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1. 发明申请

WO2006015038A8 SYSTEM AND METHOD FOR COLLECTING, STORING, PROCESSING, TRANSMITTING AND PRESENTING VERY LOW AMPLITUDE SIGNALS 审中-公开
标题翻译：收集，存储，处理，传输和呈现非常低的幅度信号的系统和方法
公开(公告)号：WO2006015038A8
公开(公告)日：2007-05-24
申请号：PCT/US2005026629
申请日：2005-07-27
申请人： NATIVIS INC , BUTTERS JOHN T , BUTTERS BENNETT M , NAUGHTON PATRICK , PUCKETTE MILLER
发明人： BUTTERS JOHN T , BUTTERS BENNETT M , NAUGHTON PATRICK , PUCKETTE MILLER
IPC分类号： G01R19/18
CPC分类号： G01N37/005 , G01F1/56 , G01F1/66
摘要： Methods and apparatus inject noise into a substance, detect the combination of the noise and the signal emitted by the substance, adjust the noise until the combination signal takes on the characteristic of the signal generated by the substance through stochastic resonance, and apply such characteristic signals to responsive chemical, biochemical, or biological systems. The generated signal may be stored, manipulated, and/or transmitted to a remote receiver.
摘要翻译：方法和装置将噪声注入物质中，检测噪声与物质发出的信号的组合，调整噪声，直到组合信号通过随机共振获得由物质产生的信号的特性，并应用这些特征信号反应化学，生物化学或生物系统。生成的信号可以被存储，操纵和/或发送到远程接收器。

2. 发明申请

WO2003083439A2 SYSTEM AND METHOD FOR CHARACTERIZING A SAMPLE BY LOW-FREQUENCY SPECTRA 审中-公开
标题翻译：通过低频特征表征样品的系统和方法
公开(公告)号：WO2003083439A2
公开(公告)日：2003-10-09
申请号：PCT/US2003/009544
申请日：2003-03-28
申请人： WAVBANK, INC. , BUTTERS, John, T. , BUTTERS, Bennett, M. , BUTTERS, Lisa, C.
发明人： BUTTERS, John, T. , BUTTERS, Bennett, M. , BUTTERS, Lisa, C.
IPC分类号： G01N
CPC分类号： G01N37/005
摘要： A method and apparatus for interrogating a sample that exhibits molecular rotation are disclosed. In practicing the method, the sample is placed in a container having both magnetic and electromagnetic shielding, and Gaussian noise is injected into the sample. An electromagnetic time-domain signal composed of sample source radiation superimposed on the injected Guassian noise is detected, and this signal is cross-correlated with a second time-domain signal produced by the same or similar sample, to produce a cross-correlated signal with frequency domain components. The latter is plotted in the frequency domain by a fast Fourier transform to produce a frequency domain spectrum in a frequency range within DC to 50KHz. From this spectrum, one or more low frequency signal components that are characteristic of the sample being interrogated are identified.
摘要翻译：公开了一种询问显示分子旋转的样品的方法和装置。在实施该方法时，将样品置于具有磁屏蔽和电磁屏蔽的容器中，并将高斯噪声注入样品。检测由叠加在注入的Guassian噪声上的样本源辐射组成的电磁时域信号，并且该信号与由相同或相似样本产生的第二时域信号交叉相关，以产生与频域组件。后者通过快速傅立叶变换在频域中绘制，以在DC至50KHz的频率范围内产生频域频谱。从该频谱中，识别被询问的样本的特征的一个或多个低频信号分量。

