Young Chun Jung , Derek Magdziak , Adam Looker , Billie J. Kline , Václav Jurcik , Beatriz Dominguez Olmo
发明人： Gerald J. Tanoury , Young Chun Jung , Derek Magdziak , Adam Looker , Billie J. Kline , Václav Jurcik , Beatriz Dominguez Olmo
IPC分类号： C07D401/14
CPC分类号： C07D471/04 , C07B2200/13 , C07D239/42 , C07F5/025 , C07F5/04
摘要： The present invention relates to processes and intermediates for the preparation of compounds useful as inhibitors of Janus kinases (JAK).

3. 发明授权

US07256302B2 Substituted paracyclophane derivatives in asymmetric catalysis 失效
标题翻译：非对称催化中的取代对环芳烃衍生物
公开(公告)号：US07256302B2
公开(公告)日：2007-08-14
申请号：US10560387
申请日：2004-06-08
申请人： Beatriz Dominguez , William Patrick Hems , Antonio Zanotti-Gerosa
发明人： Beatriz Dominguez , William Patrick Hems , Antonio Zanotti-Gerosa
IPC分类号： C07F9/30
CPC分类号： B01J31/2457 , B01J31/1608 , B01J2231/4211 , B01J2231/4261 , B01J2231/4283 , B01J2231/643 , B01J2231/645 , B01J2531/0263 , B01J2531/821 , B01J2531/822 , B01J2531/824 , B01J2531/827 , B01J2531/828 , C07B53/00 , C07B2200/07 , C07C29/145 , C07C39/42 , C07C47/55 , C07C49/813 , C07C63/72 , C07C69/76 , C07C205/12 , C07C231/18 , C07C2603/92 , C07F9/5027 , C07F9/65719 , C07F9/6581 , C07F15/0053 , C07C233/47 , C07C33/22 , C07C33/50
摘要： A substituted paracyclophane is described of formula (I) wherein X1 and X2 are linking groups comprising between 2 to 4 carbon atoms, Y1 and Y2 are selected from the group consisting of hydrogen, halide, oxygen, nitrogen, alkyl, cycloalkyl, aryl or heteroaryl, Z1, Z2 and Z3 are substituting groups that optionally contain functional groups, a, b, c, d, e and f are 0 or 1 and a+b+c+d+e+f=1 to 6. Preferably X1 and X2 are —(C2H4)— and a+b+c+d+e+f=1 or 2. The substituted paracyclophane provides transition metal catalysts that demonstrate high activity and selectivity for asymmetric reactions
摘要翻译：描述了式（I）的取代的对环芳烷，其中X 1和X 2 2是包含2至4个碳原子的连接基团，Y 1，和Y 2选自氢，卤素，氧，氮，烷基，环烷基，芳基或杂芳基，Z 1，Z 2， SUP>和Z 3是用任选含有官能团a，b，c，d，e和f分别为0或1和a + b + c + d + e + f = 1的基团 X 1和X 2优选为 - （C 2 H 4 H 4） - 和 - + b + c + d + e + f = 1或2.取代的对环烷烷提供过渡金属催化剂，其表现出对不对称反应的高活性和选择性

