专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明公开

EP1012172A4 ACYLATED PEPTIDE CYTOLYTIC PEPTIDE INHIBITORS 失效
标题翻译： ACYLIERTE PEPTIDE ALS INHIBITORENFÜRCYTOLYTISCHE PEPTIDE
公开(公告)号：EP1012172A4
公开(公告)日：2000-06-28
申请号：EP97934376
申请日：1997-08-13
申请人： COMMW SCIENT IND RES ORG , BIOMOLECULAR RESEARCH INST , CURTAIN CYRIL CURTIS , MATTHEWS BARRY ROSS , BAELL JONATHAN BAYLDON
发明人： CURTAIN CYRIL CURTIS , MATTHEWS BARRY ROSS , BAELL JONATHAN BAYLDON , RIVETT DONALD EDWARD , HEWISH DEAN RAYMOND , WERKMEISTER JEROME
IPC分类号： A61K38/00 , A61P7/00 , A61P43/00 , C07K5/065 , C07K5/078 , C07K5/087 , C07K5/093 , C07K7/06 , A61K38/04 , C07K5/068 , C07K5/08 , C07K5/097
CPC分类号： C07K7/06 , C07K5/0812 , C07K5/0819

2. 发明公开

EP1012172A1 ACYLATED PEPTIDE CYTOLYTIC PEPTIDE INHIBITORS 失效
标题翻译：酰化肽抑制剂用于细胞毒性肽
公开(公告)号：EP1012172A1
公开(公告)日：2000-06-28
申请号：EP97934376.1
申请日：1997-08-13
申请人： COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION , BIOMOLECULAR RESEARCH INSTITUTE , Curtain, Cyril Curtis , Matthews, Barry Ross , Baell, Jonathan Bayldon
发明人： CURTAIN, Cyril, Curtis , MATTHEWS, Barry, Ross , BAELL, Jonathan, Bayldon , RIVETT, Donald, Edward , HEWISH, Dean, Raymond , WERKMEISTER, Jerome
IPC分类号： C07K7/06 , C07K5/087 , C07K5/068 , C07K5/097 , C07K5/065 , C07K5/08 , A61K38/04
CPC分类号： C07K7/06 , C07K5/0812 , C07K5/0819
摘要： The present invention relates to hybrid molecules and novel peptides which inhibit cytolytic compounds such as melittin. The invention also relates to pharmaceutical compositions including these inhibitors and to methods of inhibiting cytolytic compounds.

3. 发明申请

WO2008061208A2 ARYLSULFONAMIDE COMPOUNDS 审中-公开
标题翻译：芳基磺酰胺化合物
公开(公告)号：WO2008061208A2
公开(公告)日：2008-05-22
申请号：PCT/US2007/084873
申请日：2007-11-15
申请人： GENENTECH, INC. , WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH , BAELL, Jonathan Bayldon , LESSENE, Guillaume Laurent , SLEEBS, Brad Edmund , FAIRBROTHER, Wayne J. , FLYGARE, John A. , KOEHLER, Michael F. T.
发明人： BAELL, Jonathan Bayldon , LESSENE, Guillaume Laurent , SLEEBS, Brad Edmund , FAIRBROTHER, Wayne J. , FLYGARE, John A. , KOEHLER, Michael F. T.
IPC分类号： C07D239/94 , A61K31/517 , A61P43/00
CPC分类号： C07D239/94
摘要： The invention relates generally to small molecules that mimic the biological activity of certain peptides and proteins, to compositions containing them and to their use. In particular, the invention relates to compounds of the general formula (I) that mimic the biological activity of BH3-only proteins and are capable of binding to and neutralising prosurvival Bcl-2 proteins: wherein A 1 , A 2 , B 1, B 2 , B 3 , X, Z, R 1 , R 2 , R 3 and t are as described herein. The invention also relates to processes of preparing the benzenesulfonamide compounds that mimic portions of peptides and proteins, and to the use of such compounds in the regulation of cell death and the treatment and/or prophylaxis of diseases or conditions associated with the deregulation of cell death.
摘要翻译：本发明一般涉及模拟某些肽和蛋白质的生物活性的小分子，含有它们的组合物及其用途。具体而言，本发明涉及模拟仅BH3蛋白的生物学活性并能够结合并中和促存活Bcl-2蛋白的通式（I）的化合物：其中A 1， A 2，B 1，B 2，B 3，X，Z，R 1，B 1，B 2，B 3， R 2，R 3和t如本文所述。本发明还涉及制备模拟肽和蛋白质部分的苯磺酰胺化合物的方法，并涉及这些化合物在调节细胞死亡以及治疗和/或预防与细胞死亡失调相关的疾病或病症中的用途