3. 发明申请

WO2011075692A1 AQUEOUS COMPOSITIONS AND METHODS 审中-公开
标题翻译：水性组合物和方法
公开(公告)号：WO2011075692A1
公开(公告)日：2011-06-23
申请号：PCT/US2010/061136
申请日：2010-12-17
申请人： NATIVIS, INC. , BUTTERS, B., Michael , BUTTERS, John, T. , BONZON, Christine , GYMNOPOULOS, Marco , CAMACHO, Mayra, Montes
发明人： BUTTERS, B., Michael , BUTTERS, John, T. , BONZON, Christine , GYMNOPOULOS, Marco , CAMACHO, Mayra, Montes
IPC分类号： G01N37/00
CPC分类号： G01N37/005
摘要： A method of forming an aqueous composition effective to produce an agent- specie effect on an agent-responssve chemical or biological system, when the composition is added to the system, ss disclosed. The composition is formed by exposing an aqueous medium to a tow-frequency, time-domain signal derived from the agent, until the aqueous medium acquires a detectable agent activity. Exemplary compositions are formed by exposure to a paclitaxei signal or a signal derived from a therapeutic oligonucleotide, such as GAPDH antisense RNA and PCSK9 antisense RNA Also disclosed are methods for confirming the activity of the composition, and for preparing and testing the activity of the compositions
摘要翻译：公开了一种形成水性组合物的方法，该组合物在将组合物加入到体系中时有效地对药剂 - 反应化学或生物系统产生药剂特异性效应。组合物通过将水性介质暴露于衍生自试剂的拖曳频率的时域信号形成，直到水性介质获得可检测的活性。通过暴露于紫杉醇信号或衍生自治疗性寡核苷酸（例如GAPDH反义RNA和PCSK9反义RNA）的信号形成示例性组合物。还公开了确认组合物的活性以及用于制备和测试组合物的活性的方法

4. 发明申请

WO2008063654A3 APPARATUS AND METHOD FOR TRANSDUCING AN IN VITRO OR MAMMALIAN SYSTEM WITH A LOW-FREQUENCY SIGNAL 审中-公开
标题翻译：用低频信号传送体外或哺乳动物系统的装置和方法
公开(公告)号：WO2008063654A3
公开(公告)日：2008-07-17
申请号：PCT/US2007024307
申请日：2007-11-20
申请人： NATIVIS INC , ATWOOD CHRISTOPHER G , BUTTERS BENNETT MICHAEL , BUTTERS JOHN T , MARFATIA SHIRIN M , VOGELI GABRIEL
发明人： ATWOOD CHRISTOPHER G , BUTTERS BENNETT MICHAEL , BUTTERS JOHN T , MARFATIA SHIRIN M , VOGELI GABRIEL
IPC分类号： G01N37/00
CPC分类号： G01N37/005
摘要： Method and apparatus for generating and selecting low-frequency time-domain signals capable of transducing a mammalian system, to produce an agent-specific effect on the system, are disclosed. Low-frequency time-domain signals are generated in the presence of an injected magnetic stimulus, and the resulting signals are selected by a scoring algorithm, and optionally, by testing each signal identified by the scoring algorithm for its ability to produce an agent-specific response in a in vitro system containing components that are responsive to the agent. The selected signals are used to transduce the mammalian system by applying the signals to an electromagnetic transduction coil that holds the sample.
摘要翻译：公开了用于产生和选择能够转导哺乳动物系统的低频时域信号以在系统上产生试剂特异性效应的方法和设备。在存在注入磁刺激的情况下生成低频时域信号，并且通过评分算法来选择所得信号，并且可选地，通过测试由评分算法所识别的每个信号其产生试剂特异性的能力在含有对药剂有响应的组分的体外系统中的应答。所选信号用于通过将信号施加到保持样品的电磁转换线圈来转换哺乳动物系统。

5. 发明申请

WO2006015038A2 SYSTEM AND METHOD FOR COLLECTING, STORING, PROCESSING, TRANSMITTING AND PRESENTING VERY LOW AMPLITUDE SIGNALS 审中-公开
标题翻译：收集，存储，处理，传输和呈现非常低的幅度信号的系统和方法
公开(公告)号：WO2006015038A2
公开(公告)日：2006-02-09
申请号：PCT/US2005/026629
申请日：2005-07-27
申请人： WAVBANK, INC. , BUTTERS, John, T. , BUTTERS, Bennett, M. , NAUGHTON, Patrick , PUCKETTE, Miller
发明人： BUTTERS, John, T. , BUTTERS, Bennett, M. , NAUGHTON, Patrick , PUCKETTE, Miller
IPC分类号： G01R19/18
CPC分类号： G01N37/005 , G01F1/56 , G01F1/66
摘要： Methods and apparatus inject noise into a substance, detect the combination of the noise and the signal emitted by the substance, adjust the noise until the combination signal takes on the characteristic of the signal generated by the substance through stochastic resonance, and apply such characteristic signals to responsive chemical, biochemical, or biological systems. The generated signal may be stored, manipulated, and/or transmitted to a remote receiver.
摘要翻译：方法和装置将噪声注入物质中，检测噪声与物质发出的信号的组合，调整噪声，直到组合信号通过随机共振获得由物质产生的信号的特性，并应用这些特征信号反应化学，生物化学或生物系统。生成的信号可以被存储，操纵和/或发送到远程接收器。