4. 发明申请

WO2004111065A1 LIGANDS 审中-公开
标题翻译：配体
公开(公告)号：WO2004111065A1
公开(公告)日：2004-12-23
申请号：PCT/GB2004/002426
申请日：2004-06-08
申请人： JOHNSON MATTHEY PLC , DOMINGUEZ, Beatriz, Dominguez , HEMS, William, Patrick , ZANOTTI-GEROSA, Antonio
发明人： DOMINGUEZ, Beatriz, Dominguez , HEMS, William, Patrick , ZANOTTI-GEROSA, Antonio
IPC分类号： C07F15/00
CPC分类号： B01J31/2457 , B01J31/1608 , B01J2231/4211 , B01J2231/4261 , B01J2231/4283 , B01J2231/643 , B01J2231/645 , B01J2531/0263 , B01J2531/821 , B01J2531/822 , B01J2531/824 , B01J2531/827 , B01J2531/828 , C07B53/00 , C07B2200/07 , C07C29/145 , C07C39/42 , C07C47/55 , C07C49/813 , C07C63/72 , C07C69/76 , C07C205/12 , C07C231/18 , C07C2603/92 , C07F9/5027 , C07F9/65719 , C07F9/6581 , C07F15/0053 , C07C233/47 , C07C33/22 , C07C33/50
摘要： A substituted paracyclophane is described of formula (I) wherein X l and X 2 are linking groups comprising between 2 to 4 carbon atoms, Y 1 and Y 2 are selected from the group consisting of hydrogen, halide, oxygen, nitrogen, alkyl, cycloalkyl , aryl or heteroaryl, Z 1 , Z 2 and Z 3 are substituting groups that optionally contain functional groups, a, b, c, d, e and f are 0 or l and a + b + c + d + e + f = 1 to 6. PreferablyX 1 and X 2 are -(C 2 H 4 )- and a + b + c + d + e + f = 1 or 2. The substituted paracyclophane provides transition metal catalysts that demonstrate high activity and selectivity for asymmetric reactions.
摘要翻译：描述了式（I）的式（I）化合物，其中X 1和X 2为包含2至4个碳原子的连接基团，Y 1和Y 2选自氢，卤化物，氧，氮，烷基，环烷基，芳基或杂芳基，Z 1，Z 2和Z 3代表任选地含有官能团的基团，a，b，c，d，e和f为0或 1和a + b + c + d + e + f = 1〜6。优选X 1和X 2为 - （C 2 H 4） - 和a + b + c + d + e + f = 1或2。取代的对环烷烃提供过渡金属催化剂，其表现出对不对称反应的高活性和选择性。

5. 发明申请

US20130102782A1 PROCESSES AND INTERMEDIATES FOR PRODUCING AZAINDOLES 失效
公开(公告)号：US20130102782A1
公开(公告)日：2013-04-25
申请号：US13541504
申请日：2012-07-03
申请人： Gerald J. Tanoury , Young Chun Jung , Derek Magdziak , Adam Looker , Billie J. Kline , Václav Jurcík , Beatriz Dominguez Olmo
发明人： Gerald J. Tanoury , Young Chun Jung , Derek Magdziak , Adam Looker , Billie J. Kline , Václav Jurcík , Beatriz Dominguez Olmo
IPC分类号： C07D471/04 , C07D239/42 , C07F5/04
CPC分类号： C07D471/04 , C07B2200/13 , C07D239/42 , C07F5/025 , C07F5/04
摘要： The present invention relates to processes and intermediates for the preparation of compounds useful as inhibitors of Janus kinases (JAK).

6. 发明申请

US20120077973A1 Sulphonylated Diphenylethylenediamines, Method for Their Preparation and Use in Transfer Hydrogenation Catalysis 有权
标题翻译：磺酰化二苯乙二胺，其制备方法及其在转移氢化催化中的应用
公开(公告)号：US20120077973A1
公开(公告)日：2012-03-29
申请号：US13313889
申请日：2011-12-07
申请人： Beatriz Dominguez , Antonio Zanotti-Gerosa , Gabriela Alexandra Grasa , Jonathan Alan Medlock
发明人： Beatriz Dominguez , Antonio Zanotti-Gerosa , Gabriela Alexandra Grasa , Jonathan Alan Medlock
IPC分类号： C07D223/18 , B01J31/02 , C07C311/10
CPC分类号： B01J31/1805 , B01J2231/643 , B01J2531/821 , B01J2531/822 , B01J2531/824 , B01J2531/827 , B01J2531/828 , B01J2531/842 , B01J2531/845 , B01J2531/847 , C07B2200/07 , C07C29/143 , C07C311/18 , C07C2602/10 , C07C33/46 , C07C33/22 , C07C35/32
摘要： A diamine of formula (I) is described in which A is hydrogen or a saturated or unsaturated C1-C20 alkyl group or an aryl group; B is a substituted or unsubstituted C1-C20 alkyl, cycloalkyl, alkaryl, alkaryl or aryl group or an alkylamino group and at least one of X1, X2, Y1, Y2 or Z is a C1-C10 alkyl, cycloalkyl, alkaryl, aralkyl or alkoxy substituting group. The chiral diamine may be used to prepare catalysts suitable for use in transfer hydrogenation reactions.
摘要翻译：描述了式（I）的二胺，其中A是氢或饱和或不饱和的C 1 -C 20烷基或芳基; B是取代或未取代的C 1 -C 20烷基，环烷基，烷芳基，烷芳基或芳基或烷基氨基，并且X 1，X 2，Y 1，Y 2或Z中的至少一个是C 1 -C 10烷基，环烷基，烷芳基，芳烷基或烷氧基取代基。手性二胺可用于制备适用于转移氢化反应的催化剂。

