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1. 发明申请

US20090048228A1 Heterocycle Derivatives As Histone Deacetylase (Hdac) Inhibitors 有权
标题翻译：杂环衍生物作为组蛋白脱乙酰酶（Hdac）抑制剂
公开(公告)号：US20090048228A1
公开(公告)日：2009-02-19
申请号：US11792294
申请日：2005-12-09
申请人： Barbara Attenni , Federica Ferrigno , Philip Jones , Raffaele Ingenito , Olaf Kinzel , Laura Llauger Bufi , Jesus Maria Ontoria , Giovanna Pescatore , Michael Rowley , Rita Scarpelli , Carsten Schultz
发明人： Barbara Attenni , Federica Ferrigno , Philip Jones , Raffaele Ingenito , Olaf Kinzel , Laura Llauger Bufi , Jesus Maria Ontoria , Giovanna Pescatore , Michael Rowley , Rita Scarpelli , Carsten Schultz
IPC分类号： A61K31/397 , C07D401/02 , A61K31/454 , A61K31/4164 , C07D233/61 , A61K31/4178 , A61P35/00 , A61K31/496 , C07D403/02 , C07D277/02 , A61K31/427 , A61K31/422 , C07D413/02 , C07D401/14 , A61K31/4545 , A61K31/506 , A61P25/28 , A61P25/18 , A61K31/498 , C07D241/36 , C07D215/00 , A61K31/5377 , C07D413/14 , C07D249/08 , A61K31/4196 , A61K31/4245 , C07D417/02 , A61K31/433 , A61K31/541 , C07D417/14
CPC分类号： C07D405/12 , C07D231/10 , C07D403/12 , C07D413/12 , C07D417/12
摘要： The present invention relates to compounds of formula I: or pharmaceutically acceptable salts or tautomers thereof, which are inhibitors of histone deacetylase (HDAC). The compounds of the present invention are useful for treating cellular proliferative diseases, including cancer. Further, the compounds of the present invention are useful for treating neurodegenerative diseases, schizophrenia and stroke among other diseases.
摘要翻译：本发明涉及式I化合物或其药学上可接受的盐或互变异构体，其是组蛋白脱乙酰酶（HDAC）的抑制剂。本发明的化合物可用于治疗包括癌症在内的细胞增殖性疾病。此外，本发明的化合物可用于治疗神经变性疾病，精神分裂症和中风等疾病。

2. 发明申请

US20090036443A1 Thienopyrroles as antiviral agents 失效
标题翻译：噻吩吡咯作为抗病毒剂
公开(公告)号：US20090036443A1
公开(公告)日：2009-02-05
申请号：US10571234
申请日：2004-09-07
申请人： Barbara Attenni , Jose Ignacio Martin Hernando , Savina Malancona , Frank Narjes , Jesus Maria Ontoria Ontaria , Michael Rowley
发明人： Barbara Attenni , Jose Ignacio Martin Hernando , Savina Malancona , Frank Narjes , Jesus Maria Ontoria Ontaria , Michael Rowley
IPC分类号： A61K31/5377 , C07D495/04 , A61P31/12 , A61K31/407
CPC分类号： C07D495/04
摘要： The present invention relates to thienopyrrole compounds of formula (I); wherein A, B, Y, Ar, n, Z and X1 are as defined herein, and pharmaceutically acceptable salts thereof, useful in the prevention and treatment of hepatitis C infections.
摘要翻译：本发明涉及式（I）的噻吩并吡咯化合物; 其中A，B，Y，Ar，n，Z和X1如本文所定义，及其药学上可接受的盐，其可用于预防和治疗丙型肝炎感染。

