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1. 发明专利

IL275585D0 Enantiomeric separation of racemic nicotine by addition of an o,o'-disubstituted tartaric acid enantiomer 未知
公开(公告)号：IL275585D0
公开(公告)日：2020-08-31
申请号：IL27558520
申请日：2020-06-22
申请人： SIEGFRIED AG , CONTRAF NICOTEX TOBACCO GMBH , BEAT WEBER , BEN PAN
发明人： BEAT WEBER , BEN PAN
IPC分类号： A61P25/34
摘要： The present invention relates to a method of separating racemic nicotine of Formula (1-a) as a mixture of the (R)- and (S)-enantiomers into the enantiomerically pure (S)- and (R)-nicotine represented by Formula (1-b) and (1-c), by adding a mixture of the L- and the D-enantiomer of a O,O′-disubstituted tartaric acid, wherein the molar ratio of the L- to the D-enantiomer is from 80:20 to 95:5, and obtaining the (S)-nicotine of formula (1-b), or by adding O,O′-dibenzoyl-D-tartaric acid and obtaining the (R)-nicotine of formula (1-c).

2. 发明专利

IL275584D0 Preparation of racemic nicotine by reaction of ethyl nicotinate with n-vinylpyrrolidone in the presence of an alcoholate base and subsequent process steps 未知
公开(公告)号：IL275584D0
公开(公告)日：2020-08-31
申请号：IL27558420
申请日：2020-06-22
申请人： SIEGFRIED AG , CONTRAF NICOTEX TOBACCO GMBH , BEAT WEBER , CHRISTIAN LOTHSCHUTZ , BEN PAN
发明人： BEAT WEBER , CHRISTIAN LOTHSCHUTZ , BEN PAN
IPC分类号： A61P25/34
摘要： The present invention relates to a method of preparing racemic nicotine comprising: (i) reacting ethyl nicotinate and N-vinylpyrrolidone in the presence of an alcoholate base to 3-nicotinoyl-1-vinylpyrrolidin-2-one; (ii) reacting the 3-nicotinoyl-1-vinylpyrrolidin-2-one with an acid to myosmine; (iii) reducing the myosmine to nornicotine using a reducing agent; and (iv) methylating the nornicotine to obtain the racemic nicotine.

3. 发明申请

US20090301238A1 Actuator having a reduction gear for a final controlling element for regulating a stream of gas or fluid 有权
标题翻译：执行器具有用于调节气体或流体流的最终控制元件的减速齿轮
公开(公告)号：US20090301238A1
公开(公告)日：2009-12-10
申请号：US12092540
申请日：2006-10-30
申请人： Christoph Wintsch , Beat Weber , Mario Fiorucci , Andi Furrer
发明人： Christoph Wintsch , Beat Weber , Mario Fiorucci , Andi Furrer
IPC分类号： F16H25/18 , G05G5/04
CPC分类号： F16H35/00 , F16H2035/006 , F16K31/535 , G05G1/10 , G05G5/04 , H02K7/116 , Y10T74/18808 , Y10T74/1967 , Y10T74/19684
摘要： The invention relates to an actuator (16) with a prestressed reduction gear (10), which acts via a drive organ (12), particularly in the form of a drive segment, of a linear drive or a drive spindle upon an actuator for regulating a gas or fluid flow, particularly in the fields of heating ventilation, air-conditioning and fire and smoke protection. The actuating movement is limited by end stops (34). At least one inner end stop (34) on the housing side limits the rotational freedom of an end wheel (32). which is in a positive fit with the drive organ (12), up to more than a full rotation. In a prestressed reduction gear (10), a switching device can comprise two spur gears (52, 54) which have identical diameter and can be driven in the opposite direction for changing the direction of movement of the drive organ (12), each of which have a pinion (50, 58) which can be displaced in the axial direction. Said pinions are in each axial position in a positive fit with the drive organ (12). One of the two pinions (50, 58), respectively, can be locked in a torque fixed manner with one of the two pinions (52, 54) having the same diameter.
摘要翻译：本发明涉及一种具有预应力减速齿轮（10）的致动器（16），该致动器（16）经由用于调节的致动器的直线驱动或驱动主轴的驱动部件（12），特别是驱动部件的形式气体或流体流动，特别是在加热通风，空调和防火和防烟的领域。致动运动受到止挡挡（34）的限制。壳体侧上的至少一个内端止动件（34）限制端轮（32）的旋转自由度。其与驱动器（12）正确配合，直至多于完全旋转。在预应力减速齿轮（10）中，开关装置可以包括两个具有相同直径的正齿轮（52,54），并且可以沿相反方向驱动以改变驱动器（12）的运动方向，其具有可沿轴向移位的小齿轮（50,58）。所述小齿轮处于与驱动器（12）正配合的每个轴向位置。两个小齿轮（50,58）中的一个分别可以以两个小齿轮（52,54）中的一个具有相同直径的方式以扭矩固定的方式被锁定。

