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1. 发明申请

WO1990003433A1 VACCINE 审中-公开
标题翻译：疫苗
公开(公告)号：WO1990003433A1
公开(公告)日：1990-04-05
申请号：PCT/AU1989000416
申请日：1989-09-26
申请人： BIOTECHNOLOGY AUSTRALIA PTY. LTD. , COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ... , DOPHEIDE, Theodorus, Antonius, Aloisius , FRENKEL, Maurice, Joseph , GRANT, Warwick, Norman , SAVIN, Keith, William , WAGLAND, Barry, Maxwell
发明人： BIOTECHNOLOGY AUSTRALIA PTY. LTD. , COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ...
IPC分类号： C12N15/00
CPC分类号： C07K16/20 , A61K38/00 , A61K39/00 , C07K14/245 , C07K14/4354 , C07K2319/00 , C07K2319/035 , C07K2319/40 , Y02A50/421
摘要： The invention provides excretory/secretory antigens derived from parasitic nematode species which are capable of inducing protective immunity against infection by parasitic nematode species, and related antigenic molecules. The invention also provides nucleotide sequences encoding the antigens and related molecules of the invention, recombinant DNA molecules comprising the nucleotide sequences, and transformed hosts carrying the recombinant DNA molecules. The invention further provides antibodies against the antigens and related molecules, and antibody compositions comprising the antibodies, vaccines comprising the antigens and/or related molecules and methods of treating or preventing nematode infections using the antigens and related molecules, vaccines, antibodies and/or antibody compositions of the invention.
摘要翻译：本发明提供了能够诱导针对寄生线虫物种和相关抗原分子感染的保护性免疫的来自寄生线虫种的排泄/分泌抗原。本发明还提供编码本发明的抗原和相关分子的核苷酸序列，包含核苷酸序列的重组DNA分子和携带重组DNA分子的转化宿主。本发明还提供了针对抗原和相关分子的抗体，以及包含抗体的抗体组合物，包含抗原和/或相关分子的疫苗以及使用抗原和相关分子，疫苗，抗体和/或抗体治疗或预防线虫感染的方法本发明的组合物。

2. 发明申请

WO1989000163A1 VACCINES AGAINST ANIMAL PARASITIC NEMATODES 审中-公开
标题翻译：野生动物杀虫剂疫苗
公开(公告)号：WO1989000163A1
公开(公告)日：1989-01-12
申请号：PCT/AU1988000239
申请日：1988-07-06
申请人： BIOTECHNOLOGY AUSTRALIA PTY. LTD. , COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ... , COBON, Gary, Stewart , AUSTEN, Rosemary, Ann , O'DONNELL, Ian, Joseph , FRENKEL, Maurice, Joseph , KENNEDY, William, Peter, Keith , SAVIN, Keith, William , WAGLAND, Barry, Maxwell
发明人： BIOTECHNOLOGY AUSTRALIA PTY. LTD. , COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ...
IPC分类号： C07G17/00
CPC分类号： C07K14/4354 , A61K39/00 , A61K39/0003 , C07K16/18 , Y02A50/421
摘要： The invention relates to proteins derived from parasitic nematodes which confer protective immunity aginst infection by parasitic nematodes, to nucleotide sequences encoding these proteins, to recombinant molecules containing such sequences to host cells transformed with such recombinant molecules and methods for the production of the nucleotide sequences recombinant molecules and hosts. The invention also relates to vaccines comprising proteins of the invention together with suitable carriers or diluents and to antibodies raised against proteins of the invention.
摘要翻译：本发明涉及从寄生线虫产生的蛋白质，其通过寄生线虫赋予保护性免疫原性，编码这些蛋白质的核苷酸序列，含有这样的序列的重组分子，以宿主用这种重组分子转化的细胞和用于产生核苷酸序列重组的方法分子和宿主。本发明还涉及包含本发明的蛋白质与合适的载体或稀释剂以及针对蛋白质产生的抗体的疫苗。