3. 发明授权

US08071568B2 Nucleoside aryl phosphoramidates for the treatment of RNA-dependent RNA viral infection 有权
标题翻译：用于治疗RNA依赖性RNA病毒感染的核苷芳基氨基磷酸酯
公开(公告)号：US08071568B2
公开(公告)日：2011-12-06
申请号：US12520738
申请日：2007-12-28
申请人： Frank Narjes , Cristina Gardelli , Monica Donghi , Barbara Attenni , Philippe L. Durette
发明人： Frank Narjes , Cristina Gardelli , Monica Donghi , Barbara Attenni , Philippe L. Durette
IPC分类号： A61K31/70 , C07H19/10
CPC分类号： C07H19/04 , C07H19/048 , C07H19/10 , C07H19/20
摘要： The present invention provides nucleoside aryl phosphoramidates of structural formula (I) which are precursors to inhibitors of RNA-dependent RNA viral polymerase. These compounds are precursors to inhibitors of RNA-dependent RNA viral replication and are useful for the treatment of RNA-dependent RNA viral infection. They are particularly useful as precursors to inhibitors of hepatitis C virus (HCV) NS5B polymerase, as precursors to inhibitors of HCV replication, and/or for the treatment of hepatitis C infection. The invention also describes pharmaceutical compositions containing such nucleoside aryl phosphoramidates alone or in combination with other agents active against RNA-dependent RNA viral infection, in particular HCV infection. Also disclosed are methods of inhibiting RNA-dependent RNA polymerase, inhibiting RNA-dependent RNA viral replication, and/or treating RNA-dependent RNA viral infection with the nucleoside aryl phosphoramidates of the present invention. (I)
摘要翻译：本发明提供结构式（I）的核苷芳基氨基磷酸酯，其是RNA依赖性RNA病毒聚合酶抑制剂的前体。这些化合物是RNA依赖性RNA病毒复制抑制剂的前体，可用于治疗RNA依赖性RNA病毒感染。它们特别可用作丙型肝炎病毒（HCV）NS5B聚合酶抑制剂的前体，作为HCV复制抑制剂的前体和/或治疗丙型肝炎感染。本发明还描述了单独或与其它对RNA依赖性RNA病毒感染，特别是HCV感染有活性的试剂组合的含有这种核苷芳基氨基磷酸酯的药物组合物。还公开了本发明的核苷芳基氨基磷酸酯抑制RNA依赖性RNA聚合酶，抑制RNA依赖性RNA病毒复制和/或治疗RNA依赖性RNA病毒感染的方法。（一世）

4. 发明授权

US07781431B2 Thienopyrroles as antiviral agents 失效
标题翻译：噻吩吡咯作为抗病毒剂
公开(公告)号：US07781431B2
公开(公告)日：2010-08-24
申请号：US10571234
申请日：2004-09-07
申请人： Barbara Attenni , Jose Ignacio Martin Hernando , Savina Malancona , Frank Narjes , Jesus Maria Ontoria Ontoria , Michael Rowley
发明人： Barbara Attenni , Jose Ignacio Martin Hernando , Savina Malancona , Frank Narjes , Jesus Maria Ontoria Ontoria , Michael Rowley
IPC分类号： C07D411/06 , C07D413/06 , C07D413/14 , C07D409/12 , C07D409/06 , C07D417/04 , C07D417/12 , C07D417/06 , C07D409/04 , C07D333/78 , A61K31/5377 , A61K31/496 , A61K31/4436 , A61K31/4439 , A61K31/4535 , A61K31/454 , A61K31/4155 , A61K31/4178 , A61K31/4196 , A61K31/422 , A61K31/433 , A61K31/407
CPC分类号： C07D495/04
摘要： The present invention relates to thienopyrrole compounds of formula (I); wherein A, B, Y, Ar, n, Z and X1 are as defined herein, and pharmaceutically acceptable salts thereof, useful in the prevention and treatment of hepatitis C infections.
摘要翻译：本发明涉及式（I）的噻吩并吡咯化合物; 其中A，B，Y，Ar，n，Z和X1如本文所定义，及其药学上可接受的盐，其可用于预防和治疗丙型肝炎感染。