6. 发明申请

WO2003102566A3 SYSTEM AND METHOD FOR SAMPLE DETECTION BASED ON LOW-FREQUENCY SPECTRAL COMPONENTS 审中-公开
公开(公告)号：WO2003102566A3
公开(公告)日：2003-12-11
申请号：PCT/US2003/011834
申请日：2003-04-18
申请人： WAVBANK, INC , BUTTERS, John, T. , BUTTERS, Bennett, M. , BUTTERS, Lisa, C.
发明人： BUTTERS, John, T. , BUTTERS, Bennett, M. , BUTTERS, Lisa, C.
IPC分类号： G01N27/00
摘要： Method and apparatus for detecting a selected material in a sample are disclosed. In the method, the sample (842) is placed adjacent a detector coil (846), for generating an electromagnetic time-domain signal composed of sample source radiation. The signal is first conditioned to convert the signal to an amplified conditioned signal from which frequency components above a selected frequency have been removed, then filtered to selectively pass low-frequency spectral components that are (i) in a frequency range between dc and 50KHz, and (ii) characteristic of the selected material. The filtered signal is cross-correlated with a data set of low-frequency spectral components that are (i) in a frequency range between dc and 50KHz, and (ii) characteristic of a selected material, to produce a frequency-domain spectrum in the frequency range within DC to 50KHz. This spectrum is then used to determine whether the frequency-domain spectrum contains one or more low-frequency signal components that are characteristic of the selected material, and diagnostic of the presence or absence of such material in the sample.

7. 发明申请

WO2003083439A3 SYSTEM AND METHOD FOR CHARACTERIZING A SAMPLE BY LOW-FREQUENCY SPECTRA 审中-公开
公开(公告)号：WO2003083439A3
公开(公告)日：2003-10-09
申请号：PCT/US2003/009544
申请日：2003-03-28
申请人： WAVBANK, INC. , BUTTERS, John, T. , BUTTERS, Bennett, M. , BUTTERS, Lisa, C.
发明人： BUTTERS, John, T. , BUTTERS, Bennett, M. , BUTTERS, Lisa, C.
IPC分类号： G01R33/02
摘要： The method and an apparatus are included for interrogating a sample (200) that exhibits molecular rotation. The sample is placed in a container (50) having both magnetic and electromagnetic shielding, and Gaussian noise is injected into the sample. An electromagnetic time-domain noise composed of sample source radiation superimposed on the injected noise is detected. This signal is cross-correlated with a second time-domain signal that produced by same sample for a cross-correlated signal with frequency domain components. The signal is plotted by a fast Fourier transform “fft” to produce a frequency domain spectrum on in frequency range within DC to 50KHZ. From this spectrum, one or more low frequency signal components that are characteristic of the sample being interrogated are identified.

8. 发明申请

WO2008063654A2 APPARATUS AND METHOD FOR TRANSDUCING AN IN VITRO OR MAMMALIAN SYSTEM WITH A LOW-FREQUENCY SIGNAL 审中-公开
标题翻译：用低频信号传输体外或马马里兰系统的装置和方法
公开(公告)号：WO2008063654A2
公开(公告)日：2008-05-29
申请号：PCT/US2007/024307
申请日：2007-11-20
申请人： NATIVIS, INC. , ATWOOD, Christopher, G. , BUTTERS, Bennett, Michael , BUTTERS, John, T. , MARFATIA, Shirin, M. , VOGELI, Gabriel
发明人： ATWOOD, Christopher, G. , BUTTERS, Bennett, Michael , BUTTERS, John, T. , MARFATIA, Shirin, M. , VOGELI, Gabriel
IPC分类号： G01N37/00
CPC分类号： G01N37/005
摘要： Method and apparatus for generating and selecting low-frequency time-domain signals capable of transducing a mammalian system, to produce an agent-specific effect on the system, are disclosed. Low-frequency time-domain signals are generated in the presence of an injected magnetic stimulus, and the resulting signals are selected by a scoring algorithm, and optionally, by testing each signal identified by the scoring algorithm for its ability to produce an agent-specific response in a in vitro system containing components that are responsive to the agent. The selected signals are used to transduce the mammalian system by applying the signals to an electromagnetic transduction coil that holds the sample.
摘要翻译：公开了用于产生和选择能够转导哺乳动物系统的低频时域信号以产生对系统的特定于特定效果的方法和装置。在存在注入的磁刺激的情况下产生低频时域信号，并且通过评分算法选择所得到的信号，并且可选地，通过测试由评分算法识别的每个信号的能力，以产生代理特定在体外系统中的响应包含响应于该药剂的组分。所选择的信号用于通过将信号施加到保持样品的电磁换能线圈来转导哺乳动物系统。