4. 发明申请

WO2012131297A1 PYRIDO [3',2' :4,5] THIENO [3, 2-D] PYRIMIDIN- 4 - YLAMINE DERIVATIVES AND THEIR THERAPEUTICAL USE 审中-公开
标题翻译：吡咯并[3'，2'：4,5]噻吩并[3,2-D]嘧啶-4-基氨基衍生物及其治疗用途
公开(公告)号：WO2012131297A1
公开(公告)日：2012-10-04
申请号：PCT/GB2012/000280
申请日：2012-03-27
申请人： BAELL, Jonathan Bayldon , STREET, Ian Philip , SLEEBS, Brad Edmund
发明人： BAELL, Jonathan Bayldon , STREET, Ian Philip , SLEEBS, Brad Edmund
IPC分类号： C07D495/04 , A61K31/519 , A61P25/00 , A61P35/00 , A61P29/00 , A61P3/00
CPC分类号： C07D495/04
摘要： The present invention pertains generally to the field of therapeutic compounds, and more specifically to certain fused triaryl amine compounds of the following formula (for convenience, collectively referred to herein as "FTA compounds"), which, inter alia , inhibit LIM kinase (LIMK) activity. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit LIMK activity, and in the treatment of diseases and conditions that are mediated by LIMK, that are ameliorated by the inhibition of LIMK activity, etc., including proliferative conditions such as cancer (e.g., breast cancer, prostate cancer, melanoma, glioma, etc.), as well as vasodilation (including, e.g., hypertension, angina, cerebral vasospasm, and ischemia following subarachnoid hemorrhage), neurodegenerative disorders, atherosclerosis, fibrosis, and inflammatory diseases (including, e.g., Crohn's disease and chronic obstructive pulmonary disease (COPD)), and glaucoma (also known as ocular hypertension).
摘要翻译：本发明一般涉及治疗化合物领域，更具体地涉及以下式的某些稠合三芳基胺化合物（为了方便起见，本文统称为“FTA化合物”），其特别地抑制LIM激酶（LIMK ）活动。本发明还涉及包含这些化合物的药物组合物，以及这些化合物和组合物在体外和体内的用途，以抑制LIMK活性，以及治疗由LIMK介导的疾病和病症，其被改善通过抑制LIMK活性等，包括增殖条件如癌症（例如乳腺癌，前列腺癌，黑素瘤，神经胶质瘤等），以及血管舒张（包括例如高血压，心绞痛，脑血管痉挛和蛛网膜下腔出血后的缺血），神经变性疾病，动脉粥样硬化，纤维化和炎性疾病（包括例如克罗恩病和慢性阻塞性肺病（COPD））和青光眼（也称为高眼压症）。

5. 发明申请

WO2009039553A1 BENZOTHIAZOLE COMPOUNDS 审中-公开
标题翻译：苯并噻唑化合物
公开(公告)号：WO2009039553A1
公开(公告)日：2009-04-02
申请号：PCT/AU2007/001442
申请日：2007-09-27
申请人： THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH , WATSON, Keith Geoffrey , LESSENE, Guillaume Laurent , BAELL, Jonathan Bayldon , HUANG, David Ching Siang , STREET, Ian Philip , ADAMS, Jerry McKee , COLMAN, Peter Malcolm , SLEEBS, Brad Edmund , SMITH, Brian John , CZABOTAR, Peter Edward
发明人： WATSON, Keith Geoffrey , LESSENE, Guillaume Laurent , BAELL, Jonathan Bayldon , HUANG, David Ching Siang , STREET, Ian Philip , ADAMS, Jerry McKee , COLMAN, Peter Malcolm , SLEEBS, Brad Edmund , SMITH, Brian John , CZABOTAR, Peter Edward
IPC分类号： C07D277/82 , C07D417/12 , C07D417/14 , A61P19/02 , A61P35/02 , A61K31/428 , A61P29/00 , A61P37/06
CPC分类号： C07D417/12 , C07D277/82 , C07D417/14
摘要： The present invention relates to benzothiazole compounds that mimic the activity of BH3 only proteins and are capable of binding to and neutralizing pro survival Bcl 2 proteins. The invention also relates to the use of such compounds in the regulation of cell death or cell survival and the treatment and/or prophylaxis of diseases or conditions associated with the deregulation of cell death or cell survival.
摘要翻译：本发明涉及苯并噻唑化合物，其类似于仅BH3蛋白的活性并且能够结合和中和生存的Bcl 2蛋白。本发明还涉及这些化合物在调节细胞死亡或细胞存活以及治疗和/或预防与细胞死亡或细胞存活失调相关的疾病或病症中的用途。