3. 发明申请

WO2010006360A1 PROTECTOR MEMBER FOR LIQUID IN A CONTAINER 审中-公开
标题翻译：液体容器中的保护构件
公开(公告)号：WO2010006360A1
公开(公告)日：2010-01-21
申请号：PCT/AU2009/000888
申请日：2009-07-10
申请人： CREATED BY "BRAINWAVE" PTY LTD , REES, Barry Maxwell
发明人： REES, Barry Maxwell
IPC分类号： B65D39/02 , B65D25/08 , B65D25/02 , B65D81/24
CPC分类号： B65D81/245
摘要： The specification discloses a protector member (10) capable of being introduced through a neck region (25) of an opened wine bottle (26) by being flexibly deformable, the protector member (10) being flexibly deformable to a condition enabling introduction through the wine bottle neck region (25) and once within the wine bottle (26) being expandable to a use condition where an outer peripheral edge (15, 62) of the protector member (10) is positioned adjacent to or against an inner surface of the wine bottle (26) while floating on a surface of wine held within the wine bottle (26), the protector member (10) being characterized by being either a multipart construction including a first flexible sheet (11, 19) material containing in a first zone (14) a plurality of individually sealed spaces (22) each having a volume and at least some of which contain a gas, and a second flexible sheet material (12, 19), one or both of the first or second flexible sheet materials having a radially outer edge (15) forming the outer peripheral edge of the protector member (10) extending radially beyond the first zone (14); or by being a continuous sheet member, the continuous sheet member (60) being composed of a cork or cork based material such as granulated cork bonded to form said sheet member (60); the protector member (10) being substantially liquid wine and gas impervious; the specification also discloses a device (27, 30) for introducing a protector member (10) a£ aforesaid into a wine bottle (26) the device (27, 30) having an outer flexible container (27) holding a said protector member (10) therein, the outer flexible container (27) being open or openable along at least a portion of two opposed edge regions (28, 29), the device (27, 30) further including a delivery member (30) capable of engaging and rolling the protector member (10) on itself within the outer flexible container (27) and to then insert the rolled protector member (10) through the wine bottle neck region (25) passing beyond one of said two opposed edge regions (28, 29) of the outer flexible container (27).
摘要翻译：本说明书公开了一种保护构件（10），其能够通过柔性可变形地通过打开的酒瓶（26）的颈部区域（25）引入，保护构件（10）可灵活地变形为能够通过葡萄酒引入的状态瓶颈区域（25），并且一次在酒瓶（26）内可膨胀到保护构件（10）的外周边缘（15,62）邻近或抵靠葡萄酒内表面定位的使用条件瓶子（26）在漂浮在酒瓶（26）内的葡萄酒表面上时，保护器件（10）的特征在于包括第一柔性片材（11,19）的多部分结构，（14）多个单独密封的空间（22），每个具有体积并且其中至少一些包含气体;以及第二柔性片材（12,19），所述第一或第二柔性片材中的一个或两个具有径向外侧形成保护器构件（10）的外周缘径向延伸超过第一区（14）的ge（15）。或通过作为连续的片状构件，所述连续片材构件（60）由软木或软木基材料构成，所述软木或软木基材料例如结合以形成所述片状构件（60）的颗粒状软木; 保护器构件（10）基本上是液体葡萄酒和气体不可渗透的; 该说明书还公开了一种用于将具有前述保护器构件（10）引入酒瓶（26）的装置（27,30），该装置具有容纳保护构件的外部柔性容器（27）所述外部柔性容器（27）沿着两个相对的边缘区域（28,29）的至少一部分是敞开的或可打开的，所述装置（27,30）还包括能够啮合的输送构件（30）在外部柔性容器（27）内滚动保护构件（10），然后将经过滚动的保护构件（10）插入穿过所述两个相对的边缘区域（28,29）之一的葡萄酒瓶颈部区域）的外柔性容器（27）。