4. 发明申请

US20090163711A1 Process of producing amorolfine base 审中-公开
标题翻译：生产黄曲霉碱基的过程
公开(公告)号：US20090163711A1
公开(公告)日：2009-06-25
申请号：US11795033
申请日：2006-07-27
申请人： Beat Weber , Stefan Rosenberger
发明人： Beat Weber , Stefan Rosenberger
IPC分类号： C07D265/30
CPC分类号： C07D295/03
摘要： An improved process of producing Amorolfine base, which is a compound of formula (I): said process including the steps of: (i) contacting a compound of formula (II): with a Friedel-Crafts catalyst at a temperature in the range of 20° to 30° C.; (ii) adding a 2-halogeno-2-methylbutane thereto, and wherein the reaction mixture obtained in step (i) is cooled to a temperature of from −40° to −60° C. prior to step (ii).
摘要翻译：一种改进的制备式（I）化合物的阿莫罗芬碱的方法：所述方法包括以下步骤：（i）使式（II）化合物与Friedel-Crafts催化剂在 20°至30°C。（ii）向其中加入2-卤代-2-甲基丁烷，并且其中将步骤（i）中获得的反应混合物在步骤（ii）之前冷却至-40℃至-60℃的温度。

5. 发明申请

US20070249660A1 Pharmacologically Acceptable Salts of Clopidogrel 审中-公开
标题翻译：氯吡格雷的药理学上可接受的盐
公开(公告)号：US20070249660A1
公开(公告)日：2007-10-25
申请号：US10590391
申请日：2005-02-16
申请人： Beat Weber , Michael Levis , Hon Ly
发明人： Beat Weber , Michael Levis , Hon Ly
IPC分类号： A61K31/4365 , C07D495/04
CPC分类号： C07D495/04
摘要： The invention relates to polymorphous forms of (+)-(S)-clopidogrel hydrogen bromide, described as polymorphous “form A”, polymorphous “form B”, polymorphous “form C”, polymorphous “form D”, polymorphous “form E”, and polymorphous “form F”, in addition to polymorphous forms of (+)-(S)-clopidogrel napsylate, that are described as polymorphous “form A” and polymorphous “form B” and differ in the X-ray powder diffraction diagrams (XRPD) thereof. The invention also relates to the salts clopidogrel besylate, clopidogrel tosylate and clopidogrel oxalate, and to methods for the production thereof.
摘要翻译：本发明涉及多形态的（+） - （S） - 氯吡格雷溴化氢，描述为多形态“形式A”，多形态“形式B”，多形态“形式C”，多形态“形式D”，多形态“形式E” ，和多形态“形式F”，以及被描述为多形态“形式A”和多形态“形式B”的（+） - （S） - 氯吡格雷萘磺酸盐的多形态，并且X射线粉末衍射图（XRPD）。本发明还涉及盐酸氯吡格雷苯磺酸盐，氯吡格雷甲苯磺酸盐和草酸氯吡格雷及其制备方法。

6. 发明申请

US20070021627A1 Process for the preparation of 1-[cyano(4-hydroxyphenyl)methyl]cyclohexanol compounds 审中-公开
标题翻译： 1- [氰基（4-羟基苯基）甲基]环己醇化合物的制备方法
公开(公告)号：US20070021627A1
公开(公告)日：2007-01-25
申请号：US11478154
申请日：2006-06-29
申请人： Frieder Mitzel , Beat Weber , Hans-Rudolf Marti , Richard Haldimann
发明人： Frieder Mitzel , Beat Weber , Hans-Rudolf Marti , Richard Haldimann
IPC分类号： C07C253/30
CPC分类号： C07C253/30 , C07C2601/14 , C07C255/36
摘要： Process for the preparation of I-[cyano(phenyl)methyl]cyclohexanol compounds of general formula (I): in which R1 is hydrogen, (C1-4)alkyl or (C1-4)alkoxy, wherein a compound of general formula (II): in which R1 is as defined above, is reacted with cyclohexanone, the reaction being carried out in the presence of an organic or inorganic base, and this organic or inorganic base being present in the reaction mixture in at least an equimolar amount, based on the amount of the compound of general formula (II).
摘要翻译：制备通式（I）的1- [氰基（苯基）甲基]环己醇化合物的方法：其中R 1是氢，（C 1-4）烷基或（C 1-4 - ）烷氧基，其中通式（II）的化合物（其中R 1如上定义）与环己酮反应，反应在有机或无机碱的存在下进行，并且该有机或无机碱以至少等摩尔量存在于反应混合物中，基于通式（II）的化合物的量。