7. 发明申请

US20100184998A1 ORGANIC COMPOUNDS 审中-公开
标题翻译：有机化合物
公开(公告)号：US20100184998A1
公开(公告)日：2010-07-22
申请号：US12663998
申请日：2008-06-18
申请人： Beatriz Dominguez , Alan Dyke , William Hems , Christian Mathes , Anthony C. O'Sullivan , Gottfried Sedelmeier
发明人： Beatriz Dominguez , Alan Dyke , William Hems , Christian Mathes , Anthony C. O'Sullivan , Gottfried Sedelmeier
IPC分类号： C07C69/593 , C07C57/13 , C07D413/06 , C07C67/00 , C07D321/00
CPC分类号： C07C57/13 , C07C51/09 , C07C51/353 , C07C51/36 , C07C67/475 , C07C69/593 , C07C69/602 , C07D321/00
摘要： The present invention relates to olefin metathesis processes for the manufacture of a compound of the formula (I) which is a novel useful intermediate in the synthesis of pharmaceutically active compounds.
摘要翻译：本发明涉及用于制备式（I）化合物的烯烃复分解方法，其是合成药学活性化合物的新型有用中间体。

8. 发明授权

US07601867B2 Sulphonylated diphenylethylenediamines, method for their preparation and use in transfer hydrogenation catalysis 有权
公开(公告)号：US07601867B2
公开(公告)日：2009-10-13
申请号：US11719478
申请日：2005-11-01
申请人： Beatriz Dominguez , Antonio Zanotti-Gerosa , Gabriela Alexandra Grasa , Jonathan Alan Medlock
发明人： Beatriz Dominguez , Antonio Zanotti-Gerosa , Gabriela Alexandra Grasa , Jonathan Alan Medlock
IPC分类号： C07C311/21 , C07C311/16 , C07C311/03 , C07C303/38
摘要： A diamine of formula (I) is described, in which A is hydrogen or a saturated or unsaturated C1-C20 alkyl group or an aryl group; B is a substituted or unsubstituted C1-C20 alkyl, cycloalkyl, alkaryl, alkaryl or aryl group or an alkylamino group and at least one of X1, X2, Y1, Y2 or Z is a C1-C10 alkyl, cycloalkyl, alkaryl, aralkyl or alkoxy substituting group. The chiral diamine may be used to prepare catalysts suitable for use in transfer hydrogenation reactions.

9. 发明授权

US07456325B2 Process for the production of a hydroxyalkyne by coupling reaction between acetaldehyde and a terminal alkyne 失效
标题翻译：通过乙醛和末端炔之间的偶联反应制备羟基亚氨基的方法
公开(公告)号：US07456325B2
公开(公告)日：2008-11-25
申请号：US10553464
申请日：2004-04-15
申请人： Beatriz Dominguez
发明人： Beatriz Dominguez
IPC分类号： C07C33/044 , C07C33/046
CPC分类号： C07C29/42 , C07B2200/07 , C07C29/60 , C07C33/044 , C07C33/042
摘要： A process for performing, a coupling reaction between acetaldehyde and a terminal alkyne to yield a hydroxyalkyne is described comprising the steps of; (i) reacting without solvent, a terminal alkyne with a Lewis acidic metal salt in the presence of a alkanolamine ligand and a cyclic amine base to form a metal-alkyne complex, and (ii) adding a solution of acetaldehyde to the metal-alkyne complex.
摘要翻译：描述了进行乙醛和末端炔烃之间的偶联反应以产生羟基亚氨基的方法，其包括以下步骤：（i）在烷醇胺配位体和环状胺基存在下，在无溶剂的情况下使末端炔与路易斯酸性金属盐反应，形成金属 - 炔炔络合物，和（ii）向乙炔加入乙醛溶液复杂。