4. 发明申请

WO1992013889A1 NEMATODE VACCINE 审中-公开
公开(公告)号：WO1992013889A1
公开(公告)日：1992-08-20
申请号：PCT/AU1992000040
申请日：1992-02-06
申请人： BIOTECH AUSTRALIA PTY. LIMITED , COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ... , SHARP, Phillip, John , WAGLAND, Barry, Maxwell , COBON, Gary, Stewart
发明人： BIOTECH AUSTRALIA PTY. LIMITED , COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ...
IPC分类号： C07K15/08
CPC分类号： C07K14/4354 , A61K38/00 , Y10S530/822
摘要： A substantially purified antigen derived from a first species of parasitic nematodes, which antigen is capable of providing protection to a host from parasitism by a second nematode species, which may be the same as or different from the first nematode species, following vaccination of the host with the antigen, characterized in that the antigen is proteinaceous, has a pI between 3.8 and 4.4, can be bound by lentil lectin and Helix promatia lectin and has a molecular weight of approximately 45 kD as determined by SDS-PAGE.
摘要翻译：来自第一种寄生线虫的基本上纯化的抗原，该抗原能够在宿主接种后能够向第二种线虫种类提供保护，第二种线虫可能与第一种线虫种类相同或不同其特征在于抗原蛋白质，具有3.8至4.4之间的pI，可以被扁豆凝集素和Helix promatia凝集素结合，并且通过SDS-PAGE测定具有约45kD的分子量。

5. 发明申请

WO1988000841A1 EXPANSIBLE CHAMBER DRUG INFUSER SYSTEM 审中-公开
标题翻译：可膨胀的室内药物输液系统
公开(公告)号：WO1988000841A1
公开(公告)日：1988-02-11
申请号：PCT/AU1987000255
申请日：1987-08-10
申请人： KEOGH, Edward, John , EALING, George, Henry , OLNEY, Barry, Maxwell , O'NEIL, Alexander, George, Brian
IPC分类号： A61M05/14
CPC分类号： A61M5/152
摘要： A pump suitable for the infusion of medicines comprises a elastic reservoir (1) adapted to contain medicines with an outlet controlled by a valve (7, 8). The pump utilizes the energy stored in the walls of the inflated reservoir to discharge the medicine from the reservoir. Preferably the valve is controlled by a programmable electronic timer (10) to regulate the flow of the medicine.
摘要翻译：适于输注药物的泵包括适于容纳具有由阀（7,8）控制的出口的药物的弹性储存器（1）。泵利用储存在膨胀的储存器的壁中的能量将药物从储存器排出。优选地，阀由可编程电子计时器（10）控制以调节药物的流动。

6. 发明申请

WO2006063389A1 WINE PROTECTOR DEVICE 审中-公开
标题翻译：葡萄酒保护装置
公开(公告)号：WO2006063389A1
公开(公告)日：2006-06-22
申请号：PCT/AU2005/001875
申请日：2005-12-12
申请人： REES, Barry, Maxwell , McKENZIE, Malcolm
发明人： REES, Barry, Maxwell , McKENZIE, Malcolm
IPC分类号： B65D39/02
CPC分类号： B65D81/245
摘要： The specification discloses a device (10) insertable into a wine bottle (12) after opening, the device (10) being intended to float on the surface (21) of wine remaining in the bottle (12) and minimize deterioration of the remaining wine, said device (10) including a core structure (11) having a thin spring plate (11a) capable of being deformed when the device (10) is inserted into the bottle (12) and capable of recovering its shape once inserted into the bottle (12), the core structure (11 ) further having at least one floatation means (11 b) and said device (10) including a liquid impervious outer sheath (18) having upper and lower walls (14, 15) sealed to one another to retain the core structure (11) therein, the outer sheath (18) being of a material that is non reactive with wine and including a flexible outer peripheral edge zone (42) with cuts or the like (49) formed therein, the outer peripheral edge zone (42) being adapted, in use, to contact the internal surfaces of the wine bottle (12) while floating on wine remaining in the bottle (12).
摘要翻译：该说明书公开了一种在打开后能够插入葡萄酒瓶（12）中的装置（10），该装置（10）旨在漂浮在剩余在瓶子（12）中的葡萄酒的表面（21）上并使剩余的葡萄酒的劣化最小化，所述装置（10）包括具有当所述装置（10）插入所述瓶子（12）中时能够变形并且能够在插入所述瓶子中时恢复其形状的薄弹簧板（11a）的芯结构（11）（12），所述芯结构（11）还具有至少一个浮选装置（11b），并且所述装置（10）包括具有彼此密封的上壁和下壁（14,15）的不透液体的外护套（18）为了将芯结构（11）保持在其中，外护套（18）由不与葡萄酒反应的材料构成，并且包括具有形成在其中的切口等的柔性外周缘区域（42），外护套外围边缘区域（42）在使用中适于接触葡萄酒b的内部表面（12），同时漂浮在瓶子里的葡萄酒上（12）。