6. 发明申请

WO2009149508A1 NOVEL POTASSIUM CHANNEL BLOCKERS AND USES THEREOF 审中-公开
标题翻译：新型钾通道阻塞器及其用途
公开(公告)号：WO2009149508A1
公开(公告)日：2009-12-17
申请号：PCT/AU2009/000739
申请日：2009-06-12
申请人： BIONOMICS LIMITED , HARVEY, Andrew John , FLYNN, Bernard Luke , MOULD, Jorgen Alvar , PAUL, Dharam , GILL, Gurmit Singh , RIPPER, Justin Anthony , COOKE, Rachel Christine , CROSSMAN, Julia Stephanie , BAELL, Jonathan Bayldon , KUCHEL, Nathan Wayne , SINGH, Rajinder
发明人： HARVEY, Andrew John , FLYNN, Bernard Luke , MOULD, Jorgen Alvar , PAUL, Dharam , GILL, Gurmit Singh , RIPPER, Justin Anthony , COOKE, Rachel Christine , CROSSMAN, Julia Stephanie , BAELL, Jonathan Bayldon , KUCHEL, Nathan Wayne , SINGH, Rajinder
IPC分类号： C07D263/54 , A61K31/423 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/5377 , A61K31/541 , A61P29/00 , A61P37/00 , A61P37/06 , C07D263/56 , C07D413/12
CPC分类号： C07D263/56 , C07D413/12
摘要： The present invention relates to compounds useful in the modulation of potassium channel activity in cells, in particular the activity of Kv1.3 channels found in T cells. The invention also relates to the use of these compounds in the treatment or prevention of autoimmune and inflammatory diseases, including multiple sclerosis, pharmaceutical compositions containing these compounds and methods for their preparation.
摘要翻译：本发明涉及可用于调节细胞中钾通道活性的化合物，特别是在T细胞中发现的Kv1.3通道的活性。本发明还涉及这些化合物在治疗或预防自身免疫性和炎性疾病，包括多发性硬化症中的用途，含有这些化合物的药物组合物及其制备方法。

7. 发明申请

WO2008061208A3 ARYLSULFONAMIDE COMPOUNDS 审中-公开
标题翻译：芳香酰胺化合物
公开(公告)号：WO2008061208A3
公开(公告)日：2008-07-03
申请号：PCT/US2007084873
申请日：2007-11-15
申请人： GENENTECH INC , INST MEDICAL W & E HALL , BAELL JONATHAN BAYLDON , LESSENE GUILLAUME LAURENT , SLEEBS BRAD EDMUND , FAIRBROTHER WAYNE J , FLYGARE JOHN A , KOEHLER MICHAEL F T
发明人： BAELL JONATHAN BAYLDON , LESSENE GUILLAUME LAURENT , SLEEBS BRAD EDMUND , FAIRBROTHER WAYNE J , FLYGARE JOHN A , KOEHLER MICHAEL F T
IPC分类号： C07D239/94 , A61K31/517 , A61P43/00
CPC分类号： C07D239/94
摘要： The invention relates generally to small molecules that mimic the biological activity of certain peptides and proteins, to compositions containing them and to their use. In particular, the invention relates to compounds of the general formula (I) that mimic the biological activity of BH3-only proteins and are capable of binding to and neutralising prosurvival Bcl-2 proteins: wherein A 1 , A 2 , B 1, B 2 , B 3 , X, Z, R 1 , R 2 , R 3 and t are as described herein. The invention also relates to processes of preparing the benzenesulfonamide compounds that mimic portions of peptides and proteins, and to the use of such compounds in the regulation of cell death and the treatment and/or prophylaxis of diseases or conditions associated with the deregulation of cell death.
摘要翻译：本发明一般涉及模拟某些肽和蛋白质的生物学活性的小分子，含有它们的组合物及其用途。特别地，本发明涉及模拟仅含BH3蛋白的生物学活性的通式（I）的化合物，并且能够结合并中和前病毒Bcl-2蛋白：其中A 1， B 1，B 2，B 3，X 3，Z 1，R 2， R 2，R 3和R 3如本文所述。本发明还涉及制备模仿肽和蛋白质的一部分的苯磺酰胺化合物的方法，以及这些化合物在调节细胞死亡中的用途以及治疗和/或预防与细胞死亡调节相关的疾病或病症。