10. 发明授权

US06534545B1 Unsaturated derivatives at the 4-position of 6-tert-butyl-1,1-dimethylindane and their use in human and veterinary medicine and cosmetics 失效
标题翻译： 6-叔丁基-1,1-二甲基茚满的4-位不饱和衍生物及其在人兽药和化妆品中的应用
公开(公告)号：US06534545B1
公开(公告)日：2003-03-18
申请号：US09579441
申请日：2000-05-26
申请人： Angel De Lera , Beatriz Dominguez
发明人： Angel De Lera , Beatriz Dominguez
IPC分类号： A61K3119
CPC分类号： C07D333/38 , A61K8/31 , A61K8/362 , A61K8/37 , A61K8/4926 , A61K8/4973 , A61K8/4986 , A61Q7/00 , A61Q19/00 , A61Q19/004 , C07C57/50 , C07C63/66 , C07C69/618 , C07C69/76 , Y10S977/801 , Y10S977/905 , Y10S977/906 , Y10S977/915
摘要： 6-tert-Butyl-1,1-dimethylindane derivatives which are unsaturated in the 4-position of formula: X represents: (i) either a radical of formula: (a) and Y represents a radical of formula: (b) (ii) or a radical of formula: (c) and Y represents either a radical of formula (b) or a radical of formula: Z being —O—, —S— or R1 represents —CH3, —(CH2)p—OR4, —(CH2)p—COR5 or —S(O)t—R6, p being 0, 1, 2 or 3, t being 0, 1 or 2, R2 represents H or lower alkyl, R3 represents H, lower alkyl or —COR7, R4 represents H, lower alkyl, —COR7, aryl, aralkyl, mono- or polyhydroxyalkyl, or a polyether radical, R5 represents H, lower alkyl, —OR8 or —N(r′)(r″), R6 represents H or lower alkyl, R7 represents lower alkyl, R8 represents H, alkyl, alkenyl, alkynyl, aryl, aralkyl, mono- or polyhydroxyalkyl, a sugar residue or an amino acid residue, r′ and r″ represent H, lower alkyl, —COR7, aryl, a sugar residue or an amino acid residue or r′ and r″ form a heterocycle, and the salts of the compounds of formula (I). Use in the topical and systemic treatment of dermatological conditions, as well as in cosmetics.
摘要翻译：式中X表示不饱和的6-叔丁基-1,1-二甲基茚满衍生物：（i）式（a）的基团和Y表示式（b）的基团（ ii）或式（c）的基团，Y表示式（b）的基团或式Z的基团是-O - ， - S-或R 1表示-CH 3， - （CH 2）p -OR 4， - （CH 2）p-COR 5或-S（O）t -R 6，p为0,1,2或3，t为0,1或2，R 2表示H或低级烷基，R 3表示H，低级烷基或 - COR7，R4代表H，低级烷基，-COR7，芳基，芳烷基，单或多羟基烷基或聚醚基，R5代表H，低级烷基，-OR8或-N（r'）（r“），R6代表 H或低级烷基，R 7表示低级烷基，R 8表示H，烷基，烯基，炔基，芳基，芳烷基，单或多羟基烷基，糖残基或氨基酸残基，r'和r“表示H，低级烷基， -COR 7，芳基，糖残基或氨基酸残基或r'和r“形成杂环，和式（I）化合物的盐。使用皮肤病学的局部和全身治疗，以及化妆品。

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