7. 发明申请

WO1992013890A1 NEMATODE VACCINE 审中-公开
公开(公告)号：WO1992013890A1
公开(公告)日：1992-08-20
申请号：PCT/AU1992000041
申请日：1992-02-06
申请人： BIOTECH AUSTRALIA PTY LIMITED , COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ... , SHARP, Phillip, John , WAGLAND, Barry, Maxwell
发明人： BIOTECH AUSTRALIA PTY LIMITED , COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ...
IPC分类号： C07K15/08
CPC分类号： C07K16/18 , A61K39/00 , C07K14/4354 , C12N2799/026
摘要： A substantially purified antigen derived from a first parasitic nematode species which, when administered to a host animal, is capable of protecting the host animal from infestation by a second parasitic nematode species, wherein the first and second parasitic nematode species may be the same or different, and the antigen has an apparent molecular weight of 40 kD as determined by SDS-PAGE under reducing conditions.
摘要翻译：一种基本上纯化的抗原，其来源于第一寄生线虫物种，其在施用于宿主动物时能够通过第二寄生线虫种保护宿主动物免于侵染，其中第一和第二寄生线虫物种可以相同或不同，并且抗原在还原条件下通过SDS-PAGE测定具有40kD的表观分子量。

8. 发明申请

US20120179086A1 ANCHORS WITH OPEN HEADS 有权
标题翻译：带开头的锚杆
公开(公告)号：US20120179086A1
公开(公告)日：2012-07-12
申请号：US13394975
申请日：2010-09-10
申请人： Peter Shank , David A. Melanson , Barry Maxwell , Sean K. Holmes , James Loper , Ian K. Parker , Andy H. Levine
发明人： Peter Shank , David A. Melanson , Barry Maxwell , Sean K. Holmes , James Loper , Ian K. Parker , Andy H. Levine
IPC分类号： A61F2/04
CPC分类号： A61F2/04 , A61F2/2409 , A61F2/848 , A61F5/0076 , A61F5/0089 , A61F2002/045 , A61F2002/8483 , A61F2220/0008 , A61F2220/0016 , A61F2230/0091 , A61F2250/0031
摘要： An implant (100) includes a protrusion (110) with an open or rounded loop (112) (or open head) connected to a collapsible anchor. The protrusion may include a straight length of wire (114) or a helical length wire, with one or more wire loops (112) at the end of the length forming the loop. Upon deployment within the gastrointestinal tract, the protrusion expands from a collapsed state, alongside the anchor, to a relaxed state, in which the protrusion extends outward from the anchor. As the protrusion expands to its relaxed state, it pushes the loop into the wall of the duodenum, causing the loop to penetrate the duodenal wall. A pocket of scar tissue forms about the head and possibly through an opening in the head, securing the anchor within the duodenum. The implant may also include a thin-walled sleeve that is coupled to the anchor and extended from the anchor into the intestine.
摘要翻译：植入物（100）包括具有连接到可折叠锚的开放或圆形回路（112）（或开放头）的突起（110）。突起可以包括直线长度的线（114）或螺旋长度线，其中一个或多个线环（112）在长度的端部形成环。在胃肠道内展开时，突起从锚固体的折叠状态膨胀到松弛状态，其中突起从锚向外延伸。当突起膨胀到其松弛状态时，它将环推入十二指肠的壁中，导致环穿透十二指肠壁。疤痕组织的口袋形成在头部周围并且可能通过头部中的开口，将锚固件固定在十二指肠内。植入物还可以包括薄壁套筒，其耦合到锚固件并从锚固件延伸到肠中。