7. 发明授权

US09548682B2 Actuator with electric motor and motor controller 有权
标题翻译：带电动机和电机控制器的执行机构
公开(公告)号：US09548682B2
公开(公告)日：2017-01-17
申请号：US14001416
申请日：2011-03-02
申请人： Paul F. Guyer , Atilla Beker , Beat Weber
发明人： Paul F. Guyer , Atilla Beker , Beat Weber
IPC分类号： H02P3/00 , G05B19/18 , B25J9/18 , H02P5/46 , G05B19/414
CPC分类号： H02P5/46 , G05B19/414 , G05B2219/42186 , G05B2219/42188
摘要： An actuator (1M, 1S) with a motor (12) and a motor controller (11) is configurable to operate as a master or a slave to another actuator which is coupled mechanically for driving a common load. For the case where the actuator (1M) is set as the master, the motor controller (11) receives on an input terminal (Y3) an external position control signal (pC), generates a motor control signal (sC) for controlling the motor (12) based on the position control signal (pC), and supplies the motor control signal (sC) to an output terminal (U5) for controlling a slave. For the case where the actuator (1S) is set as the slave, the motor controller (11) controls the motor (12) by supplying to the motor (12) the motor control signal (sC) received from the master. Controlling the actuators with a master improves workload balancing and reduces damages to transmission mechanics of the actuators.
摘要翻译：具有马达（12）和马达控制器（11）的致动器（1M，1S）可配置为作为主机或从机运行至另一个致动器，该致动器机械地联接以驱动公共负载。对于执行器（1M）设置为主机的情况，电动机控制器（11）在输入端子（Y3）上接收外部位置控制信号（pC），生成用于控制电动机的电动机控制信号（sC）（pC），并将电动机控制信号（sC）提供给用于控制从动装置的输出端子（U5）。对于执行器（1S）被设置为从站的情况，电动机控制器（11）通过向马达（12）提供从主机接收的电动机控制信号（sC）来控制电动机（12）。使用母盘控制执行器可提高工作负载平衡，并减少执行器传动机构的损坏。

8. 发明授权

US08921557B2 Preparation of low impurity opiates in a continuous flow reactor 有权
标题翻译：在连续流动反应器中制备低杂质鸦片剂
公开(公告)号：US08921557B2
公开(公告)日：2014-12-30
申请号：US13582334
申请日：2011-03-21
申请人： Beat Weber , Stefan Sahli
发明人： Beat Weber , Stefan Sahli
IPC分类号： C07D471/00 , C07D491/00 , C07D498/00 , C07D513/00 , C07D515/00 , C07D489/00 , C07D489/08
CPC分类号： C07D489/08
摘要： The present invention relates to a novel process for preparing opiates or salts thereof. More particularly, the present invention relates to oxidizing the starting material in a continuous flow reactor, followed by either an isolation of the intermediate, or a direct reduction reaction.
摘要翻译：本发明涉及一种制备阿片剂或其盐的新方法。更具体地说，本发明涉及在连续流动反应器中氧化原料，随后分离中间体或直接还原反应。

9. 发明申请

US20100311967A1 PRODUCTION OF BEPROMOLINE 有权
标题翻译：生产苯酚
公开(公告)号：US20100311967A1
公开(公告)日：2010-12-09
申请号：US12858273
申请日：2010-08-17
申请人： Beat Weber , Stefan Rosenberger
发明人： Beat Weber , Stefan Rosenberger
IPC分类号： C07D265/30
CPC分类号： C07D295/023 , C07D295/03
摘要： A process for the preparation of a compound of formula (Ib): including contacting a compound of formula (Ia): with toluene and HCl gas to provide the compound of formula (Ib).
摘要翻译：制备式（Ib）化合物的方法：包括使式（Ia）化合物与甲苯和HCl气体接触以提供式（Ib）化合物。

10. 发明申请

US20080269483A1 Production of bepromoline 有权
标题翻译：生产甲基溴
公开(公告)号：US20080269483A1
公开(公告)日：2008-10-30
申请号：US12010635
申请日：2008-01-28
申请人： Beat Weber , Stefan Rosenberger
发明人： Beat Weber , Stefan Rosenberger
IPC分类号： C07D265/30
CPC分类号： C07D295/023 , C07D295/03
摘要： A process for the preparation of a compound of formula (Ia): includes: (i) contacting a compound of formula (III): with a compound of formula (IV): in the presence of a palladium catalyst, methanol and hydrogen gas, the step (i) preferably being conducted under basic conditions with acetic acid being added to the medium of reaction once the consumption of the hydrogen gas has ceased.
摘要翻译：制备式（Ia）化合物的方法包括：（i）使式（III）化合物与式（IV）化合物在钯催化剂，甲醇和氢气存在下接触，步骤（i）优选在碱性条件下进行，一旦氢气的消耗停止，将乙酸加入到反应介质中。

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