9. 发明申请

WO2003102566A2 SYSTEM AND METHOD FOR SAMPLE DETECTION BASED ON LOW-FREQUENCY SPECTRAL COMPONENTS 审中-公开
标题翻译：基于低频光谱分量的样本检测系统和方法
公开(公告)号：WO2003102566A2
公开(公告)日：2003-12-11
申请号：PCT/US2003/011834
申请日：2003-04-18
申请人： WAVBANK, INC , BUTTERS, John, T. , BUTTERS, Bennett, M. , BUTTERS, Lisa, C.
发明人： BUTTERS, John, T. , BUTTERS, Bennett, M. , BUTTERS, Lisa, C.
IPC分类号： G01N27/00
CPC分类号： G01N37/005 , H01Q1/22 , H01Q7/08
摘要： Method and apparatus for detecting a selected material in a sample are disclosed. In the method, the sample (842) is placed adjacent a detector coil (846), for generating an electromagnetic time-domain signal composed of sample source radiation. The signal is first conditioned to convert the signal to an amplified conditioned signal from which frequency components above a selected frequency have been removed, then filtered to selectively pass low-frequency spectral components that are (i) in a frequency range between dc and 50KHz, and (ii) characteristic of the selected material. The filtered signal is cross-correlated with a data set of low-frequency spectral components that are (i) in a frequency range between dc and 50KHz, and (ii) characteristic of a selected material, to produce a frequency-domain spectrum in the frequency range within DC to 50KHz. This spectrum is then used to determine whether the frequency-domain spectrum contains one or more low-frequency signal components that are characteristic of the selected material, and diagnostic of the presence or absence of such material in the sample.
摘要翻译：公开了用于检测样品中选定材料的方法和装置。在该方法中，将样本（842）放置在检测器线圈（846）附近，以产生由样本源辐射组成的电磁时域信号。该信号首先被调节为将信号转换成已被去除频率分量高于选定频率的放大调节信号，然后滤波以选择性地传递（i）在dc和50KHz之间的频率范围内的低频频谱分量，和（ii）所选材料的特性。经滤波的信号与低频频谱分量的数据集交叉相关，其中（i）在dc和50KHz之间的频率范围内，以及（ii）所选择的材料的特性，以产生频域谱频率范围在DC到50KHz之间。然后使用该频谱来确定频域频谱是否包含作为所选材料的特征的一个或多个低频信号分量，以及在样品中是否存在这种材料的诊断。

10. 发明申请

WO2006015038A3 SYSTEM AND METHOD FOR COLLECTING, STORING, PROCESSING, TRANSMITTING AND PRESENTING VERY LOW AMPLITUDE SIGNALS 审中-公开
标题翻译：收集，存储，处理，传输和呈现非常低的幅度信号的系统和方法
公开(公告)号：WO2006015038A3
公开(公告)日：2008-10-16
申请号：PCT/US2005026629
申请日：2005-07-27
申请人： NATIVIS INC , BUTTERS JOHN T , BUTTERS BENNETT M , NAUGHTON PATRICK , PUCKETTE MILLER
发明人： BUTTERS JOHN T , BUTTERS BENNETT M , NAUGHTON PATRICK , PUCKETTE MILLER
IPC分类号： G01N1/00 , G01N31/00 , G01N33/48
CPC分类号： G01N37/005 , G01F1/56 , G01F1/66
摘要： Methods and apparatus inject noise into a substance, detect the combination of the noise and the signal emitted by the substance, adjust the noise until the combination signal takes on the characteristic of the signal generated by the substance through stochastic resonance, and apply such characteristic signals to responsive chemical, biochemical, or biological systems. The generated signal may be stored, manipulated, and/or transmitted to a remote receiver.
摘要翻译：方法和装置将噪声注入物质中，检测噪声与物质发出的信号的组合，调整噪声，直到组合信号通过随机共振获得由物质产生的信号的特性，并应用这些特征信号反应化学，生物化学或生物系统。生成的信号可以被存储，操纵和/或发送到远程接收器。

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