5. 发明申请

US20100035835A1 NUCLEOSIDE ARYL PHOSPHORAMIDATES FOR THE TREATMENT OF RNA-DEPENDENT RNA VIRAL INFECTION 有权
标题翻译：用于治疗RNA依赖性RNA病毒感染的核苷类ARYL磷酸酯
公开(公告)号：US20100035835A1
公开(公告)日：2010-02-11
申请号：US12520738
申请日：2007-12-28
申请人： Frank Narjes , Cristina Gardelli , Monica Donghi , Barbara Attenni , Philippe L. Durette
发明人： Frank Narjes , Cristina Gardelli , Monica Donghi , Barbara Attenni , Philippe L. Durette
IPC分类号： A61K31/7068 , C07H19/10 , A61P31/00
CPC分类号： C07H19/04 , C07H19/048 , C07H19/10 , C07H19/20
摘要： The present invention provides nucleoside aryl phosphoramidates of structural formula (I) which are precursors to inhibitors of RNA-dependent RNA viral polymerase. These compounds are precursors to inhibitors of RNA-dependent RNA viral replication and are useful for the treatment of RNA-dependent RNA viral infection. They are particularly useful as precursors to inhibitors of hepatitis C virus (HCV) NS5B polymerase, as precursors to inhibitors of HCV replication, and/or for the treatment of hepatitis C infection. The invention also describes pharmaceutical compositions containing such nucleoside aryl phosphoramidates alone or in combination with other agents active against RNA-dependent RNA viral infection, in particular HCV infection. Also disclosed are methods of inhibiting RNA-dependent RNA polymerase, inhibiting RNA-dependent RNA viral replication, and/or treating RNA-dependent RNA viral infection with the nucleoside aryl phosphoramidates of the present invention.
摘要翻译：本发明提供结构式（I）的核苷芳基氨基磷酸酯，其是RNA依赖性RNA病毒聚合酶抑制剂的前体。这些化合物是RNA依赖性RNA病毒复制抑制剂的前体，可用于治疗RNA依赖性RNA病毒感染。它们特别可用作丙型肝炎病毒（HCV）NS5B聚合酶抑制剂的前体，作为HCV复制抑制剂的前体和/或治疗丙型肝炎感染。本发明还描述了单独或与其它对RNA依赖性RNA病毒感染，特别是HCV感染有活性的试剂组合的含有这种核苷芳基氨基磷酸酯的药物组合物。还公开了本发明的核苷芳基氨基磷酸酯抑制RNA依赖性RNA聚合酶，抑制RNA依赖性RNA病毒复制和/或治疗RNA依赖性RNA病毒感染的方法。

6. 发明授权

US07863294B2 Heterocycle derivatives as histone deacetylase (HDAC) inhibitors 有权
标题翻译：杂环衍生物作为组蛋白脱乙酰酶（HDAC）抑制剂
公开(公告)号：US07863294B2
公开(公告)日：2011-01-04
申请号：US11792294
申请日：2005-12-09
申请人： Barbara Attenni , Federica Ferrigno , Philip Jones , Raffaele Ingenito , Olaf Kinzel , Laura Llauger Bufi , Jesus Maria Ontoria , Giovanna Pescatore , Michael Rowley , Rita Scarpelli , Carsten Schultz
发明人： Barbara Attenni , Federica Ferrigno , Philip Jones , Raffaele Ingenito , Olaf Kinzel , Laura Llauger Bufi , Jesus Maria Ontoria , Giovanna Pescatore , Michael Rowley , Rita Scarpelli , Carsten Schultz
IPC分类号： A61K31/4709 , C07D215/227
CPC分类号： C07D405/12 , C07D231/10 , C07D403/12 , C07D413/12 , C07D417/12
摘要： The present invention relates to compounds of formula I: or pharmaceutically acceptable salts or tautomers thereof, which are inhibitors of histone deacetylase (HDAC). The compounds of the present invention are useful for treating cellular proliferative diseases, including cancer. Further, the compounds of the present invention are useful for treating neurodegenerative diseases, schizophrenia and stroke among other diseases.
摘要翻译：本发明涉及式I化合物或其药学上可接受的盐或互变异构体，其是组蛋白脱乙酰酶（HDAC）的抑制剂。本发明的化合物可用于治疗包括癌症在内的细胞增殖性疾病。此外，本发明的化合物可用于治疗神经变性疾病，精神分裂症和中风等疾病。

7. 发明申请

US20100152128A1 Antiviral Agents 审中-公开
标题翻译：抗病毒药物
公开(公告)号：US20100152128A1
公开(公告)日：2010-06-17
申请号：US12601002
申请日：2008-05-19
申请人： Barbara Attenni , Monica Donghi , Cristina Gardelli , Malte Meppen , Frank Narjes , Barbara Pacini
发明人： Barbara Attenni , Monica Donghi , Cristina Gardelli , Malte Meppen , Frank Narjes , Barbara Pacini
IPC分类号： A61K31/7068 , C07H19/10 , C07H19/14 , A61P31/12 , A61P31/14
CPC分类号： C07H19/10 , A61K31/706 , A61K31/7064 , A61K31/7076 , C07H19/04 , C07H19/20
摘要： A compound of formula (I) and pharmaceutically acceptable salts thereof; compositions containing it and its use in medicine, particularly for the treatment or inhibition of HCV infections, and processes for making it are disclosed.
摘要翻译：式（I）化合物及其药学上可接受的盐; 公开了含有它的组合物及其在药物中的用途，特别是用于治疗或抑制HCV感染的药物及其制备方法。

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