8. 发明申请

WO2012003544A1 PROTEIN KINASE INHIBITORS AND METHODS OF TREATMENT 审中-公开
标题翻译：蛋白激酶抑制剂和治疗方法
公开(公告)号：WO2012003544A1
公开(公告)日：2012-01-12
申请号：PCT/AU2011/000858
申请日：2011-07-08
申请人： THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH , LUDWIG INSTITUTE FOR CANCER RESEARCH LIMITED , LESSENE, Guillaume Laurent , BAELL, Jonathan Bayldon , BURGESS, Antony Wilks , MARUTA, Hiroshi
发明人： LESSENE, Guillaume Laurent , BAELL, Jonathan Bayldon , BURGESS, Antony Wilks , MARUTA, Hiroshi
IPC分类号： C07D487/04 , A61K31/519 , A61P29/00 , A61P19/02 , A61P35/00 , A61P35/02 , C07D231/38
CPC分类号： C07D487/04 , A61K31/519
摘要： The present invention relates to chemical compounds of formula (I) and methods for their use and preparation. In particular, the invention relates to substituted pyrazolo[3,4-d]pyrimidine based compounds which can be used in treating proliferative disorders, use of these compounds in methods of therapy and the manufacture of medicaments as well as compositions containing these compounds.
摘要翻译：本发明涉及式（I）的化合物及其使用和制备方法。特别地，本发明涉及可用于治疗增殖性疾病的取代的吡唑并[3,4-d]嘧啶基化合物，在治疗方法和制备药物中使用这些化合物以及含有这些化合物的组合物。

9. 发明申请

WO2009043117A1 NOVEL ARYL POTASSIUM CHANNEL BLOCKERS AND USES THEREOF 审中-公开
标题翻译：新ARYL钾通道阻塞器及其用途
公开(公告)号：WO2009043117A1
公开(公告)日：2009-04-09
申请号：PCT/AU2008/001480
申请日：2008-10-03
申请人： BIONOMICS LIMITED , FLYNN, Bernard, Luke , BAELL, Jonathan, Bayldon , CHAPLIN, Jason, Hugh , GILL, Gurmit, Singh , GROBELNY, Damian, Wojciech , HARVEY, Andrew, John , MOULD, Jorgen, Alvar , PAUL, Dharam
发明人： FLYNN, Bernard, Luke , BAELL, Jonathan, Bayldon , CHAPLIN, Jason, Hugh , GILL, Gurmit, Singh , GROBELNY, Damian, Wojciech , HARVEY, Andrew, John , MOULD, Jorgen, Alvar , PAUL, Dharam
IPC分类号： C07C217/52 , A61K31/4965 , C07D211/38 , A61K31/397 , A61K31/5375 , C07D211/46 , A61K31/40 , A61K31/54 , C07D213/30 , A61K31/415 , A61P37/06 , C07D233/60 , A61K31/4196 , C07C211/27 , C07D241/18 , A61K31/4402 , C07D205/08 , C07D249/08 , A61K31/4453 , C07D207/10 , C07D265/30 , A61K31/45 , C07D211/74 , C07D279/12 , C07D295/088
CPC分类号： C07C217/22 , C07C49/84 , C07C2601/08 , C07D205/04 , C07D205/08 , C07D207/10 , C07D211/38 , C07D211/46 , C07D211/74 , C07D213/30 , C07D233/60 , C07D241/18 , C07D249/08 , C07D265/30 , C07D295/088
摘要： The present invention relates to compounds useful in the modulation of potassium channel activity in cells, in particular the activity of Kv1.3 channels found in T cells. The invention also relates to the use of these compounds in the treatment or prevention of autoimmune and inflammatory diseases, including multiple sclerosis, pharmaceutical compositions containing these compounds and methods for their preparation.
摘要翻译：本发明涉及可用于调节细胞中钾通道活性的化合物，特别是在T细胞中发现的Kv1.3通道的活性。本发明还涉及这些化合物在治疗或预防自身免疫性和炎性疾病，包括多发性硬化症中的用途，含有这些化合物的药物组合物及其制备方法。

10. 发明申请

WO2008046135A1 NOVEL ANXIOLYTIC COMPOUNDS 审中-公开
标题翻译：新型防腐化合物
公开(公告)号：WO2008046135A1
公开(公告)日：2008-04-24
申请号：PCT/AU2007/001566
申请日：2007-10-16
申请人： BIONOMICS LIMITED , BAELL, Jonathan Bayldon , SLEEBS, Brad , FLYNN, Bernard Luke , STREET, Ian Phillip , QUAZI, Nurul , BUI, Chinh Thien
发明人： BAELL, Jonathan Bayldon , SLEEBS, Brad , FLYNN, Bernard Luke , STREET, Ian Phillip , QUAZI, Nurul , BUI, Chinh Thien
IPC分类号： C07D471/04 , A61K31/5025 , A61P25/22 , A61K31/4375 , A61K31/519 , C07D471/12 , A61K31/4985 , A61P25/00
CPC分类号： C07D471/04 , A61K45/06
摘要： The present invention relates to chemical compounds of general formula (I) which may possess useful therapeutic activity in a range of central nervous system disorders, and in particular, anxiety disorders.
摘要翻译：本发明涉及通式（I）的化合物，其可以在一系列中枢神经系统疾病，特别是焦虑症中具有有用的治疗活性。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式