9. 发明申请

US20110185922A1 PROTECTOR MEMBER FOR LIQUID IN A CONTAINER 审中-公开
公开(公告)号：US20110185922A1
公开(公告)日：2011-08-04
申请号：US13003622
申请日：2009-07-10
申请人： Barry Maxwell Rees
发明人： Barry Maxwell Rees
IPC分类号： C12H1/00
CPC分类号： B65D81/245
摘要： The specification discloses a protector member (10) capable of being introduced through a neck region (25) of an opened wine bottle (26) by being flexibly deformable, the protector member (10) being flexibly deformable to a condition enabling introduction through the wine bottle neck region (25) and once within the wine bottle (26) being expandable to a use condition where an outer peripheral edge (15, 62) of the protector member (10) is positioned adjacent to or against an inner surface of the wine bottle (26) while floating on a surface of wine held within the wine bottle (26), the protector member (10) being characterized by being either a multipart construction including a first flexible sheet (11, 19) material containing in a first zone (14) a plurality of individually sealed spaces (22) each having a volume and at least some of which contain a gas, and a second flexible sheet material (12, 19), one or both of the first or second flexible sheet materials having a radially outer edge (15) forming the outer peripheral edge of the protector member (10) extending radially beyond the first zone (14); or by being a continuous sheet member, the continuous sheet member (60) being composed of a cork or cork based material such as granulated cork bonded to form said sheet member (60); the protector member (10) being substantially liquid wine and gas impervious; the specification also discloses a device (27, 30) for introducing a protector member (10) as aforesaid into a wine bottle (26) the device (27, 30) having an outer flexible container (27) holding a said protector member (10) therein, the outer flexible container (27) being open or openable along at least a portion of two opposed edge regions (28, 29), the device (27, 30) further including a delivery member (30) capable of engaging and rolling the protector member (10) on itself within the outer flexible container (27) and to then insert the rolled protector member (10) through the wine bottle neck region (25) passing beyond one of said two opposed edge regions (28, 29) of the outer flexible container (27).

10. 发明申请

US20100305590A1 Transpyloric Anchoring 审中-公开
标题翻译：透视锚
公开(公告)号：US20100305590A1
公开(公告)日：2010-12-02
申请号：US12787531
申请日：2010-05-26
申请人： Sean K. Holmes , Barry Maxwell , Ezra S. Fishman
发明人： Sean K. Holmes , Barry Maxwell , Ezra S. Fishman
IPC分类号： A61B17/00
CPC分类号： A61F5/0076 , A61B17/11 , A61B17/1114 , A61B2017/00849 , A61B2017/0641 , A61F5/0079
摘要： Gastrointestinal implants can be used to secure thin-walled sleeves, restrictor plates, and other devices within the gastrointestinal tract. An example implant includes three elements: a stomach anchor to resist distally oriented forces; a duodenal anchor to resist proximally oriented forces; and a connector element to keep the stomach anchor fixed relative to the stomach anchor. The implant is inserted into the gastrointestinal tract with a delivery device that holds the implant in a compressed state for minimally invasive delivery until the implant is positioned properly. Upon releasing from the delivery device, the implant expands to a relaxed state across the pylorus, allowing prongs that extending outward from the stomach and duodenal anchors to engage tissue in the gastrointestinal tract. The deployed implant may also include a thin-walled sleeve that extends into the intestine from the stomach anchor, duodenal anchor, or connector element.
摘要翻译：胃肠道植入物可用于固定胃肠道内的薄壁袖子，限制器板和其他装置。示例性植入物包括三个元件：胃锚以抵抗远端取向的力; 十二指肠锚抵抗近端取向的力量; 以及用于保持胃锚固件相对于胃锚的连接器元件。植入物通过输送装置插入胃肠道中，该输送装置将植入物保持在压缩状态以进行微创递送，直到植入物被适当地定位。当从输送装置释放时，植入物通过幽门扩张到松弛状态，允许从胃和十二指肠锚定体向外延伸的插管接合胃肠道中的组织。部署的植入物还可以包括从胃锚，十二指肠锚或连接器元件延伸到肠内的薄壁套管。

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